Tedisamil (BioDeep_00000184182)

   

human metabolite blood metabolite


代谢物信息卡片


3,7-bis(cyclopropylmethyl)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1-cyclopentane]

化学式: C19H32N2 (288.2565352)
中文名称: 替地沙米
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1CC1)N1CC2CN(CC3CC3)CC(C1)C21CCCC1
InChI: InChI=1S/C19H32N2/c1-2-8-19(7-1)17-11-20(9-15-3-4-15)12-18(19)14-21(13-17)10-16-5-6-16/h15-18H,1-14H2

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BD - Antiarrhythmics, class iii
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D020011 - Protective Agents > D002316 - Cardiotonic Agents

同义名列表

3 个代谢物同义名

3,7-bis(cyclopropylmethyl)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1-cyclopentane]; 3,7-Di-(cyclopropylmethyl)-9,9-tetramethylene-3,7-diazabicyclo(3.3.1)nonane; Tedisamil



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aernout D van Haarst, Anneke C Dijkmans, Hans-Josef Weimann, Michiel J B Kemme, Jacobus J Bosch, Rik C Schoemaker, Adam F Cohen, Jacobus Burggraaf. Clinically important interaction between tedisamil and verapamil. Journal of clinical pharmacology. 2009 May; 49(5):560-7. doi: 10.1177/0091270009332812. [PMID: 19299533]
  • S A Doggrell. Tedisamil: master switch of nature?. Expert opinion on investigational drugs. 2001 Jan; 10(1):129-38. doi: 10.1517/13543784.10.1.129. [PMID: 11116286]
  • V Mitrovic, A Miskovic, M Strau, J Thormann, H Pitschner, C Hamm. Hemodynamic, antiischemic, and neurohumoral effects of tedisamil and atenolol in patients with coronary artery disease. Cardiovascular drugs and therapy. 2000 Oct; 14(5):511-21. doi: 10.1023/a:1007841223208. [PMID: 11101199]
  • V Mitrovic, E Oehm, J Thormann, H Pitschner, C Hamm. Potassium channel openers and blockers in coronary artery disease. Comparison to betablockers and calcium antagonists. Herz. 2000 Mar; 25(2):130-42. doi: 10.1007/pl00001951. [PMID: 10829253]
  • V Mitrovic, A Miskovic, M Straub, K Beckmann, J Thormann, H Pitschner. [Effects of the K(+) channel blocker tedisamil on hemodynamics, myocardial ischemia and neurohumoral systems in patients with stable angina pectoris. A comparison with the beta blocker atenolol]. Zeitschrift fur Kardiologie. 1999 Oct; 88(10):838-49. doi: 10.1007/s003920050360. [PMID: 10552188]
  • V Mitrovic, E Oehm, J Thormann, H Pitschner, W Haberbosch. Comparison of the potassium channel blocker tedisamil with the beta-adrenoceptor blocker esmolol and the calcium antagonist gallopamil in patients with coronary artery disease. Clinical cardiology. 1998 Jul; 21(7):492-502. doi: 10.1002/clc.4960210708. [PMID: 9669058]
  • V Mitrovic, E Oehm, R Strasser, M Schlepper, H F Pitschner. [The new potassium channel blocker tedisamil and its hemodynamic, anti-ischemic and neurohumoral effect in patients with coronary heart disease]. Zeitschrift fur Kardiologie. 1996 Dec; 85(12):961-72. doi: NULL. [PMID: 9082675]
  • H Rupp, V Elimban, N S Dhalla. Modification of myosin isozymes and SR Ca(2+)-pump ATPase of the diabetic rat heart by lipid-lowering interventions. Molecular and cellular biochemistry. 1994 Mar; 132(1):69-80. doi: 10.1007/bf00925676. [PMID: 8078510]