Chlorthalidone (BioDeep_00000017962)

Main id: BioDeep_00000014953

 

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide

化学式: C14H11ClN2O4S (338.01280360000004)
中文名称: 氯塞酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O
InChI: InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)

描述信息

Chlorthalidone is only found in individuals that have used or taken this drug. It is a benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. [PubChem]Chlorthalidone inhibits sodium ion transport across the renal tubular epithelium in the cortical diluting segment of the ascending limb of the loop of Henle. By increasing the delivery of sodium to the distal renal tubule, Chlorthalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism.
C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators

同义名列表

24 个代谢物同义名

2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzene-1-sulfonamide; 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulphonamide; 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide; 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulphonamide; 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide; 1-Keto-3-(3-sulphamyl-4-chlorophenyl)-3-hydroxyisoindoline; 1-Keto-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline; 1-oxo-3-(3-Sulphamyl-4-chlorophenyl)-3-hydroxyisoindoline; 1-oxo-3-(3-Sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline; 3-(4-Chloro-3-sulphamoylphenyl)-3-hydroxyphthalimidine; 3-Hydroxy-3-(4-chloro-3-sulphamylphenyl)phthalimidine; 3-(4-Chloro-3-sulfamoylphenyl)-3-hydroxyphthalimidine; 3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine; Chlorphthalidolone; Chlorphthalidone; Chlorothalidone; chlorthalidone; Phthalamodine; Chlortalidone; Chlorthalidon; Phthalamudine; Thalitone; Oxodoline; Hygroton



