Exact Mass: 216.1235768

Girgensonine

gamma-Glutamyl-gamma-aminobutyraldehyde

γ-Glutamyl-γ-aminobutyraldehyde

An L-glutamine derivative that is L-glutamine in which a hydrogen attached to the amide nitrogen is replaced by a 4-oxobutyl group.

N-acetylarginine

(2S)-5-carbamimidamido-2-acetamidopentanoic acid

C8H16N4O3 (216.1222346)

N-alpha-Acetyl-L-arginine, also known as N-alpha-acetylarginine, belongs to the class of organic compounds known as N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. N-Acetylarginine can also be classified as an alpha amino acid or a derivatized alpha amino acid. Technically, N-Acetylarginine is a biologically available N-terminal capped form of the proteinogenic alpha amino acid L-arginine. N-acetyl amino acids can be produced either via direct synthesis of specific N-acetyltransferases or via the proteolytic degradation of N-acetylated proteins by specific hydrolases. N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins (PMID: 16465618). About 85\\\% of all human proteins and 68\\\% of all yeast proteins are acetylated at their N-terminus (PMID: 21750686). Several proteins from prokaryotes and archaea are also modified by N-terminal acetylation. The majority of eukaryotic N-terminal-acetylation reactions occur through N-acetyltransferase enzymes or NAT‚Äôs (PMID: 30054468). These enzymes consist of three main oligomeric complexes NatA, NatB, and NatC, which are composed of at least a unique catalytic subunit and one unique ribosomal anchor. The substrate specificities of different NAT enzymes are mainly determined by the identities of the first two N-terminal residues of the target protein. The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G) (PMID: 30054468). NatA also exists in a monomeric state and can post-translationally acetylate acidic N-termini residues (D-, E-). NatB and NatC acetylate N-terminal methionine with further specificity determined by the identity of the second amino acid. N-acetylated amino acids, such as N-acetylarginine can be released by an N-acylpeptide hydrolase from peptides generated by proteolytic degradation (PMID: 16465618). In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free arginine can also occur. Many N-acetylamino acids, including N-acetylarginine are classified as uremic toxins if present in high abundance in the serum or plasma (PMID: 26317986; PMID: 20613759; PMID: 7777105). Uremic toxins are a diverse group of endogenously produced molecules that, if not properly cleared or eliminated by the kidneys, can cause kidney damage, cardiovascular disease and neurological deficits (PMID: 18287557). N-alpha-Acetyl-L-arginine serum levels (and other guanidino compounds) were elevated of all the hyperargininemic patients are higher than the normal range. Untreated hyperargininemic patients have the highest guanidino compound levels in cerebrospinal fluid. N-alpha-Acetyl-L-arginine is also increased in the urine or hyperargininemic patients. N-alpha-Acetyl-L-arginine is one of the guanidino compounds found elevated in the serum of hemodialyzed renal insufficient (uremic) pediatric patients. N-alpha-Acetylarginine is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population. (PMID 7777105) N-Acetyl-L-arginine (Ac-Arg-OH) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.

Valylvaline

(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-methylbutanoic acid

C10H20N2O3 (216.147385)

Valylvaline is a dipeptide composed of two valine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. H-VAL-VAL-OH is a dipeptide of the amino acid valine, an essential amino acid[1].

Nb-Methyltetrahydroharmol

1,2-dimethyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-7-ol

Nb-Methyltetrahydroharmol is found in fruits. Nb-Methyltetrahydroharmol is an alkaloid from Elaeagnus angustifolia (Russian olive Alkaloid from Elaeagnus angustifolia (Russian olive). Nb-Methyltetrahydroharmol is found in fruits.

Nb-Acetyl-Nb-methyltryptamine

N-[2-(1H-indol-3-yl)ethyl]-N-methylacetamide

Nb-Acetyl-Nb-methyltryptamine is found in beverages. Nb-Acetyl-Nb-methyltryptamine is an alkaloid from stems of Limonia acidissima (wood apple

Undecanedioic acid

1,9-Nonanedicarboxylic acid

Undecanedioic acid has been found in parts of human aortas with advanced atherosclerotic lesions associated with intercellular matrix macromolecules and specifically with elastin, and may be the result of an increased hydrolysis of esters and (or) a decreased esterification. (PMID:131675). Undecanedioic acid has been found (among other unusual dicarboxylic acids) in the urine from patients under hopantenate therapy during episodes of Reyes-like syndrome. (PMID:2331533). Undecanedioic acid has been found in parts of human aortas with advanced atherosclerotic lesions associated with intercellular matrix macromolecules and specifically with elastin, and may be the result of an increased hydrolysis of esters and (or) a decreased esterification. (PMID: 131675) Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin.

3-[4-Hydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propenal

(2E)-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]prop-2-enal

3-[4-Hydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propenal is found in citrus. 3-[4-Hydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propenal is produced by injured peel of grapefruit (Citrus paradisi) and orange (Citrus sinensis). Production by injured peel of grapefruit (Citrus paradisi) and orange (Citrus sinensis). 3-[4-Hydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propenal is found in citrus.

Prolyl-Threonine

3-Hydroxy-2-{[hydroxy(pyrrolidin-2-yl)methylidene]amino}butanoate

Prolyl-Threonine is a dipeptide composed of proline and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.

