Exact Mass: 244.0075292

KEIO_ID D101

Fucose 1-phosphate

{[(2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}phosphonic acid

Fucose 1-phosphate (CAS: 16562-58-6) belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphate group linked to the carbohydrate unit. Fucose 1-phosphate is an intermediate in the reversible synthesis of GDP-L-fucose catalyzed by the enzyme guanosine triphosphate fucose pyrophosphorylase (GFPP, EC 2.7.7.30). The reversible reaction is magnesium-dependent, although the enzyme is partially active when cobalt or manganese is substituted. The reaction is unusual in that, of the four canonical nucleoside triphosphates, only guanosine can be utilized efficiently to form a nucleotide-sugar. Free cytosolic fucose is phosphorylated by L-fucokinase (EC 2.7.1.52) to form fucose-1-phosphate in the salvage pathway of GDP-L-fucose (PMID: 16185085, 14686921). Fucose-1-phosphate is an intermediate in the reversible synthesis of GDP-L-fucose, in a reaction catalyzed by the enzyme guanosine triphosphate fucose pyrophosphorylase (GFPP, E.C. 2.7.7.30) . The reversible reaction is magnesium-dependent, although the enzyme is partially active when cobalt or manganese is substituted. The reaction is unusual in that, of the four canonical nucleoside triphosphates, only guanosine can be utilized efficiently to form a nucleotide-sugar. Free cytosolic fucose is phosphorylated by L-fucokinase (EC 2.7.1.52) to form fucose-1-phosphate in the salvage pathway of GDP-L-fucose. (PMID: 16185085, 14686921) [HMDB]

L-Fuculose 1-phosphate

C9H10Cl2N4 (244.02824800000002)

Apraclonidine

2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine

Apraclonidine is only found in individuals that have used or taken this drug.Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy.Apraclonidine is a relatively selective alpha2 adrenergic receptor agonist that stimulates alpha1 receptors to a lesser extent. It has a peak ocular hypotensive effect occurring at two hours post-dosing. The exact mechanism of action is unknown, but fluorophotometric studies in animals and humans suggest that Apraclonidine has a dual mechanism of action by reducing aqueous humor production through the constriction of afferent ciliary process vessels, and increasing uveoscleral outflow. S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EA - Sympathomimetics in glaucoma therapy C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists

Gentisein

1,3,7-Trihydroxy-9H-xanthen-9-one, 9CI

Gentisein is a member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 7. It has a role as a plant metabolite. It is a member of xanthones and a polyphenol. Gentisein is a natural product found in Hypericum scabrum, Cratoxylum formosum, and other organisms with data available. A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 7. Gentisein is found in alcoholic beverages. Gentisein is isolated from Gentiana lutea (yellow gentian Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 μM[1][2]. Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 μM[1][2]. Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 μM[1][2].

Mesuaxanthone B

1,5,6-Trihydroxyxanthone

A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 5 and 6.

1,3,5-Trihydroxyxanthone

C9H12N2O4S (244.05177519999998)

A member of the class of xanthones that is xanthone substituted by hydroxy groups at positions 1, 3 and 5. It has been isolated from Anaxagorea luzonensis.

Penicillenic acid

3-Mercapto-N-[(5-oxo-4(5H)-oxazolylidene)methyl]-valine

Cgp 52608

1-methyl-3-[(Z)-(4-oxo-3-prop-2-enyl-1,3-thiazolidin-2-ylidene)amino]thiourea

C8H12N4OS2 (244.04525019999997)

ZINC lactate

DTXSID70908362

C6H12O6Zn (243.9925302)

MCPA-thioethyl

2-(4-chloro-2-methylphenoxy)-1-(ethylsulfanyl)ethan-1-one

C11H13ClO2S (244.03247480000002)

6-Sulfoquinovose

Sulfoquinovose; 6-Deoxy-6-sulfo-D-glucopyranose; 6-Deoxy-6-sulfo-D-glucose

C6H12O8S (244.0252872)

6-Deoxy-6-sulfo-D-fructose

6-deoxy-6-sulfo-D-fructofuranose

C6H12O8S (244.0252872)

Plutonium

Pu (244)

L-Rhamnulose 1-phosphate

A deoxyketohexose phosphate consisting of L-rhamnulose having a monophosphate group at the 1-position.