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis. The Cochrane database of systematic reviews. 2023 Aug; 8(?):CD013573. doi: 10.1002/14651858.cd013573.pub2. [PMID: 37565307]
  • Stephen Y Wang, Jonathan M Hanna, Prajesh Gongal, Oyere K Onuma, Michael G Nanna. Choice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial. American heart journal. 2022 Dec; 254(?):30-34. doi: 10.1016/j.ahj.2022.07.006. [PMID: 35932912]
  • Panagiotis I Georgianos, Rajiv Agarwal. Management of hypertension in advanced kidney disease. Current opinion in nephrology and hypertension. 2022 07; 31(4):374-379. doi: 10.1097/mnh.0000000000000812. [PMID: 35727171]
  • Seth B Furgeson, Stuart Linas. Chlorthalidone and Advanced Chronic Kidney Disease. Clinical journal of the American Society of Nephrology : CJASN. 2022 Jul; 17(7):1076-1078. doi: 10.2215/cjn.01380222. [PMID: 35577563]
  • Pau Llàcer, Julio Núñez, Marina García, Raúl Ruiz, Genoveva López, Martín Fabregate, Cristina Fernández, François Croset, Beatriz Del Hoyo, Antonio Gomis, Luis Manzano. Comparison of chlorthalidone and spironolactone as additional diuretic therapy in patients with acute heart failure and preserved ejection fraction. European heart journal. Acute cardiovascular care. 2022 Jun; 11(4):350-355. doi: 10.1093/ehjacc/zuac006. [PMID: 35167653]
  • Sonali R Gnanenthiran, Nelson Wang, Gian Luca Di Tanna, Abdul Salam, Ruth Webster, H Asita de Silva, Rama Guggilla, Stephen Jan, Pallab K Maulik, Nitish Naik, Vanessa Selak, Simon Thom, Dorairaj Prabhakaran, Aletta E Schutte, Anushka Patel, Anthony Rodgers. Association of Low-Dose Triple Combination Therapy vs Usual Care With Time at Target Blood Pressure: A Secondary Analysis of the TRIUMPH Randomized Clinical Trial. JAMA cardiology. 2022 06; 7(6):645-650. doi: 10.1001/jamacardio.2022.0471. [PMID: 35416909]
  • Deidra C Crews. In advanced CKD with poorly controlled hypertension, chlorthalidone reduced BP at 12 wk. Annals of internal medicine. 2022 03; 175(3):JC29. doi: 10.7326/j22-0007. [PMID: 35226524]
  • Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan and Chlorthalidone Compared to Concurrent Administration of the Separate Components. Clinical pharmacology in drug development. 2022 01; 11(1):91-99. doi: 10.1002/cpdd.963. [PMID: 34159751]
  • David C Wheeler. Chlorthalidone in Advanced Chronic Kidney Disease - Have We Missed a Trick?. The New England journal of medicine. 2021 12; 385(27):2574-2575. doi: 10.1056/nejme2118149. [PMID: 34965342]
  • Rajiv Agarwal, Arjun D Sinha, Andrew E Cramer, Mary Balmes-Fenwick, Jazmyn H Dickinson, Fangqian Ouyang, Wanzhu Tu. Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease. The New England journal of medicine. 2021 12; 385(27):2507-2519. doi: 10.1056/nejmoa2110730. [PMID: 34739197]
  • Bahia Abbas Moussa, Hanaa M A Hashem, Marianne Alphonse Mahrouse, Sally Tarek Mahmoud. Synchronized determination of sacubitril and valsartan with some co-administered drugs in human plasma via UPLC-MS/MS method using solid-phase extraction. Biomedical chromatography : BMC. 2021 Nov; 35(11):e5203. doi: 10.1002/bmc.5203. [PMID: 34145610]
  • Nathan K Itoga, Daniel S Tawfik, Maria E Montez-Rath, Tara I Chang. Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study. Journal of the American College of Cardiology. 2021 10; 78(17):1671-1678. doi: 10.1016/j.jacc.2021.08.035. [PMID: 34674811]
  • Nicola C Edwards, Anna M Price, Samir Mehta, Thomas F Hiemstra, Amreen Kaur, Peter J Greasley, David J Webb, Neeraj Dhaun, Iain M MacIntyre, Tariq Farrah, Vanessa Melville, Anna S Herrey, Gemma Slinn, Rebekah Wale, Natalie Ives, David C Wheeler, Ian Wilkinson, Richard P Steeds, Charles J Ferro, Jonathan N Townend. Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease: A Randomized, Open-Label Trial. Clinical journal of the American Society of Nephrology : CJASN. 2021 10; 16(10):1491-1501. doi: 10.2215/cjn.01930221. [PMID: 34462286]
  • Svenja Ravioli, Shawki Bahmad, Georg-Christian Funk, Christoph Schwarz, Aristomenis Exadaktylos, Gregor Lindner. Risk of Electrolyte Disorders, Syncope, and Falls in Patients Taking Thiazide Diuretics: Results of a Cross-Sectional Study. The American journal of medicine. 2021 09; 134(9):1148-1154. doi: 10.1016/j.amjmed.2021.04.007. [PMID: 33974908]
