Lycorine (BioDeep_00000000194)

   

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-

化学式: C16H17NO4 (287.1157522)
中文名称: 石蒜碱盐酸盐, 石蒜碱
谱图信息: 最多检出来源 Viridiplantae(plant) 0.24%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

Lycorine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/lycorine (retrieved 2024-11-25) (BioDeep RN: BioDeep_00000000194). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CN2CC3=CC4=C(C=C3C5C2C1=CC(C5O)O)OCO4
InChI: InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2

描述信息

Lycorine is an indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity. It has a role as a protein synthesis inhibitor, an antimalarial, a plant metabolite and an anticoronaviral agent. It derives from a hydride of a galanthan.
Lycorine is a natural product found in Sternbergia clusiana, Pancratium trianthum, and other organisms with data available.
Lycorine is a toxic crystalline alkaloid found in various Amaryllidaceae species, such as the cultivated bush lily (Clivia miniata), surprise lilies (Lycoris), and daffodils (Narcissus). It may be highly poisonous, or even lethal, when ingested in certain quantities. Symptoms of lycorine toxicity are vomiting, diarrhea, and convulsions. Lycorine, definition at mercksource.com Regardless, it is sometimes used medicinally, a reason why some groups may harvest the very popular Clivia miniata.
An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.144
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.136
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.138
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2316
INTERNAL_ID 2316; CONFIDENCE Reference Standard (Level 1)
[Raw Data] CBA60_Lycorine_pos_30eV.txt
[Raw Data] CBA60_Lycorine_pos_10eV.txt
[Raw Data] CBA60_Lycorine_pos_50eV.txt
[Raw Data] CBA60_Lycorine_pos_40eV.txt
[Raw Data] CBA60_Lycorine_pos_20eV.txt
Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription[2]. Lycorine is also a melanoma vasculogenic inhibitor[3]. Lycorine can be used for the study of prostate cancer and metabolic diseases[2].

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription[2]. Lycorine is also a melanoma vasculogenic inhibitor[3]. Lycorine can be used for the study of prostate cancer and metabolic diseases[2].

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription[2]. Lycorine is also a melanoma vasculogenic inhibitor[3]. Lycorine can be used for the study of prostate cancer and metabolic diseases[2].

同义名列表

46 个代谢物同义名

1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-; (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.0?,??.0?,?.0??,??]nonadeca-2,4(8),9,15-tetraene-17,18-diol; (1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol; 2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, (1S,2S,12bS, 12cS)-; (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol; (1S,2S,12BS,12CS)-2,4,5,7,12B,12C-HEXAHYDRO-1H-(1,3)DIOXOLO(4,5-J)PYRROLO(3,2,1-DE)PHENANTHRIDINE-1,2-DIOL; (1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol; 2,4,5,7,12b,12c-hexahydro-1H-(1,3)dioxolo- (4,5-j)pyrrolo(3,2,1-de)phenanthridine-1,2-diol; 2,5,7,12b,12c-Hexahydro-1H-[1,3]-dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol; Galanthan-1,2-diol, 3,12-didehydro-9,10-(methylenebis(oxy))-, (1-alpha,2-beta)-; Galanthan-1, 3,12-didehydro-9,10-[methylenebis(oxy)]-, (1.alpha.,2.beta.)-; Galanthan-1, 3,4-didehydro-11,12-[methylenebis(oxy)]-, (1.alpha.,2.beta.)-; 9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alpha,2beta-diol; 3,12-[methylenebis(oxy)]-galanthan-1.alpha.,2.beta.-diol; Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-; Lycoran-1.alpha.,2.beta.-diol, 3,3a-didehydro-; lycorine hydrochloride, (1alpha,2beta)-isomer; Lycoran-1alpha,2beta-diol, 3,3a-didehydro-; 3,3a-Didehydrolycoran-1alpha,2beta-diol; Lycoran-1.alpha., 3,3a-didehydro-; BCBcMAP01_000100; UNII-I9Q105R5BU; 3,2.beta.-diol; LYCORINE [MI]; Galanthidine; (-)-Lycorine; KBio3_000043; NCI60_003767; KBio2_005158; KBio2_000022; KBio2_002590; KBio3_000044; IDI1_033772; Bio2_000022; QTL1_000052; Bio2_000502; SMP1_000184; I9Q105R5BU; Amarylline; Narcissine; Lycorine; Licorine; Likorin; 3KD; 2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol; Lycorine



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

  • Amaryllidacea alkaloids biosynthesis: 4'-O-methylnorbelladine + O2 + a reduced [NADPH-hemoprotein reductase] ⟶ (4aS,10bR)-noroxomaritidine + H2O + an oxidized [NADPH-hemoprotein reductase]

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

299 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pingping Tuo, Risheng Zhao, Ning Li, Shuang Yan, Gege Yang, Chunmei Wang, Jinghui Sun, Haiming Sun, Mengyang Wang. Lycorine inhibits Ang II-induced heart remodeling and inflammation by suppressing the PI3K-AKT/NF-κB pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155464. doi: 10.1016/j.phymed.2024.155464. [PMID: 38484625]
  • Zhe Zhou, Mingzhu Wu, Bin Sun, Jie Li, Junde Li, Zhengtai Liu, Meng Gao, Lei Xue, Sheng Xu, Ren Wang. Identification of transcription factor genes responsive to MeJA and characterization of a LaMYC2 transcription factor positively regulates lycorine biosynthesis in Lycoris aurea. Journal of plant physiology. 2024 May; 296(?):154218. doi: 10.1016/j.jplph.2024.154218. [PMID: 38490054]
  • Borjana Sidjimova, Rumen Denev, Milena Nikolova, Jaume Bastida, Strahil Berkov. Dynamics of alkaloid accumulation in Narcissus cv. Hawera: a source of Sceletium-type alkaloids. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2024 Mar; 79(3-4):73-79. doi: 10.1515/znc-2023-0149. [PMID: 38516999]
  • Elder Luis Lima Leite, Ana Sheila de Queiroz Souza, Paulo Riceli Vasconcelos Ribeiro, Rita de Cássia Alves Pereira, Natália Florêncio Martins, Maria Kueirislene Amâncio Ferreira, Jane Eire Silva Alencar de Menezes, Hélcio Silva Dos Santos, Otília Deusdênia Loiola Pessoa, Kirley Marques Canuto. Molecular Docking and GC/MS-Based Approach for Identification of Anxiolytic Alkaloids from Griffinia (Amaryllidaceae) Species in a Zebrafish Model. Chemistry & biodiversity. 2024 Mar; 21(3):e202302122. doi: 10.1002/cbdv.202302122. [PMID: 38354224]
  • Xin Zhou, Zhenli Guo, Shizhong Liu, Zhijian Chen, Yan Wang, Rui Yang, Xinzhi Li, Ketao Ma. Transcriptomics and molecular docking reveal the potential mechanism of lycorine against pancreatic cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155128. doi: 10.1016/j.phymed.2023.155128. [PMID: 37839227]
  • Ayca Cimen, Yavuz Baba, Arzu Birinci Yildirim, Arzu Ucar Turker. Do Vermicompost Applications Improve Growth Performance, Pharmaceutically Important Alkaloids, Phenolic Content, Free Radical Scavenging Potency and Defense Enzyme Activities in Summer Snowflake (Leucojum aestivum L.)?. Chemistry & biodiversity. 2023 Oct; ?(?):e202301074. doi: 10.1002/cbdv.202301074. [PMID: 37779102]
  • Jindan Qi, Mei Meng, Juntao Liu, Xiaoxiao Song, Yu Chen, