Efonidipine (BioDeep_00000178631)

   

human metabolite blood metabolite


代谢物信息卡片


5-(5,5-Dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-(phenyl(phenylmethyl)amino) ethyl ester, p-oxide, hydrochloride

化学式: C34H38N3O7P (631.2447248)
中文名称: 依福地平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5
InChI: InChI=1S/C34H38N3O7P/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45/h5-17,20,31,35H,18-19,21-23H2,1-4H3

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D000077264 - Calcium-Regulating Hormones and Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

6 个代谢物同义名

5-(5,5-Dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-(phenyl(phenylmethyl)amino) ethyl ester, p-oxide, hydrochloride; 2-[Benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid; 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; Enfonidipine hydrochloride; Efonidipine HCL; Efonidipine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rashmi Rajput, Vishal Chavda, Snehal S Patel, George E Barreto, Ghulam Md Ashraf. Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats. Journal of molecular neuroscience : MN. 2021 Sep; 71(9):1884-1896. doi: 10.1007/s12031-021-01857-z. [PMID: 34056691]
  • Mohammad Hassan Baig, Tanuj Sharma, Irfan Ahmad, Mohammed Abohashrh, Mohammad Mahtab Alam, Jae-June Dong. Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061678. [PMID: 33802860]
  • Mohammad M Ghahremanpour, Julian Tirado-Rives, Maya Deshmukh, Joseph A Ippolito, Chun-Hui Zhang, Israel Cabeza de Vaca, Maria-Elena Liosi, Karen S Anderson, William L Jorgensen. Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2. ACS medicinal chemistry letters. 2020 Dec; 11(12):2526-2533. doi: 10.1021/acsmedchemlett.0c00521. [PMID: 33324471]
  • Fuyan Xu, Weixi Xiong, Yiman Huang, Jianghua Shen, Dong Zhou, Lin Tang. Structural basis for efonidipine block of a voltage-gated Ca2+ channel. Biochemical and biophysical research communications. 2019 06; 513(3):631-634. doi: 10.1016/j.bbrc.2019.03.176. [PMID: 30981510]
  • Juthamas Khamseekaew, Sirinart Kumfu, Siripong Palee, Suwakon Wongjaikam, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C Chattipakorn, Nipon Chattipakorn. Effects of the iron chelator deferiprone and the T-type calcium channel blocker efonidipine on cardiac function and Ca2+ regulation in iron-overloaded thalassemic mice. Cell calcium. 2018 06; 72(?):18-25. doi: 10.1016/j.ceca.2018.01.004. [PMID: 29748130]
  • Miki Hosaka, Ryusuke Inoue, Michihiro Satoh, Daisuke Watabe, Tomohiro Hanazawa, Takayoshi Ohkubo, Kei Asayama, Taku Obara, Yutaka Imai. Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients. Clinical and experimental hypertension (New York, N.Y. : 1993). 2018; 40(5):468-475. doi: 10.1080/10641963.2017.1403617. [PMID: 29172732]
  • Juthamas Khamseekaew, Sirinart Kumfu, Suwakon Wongjaikam, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C Chattipakorn, Nipon Chattipakorn. Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice. European journal of pharmacology. 2017 Mar; 799(?):118-127. doi: 10.1016/j.ejphar.2017.02.015. [PMID: 28192097]
  • Man Liu, Ming Deng, Dan Zhang, Xiaolin Wang, Jingyi Ma, Hongna Zhao, Lina Zhang, Yang Tong, Huichen Liu. A chiral LC-MS/MS method for the stereospecific determination of efonidipine in human plasma. Journal of pharmaceutical and biomedical analysis. 2016 Apr; 122(?):35-41. doi: 10.1016/j.jpba.2016.01.039. [PMID: 26845200]
