Classification Term: 1829
Long-chain 3-oxoacyl CoAs (ontology term: CHEMONTID:0003176)
Organic compounds containing a coenzyme A derivative, which is 3-oxo acylated long aliphatic chain of 13 to 21 carbon atoms." []
found 13 associated metabolites at no_class-level_7 metabolite taxonomy ontology rank level.
Ancestor: 3-oxo-acyl CoAs
Child Taxonomies: There is no child term of current ontology term.
3-Oxohexadecanoyl-CoA
3-Oxohexadecanoyl-CoA has a role in the synthesis and oxidation of fatty acid. It is involved in the pathway, fatty acid elongation in mitochondria. In this pathway Acetyl-CoA is acted upon by the enzyme, acetyl-CoA C-acyltransferase to produce 3-Oxohexadecanoyl-CoA. Since coenzyme A is chemically a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. It assists in transferring fatty acids from the cytoplasm to the mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group it is usually referred to as CoASH or HSCoA. [HMDB] 3-Oxohexadecanoyl-CoA has a role in the synthesis and oxidation of fatty acid. It is involved in the pathway, fatty acid elongation in mitochondria. In this pathway Acetyl-CoA is acted upon by the enzyme, acetyl-CoA C-acyltransferase to produce 3-Oxohexadecanoyl-CoA. Since coenzyme A is chemically a thiol, it can react with carboxylic acids to form thioesters, thus functioning as an acyl group carrier. It assists in transferring fatty acids from the cytoplasm to the mitochondria. A molecule of coenzyme A carrying an acetyl group is also referred to as acetyl-CoA. When it is not attached to an acyl group it is usually referred to as CoASH or HSCoA.
3-Oxotetradecanoyl-CoA
3-Oxotetradecanoyl-CoA is a product of the peroxisomal beta oxidation of hexadenoic acid by the enzyme acyl-CoA oxidase which results in long-chain 3-oxoacyl-CoA-esters. (PMID: 7548202). Myristoyl-CoA:protein N-myristoyltransferase (E.C. 2.3.1.97) is a eukaryotic enzyme that catalyzes the transfer of myristate (C14:O) from myristoyl-CoA to the amino nitrogen of glycine. This covalent protein modification occurs cotranslationally, is apparently irreversible, and affects proteins with diverse functions. (PMID: 2818568). 3-Oxotetradecanoyl-CoA is a product of the peroxisomal beta oxidation of hexadenoic acid by the enzyme acyl-CoA oxidase which results in long-chain 3-oxoacyl-CoA-esters. (PMID: 7548202)
3-Oxooctadecanoyl-CoA
3-Oxooctadecanoyl-CoA is a metabolite intermediate in the microsomal fatty acid chain elongation system. Microsomal electron-transport components NADPH-cytochrome P450 reductase (EC 1.6.2.4) and cytochrome b5 (EC 1.6.2.2) participate in the conversion from 3-Oxooctadecanoyl-CoA to beta-hydroxystearoyl-CoA, the first reductive step of the microsomal chain elongating system initiated by NADPH. (PMID: 6404652) [HMDB] 3-Oxooctadecanoyl-CoA is a metabolite intermediate in the microsomal fatty acid chain elongation system. Microsomal electron-transport components NADPH-cytochrome P450 reductase (EC 1.6.2.4) and cytochrome b5 (EC 1.6.2.2) participate in the conversion from 3-Oxooctadecanoyl-CoA to beta-hydroxystearoyl-CoA, the first reductive step of the microsomal chain elongating system initiated by NADPH. (PMID: 6404652).
3-Oxoeicosa-cis,cis-11,14-dienoyl-CoA
This compound belongs to the family of 3-Oxo-acyl CoAs. These are organic compounds containing a 3-oxo acylated coenzyme A derivative.
16,18-Oxo-18-CoA-dinor-LTE4
16,18-oxo-18-CoA-dinor-LTE4 is a metabolite through lipid oxidation of Leukotriene E4 (LTE4).Leukotriene E4 (LTE4) is a cysteinyl leukotriene. Cysteinyl leukotrienes (CysLTs) are a family of potent inflammatory mediators that appear to contribute to the pathophysiologic features of allergic rhinitis. Nasal blockage induced by CysLTs is mainly due to dilatation of nasal blood vessels, which can be induced by the nitric oxide produced through CysLT1 receptor activation. LTE4, activate contractile and inflammatory processes via specific interaction with putative seven transmembrane-spanning receptors that couple to G proteins and subsequent intracellular signaling pathways. LTE4 is metabolized from leukotriene C4 in a reaction catalyzed by gamma-glutamyl transpeptidase and a particulate dipeptidase from kidney. (PMID: 12607939, 12432945, 6311078). Leukotrienes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signalling pathways. 16,18-oxo-18-CoA-dinor-LTE4 is a metabolite through lipid oxidation of Leukotriene E4 (LTE4).Leukotriene E4 (LTE4) is a cysteinyl leukotriene. Cysteinyl leukotrienes (CysLTs) are a family of potent inflammatory mediators that appear to contribute to the pathophysiologic features of allergic rhinitis. Nasal blockage induced by CysLTs is mainly due to dilatation of nasal blood vessels, which can be induced by the nitric oxide produced through CysLT1 receptor activation. LTE4, activate contractile and inflammatory processes via specific interaction with putative seven transmembrane-spanning receptors that couple to G proteins and subsequent intracellular signaling pathways. LTE4 is metabolized from leukotriene C4 in a reaction catalyzed by gamma-glutamyl transpeptidase and a particulate dipeptidase from kidney. (PMID: 12607939, 12432945, 6311078)
3-Oxopristanoyl-CoA
This compound belongs to the family of 3-Oxo-acyl CoAs. These are organic compounds containing a 3-oxo acylated coenzyme A derivative.