  • Cedric Edwards, Gregory L Hundemer, William Petrcich, Mark Canney, Greg Knoll, Kevin Burns, Ann Bugeja, Manish M Sood. Comparison of Clinical Outcomes and Safety Associated With Chlorthalidone vs Hydrochlorothiazide in Older Adults With Varying Levels of Kidney Function. JAMA network open. 2021 09; 4(9):e2123365. doi: 10.1001/jamanetworkopen.2021.23365. [PMID: 34524440]
  • Christos Chatzikyrkou, Roland E Schmieder, Mario Schiffer. Update on Treatment of Hypertension After Renal Transplantation. Current hypertension reports. 2021 05; 23(5):25. doi: 10.1007/s11906-021-01151-8. [PMID: 33961145]
  • Nancy S Krieger, John Asplin, Ignacio Granja, Luojing Chen, Daiana Spataru, Tong Tong Wu, Marc Grynpas, David A Bushinsky. Chlorthalidone with potassium citrate decreases calcium oxalate stones and increases bone quality in genetic hypercalciuric stone-forming rats. Kidney international. 2021 05; 99(5):1118-1126. doi: 10.1016/j.kint.2020.12.023. [PMID: 33417997]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Syed Faisal Badshah, Naveed Akhtar, Muhammad Usman Minhas, Kifayat Ullah Khan, Samiullah Khan, Orva Abdullah, Abid Naeem. Porous and highly responsive cross-linked β-cyclodextrin based nanomatrices for improvement in drug dissolution and absorption. Life sciences. 2021 Feb; 267(?):118931. doi: 10.1016/j.lfs.2020.118931. [PMID: 33359243]
  • Xianglin L Du, Lara M Simpson, Brian C Tandy, Judith L Bettencourt, Barry R Davis. Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker. PloS one. 2021; 16(11):e0260107. doi: 10.1371/journal.pone.0260107. [PMID: 34793552]
  • Rajiv Agarwal. Refractory Hypertension and Kidney Failure: Focusing on the Social Determinants of Health. Hypertension (Dallas, Tex. : 1979). 2021 01; 77(1):82-84. doi: 10.1161/hypertensionaha.120.15322. [PMID: 33296245]
  • Ahmed Elsonbaty, Mohamed A Hasan, Maya S Eissa, Wafaa S Hassan, Sara Abdulwahab. Synchronous Spectrofluorimetry Coupled with Third-Order Derivative Signal Processing for the Simultaneous Quantitation of Telmisartan and Chlorthalidone Drug Combination in Human Plasma. Journal of fluorescence. 2021 Jan; 31(1):97-106. doi: 10.1007/s10895-020-02639-3. [PMID: 33089428]
  • Hernando Trujillo, Fernando Caravaca-Fontán, Jara Caro, Enrique Morales, Manuel Praga. The Forgotten Antiproteinuric Properties of Diuretics. American journal of nephrology. 2021; 52(6):435-449. doi: 10.1159/000517020. [PMID: 34233330]
  • Ami Kwon, Gee-Hee Kim. Single-pill Combination Therapy of Azilsartan Medoxomil/Chlorthalidone for Treatment of Hypertension: A Systematic Review. Clinical therapeutics. 2020 07; 42(7):1390-1403. doi: 10.1016/j.clinthera.2020.05.015. [PMID: 32595000]
  • Stephen P Juraschek, Lara M Simpson, Barry R Davis, Robert H Shmerling, Jennifer L Beach, Anthony Ishak, Kenneth J Mukamal. The effects of antihypertensive class on gout in older adults: secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Journal of hypertension. 2020 05; 38(5):954-960. doi: 10.1097/hjh.0000000000002359. [PMID: 31977576]
  • George Hripcsak, Marc A Suchard, Steven Shea, RuiJun Chen, Seng Chan You, Nicole Pratt, David Madigan, Harlan M Krumholz, Patrick B Ryan, Martijn J Schuemie. Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension. JAMA internal medicine. 2020 04; 180(4):542-551. doi: 10.1001/jamainternmed.2019.7454. [PMID: 32065600]
  • Rajiv Agarwal, Andrew E Cramer, Mary Balmes-Fenwick, Arjun D Sinha, Fangqian Ouyang, Wanzhu Tu. Design and Baseline Characteristics of the Chlorthalidone in Chronic Kidney Disease (CLICK) Trial. American journal of nephrology. 2020; 51(7):542-552. doi: 10.1159/000508700. [PMID: 32663820]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Stela Dineva, Katya Uzunova, Velichka Pavlova, Elena Filipova, Krassimir Kalinov, Toni Vekov. Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis. Journal of human hypertension. 2019 11; 33(11):766-774. doi: 10.1038/s41371-019-0255-2. [PMID: 31595024]