  • Sirinart Kumfu, Siriporn C Chattipakorn, Suthat Fucharoen, Nipon Chattipakorn. Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice. Experimental physiology. 2016 Apr; 101(4):521-39. doi: 10.1113/ep085517. [PMID: 26824522]
  • Man Liu, Hongna Zhao, Yang Tong, Dan Zhang, Xiaolin Wang, Lina Zhang, Jing Han, Huichen Liu. Determination of efonidipine in human plasma by LC-MS/MS for pharmacokinetic applications. Journal of pharmaceutical and biomedical analysis. 2015 Jan; 103(?):1-6. doi: 10.1016/j.jpba.2014.11.001. [PMID: 25462114]
  • Romulo Hurtado, Gil Bub, Doris Herzlinger. A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Feb; 28(2):730-9. doi: 10.1096/fj.13-237289. [PMID: 24189942]
  • Chika Ogura, Koh Ono, Shoichi Miyamoto, Akiko Ikai, Satoko Mitani, Naozo Sugimoto, Shiro Tanaka, Masatoshi Fujita. L/T-type and L/N-type calcium-channel blockers attenuate cardiac sympathetic nerve activity in patients with hypertension. Blood pressure. 2012 Dec; 21(6):367-71. doi: 10.3109/08037051.2012.694200. [PMID: 22747420]
  • Chunyan Hu, Takefumi Mori, Yi Lu, Qi Guo, Ying Sun, Yoshimi Yoneki, Yusuke Ohsaki, Takashi Nakamichi, Ikuko Oba, Emiko Sato, Susumu Ogawa, Bryan C Dickinson, Christopher J Chang, Toshio Miyata, Hiroshi Sato, Sadayoshi Ito. Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation. Journal of hypertension. 2012 Aug; 30(8):1620-31. doi: 10.1097/hjh.0b013e3283550e9f. [PMID: 22688264]
  • Sirinart Kumfu, Siriporn Chattipakorn, Kroekkiat Chinda, Suthat Fucharoen, Nipon Chattipakorn. T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice. European journal of haematology. 2012 Jun; 88(6):535-48. doi: 10.1111/j.1600-0609.2012.01779.x. [PMID: 22404220]
  • Cheng Li, Dong-Hyun Choi, Jun-Shik Choi. Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine. Journal of pharmacokinetics and pharmacodynamics. 2012 Feb; 39(1):99-108. doi: 10.1007/s10928-011-9234-0. [PMID: 22210483]
  • Hirohisa Matsuda, Tatsuhiko Mori, Daisuke Kurumazuka, Kento Kitada, Tetsuya Hayashi, Katsuyuki Nagatoya, Toru Inoue, Akira Ukimura, Yasuo Matsumura, Nobukazu Ishizaka, Yasushi Kitaura. Inhibitory effects of T/L-type calcium channel blockers on tubulointerstitial fibrosis in obstructed kidneys in rats. Urology. 2011 Jan; 77(1):249.e9-15. doi: 10.1016/j.urology.2010.07.496. [PMID: 21071071]
  • Koichi Hayashi, Takao Saruta, Yoshio Goto, Masao Ishii. Impact of renal function on cardiovascular events in elderly hypertensive patients treated with efonidipine. Hypertension research : official journal of the Japanese Society of Hypertension. 2010 Nov; 33(11):1211-20. doi: 10.1038/hr.2010.162. [PMID: 20844543]
  • Takafumi Okura. Efonidipine improves renal function and decreases proteinuria in elderly hypertensive patients in the JATOS study. Hypertension research : official journal of the Japanese Society of Hypertension. 2010 Nov; 33(11):1112-3. doi: 10.1038/hr.2010.150. [PMID: 20811385]
  • Sadayoshi Ito. Is renal antiaging possible?. Hypertension research : official journal of the Japanese Society of Hypertension. 2010 Nov; 33(11):1110-1. doi: 10.1038/hr.2010.165. [PMID: 20861840]
  • Shinji Takai, Denan Jin, Hiroshi Sakonjo, Mizuo Miyazaki. Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats. Hypertension research : official journal of the Japanese Society of Hypertension. 2010 Sep; 33(9):953-9. doi: 10.1038/hr.2010.90. [PMID: 20520612]