Urolithin C

3,8,9-trihydroxy-6H-benzo[c]chromen-6-one

Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation[1][2].

urolithin M7

Urolithin M-7

p-Coumaric acid sulfate

(2E)-3-[4-(Sulphooxy)phenyl]prop-2-enoic acid

p-Coumaric acid sulfate (CAS: 376374-66-2) is an endogenous phenolic acid metabolite. p-Coumaric acid sulfate was found to be elevated in rat urine after whole rye consumption which makes this compound a potential urinary biomarker of whole grain intake (PMID: 26862900). BioTransformer predicts that p-coumaric acid sulfate is a product of p-coumaric acid metabolism via a 4-O-sulfation-of-phenolic-compound reaction catalyzed by sulfotransferase 1A3 (P0DMM9) and sulfotransferase enzymes (PMID: 30612223).

Urolithin C

3,8,9-trihydroxy-6H-benzo[c]chromen-6-one

C10H12O5S (244.04054219999998)

A polyphenol metabolite detected in biological fluids [PhenolExplorer] Urolithin C is a biomarker of nut consumption in urine. Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation[1][2].

4-phenylbutanic acid-O-sulphate

4-Phenylbutanic acid-O-sulphuric acid

4-phenylbutanic acid-O-sulphate is a conjugate of 4-phenylbutanic acid and sulphate. 4-phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation. (CHEBI:41500)

(2E)-3-[3-(sulfooxy)phenyl]prop-2-enoic acid

(2E)-3-[3-(Sulphooxy)phenyl]prop-2-enoic acid

(2e)-3-[3-(sulfooxy)phenyl]prop-2-enoic acid is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of (2e)-3-(3-hydroxyphenyl)prop-2-enoic acid. It is generated by Sulfotransferase 1A3 (P0DMM9) and Sulfotransferase enzymes via a -3-O-sulfation-of-phenolic-compound reaction. This -3-O-sulfation-of-phenolic-compound occurs in humans.

O-Coumaric acid sulfate

3-[2-(Sulphooxy)phenyl]prop-2-enoic acid

cis-p-Coumaric acid sulfate

(2Z)-3-[4-(Sulphooxy)phenyl]prop-2-enoic acid

1,4-Diacetoxy-2,3-dicyanobenzene

4-(acetyloxy)-2,3-dicyanophenyl acetate

C12H8N2O4 (244.0484048)

2-Deoxy-D-glucopyranose 6-phosphate

(3,4,6-Trihydroxyoxan-2-yl)methyl dihydrogen phosphate

2-Deoxy-D-arabino-hexose 6-(dihydrogen phosphate)

2-Deoxy-D-arabino-hexose 6-(dihydrogen phosphoric acid)

C11H7F3O3 (244.03472680000002)

7-Methoxy-4-(trifluoromethyl)coumarin

7-methoxy-4-(trifluoromethyl)-2H-chromen-2-one

(5R,6S)-3-(Aminomethyl)-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-(aminomethyl)-6-[(1R)-1-hydroxyethyl]-7-oxo-, (5R,6S)-

C9H12N2O4S (244.05177519999998)

3-Pyroglutamylthiazolidine-4-carboxylic acid

3-(5-Hydroxy-3,4-dihydro-2H-pyrrole-2-carbonyl)-1,3-thiazolidine-4-carboxylate

C9H12N2O4S (244.05177519999998)

D007155 - Immunologic Factors

Longissiminone B

C10H9ClO5 (244.01384939999997)

1,2,8-Trihydroxyxanthone

Zosteric acid

1,2,5-Trihydroxyxanthone