Antazoline (BioDeep_00000026906)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine

化学式: C17H19N3 (265.1579)
中文名称: 安他唑啉, 安达唑啉
谱图信息: 最多检出来源 Homo sapiens(blood) 49.41%

分子结构信息

SMILES: C(N(CC1=CC=CC=C1)C1=CC=CC=C1)C1=NCCN1
InChI: InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)

描述信息

Antazoline is only found in individuals that have used or taken this drug. It is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.Antazoline binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AC - Antiallergic agents, excl. corticosteroids
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Antazoline (Phenazoline) is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect[1][2][3].

同义名列表

21 个代谢物同义名

4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine; N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline; 2-(N-Phenyl-N-benzylaminomethyl)imidazoline; 2-(N-Benzylanilinomethyl)-2-imidazoline; Lannett brand OF antazoline phosphate; Antazoline phosphate (1:1); Hydrochloride, antazoline; Antazoline Hydrochloride; Phosphate, antazoline; Antazoline phosphate; Antazolinum; Phenazoline; Phenazolin; Antazolina; Analergine; antazoline; Antistine; Imidamine; Antasten; Arithmin; Antazoline



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

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  • Joanna Giebułtowicz, Natalia Korytowska, Monika Sobiech, Sebastian Polak, Barbara Wiśniowska, Roman Piotrowski, Piotr Kułakowski, Piotr Luliński. Magnetic Core-Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma-Material Characterization, Theoretical Analysis and Pharmacokinetics. International journal of molecular sciences. 2021 Apr; 22(7):. doi: 10.3390/ijms22073665. [PMID: 33915912]
  • Joanna Giebułtowicz, Natalia Korytowska, Roman Piotrowski, Piotr Kułakowski, Gniewomir Latacz, Ewa Szymańska, Barbara Wiśniowska, Sebastian Polak. Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry. International journal of molecular sciences. 2020 Dec; 21(24):. doi: 10.3390/ijms21249693. [PMID: 33353167]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Roman Piotrowski, Joanna Giebułtowicz, Jakub Baran, Agnieszka Sikorska, Dagmara Gralak-Łachowska, Małgorzata Soszyńska, Piotr Wroczyński, Piotr Kułakowski. Antazoline-insights into drug-induced electrocardiographic and hemodynamic effects: Results of the ELEPHANT II substudy. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2017 Sep; 22(5):. doi: 10.1111/anec.12441. [PMID: 28236352]
  • Joanna Giebułtowicz, Grzegorz Kojro, Roman Piotrowski, Piotr Kułakowski, Piotr Wroczyński. Cloud-point extraction is compatible with liquid chromatography coupled to electrospray ionization mass spectrometry for the determination of antazoline in human plasma. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 128(?):294-301. doi: 10.1016/j.jpba.2016.05.042. [PMID: 27289300]
  • Joanna Giebułtowicz, Roman Piotrowski, Jakub Baran, Piotr Kułakowski, Piotr Wroczyński. Application of a novel liquid chromatography/tandem mass spectrometry method for the determination of antazoline in human plasma: Result of ELEPHANT-I [ELEctrophysiological, pharmacokinetic and hemodynamic effects of PHenazolinum (ANTazoline mesylate)] human pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2016 May; 123(?):113-9. doi: 10.1016/j.jpba.2016.01.060. [PMID: 26895496]
  • Rui Wang, Yanle Chu, Xiaotian Li, Baoluo Wan, Tong Yu, Linxi Wang, Lianqi Hao, Maowen Guo. Determination of antazoline hydrochloride in rat plasma and excreta by reversed-phase ion-pair chromatography and its application to pharmacokinetics. Biomedical chromatography : BMC. 2013 Dec; 27(12):1595-602. doi: 10.1002/bmc.2965. [PMID: 23847054]
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