  • Nobuyuki Nakano, Toshihiko Ishimitsu, Toshiaki Takahashi, Hideki Inada, Atsushi Okamura, Shuichi Ohba, Hiroaki Matsuoka. Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. International heart journal. 2010 May; 51(3):188-92. doi: 10.1536/ihj.51.188. [PMID: 20558909]
  • Takehiro Ko, Yutaka Kakizoe, Naoki Wakida, Manabu Hayata, Kohei Uchimura, Naoki Shiraishi, Taku Miyoshi, Masataka Adachi, Shizuka Aritomi, Tomoyuki Konda, Kimio Tomita, Kenichiro Kitamura. Regulation of adrenal aldosterone production by serine protease prostasin. Journal of biomedicine & biotechnology. 2010; 2010(?):793843. doi: 10.1155/2010/793843. [PMID: 20204133]
  • Koichi Hayashi, Koichiro Homma, Shu Wakino, Hirobumi Tokuyama, Naoki Sugano, Takao Saruta, Hiroshi Itoh. T-type Ca channel blockade as a determinant of kidney protection. The Keio journal of medicine. 2010; 59(3):84-95. doi: 10.2302/kjm.59.84. [PMID: 20881449]
  • Hidehisa Sasaki, Atsuhito Saiki, Kei Endo, Noriko Ban, Takashi Yamaguchi, Hidetoshi Kawana, Daizi Nagayama, Masahiro Ohhira, Tomokazu Oyama, Yoh Miyashita, Kohji Shirai. Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy. Journal of atherosclerosis and thrombosis. 2009 Oct; 16(5):568-75. doi: 10.5551/jat.1628. [PMID: 19749494]
  • Takayoshi Tsutamoto, Toshinari Tanaka, Keizo Nishiyama, Masayuki Yamaji, Chiho Kawahara, Masanori Fujii, Takashi Yamamoto, Minoru Horie. Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. 2009 Aug; 32(8):670-4. doi: 10.1038/hr.2009.78. [PMID: 19498438]
  • Satoshi Morimoto, Fusakazu Jo, Kei Maki, Toshiji Iwasaka. Effects of efonidipine hydrochloride on heart rate and circulatory changes due to stress. Clinical and experimental hypertension (New York, N.Y. : 1993). 2009 Feb; 31(1):83-91. doi: 10.1080/10641960802627363. [PMID: 19172462]
  • Narutaka Ohashi, Hideo Mitamura, Satoshi Ogawa. Development of newer calcium channel antagonists: therapeutic potential of efonidipine in preventing electrical remodelling during atrial fibrillation. Drugs. 2009; 69(1):21-30. doi: 10.2165/00003495-200969010-00002. [PMID: 19192934]
  • N Wang, L Ye, B Q Zhao, J X Yu. Spectroscopic studies on the interaction of efonidipine with bovine serum albumin. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2008 Jul; 41(7):589-95. doi: 10.1590/s0100-879x2008000700007. [PMID: 18719740]
  • N Sugano, S Wakino, T Kanda, S Tatematsu, K Homma, K Yoshioka, K Hasegawa, Y Hara, Y Suetsugu, T Yoshizawa, Y Hara, Y Utsunomiya, G Tokudome, T Hosoya, T Saruta, K Hayashi. T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy. Kidney international. 2008 Apr; 73(7):826-34. doi: 10.1038/sj.ki.5002793. [PMID: 18200001]
  • Toshinari Tanaka, Takayoshi Tsutamoto, Hiroshi Sakai, Masanori Fujii, Takashi Yamamoto, Minoru Horie. Comparison of the effects of efonidipine and amlodipine on aldosterone in patients with hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. 2007 Aug; 30(8):691-7. doi: 10.1291/hypres.30.691. [PMID: 17917316]
  • Toshihiko Ishimitsu, Tomoko Kameda, Akira Akashiba, Toshiaki Takahashi, Satoshi Ohta, Masayoshi Yoshii, Junichi Minami, Hidehiko Ono, Atsushi Numabe, Hiroaki Matsuoka. Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis. Hypertension research : official journal of the Japanese Society of Hypertension. 2007 Jul; 30(7):621-6. doi: 10.1291/hypres.30.621. [PMID: 17785930]
