3-Pyroglutamylthiazolidine-4-carboxylic acid (BioDeep_00001878154)
代谢物信息卡片
[S-(R*,S*)]-3-[(5-Oxo-2-pyrrolidinyl)carbonyl]-4-thiazolidinecarboxylic acid
化学式: C9H12N2O4S (244.0518)
中文名称: [S-(R*,S*)]-3-[(5-氧代-2-吡咯烷基)羰基]-4-噻唑烷羧酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(=O)NC1C(=O)N2CSCC2C(=O)O
InChI: InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)
描述信息
D007155 - Immunologic Factors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Weilong Zhang, Jihan Huang, Hongxia Liu, Xin Wen, Qingshan Zheng, Lujin Li. Whether Immunostimulants Are Effective in Susceptible Children Suffering From Recurrent Respiratory Tract Infections: A Modeling Analysis Based on Literature Aggregate Data.
Journal of clinical pharmacology.
2022 02; 62(2):245-253. doi:
10.1002/jcph.1969. [PMID: 34535904] - Ashok Mahashur, Agam Vora, Pradyut Waghray, S Z Jafrey, Archana Karadkhele, Snehal Muchhala, Rahul Rathod, Viraj Suvarna. Expert Opinion on Usage of Pidotimod in Adult Patients with Chronic Obstructive Pulmonary Disease: An Indian Perspective.
The Journal of the Association of Physicians of India.
2021 Sep; 69(9):11-12. doi:
NULL. [PMID: 34585899] - Amar Nath Chatterjee, Fahad Al Basir. A Model for SARS-CoV-2 Infection with Treatment.
Computational and mathematical methods in medicine.
2020; 2020(?):1352982. doi:
10.1155/2020/1352982. [PMID: 32908574] - Francesca Santamaria, Silvia Montella, Matteo Stocchero, Paola Pirillo, Sara Bozzetto, Giuseppe Giordano, Marco Poeta, Eugenio Baraldi. Effects of pidotimod and bifidobacteria mixture on clinical symptoms and urinary metabolomic profile of children with recurrent respiratory infections: a randomized placebo-controlled trial.
Pulmonary pharmacology & therapeutics.
2019 10; 58(?):101818. doi:
10.1016/j.pupt.2019.101818. [PMID: 31302340] - Hui Niu, Rui Wang, Yu-Ting Jia, Yun Cai. Pidotimod, an immunostimulant in pediatric recurrent respiratory tract infections: A meta-analysis of randomized controlled trials.
International immunopharmacology.
2019 Feb; 67(?):35-45. doi:
10.1016/j.intimp.2018.11.043. [PMID: 30530167] - Ruili Zhang, Mei Qiu, Li Zhao, Liangliang Cui, Chunyuan Wang, Jiajia Zhu, Zhihui Hao. Pharmacokinetics of pidotimod in broiler chickens by UHPLC-MS/MS after oral and intravenous administration.
Biomedical chromatography : BMC.
2018 Mar; 32(3):. doi:
10.1002/bmc.4130. [PMID: 29105801] - Shaoqi Qu, Cunchun Dai, Mei Qiu, Ruili Zhang, Chunyuan Wang, Liangliang Cui, Zhihui Hao. Effects of pidotimod soluble powder and immune enhancement of Newcastle disease vaccine in chickens.
Immunology letters.
2017 07; 187(?):14-18. doi:
10.1016/j.imlet.2017.05.001. [PMID: 28487096] - Guangji Wang, Qian Wang, Tai Rao, Boyu Shen, Dian Kang, Yuhao Shao, Jingcheng Xiao, Huimin Chen, Yan Liang. A robust LC-MS/MS method for the determination of pidotimod in different biological matrixes and its application to in vivo and in vitro pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1023-1024(?):36-43. doi:
10.1016/j.jchromb.2016.04.047. [PMID: 27179190] - Ying Zhao, Bo Huang, Shiguang Huang, Huanqin Zheng, Yun-quan Li, Zhao-rong Lun, Jilong Shen, Yong Wang, Lloyd H Kasper, Fangli Lu. Evaluation of the adjuvant effect of pidotimod on the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models.
Parasitology research.
