3'-Monoiodo-L-thyronine (BioDeep_00000055028)

   

human metabolite


代谢物信息卡片


(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)phenyl]propanoic acid

化学式: C15H14INO4 (398.9968)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 17.39%

分子结构信息

SMILES: C1=CC(=CC=C1CC(C(=O)O)N)OC2=CC(=C(C=C2)O)I
InChI: InChI=1S/C15H14INO4/c16-12-8-11(5-6-14(12)18)21-10-3-1-9(2-4-10)7-13(17)15(19)20/h1-6,8,13,18H,7,17H2,(H,19,20)/t13-/m0/s1

描述信息

3-Monoiodo-L-thyronine, also known as 3-Iodothyronine, belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 3-Monoiodo-L-thyronine is a very strong basic compound (based on its pKa).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

12 个代谢物同义名

(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)phenyl]propanoic acid; (2S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)phenyl]propanoate; O-(4-Hydroxy-3-iodophenyl)-L-tyrosine; 3-Monoiodothyronine, (D-tyr)-isomer; 3’-Monoiodo-L-thyronine; 3-Monoiodo-L-thyronine; 3-monoiodothyronine; 3’-Iodo-L-thyronine; 3-Iodo-L-thyronine; 3’-Iodothyronine; 3-Iodothyronine; 3-T1



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

1 个相关的代谢反应过程信息。

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BioCyc(1)

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Plant Reactome(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sing-Yung Wu, Daniel H Polk, Wen-Sheng Huang, Eugene Ho, Jaffer M Kattan, Delbert A Fisher. 3'-monoiodothyronine sulfate and Triac sulfate are thyroid hormone metabolites in developing sheep. Pediatric research. 2008 Feb; 63(2):149-53. doi: 10.1203/pdr.0b013e31815f6551. [PMID: 18091342]
  • J J DiStefano, D Feng. Comparative aspects of the distribution, metabolism, and excretion of six iodothyronines in the rat. Endocrinology. 1988 Nov; 123(5):2514-25. doi: 10.1210/endo-123-5-2514. [PMID: 3168932]
  • R C Smallridge, N E Whorton. 3'-Monoiodothyronine degradation in rat liver homogenate: enzyme characteristics and documentation of deiodination by high-pressure liquid chromatography. Metabolism: clinical and experimental. 1984 Nov; 33(11):1034-8. doi: 10.1016/0026-0495(84)90233-6. [PMID: 6493046]
  • I J Chopra, T S Huang, R E Hurd, D H Solomon. Thyromimetic effects of 3,5-dimethyl,3'-isopropyl thyronine (DIMIT) and 3,5-diethyl,3'-isopropyl thyronine (DIET) in various tissues of the rat. Metabolism: clinical and experimental. 1984 Jul; 33(7):622-8. doi: 10.1016/0026-0495(84)90060-x. [PMID: 6738362]
  • I J Chopra, T S Huang, R E Hurd, D H Solomon. Effect of 3,5,3'-triiodothyronine-induced hyperthyroidism on iodothyronine metabolism in the rat: evidence for tissue differences in metabolic responses. Endocrinology. 1984 Apr; 114(4):1454-9. doi: 10.1210/endo-114-4-1454. [PMID: 6705742]
  • J Faber, J Heaf, C Kirkegaard, I B Lumholtz, K Siersbaek-Nielsen, K Kølendorf, T Friis. Simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3'-, and 3',5'- diiodothyronine, and 3'-monoiodothyronine in chronic renal failure. The Journal of clinical endocrinology and metabolism. 1983 Feb; 56(2):211-7. doi: 10.1210/jcem-56-2-211. [PMID: 6401746]
  • J Faber, I B Lumholtz, C Kirkegaard, K Siersbaek-Nielsen, T Friis. Isolation of radioactive iodothyronines for kinetic studies: a comparison of two methods. Acta endocrinologica. 1982 Jan; 99(1):64-71. doi: 10.1530/acta.0.0990064. [PMID: 7058678]
  • J Faber, H F Thomsen, I B Lumholtz, C Kirkegaard, K Siersbaek-Nielsen, T Friis. Kinetic studies of thyroxine, 3,5,3'-triiodothyronine, 3,3,5'-triiodothyronine, 3',5'-diiodothyronine, 3,3'-diiodothyronine, and 3'-monoiodothyronine in patients with liver cirrhosis. The Journal of clinical endocrinology and metabolism. 1981 Nov; 53(5):978-84. doi: 10.1210/jcem-53-5-978. [PMID: 7287881]
  • J M Corcoran, C J Eastman. Measurement of 3'-monoiodothyronine in human serum. Clinical endocrinology. 1981 Jul; 15(1):11-8. doi: 10.1111/j.1365-2265.1981.tb02742.x. [PMID: 7307281]
  • R C Smallridge, K D Burman, K E Ward, L Wartofsky, R C Dimond, F D Wright, K R Latham. 3',5'-diiodothyronine to 3'-monoiodothyronine conversion in the fed and fasted rat: enzyme characteristics and evidence for two distinct 5'-deiodinases. Endocrinology. 1981 Jun; 108(6):2336-45. doi: 10.1210/endo-108-6-2336. [PMID: 7227308]
  • H L Wray, K D Burman, R C Smallridge, J P Alford, V M Butler, F D Wright, L Wartofsky. Effect of 3,5,3'-triiodothyronine and 3,3',5'-triiodothyronine administration on serum tri-, di-, and monoiodothyronines and plasma cyclic nucleotides in sheep. Endocrinology. 1980 Jul; 107(1):130-6. doi: 10.1210/endo-107-1-130. [PMID: 6247133]