Isoindolin-1-one (BioDeep_00000180155)

   

human metabolite blood metabolite


代谢物信息卡片


2,3-Dihydro-3-oxo-1H-isoindole

化学式: C8H7NO (133.0527612)
中文名称: 1-异吲哚酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2=CC=CC=C2C(=O)N1
InChI: InChI=1S/C8H7NO/c10-8-7-4-2-1-3-6(7)5-9-8/h1-4H,5H2,(H,9,10)

描述信息

同义名列表

7 个代谢物同义名

2,3-Dihydro-3-oxo-1H-isoindole; 2,3-Dihydro-1H-isoindol-1-one; Dihydro-isoindol-1-one; 1-oxo-Isoindoline; Isoindolin-1-one; Isoindolinone; Phthalimidine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jon H Come, Philip N Collier, James A Henderson, Albert C Pierce, Robert J Davies, Arnaud Le Tiran, Hardwin O'Dowd, Upul K Bandarage, Jingrong Cao, David Deininger, Ron Grey, Elaine B Krueger, Derek B Lowe, Jianglin Liang, Yusheng Liao, David Messersmith, Suganthi Nanthakumar, Emmanuelle Sizensky, Jian Wang, Jinwang Xu, Elaine Y Chin, Veronique Damagnez, John D Doran, Wojciech Dworakowski, James P Griffith, Marc D Jacobs, Suvarna Khare-Pandit, Sudipta Mahajan, Cameron S Moody, Alex M Aronov. Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). Journal of medicinal chemistry. 2018 06; 61(12):5245-5256. doi: 10.1021/acs.jmedchem.8b00085. [PMID: 29847724]
  • Ying Yin, Qiang Fu, Wenhui Wu, Menghao Cai, Xiangshan Zhou, Yuanxing Zhang. Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway. Marine drugs. 2017 Jul; 15(7):. doi: 10.3390/md15070214. [PMID: 28678182]
  • Nianhang Chen, Lian Wen, Henry Lau, Sekhar Surapaneni, Gondi Kumar. Pharmacokinetics, metabolism and excretion of [(14)C]-lenalidomide following oral administration in healthy male subjects. Cancer chemotherapy and pharmacology. 2012 Mar; 69(3):789-97. doi: 10.1007/s00280-011-1760-3. [PMID: 22037879]
  • Tetsuro Shirasaka, Takato Kunitake, Isao Tsuneyoshi. Cardiovascular responses to intravenous injection of a novel isoindolin-1-one derivate in conscious rats. Brain research. 2009 Dec; 1300(?):105-13. doi: 10.1016/j.brainres.2009.08.092. [PMID: 19747460]
  • Joa Kyum Kim, Young Ha Kim, Ho Tae Nam, Bum Tae Kim, Jung-Nyoung Heo. Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction. Organic letters. 2008 Aug; 10(16):3543-6. doi: 10.1021/ol801291k. [PMID: 18642834]
  • J M Chapman, G H Cocolas, I H Hall. Hypolipidemic activity of phthalimide derivatives. 3. A comparison of phthalimide and 1,2-benzisothiazolin-3-one 1,1-dioxide derivatives to phthalimidine and 1,2-benzisothiazoline 1,1-dioxide congeners. Journal of medicinal chemistry. 1983 Feb; 26(2):243-6. doi: 10.1021/jm00356a023. [PMID: 6827542]