Classification Term: 720

Isoindolones (ontology term: CHEMONTID:0001820)

Aromatic polycyclic compounds that an isoindole bearing a ketone." []

found 23 associated metabolites at category metabolite taxonomy ontology rank level.

Child Taxonomies: Phthalimides

Tetramethrin

2,2-Dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic acid, ester with N-(hydroxymethyl)-1-cyclo hexene 1,2-dicarboximide

C19H25NO4 (331.178349)

P - Antiparasitic products, insecticides and repellents > P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents > P03B - Insecticides and repellents > P03BA - Pyrethrines D010575 - Pesticides > D007306 - Insecticides > D011722 - Pyrethrins D016573 - Agrochemicals

Pyrodone

4-(2-ethylhexyl)-4-azatricyclo[5.2.1.0²,⁶]dec-8-ene-3,5-dione

C17H25NO2 (275.188519)

Trichloromethylthio-1,2,5,6-tetrahydrophthalamide

2-[(trichloromethyl)sulfanyl]-2,3,3a,4,7,7a-hexahydro-1H-isoindole-1,3-dione

C9H8Cl3NO2S (298.93413180000005)

D016573 - Agrochemicals D010575 - Pesticides

Captafol

3a,4,7,7a-Tetrahydro-2-[(1,1,2,2-tetrachloroethyl)thio]-1H-isoindole-1,3(2H)-dione, 9ci

C10H9Cl4NO2S (346.9108094)

Nonsystemic foliar agricultural fungicide, especially for potatoe D016573 - Agrochemicals D010575 - Pesticides

Chlorthalidone

2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide

C14H11ClN2O4S (338.01280360000004)

Chlorthalidone is only found in individuals that have used or taken this drug. It is a benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. [PubChem]Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism. C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D049990 - Membrane Transport Modulators

(Z)-Narceine imide

(1Z)-1-({6-[2-(dimethylamino)ethyl]-4-methoxy-2H-1,3-benzodioxol-5-yl}methylidene)-4,5-dimethoxy-1H-isoindol-3-ol

C23H26N2O6 (426.1790776)

(Z)-Narceine imide is an alkaloid from Papaver somniferum (opium poppy

3alpha,4,7,7alpha-Tetrahydro-1H-isoindole-1,3(2H)-dione

3-alpha,4,7,7-alpha-Tetrahydro-1H-isoindole-1,3(2H)-dione

C8H9NO2 (151.0633254)

Potential food contaminant arising from the metabolism of Captan CXH76-I.

Hericerin

6-[(2Z)-3,7-dimethylocta-2,6-dien-1-yl]-7-hydroxy-5-methoxy-2-(2-phenylethyl)-2,3-dihydro-1H-isoindol-1-one

C27H33NO3 (419.2460308000001)

Hericerin is found in mushrooms. Hericerin is isolated from the edible lions mane mushroom (Hericium erinaceum). Isolated from the edible lions mane mushroom (Hericium erinaceum). Hericerin is found in mushrooms. D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams

Hericenone B

6-[(2Z)-3,7-dimethyl-5-oxoocta-2,6-dien-1-yl]-7-hydroxy-5-methoxy-2-(2-phenylethyl)-2,3-dihydro-1H-isoindol-1-one

C27H31NO4 (433.22529660000004)

Hericenone B is found in mushrooms. Hericenone B is isolated from the edible lions mane mushroom (Hericium erinaceum). Isolated from the edible lions mane mushroom (Hericium erinaceum). Hericenone B is found in mushrooms.

Lenalidomide

3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione

C13H13N3O3 (259.0956868)

Lenalidomide (initially known as CC-5013 and marketed as Revlimid by Celgene) is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic modality, but has also shown efficacy in the hematological disorders known as the myelodysplastic syndromes. [Wikipedia] C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent > C157388 - Immunomodulatory Imide Drug L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor D006133 - Growth Substances > D006131 - Growth Inhibitors D007155 - Immunologic Factors Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

Thalidomide arene oxide

3-{3,5-dioxo-1aH,3H,4H,5H,6aH-oxireno[2,3-f]isoindol-4-yl}piperidine-2,6-dione

C13H10N2O5 (274.058969)

Thalidomide arene oxide is a metabolic intermediate of thalidomide which subsequently converts to 5-hydroxythalidomide. It belongs to the family of Isoindolones. These are aromatic polycyclic compounds that an isolindole bearing a ketone.

3alpha,4,5,7alpha-Tetrahydro-5-hydroxy-1H-isoindole-1,3(2H)-dione

C8H9NO3 (167.0582404)

3alpha,4,5,7alpha-Tetrahydro-5-hydroxy-1H-isoindole-1,3(2H)-dione is found in milk and milk products. Potential food contaminant arising from the metabolism of Captan CXH76-I. 3alpha,4,5,7alpha-Tetrahydro-5-hydroxy-1H-isoindole-1,3(2H)-dione is detected in mil Potential food contaminant arising from the metabolism of Captan CXH76-I. Detected in milk. 3alpha,4,5,7alpha-Tetrahydro-5-hydroxy-1H-isoindole-1,3(2H)-dione is found in milk and milk products.

3alpha,4,7,7alpha-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione

C8H9NO3 (167.0582404)

3alpha,4,7,7alpha-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione is found in milk and milk products. Potential food contaminant arising from the metabolism of Captan CXH76-I. 3alpha,4,7,7alpha-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione is detected in mil Potential food contaminant arising from the metabolism of Captan CXH76-I. Detected in milk. 3alpha,4,7,7alpha-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione is found in milk and milk products.

3,4,5,6-Tetrahydrophthalimide

2,3,4,5,6,7-hexahydro-1H-isoindole-1,3-dione

C8H9NO2 (151.0633254)

Taglutimida

4-(2,6-dioxopiperidin-3-yl)-4-azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione

C14H16N2O4 (276.1110016)

DMS-Cl

4-(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-2-methoxybenzene-1-sulfonyl chloride

C17H16ClNO6S (397.0386826)

Falipamil

2-(3-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}propyl)-5,6-dimethoxy-2,3-dihydro-1H-isoindol-1-one

C24H32N2O5 (428.2311102)

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker

Iberdomide

3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione

C25H27N3O5 (449.19506120000005)

Indobufen

2-[4-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)phenyl]butanoic acid

C18H17NO3 (295.1208372)

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D004791 - Enzyme Inhibitors