Threonylproline

(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carboxylic acid

Threonylproline is a dipeptide composed of threonine and proline. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.

(R)-2-Amino-N-(2,2,4,4-tetramethyl-3-thietanyl)propanamide

C10H20N2OS (216.129627)

Aqueous degradation production of Alitame KQS52-O Aqueous degradation produced of Alitame KQS52-O

Butyl butyryllactate

Butanoic acid, 2-butoxy-1-methyl-2-oxoethyl ester

Butyl butyryllactate is present in fruits of two Korean strawberry cultivars (Bogyojosaeng and suhong). Butyl butyryllactate is a flavouring ingredient. Present in fruits of two Korean strawberry cultivars (Bogyojosaeng and suhong). Flavouring ingredient.

Sakacin P

tert-butyl N-(1-carbamoyl-1-oxopropan-2-yl)carbamate

Sakacin P is found in animal foods. Sakacin P is produced by Lactobacillus sake LTH 673 isolated from fermented dry sausage. Production by Lactobacillus sake LTH 673 isolated from fermented dry sausage. Sakacin P is found in animal foods. D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D001430 - Bacteriocins

N2,N5-Diacetylornithine

(2S)-2,5-diacetamidopentanoic acid

N2,N5-Diacetylornithine, also known as bisorcic, belongs to the class of organic compounds known as N-acyl-L-alpha-amino acids. These are N-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N2,N5-Diacetylornithine is an N-acetyl-L-amino acid that is L-ornithine carrying two acetyl substituents at positions N-2 and N-5. N2,N5-Diacetylornithine was identified as one of forty plasma metabolites that could be used to predict gut microbiome Shannon diversity (PMID: 31477923). Shannon diversity is a metric that summarizes both species abundance and evenness, and it has been suggested as a marker for microbiome health. C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent

2,5-Bis(acetylamino)pentanoic acid

2,5-Bis[(1-hydroxyethylidene)amino]pentanoate

Cirazoline

2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists D019141 - Respiratory System Agents > D014663 - Nasal Decongestants D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents

Efaroxan

2-(2-ethyl-2,3-dihydro-1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists

Tetrahydroharmine

7-methoxy-1-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indole

[(2S,3R)-2-Amino-3-hydroxybutanoyl] (2S)-pyrrolidine-2-carboxylate

[(2S,3R)-2-Amino-3-hydroxybutanoyl] (2S)-pyrrolidine-2-carboxylic acid

Trimethylolmelamine

({4,6-bis[(hydroxymethyl)amino]-1,3,5-triazin-2-yl}amino)methanol

C6H12N6O3 (216.0970842)

7-Methoxy-1-methyl-4,4a,9,9a-tetrahydro-1H-pyrido[3,4-b]indole

Isoketocamphoric acid

3-(2-methyl-3-oxobutan-2-yl)pentanedioic acid

Isoketocamphoric acid, also known as isoketocamphate, is a member of the class of compounds known as medium-chain fatty acids. Medium-chain fatty acids are fatty acids with an aliphatic tail that contains between 4 and 12 carbon atoms. Isoketocamphoric acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa). Isoketocamphoric acid can be found in common sage, which makes isoketocamphoric acid a potential biomarker for the consumption of this food product.

Longiflorone

5,5a,6,7-Tetrahydro-1,5-dimethylnaphtho[2,1-b]furan-8(4H)-one

Liguhodgsonal

(R)-5,6,7,8-Tetrahydro-3-hydroxy-7-(1-methylethenyl)-1-naphthalenecarboxaldehyde

methyl azelate

Nonanedioc acid,dimethyl ester

A fatty acid methyl ester that is nonanedioic acid in which both carboxy groups are replaced by methoxycarbonyl groups.

Debromolaurinterol

[1S-(1alpha,2beta,5alpha)]-2-(1,2-Dimethylbicyclo[3.1.0]hex-2-yl)-5-methylphenol

A sesquiterpenoid that is laurinterol in which the bromo group has been replaced by a hydrogen. Isolated from Laurencia intermedia and Aplysia kurodai, it exhibits antimicrobial activity.

R-(-)-alpha-Cuparenone

(-)-R-(-)-alpha-Cuparenone

Mutisianthol

cis-Dehydrodendrolasin

(Z,Z,E)-3-(4,8-Dimethyl-2,4,6-nonatrienyl)-furan

(E,Z)-2-(2,6-Dimethyl-1,5,7-octatrienyl)-4-methylfuran

(Z,E)-2-(2,6-Dimethyl-2,5,7-octatrienyl)-4-methylfuran

Diethyl 2-acetylsuccinate

2-{[4-(2-Cyanoallyl)piperazino]methyl}acrylonitrile

C12H16N4 (216.13748959999998)

{[[(4-Cyanobenzyl)amino](imino)methyl]amino}methanimidamide

C10H12N6 (216.1123392)

Homononactic acid

MEGxm0_000216

3Alpha-Hydroxy-4,4-Bisnor-8,11,13-Podocarpatriene

NCGC00381387-02

(Z)-8-Pentadecene-11,13-diyn-2-one

4,6,12-Tetradecatriene-8,10-diyne-1,3-diol