1',3'-Dimethylspiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,4'-1,3-diazinane]-2'-one (BioDeep_00000181008)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H25N3O2 (339.194667)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC2(CCN3CCC4=C(C3C2)OC5=CC=CC=C45)N(C1=O)C
InChI: InChI=1S/C20H25N3O2/c1-21-11-8-20(22(2)19(21)24)9-12-23-10-7-15-14-5-3-4-6-17(14)25-18(15)16(23)13-20/h3-6,16H,7-13H2,1-2H3
描述信息
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
同义名列表
3 个代谢物同义名
1,5-dimethyl-17-oxa-7-azaspiro[1,5-diazinane-2,4-tetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadecane]-1(10),11,13,15-tetraen-6-one; 1,3-Dimethylspiro(1,3,4,5,6,6,7,12b-octahydro-2H-benzo(b)furo(2,3-a)quinolizine)-2,4-pyrimidin-2-one; 1,3-Dimethylspiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,4-1,3-diazinane]-2-one
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Luisa R Jiménez-Mena, Saurabh Gupta, Enriqueta Muñoz-Islas, Jair Lozano-Cuenca, Araceli Sánchez-López, David Centurión, Suneet Mehrotra, Antoinette MaassenVanDenBrink, Carlos M Villalón. Clonidine inhibits the canine external carotid vasodilatation to capsaicin by alpha2A/2C-adrenoceptors.
European journal of pharmacology.
2006 Aug; 543(1-3):68-76. doi:
10.1016/j.ejphar.2006.05.041. [PMID: 16814767] - Daniel Cussac, Stéphane Schaak, Céline Gales, Christodoulos Flordellis, Colette Denis, Hervé Paris. alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells.
American journal of physiology. Renal physiology.
2002 May; 282(5):F943-52. doi:
10.1152/ajprenal.0108.2001. [PMID: 11934705] - A Robichaud, C Savoie, P B Stamatiou, N Lachance, P Jolicoeur, R Rasori, C C Chan. Assessing the emetic potential of PDE4 inhibitors in rats.
British journal of pharmacology.
2002 Jan; 135(1):113-8. doi:
10.1038/sj.bjp.0704457. [PMID: 11786486] - S Uhlén, M Dambrova, J Näsman, H B Schiöth, Y Gu, A Wikberg-Matsson, J E Wikberg. [3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine.
European journal of pharmacology.
1998 Feb; 343(1):93-101. doi:
10.1016/s0014-2999(97)01521-5. [PMID: 9551719] - C Shiue, R C Pleus, G G Shiue, J A Rysavy, J J Sunderland, K G Cornish, S D Young, D B Bylund. Synthesis and biological evaluation of [11C]MK-912 as an alpha2-adrenergic receptor radioligand for PET studies.
Nuclear medicine and biology.
1998 Feb; 25(2):127-33. doi:
10.1016/s0969-8051(97)00167-4. [PMID: 9468027] - A Wikberg-Matsson, J E Wikberg, S Uhlén. Identification of drugs subtype-selective for alpha 2A-, alpha 2B-, and alpha 2C-adrenoceptors in the pig cerebellum and kidney cortex.
European journal of pharmacology.
1995 Sep; 284(3):271-9. doi:
10.1016/0014-2999(95)00354-n. [PMID: 8666009] - S Uhlén, R Muceniece, N Rangel, G Tiger, J E Wikberg. Comparison of the binding activities of some drugs on alpha 2A, alpha 2B and alpha 2C-adrenoceptors and non-adrenergic imidazoline sites in the guinea pig.
Pharmacology & toxicology.
1995 Jun; 76(6):353-64. doi:
10.1111/j.1600-0773.1995.tb00161.x. [PMID: 7479575] - A Bouloumié, V Planat, J C Devedjian, P Valet, J S Saulnier-Blache, M Record, M Lafontan. Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.
The Journal of biological chemistry.
1994 Dec; 269(48):30254-9. doi:
10.1016/s0021-9258(18)43805-7. [PMID: 7982935] - M D Okusa, K R Lynch, D L Rosin, L Huang, Y Y Wei. Apical membrane and intracellular distribution of endogenous alpha 2A-adrenergic receptors in MDCK cells.
The American journal of physiology.
1994 Sep; 267(3 Pt 2):F347-53. doi:
10.1152/ajprenal.1994.267.3.f347. [PMID: 7916533] - J C Muir, L Huang, J K Harrison, D L Rosin, M D Okusa. Regulation of rat renal alpha 2 B-adrenergic receptors by potassium depletion.
The American journal of physiology.
1994 Feb; 266(2 Pt 2):F316-24. doi:
10.1152/ajprenal.1994.266.2.f316. [PMID: 7908173] - Y Xia, S Uhlén, V Chhajlani, E J Lien, J E Wikberg. Further evidence for the existence of two forms of alpha 2B-adrenoceptors in rat.
Pharmacology & toxicology.
1993 Jan; 72(1):40-9. doi:
10.1111/j.1600-0773.1993.tb01337.x. [PMID: 8095097] - F J Ortiz-Alonso, W H Herman, B J Gertz, V C Williams, M J Smith, J B Halter. Effect of an oral alpha 2-adrenergic blocker (MK-912) on pancreatic islet function in non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental.
1991 Nov; 40(11):1160-7. doi:
10.1016/0026-0495(91)90210-n. [PMID: 1682787] - B J Gertz, P H Vlasses, M L Rocci, L D Coker, V Williams, T D Bjornsson, K H Jones. Clinical evaluation of a benzofuroquinolizine alpha 2-adrenoceptor antagonist.
Clinical pharmacology and therapeutics.
1989 Nov; 46(5):566-75. doi:
10.1038/clpt.1989.187. [PMID: 2573444] - J B Warren, C T Dollery, R W Fuller, V C Williams, B J Gertz. Assessment of MK-912, an alpha 2-adrenoceptor antagonist, with use of intravenous clonidine.
Clinical pharmacology and therapeutics.
1989 Jul; 46(1):103-9. doi:
10.1038/clpt.1989.113. [PMID: 2568210] - M L Constanzer, B K Matuszewski, J K Hsieh, W F Bayne. Determination of picogram levels of a novel alpha 2-adrenergic receptor antagonist in plasma using solid-phase extraction and capillary gas chromatography with nitrogen-selective detection.
Journal of chromatography.
1989 Mar; 488(2):476-81. doi:
10.1016/s0378-4347(00)82972-2. [PMID: 2568365]