  • Stephen P Juraschek, Lara M Simpson, Barry R Davis, Jennifer L Beach, Anthony Ishak, Kenneth J Mukamal. Effects of Antihypertensive Class on Falls, Syncope, and Orthostatic Hypotension in Older Adults: The ALLHAT Trial. Hypertension (Dallas, Tex. : 1979). 2019 10; 74(4):1033-1040. doi: 10.1161/hypertensionaha.119.13445. [PMID: 31476905]
  • Nancy S Krieger, John R Asplin, Ignacio Granja, Felix M Ramos, Courtney Flotteron, Luojing Chen, Tong Tong Wu, Marc D Grynpas, David A Bushinsky. Chlorthalidone Is Superior to Potassium Citrate in Reducing Calcium Phosphate Stones and Increasing Bone Quality in Hypercalciuric Stone-Forming Rats. Journal of the American Society of Nephrology : JASN. 2019 07; 30(7):1163-1173. doi: 10.1681/asn.2018101066. [PMID: 31101664]
  • Mai Mehanna, Zhiying Wang, Yan Gong, Caitrin W McDonough, Amber L Beitelshees, John G Gums, Arlene B Chapman, Gary L Schwartz, Kent R Bailey, Julie A Johnson, Stephen T Turner, Rhonda M Cooper-DeHoff. Plasma Renin Activity Is a Predictive Biomarker of Blood Pressure Response in European but not in African Americans With Uncomplicated Hypertension. American journal of hypertension. 2019 06; 32(7):668-675. doi: 10.1093/ajh/hpz022. [PMID: 30753254]
  • Kyle Johnson, Suzanne Oparil, Barry R Davis, Larisa G Tereshchenko. Prevention of Heart Failure in Hypertension-Disentangling the Role of Evolving Left Ventricular Hypertrophy and Blood Pressure Lowering: The ALLHAT Study. Journal of the American Heart Association. 2019 04; 8(8):e011961. doi: 10.1161/jaha.119.011961. [PMID: 30943832]
  • Ruth Webster, Abdul Salam, H Asita de Silva, Vanessa Selak, Sandrine Stepien, Senaka Rajapakse, Stanley Amarasekara, Naomali Amarasena, Laurent Billot, Arjuna P de Silva, Mervyn Fernando, Rama Guggilla, Stephen Jan, Jayanthimala Jayawardena, Pallab K Maulik, Sepalika Mendis, Suresh Mendis, Janake Munasinghe, Nitish Naik, Dorairaj Prabhakaran, Gotabaya Ranasinghe, Simon Thom, Nirmali Tisserra, Vajira Senaratne, Sanjeewa Wijekoon, Santharaj Wijeyasingam, Anthony Rodgers, Anushka Patel. Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial. JAMA. 2018 08; 320(6):566-579. doi: 10.1001/jama.2018.10359. [PMID: 30120478]
  • Michael A Weber, Peter Sever, Attila Juhasz, Andrew Roberts, Charlie Cao. A randomized trial of the efficacy and safety of azilsartan medoxomil combined with chlorthalidone. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2018 Jul; 19(3):1470320318795000. doi: 10.1177/1470320318795000. [PMID: 30175930]
  • Sang-Ho Jo, Sung-Ji Park, Eung Ju Kim, Soo-Joong Kim, Hyun-Jae Cho, Jong-Min Song, Jinho Shin, Jin Joo Park, Joon-Han Shin, Kyoo-Rok Han, Dong-Ju Choi. S-amlodipine plus chlorthalidone vs. S-amlodipine plus telmisartan in hypertensive patients unresponsive to amlodipine monotherapy: study protocol for a randomized controlled trial. Trials. 2018 Jun; 19(1):324. doi: 10.1186/s13063-018-2636-1. [PMID: 29925421]
  • George L Bakris, Lin Zhao, Stuart Kupfer, Attila Juhasz, Michie Hisada, Eric Lloyd, Suzanne Oparil. Long-term efficacy and tolerability of azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide in chronic kidney disease. Journal of clinical hypertension (Greenwich, Conn.). 2018 04; 20(4):694-702. doi: 10.1111/jch.13230. [PMID: 29504252]
  • William C Cushman, George L Bakris, William B White, Michael A Weber, Domenic Sica, Andrew Roberts, Eric Lloyd, Stuart Kupfer. A randomized titrate-to-target study comparing fixed-dose combinations of azilsartan medoxomil and chlorthalidone with olmesartan and hydrochlorothiazide in stage-2 systolic hypertension. Journal of hypertension. 2018 04; 36(4):947-956. doi: 10.1097/hjh.0000000000001647. [PMID: 29334491]
  • Thomas A Dewland, Elsayed Z Soliman, Jose-Miguel Yamal, Barry R Davis, Alvaro Alonso, Christine M Albert, Lara M Simpson, L Julian Haywood, Gregory M Marcus. Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Circulation. Arrhythmia and electrophysiology. 2017 Dec; 10(12):. doi: 10.1161/circep.117.005463. [PMID: 29212812]