  • Satoshi Okayama, Keiichi Imagawa, Noriyuki Naya, Hajime Iwama, Satoshi Somekawa, Hiroyuki Kawata, Manabu Horii, Tamio Nakajima, Shiro Uemura, Yoshihiko Saito. Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers. Hypertension research : official journal of the Japanese Society of Hypertension. 2006 Jul; 29(7):493-7. doi: 10.1291/hypres.29.493. [PMID: 17044661]
  • Koichi Hayashi, Shu Wakino, Koichiro Homma, Naoki Sugano, Takao Saruta. Pathophysiological significance of T-type Ca2+ channels: role of T-type Ca2+ channels in renal microcirculation. Journal of pharmacological sciences. 2005 Nov; 99(3):221-7. doi: 10.1254/jphs.fmj05002x6. [PMID: 16293936]
  • Taiji Furukawa, Reiko Miura, Mitsuyoshi Honda, Natsuko Kamiya, Yasuo Mori, Satoshi Takeshita, Takaaki Isshiki, Toshihide Nukada. Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels. British journal of pharmacology. 2004 Dec; 143(8):1050-7. doi: 10.1038/sj.bjp.0705944. [PMID: 15545287]
  • Koichi Hayashi, Hiroo Kumagai, Takao Saruta. Effect of efonidipine and ACE inhibitors on proteinuria in human hypertension with renal impairment. American journal of hypertension. 2003 Feb; 16(2):116-22. doi: 10.1016/s0895-7061(02)03147-3. [PMID: 12559677]
  • Masuhisa Nakamura, Mitsuru Notoya, Yuka Kohda, Junji Yamashita, Yuko Takashita, Munekazu Gemba. Effects of efonidipine hydrochloride on renal arteriolar diameters in spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. 2002 Sep; 25(5):751-5. doi: 10.1291/hypres.25.751. [PMID: 12452329]
  • Hikaru Tanaka, Koki Shigenobu. Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels. Cardiovascular drug reviews. 2002; 20(1):81-92. doi: 10.1111/j.1527-3466.2002.tb00084.x. [PMID: 12070536]
  • M Honda, K Hayashi, H Matsuda, E Kubota, H Tokuyama, K Okubo, I Takamatsu, Y Ozawa, T Saruta. Divergent renal vasodilator action of L- and T-type calcium antagonists in vivo. Journal of hypertension. 2001 Nov; 19(11):2031-7. doi: 10.1097/00004872-200111000-00014. [PMID: 11677369]
  • M Honda, K Hayashi, H Matsuda, E Kubota, H Tokuyama, K Okubo, Y Ozawa, T Saruta. Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis. Clinical science (London, England : 1979). 2001 Oct; 101(4):421-7. doi: NULL. [PMID: 11566080]
  • S Watanabe, H Ono, T Ishimitsu, H Matsuoka, Y Ono, T Fujimori. Calcium antagonist inhibits glomerular cell apoptosis and injuries of L-NAME exacerbated nephrosclerosis in SHR. Hypertension research : official journal of the Japanese Society of Hypertension. 2000 Nov; 23(6):683-91. doi: 10.1291/hypres.23.683. [PMID: 11131282]
  • S Kaneko, H Takizawa, M Takeda, I Shou, Y Tomino. Effects of the antihypertensive drug nifedipine on albuminuria and renal histopathology in young spontaneously hypertensive rats with diabetes. General pharmacology. 1999 Nov; 33(5):363-7. doi: 10.1016/s0306-3623(98)00254-7. [PMID: 10553876]
  • M Kawabata, T Ogawa, W H Han, T Takabatake. Renal effects of efonidipine hydrochloride, a new calcium antagonist, in spontaneously hypertensive rats with glomerular injury. Clinical and experimental pharmacology & physiology. 1999 Sep; 26(9):674-9. doi: 10.1046/j.1440-1681.1999.03114.x. [PMID: 10499155]
  • M Takeda, I Shou, Y Tomino. Effects of the antihypertensive drug efonidipine hydrochloride on albuminuria and renal histopathology in young spontaneously hypertensive rats with diabetes. General pharmacology. 1998 May; 30(5):749-52. doi: 10.1016/s0306-3623(97)00337-6. [PMID: 9559329]
