Cevimeline (BioDeep_00000033203)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2R)-5-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,2-[1,4]oxathiolane]

化学式: C10H17NOS (199.1030792)
中文名称: 西维美林
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1OC2(CN3CCC2CC3)CS1
InChI: InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8?,10-/m1/s1

描述信息

Cevimeline is only found in individuals that have used or taken this drug. It is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögrens syndrome. [Wikipedia] Muscarinic agonists such as cevimeline bind and activate the muscarinic M1 and M3 receptors. The M1 receptors are common in secretory glands (exocrine glands such as salivary and sweat glands), and their activation results in an increase in secretion from the secretory glands. The M3 receptors are found on smooth muscles and in many glands which help to stimulate secretion in salivary glands, and their activation generally results in smooth muscle contraction and increased glandular secretions. Therefore, as saliva excretion is increased, the symptoms of dry mouth are relieved.
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics

同义名列表

16 个代谢物同义名

(2R)-5-methyl-4-azaspiro[bicyclo[2.2.2]octane-2,2-[1,4]oxathiolane]; 2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine; Cevimeline hydrochloride hemihydrate; Cevimeline hydrochloride hydrate; AF 102b, (cis-(+))-isomer; Cevimeline hydrochloride; AF 102b, (trans)-isomer; Cevimelinum; Cevimeline; Cevimelina; Sni 2011; FKS 508; AF 102b; FKS-508; AF-102b; Evoxac



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jiamei Lian, Chao Deng. The dosage-dependent effects of cevimeline in preventing olanzapine-induced metabolic side-effects in female rats. Pharmacology, biochemistry, and behavior. 2020 04; 191(?):172878. doi: 10.1016/j.pbb.2020.172878. [PMID: 32112786]
  • Di Wang, Zhenfang Yuan, Noriko Inoue, Gota Cho, Masayuki Shono, Yasuko Ishikawa. Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats. Biochimica et biophysica acta. 2011 May; 1810(5):543-54. doi: 10.1016/j.bbagen.2011.01.013. [PMID: 21295117]
  • Shinichiro Tajiri, Taro Kanamaru, Kazuhiro Yoshida, Yasue Hosoi, Tsutomu Konno, Shuichi Yada, Hiroaki Nakagami. The relationship between the drug concentration profiles in plasma and the drug doses in the colon. Chemical & pharmaceutical bulletin. 2010 Oct; 58(10):1295-300. doi: 10.1248/cpb.58.1295. [PMID: 20930393]
  • Shinichiro Tajiri, Taro Kanamaru, Makoto Kamada, Kamada Makoto, Tsutomu Konno, Hiroaki Nakagami. Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations. International journal of pharmaceutics. 2010 Jan; 383(1-2):99-105. doi: 10.1016/j.ijpharm.2009.09.007. [PMID: 19747964]
  • Yan Pan, Fusako Iwata, Di Wang, Masahiro Muraguchi, Keiko Ooga, Yasukazu Ohmoto, Masaaki Takai, Gota Cho, Jinsen Kang, Masayuki Shono, Xue-jun Li, Ko Okamura, Toyoki Mori, Yasuko Ishikawa. Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva. Biochimica et biophysica acta. 2009 Jan; 1790(1):49-56. doi: 10.1016/j.bbagen.2008.08.009. [PMID: 18822351]
  • Di Wang, Fusako Iwata, Masahiro Muraguchi, Keiko Ooga, Yasukazu Ohmoto, Masaaki Takai, Toyoki Mori, Yasuko Ishikawa. Correlation between salivary secretion and salivary AQP5 levels in health and disease. The journal of medical investigation : JMI. 2009; 56 Suppl(?):350-3. doi: 10.2152/jmi.56.350. [PMID: 20224222]
  • Yasuko Ishikawa, Zhenfang Yuan, Noriko Inoue, Mariusz T Skowronski, Yoshiko Nakae, Masayuki Shono, Gota Cho, Masato Yasui, Peter Agre, Søren Nielsen. Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland. American journal of physiology. Cell physiology. 2005 Nov; 289(5):C1303-11. doi: 10.1152/ajpcell.00211.2005. [PMID: 16107506]
  • Michael Samarkos, Haralampos M Moutsopoulos. Recent advances in the management of ocular complications of Sjögren's syndrome. Current allergy and asthma reports. 2005 Jul; 5(4):327-32. doi: 10.1007/s11882-005-0077-x. [PMID: 15967078]
  • S G O'Brien, P Meinhardt, E Bond, J Beck, B Peng, C Dutreix, G Mehring, S Milosavljev, C Huber, R Capdeville, T Fischer. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. British journal of cancer. 2003 Nov; 89(10):1855-9. doi: 10.1038/sj.bjc.6601152. [PMID: 14612892]
  • N Inoue, H Iida, Z Yuan, Y Ishikawa, H Ishida. Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands. Journal of dental research. 2003 Jun; 82(6):476-80. doi: 10.1177/154405910308200614. [PMID: 12766202]
  • Takuo Washio, Kazuhiro Kohsaka, Hirohiko Arisawa, Hiroaki Masunaga. Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittel-Forschung. 2003; 53(1):26-33. doi: 10.1055/s-0031-1297066. [PMID: 12608011]
  • Takuo Washio, Kazuhiro Kohsaka, Hirohiko Arisawa, Hiroaki Masunaga, Shin-ichiro Nagatsuka, Yoshiaki Satoh. Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011. Arzneimittel-Forschung. 2003; 53(2):80-6. doi: 10.1055/s-0031-1297076. [PMID: 12642962]
  • Hirohiko Arisawa, Kenji Fukui, Eiichi Imai, Nobuaki Fujise, Hiroaki Masunaga. General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 4th communication: Effects on gastrointestinal, urinary and reproductive systems and other effects. Arzneimittel-Forschung. 2002; 52(4):225-32. doi: 10.1055/s-0031-1299885. [PMID: 12040964]
  • T Washio, H Arisawa, K Kohsaka, H Yasuda. Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011. Biological & pharmaceutical bulletin. 2001 Nov; 24(11):1263-6. doi: 10.1248/bpb.24.1263. [PMID: 11725960]
  • Y Ishikawa, M T Skowronski, H Ishida. Persistent increase in the amount of aquaporin-5 in the apical plasma membrane of rat parotid acinar cells induced by a muscarinic agonist SNI-2011. FEBS letters. 2000 Jul; 477(3):253-7. doi: 10.1016/s0014-5793(00)01763-4. [PMID: 10908730]
  • H Masunaga, H Ogawa, Y Uematsu, T Tomizuka, H Yasuda, Y Takeshita. Long-lasting salivation induced by a novel muscarinic receptor agonist SNI-2011 in rats and dogs. European journal of pharmacology. 1997 Nov; 339(1):1-9. doi: 10.1016/s0014-2999(97)01338-1. [PMID: 9450610]