Exact Mass: 294.9593
Exact Mass Matches: 294.9593
Found 88 metabolites which its exact mass value is equals to given mass value 294.9593,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Chlorothiazide
Chlorothiazide is only found in individuals that have used or taken this drug. It is a thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents CONFIDENCE standard compound; EAWAG_UCHEM_ID 3256 D049990 - Membrane Transport Modulators
3-(2-Chlorophenyl)-2-(1,3-dithian-2-yliden)-3-oxopropanenitrile
3-AMINO-4-(ISOPROPYLSULFONYL)-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLIC ACID
3-[5-(4-bromophenyl)-1,2-oxazol-3-yl]propanoic acid
ethyl 6-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate
ethyl 1-(5-bromopyridin-2-yl)pyrazole-4-carboxylate
3-[5-(4-bromophenyl)-1,3-oxazol-2-yl]propanoic acid
2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE
methyl 5-chloro-7-(trifluoromethyl)thieno[3,2-b]pyridine-3-carboxylate
3-(2-BROMO-PHENYL)-ISOXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
5-(4-Bromophenyl)-2-chloropyridine-3-carboxaldehyde
N-[2-(3-BROMO-PHENYL)-ETHYL]-2,2,2-TRIFLUORO-ACETAMIDE
Methyl 5-bromo-8-methyl-4-oxo-1,4-dihydroquinoline-2-carboxylate
4-Diazo-3,4-dihydro-7-nitro-3-oxo-1-naphthalenesulfonic acid
2-BROMO-1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)-1-ETHANONE
6-Chloro-4-hydroxy-3-methoxycarbonyl-2H-thieno[2,3-e]-1,2-thiazine-1,1-dioxide
3-Quinolinecarboxylic acid, 7-bromo-3,4-dihydro-4-oxo-, ethyl ester
4-(N-Acetylacetamido)benzenesulfonate potassium salt
ETHYL5-BROMO-1-(PYRIDIN-2-YL)-1H-PYRAZOLE-4-CARBOXYLATE
Cyclopropanamine, 1-(3-iodophenyl)-, hydrochloride (1:1)Cyclopropanamine, 1-(3-iodophenyl)-, hydrochloride (1:1)
4-(4,6-DICHLORO-5-(2-CHLOROETHYL)PYRIMIDIN-2-YL)MORPHOLINE
4-ALLYL-5-(4-BROMOPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL
1-(4-bromo-2-fluorophenyl)-2,5-dimethylpyrrole-3-carbaldehyde
7-iodo-1,2,3,4-tetrahydro-isoquinoline hydrochloride
(S)-N-(1-(4-bromophenyl)ethyl)-2,2,2-trifluoroacetamide
Manganese,bis(dimethylcarbamodithioato-kS,kS)-, (T-4)- (9CI)
ETHYL 6-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
(1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol
Methyl 4-chloro-2-(trifluoromethyl)thieno[3,4-b]pyridine-7-carboxylate
5-(5,6-dichloro-1H-indol-2-yl)furan-2-carboxylic acid
ETHYL 7-BROMO-2-OXO-1,2-DIHYDROQUINOLINE-4-CARBOXYLATE
1-(4-BROMOBENZYL)-5-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC ACID
8-nitronaphth[1,2-d][1,2,3]oxadiazole-5-sulphonic acid
5-[(2-chlorophenyl)methyl]thieno[3,2-c]pyridin-5-ium,chloride
5-(3-BROMO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
ETHYL 7-BROMO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE
3-[1-(3,5-Dichlorophenyl)-5-tetrazolyl]-5-methylisoxazole
chlorothiazide
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D049990 - Membrane Transport Modulators