  • K Fujiwara, Y Kanno, K Hayashi, T Takenaka, T Saruta. Renal protective effects of efonidipine in partially nephrectomized spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993). 1998 Apr; 20(3):295-312. doi: 10.3109/10641969809052123. [PMID: 9605384]
  • C Shudo, Y Masuda, H Sugita, T Tamura, S Furukawa, K Hayashi, H Hirata, K Shikada, S Tanaka, K Tomita. Effects of efonidipine, nicardipine and captopril on proteinuria in aged spontaneously hypertensive rats. Arzneimittel-Forschung. 1996 Sep; 46(9):852-4. doi: NULL. [PMID: 8876932]
  • T Saito, K Fujii, T Takizawa, T Toyosaki, Y Kuwabara, S Kobayashi, H Ichikawa, A Karaki, Y Yamazaki, J Iwata, K Yamada, H Tomiya, K Takeda, Y Inagaki. Effects of the new calcium antagonist efonidipine hydrochloride on resting and exercise hemodynamics in patients with stable effort angina. Arzneimittel-Forschung. 1996 Sep; 46(9):861-7. doi: NULL. [PMID: 8876934]
  • H Nakabeppu, M Asada, T Oda, Y Shinozaki, T Yajima. Plasma and urinary metabolites of efonidipine hydrochloride in man. Xenobiotica; the fate of foreign compounds in biological systems. 1996 Feb; 26(2):229-39. doi: 10.3109/00498259609046703. [PMID: 8868006]
  • H Nakabeppu, A Nakajima, Y Kamikawaji, Y Shinozaki. Identification of efonidipine hydrochloride metabolites in rats. Arzneimittel-Forschung. 1995 Jul; 45(7):766-70. doi: NULL. [PMID: 8573219]
  • T Yotsumoto, Y Masuda, C Shudo, H Sugita, T Yamashita, S Tanaka. Effects of efonidipine hydrochloride (NZ-105), a calcium antagonist, on renal function in conscious spontaneously hypertensive rats. General pharmacology. 1995 Mar; 26(2):333-7. doi: 10.1016/0306-3623(94)00192-p. [PMID: 7590083]
  • C Shudo, Y Masuda, H Sugita, S Furukawa, K Hayashi, H Hirata, S Tanaka, K Tomita. Renal protective effect of efonidipine hydrochloride (NZ-105), a new calcium antagonist, in spontaneously hypertensive rats. General pharmacology. 1994 Dec; 25(8):1567-75. doi: 10.1016/0306-3623(94)90356-5. [PMID: 7721030]
  • C Shudo, Y Masuda, H Sugita, S Tanaka, K Tomita. Effects of efonidipine hydrochloride (NZ-105), a new calcium antagonist, against acute renal failure in rats. General pharmacology. 1994 Nov; 25(7):1451-8. doi: 10.1016/0306-3623(94)90173-2. [PMID: 7896060]
  • K Toyoda, M Kitahara, T Yamashita, C Shudo, Y Masuda, M Sakashita, S Tanaka, Y Saito. [Effect of efonidipine hydrochloride (NZ-105), a new dihydropyridine calcium antagonist, on the experimental atherosclerosis in cholesterol-fed rabbits]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1994 May; 103(5):231-9. doi: 10.1254/fpj.103.231. [PMID: 8188119]
  • C Shudo, Y Masuda, T Sakai, S Tanaka, K Shigenobu, Y Kasuya. Effects of long-term oral administration of NZ-105, a novel calcium antagonist, with or without propranolol in spontaneously hypertensive rats. The Journal of pharmacy and pharmacology. 1993 Jun; 45(6):525-9. doi: 10.1111/j.2042-7158.1993.tb05592.x. [PMID: 8103100]
  • T Yokoyama, Y Masuda, T Sakai, S Tanaka, K Tomita. Effects of NZ-105, a new calcium antagonist, on renal function in anesthetized spontaneously hypertensive rats. Journal of cardiovascular pharmacology. 1992 Jun; 19(6):851-6. doi: 10.1097/00005344-199206000-00002. [PMID: 1376803]
  • S Yokoyama, T Kaburagi, N Mori, K Sakata, H Yoshida, T Hoshino. [Antihypertensive effects and pharmacokinetics of NZ-105 single administration in patients with hypertension]. Nihon Jinzo Gakkai shi. 1992 Feb; 34(2):199-205. doi: NULL. [PMID: 1588771]