  • Sergio García-Blas, Clara Bonanad, Pau Llàcer, Silvia Ventura, José María Núñez, Ruth Sánchez, Carlos Chamorro, Lorenzo Fácila, Rafael de la Espriella, Juana María Vaquer, Alberto Cordero, Mercè Roqué, Víctor Ortiz, Paolo Racugno, Vicent Bodí, Ernesto Valero, Enrique Santas, María Del Carmen Moreno, Gema Miñana, Arturo Carratalá, Lourdes Bondanza, Ana Payá, Ingrid Cardells, Raquel Heredia, Mauricio Pellicer, Guillermo Valls, Patricia Palau, María José Bosch, Rafael Raso, Andrés Sánchez, Vicente Bertomeu-González, Vicente Bertomeu-Martínez, Vicente Montagud-Balaguer, Cristina Albiach-Montañana, Jezabel Pendás-Meneau, Goitzane Marcaida, Sonia Cervantes-García, Rodolfo San Antonio, Elisabet de Mingo, Francisco J Chorro, Juan Sanchis, Julio Núñez. Diuretic Strategies in Acute Heart Failure and Renal Dysfunction: Conventional vs Carbohydrate Antigen 125-guided Strategy. Clinical Trial Design. Revista espanola de cardiologia (English ed.). 2017 Dec; 70(12):1067-1073. doi: 10.1016/j.rec.2017.02.028. [PMID: 28341415]
  • Wenjing Liang, Hui Ma, Luxi Cao, Wenjiang Yan, Jingjing Yang. Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis. Journal of cellular and molecular medicine. 2017 Nov; 21(11):2634-2642. doi: 10.1111/jcmm.13205. [PMID: 28631393]
  • Manvir K Hayer, Nicola C Edwards, Gemma Slinn, William E Moody, Rick P Steeds, Charles J Ferro, Anna M Price, Cecilio Andujar, Mary Dutton, Rachel Webster, David J Webb, Scott Semple, Iain MacIntyre, Vanessa Melville, Ian B Wilkinson, Thomas F Hiemstra, David C Wheeler, Anna Herrey, Margaret Grant, Samir Mehta, Natalie Ives, Jonathan N Townend. A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial. American heart journal. 2017 Sep; 191(?):37-46. doi: 10.1016/j.ahj.2017.05.008. [PMID: 28888268]
  • Bhargav Patel, Arvind G Jangid, B N Suhagia, Nirmal Desai. The simultaneous UPLC-MS/MS determination of emerging drug combination; candesartan and chlorthalidone in human plasma and its application. Biomedical chromatography : BMC. 2017 Sep; 31(9):. doi: 10.1002/bmc.3946. [PMID: 28178366]
  • Sanket S Dhruva, Chenxi Huang, Erica S Spatz, Andreas C Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Xiao Xu, Curt D Furberg, Barry R Davis, Sara L Pressel, Ronald R Coifman, Harlan M Krumholz. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Hypertension (Dallas, Tex. : 1979). 2017 07; 70(1):94-102. doi: 10.1161/hypertensionaha.117.09221. [PMID: 28559399]
  • Arthur D Moes, Dennis A Hesselink, Anton H van den Meiracker, Robert Zietse, Ewout J Hoorn. Chlorthalidone Versus Amlodipine for Hypertension in Kidney Transplant Recipients Treated With Tacrolimus: A Randomized Crossover Trial. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2017 Jun; 69(6):796-804. doi: 10.1053/j.ajkd.2016.12.017. [PMID: 28259499]
  • Santosh Kumar Puttrevu, Rachumallu Ramakrishna, Manisha Bhateria, Moon Jain, Kashif Hanif, Rabi Sankar Bhatta. Pharmacokinetic-pharmacodynamic modeling of the antihypertensive interaction between azilsartan medoxomil and chlorthalidone in spontaneously hypertensive rats. Naunyn-Schmiedeberg's archives of pharmacology. 2017 May; 390(5):457-470. doi: 10.1007/s00210-017-1339-6. [PMID: 28190245]
  • Sripal Bangalore, Barry R Davis, William C Cushman, Sara L Pressel, Paul M Muntner, David A Calhoun, John B Kostis, Paul K Whelton, Jeffrey L Probstfield, Mahboob Rahman, Henry R Black. Treatment-Resistant Hypertension and Outcomes Based on Randomized Treatment Group in ALLHAT. The American journal of medicine. 2017 Apr; 130(4):439-448.e9. doi: 10.1016/j.amjmed.2016.10.002. [PMID: 27984005]
  • Rachel Puttnam, Barry R Davis, Sara L Pressel, Paul K Whelton, William C Cushman, Gail T Louis, Karen L Margolis, Suzanne Oparil, Jeffrey Williamson, Alokananda Ghosh, Paula T Einhorn, Joshua I Barzilay. Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial. JAMA internal medicine. 2017 Jan; 177(1):67-76. doi: 10.1001/jamainternmed.2016.6821. [PMID: 27893045]
  • Michael E Ernst, Barry R Davis, Elsayed Z Soliman, Ronald J Prineas, Peter M Okin, Alokananda Ghosh, William C Cushman, Paula T Einhorn, Suzanne Oparil, Richard H Grimm. Electrocardiographic measures of left ventricular hypertrophy in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Journal of the American Society of Hypertension : JASH. 2016 12; 10(12):930-938.e9. doi: 10.1016/j.jash.2016.10.010. [PMID: 27938852]
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