3'-Monoiodo-L-thyronine
3-Monoiodo-L-thyronine, also known as 3-Iodothyronine, belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 3-Monoiodo-L-thyronine is a very strong basic compound (based on its pKa). D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
(6E,8E,10R,12Z)-10-Hydroxy-3-oxooctadecatrienoyl-CoA
(6E,8E,10R,12Z)-10-Hydroxy-3-oxooctadecatrienoyl-CoA, also known as 3-oxo-10(R)-hydroxy-octadeca-6E,8E,12Z-trienoyl-CoA, belongs to the class of organic compounds known as long-chain 3-oxoacyl CoAs. These are organic compounds containing a coenzyme A derivative which has a 3-oxo acylated long aliphatic chain of 13 to 21 carbon atoms. (6E,8E,10R,12Z)-10-Hydroxy-3-oxooctadecatrienoyl-CoA is considered to be a practically insoluble (in water) and relatively neutral molecule.
(6E,8E,10S,12Z)-10-Hydroxy-3-oxooctadecatrienoyl-CoA
(6E,8E,10S,12Z)-10-Hydroxy-3-oxooctadecatrienoyl-CoA, also known as 3-oxo-10(S)-hydroxy-octadeca-6E,8E,12Z-trienoyl-CoA, belongs to the class of organic compounds known as long-chain 3-oxoacyl CoAs. These are organic compounds containing a coenzyme A derivative which has a 3-oxo acylated long aliphatic chain of 13 to 21 carbon atoms. (6E,8E,10S,12Z)-10-Hydroxy-3-oxooctadecatrienoyl-CoA is considered to be a practically insoluble (in water) and relatively neutral molecule.
3-oxo-11-cis-octadecenoyl-CoA
3-oxo-11-cis-octadecenoyl-CoA is also known as (11Z)-3-Ketooctadecenoyl-CoA(4-) or 3-keto-(11Z)-Octadecenoyl-coenzyme A(4-). 3-oxo-11-cis-octadecenoyl-CoA is considered to be slightly soluble (in water) and acidic
(5S,6Z,8E,12R,14Z)-5,12-Dihydroxy-3-oxoicosatrienoyl-CoA
(5S,6Z,8E,12R,14Z)-5,12-Dihydroxy-3-oxoicosatrienoyl-CoA, also known as 3-oxo-5(S),12(R)-dihydroxy-eicosa-8-trans-6,14-cis-trienoyl-CoA, belongs to the class of organic compounds known as long-chain 3-oxoacyl CoAs. These are organic compounds containing a coenzyme A derivative which has a 3-oxo acylated long aliphatic chain of 13 to 21 carbon atoms. (5S,6Z,8E,12R,14Z)-5,12-Dihydroxy-3-oxoicosatrienoyl-CoA is considered to be a practically insoluble (in water) and relatively neutral molecule.
(13Z,16Z,19Z)-3-Oxodocosatrienoyl-CoA
(13Z,16Z,19Z)-3-Oxodocosatrienoyl-CoA, also known as 3-oxo-docosa-13,16,19-all-cis-trienoyl-CoA, belongs to the class of organic compounds known as very-long-chain 3-oxoacyl CoAs. These are organic compounds containing a coenzyme A derivative which has a 3-oxo acylated long aliphatic chain of 22 carbon atoms or more. (13Z,16Z,19Z)-3-Oxodocosatrienoyl-CoA is considered to be a practically insoluble (in water) and relatively neutral molecule.
3-oxo-eicosatrienoyl-CoA
3-oxo-eicosatrienoyl-coa, also known as (11z,14z,17z)-3-oxoeicosatrienoyl-conezyme a(4-) or 3-keto-(11cis,14cis,17cis)-icosatrienoyl-coa(4-), is a member of the class of compounds known as long-chain 3-oxoacyl coas. Long-chain 3-oxoacyl coas are organic compounds containing a coenzyme A derivative, which is 3-oxo acylated long aliphatic chain of 13 to 21 carbon atoms. 3-oxo-eicosatrienoyl-coa is practically insoluble (in water) and an extremely strong acidic compound (based on its pKa). 3-oxo-eicosatrienoyl-coa can be found in a number of food items such as sourdock, tartary buckwheat, cornmint, and macadamia nut (m. tetraphylla), which makes 3-oxo-eicosatrienoyl-coa a potential biomarker for the consumption of these food products.