2013 Sep; 112(9):3151-60. doi:
10.1007/s00436-013-3491-3. [PMID: 23783399] - Ji-Han Huang, Xiao-Hui Huang, Kun Wang, Jian-Chun Li, Xue-Feng Xie, Chen-Lin Shen, Lu-Jin Li, Qing-Shan Zheng. Bioequivalence evaluation of two formulations of pidotimod using a limited sampling strategy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2013 Jul; 67(6):475-80. doi:
10.1016/j.biopha.2013.03.009. [PMID: 23639228] - G V Zuccotti, C Mameli, D Trabattoni, S Beretta, M Biasin, L Guazzarotti, M Clerici. Immunomodulating activity of Pidotimod in children with Down syndrome.
Journal of biological regulators and homeostatic agents.
2013 Jan; 27(1):253-8. doi:
NULL. [PMID: 23489705] - H-G Lou, Z-R Ruan, B Jiang. Quantitative determination of pidotimod in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study.
Arzneimittel-Forschung.
2012 Feb; 62(2):99-104. doi:
10.1055/s-0031-1297983. [PMID: 22344555] - Xiaole Qi, Lishuang Wang, Jiabi Zhu, Zhenyi Hu, Jie Zhang. Self-double-emulsifying drug delivery system (SDEDDS): a new way for oral delivery of drugs with high solubility and low permeability.
International journal of pharmaceutics.
2011 May; 409(1-2):245-51. doi:
10.1016/j.ijpharm.2011.02.047. [PMID: 21356300] - Zhili Xiong, Yi Zhang, Feng Qin, Ting Qin, Shuyan Yang, Famei Li. Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Aug; 878(23):2111-6. doi:
10.1016/j.jchromb.2010.06.024. [PMID: 20630813] - Yi Zhang, Zhili Xiong, Feng Qin, Shan Lu, Wei Liu, Famei Li. High-performance liquid chromatography-tandem mass spectrometry for the determination of pidotimod in human plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Aug; 877(24):2566-70. doi:
10.1016/j.jchromb.2009.06.038. [PMID: 19604731] - Fei Du Xiao, Cheng Zhe Jiang, Chun Fu Wu, Eun Kyung Won, Se Young Choung. Synergistic immunostimulatory effect of pidotimod and red ginseng acidic polysaccharide on humoral immunity of immunosuppressed mice.
Die Pharmazie.
2008 Dec; 63(12):904-8. doi:
NULL. [PMID: 19177908] - Xiao Fei Du, Cheng Zhe Jiang, Chun Fu Wu, Eun Kyung Won, Se Young Choung. Synergistic immunostimulating activity of pidotimod and red ginseng acidic polysaccharide against cyclophosphamide-induced immunosuppression.
Archives of pharmacal research.
2008 Sep; 31(9):1153-9. doi:
10.1007/s12272-001-1282-6. [PMID: 18806958] - G Coppi, S Silingardi. Pharmacokinetics of pidotimod in rats and dogs.
Arzneimittel-Forschung.
1994 Dec; 44(12A):1460-4. doi:
NULL. [PMID: 7857342] - F Mailland, G Coppi, S Silingardi. Pharmacokinetics and oral bioavailability of pidotimod in humans.
Arzneimittel-Forschung.
1994 Dec; 44(12A):1465-9. doi:
NULL. [PMID: 7857343] - A Chiarenza, M P Iurato, N Barbera, L Lempereur, G Cantarella, U Scapagnini, G Scapagnini, R Bernardini. Effects of pidotimod on the immune and the neuroendocrine system in the aging rat.
Arzneimittel-Forschung.
1994 Dec; 44(12A):1437-40. doi:
NULL. [PMID: 7857338] - D Spotti, M Biffi, G Coppi, S Silingardi, F Mailland. Pharmacokinetics of pidotimod in elderly volunteers and in renal failure patients.
Arzneimittel-Forschung.
1994 Dec; 44(12A):1470-2. doi:
NULL. [PMID: 7857344] - L D'Angelo, F De Ponti, F Crema, M Caravaggi, A Crema. Effect of food on the bioavailability of pidotimod in healthy volunteers.
Arzneimittel-Forschung.
1994 Dec; 44(12A):1473-5. doi:
NULL. [PMID: 7857345] - L Dal Bo, G P Broccali, S Silingardi, G Coppi. A new HPLC method for pidotimod plasma levels determination.
Bollettino chimico farmaceutico.
1993 Apr; 132(4):126-8. doi:
NULL. [PMID: 8333918] - G Coppi, M Barchielli. Simple high-performance liquid chromatographic method for the determination of PGT/1A, a new immunostimulating drug, in biological fluids.
Journal of chromatography.
1991 Feb; 563(2):385-91. doi:
10.1016/0378-4347(91)80046-f. [PMID: 2056003]
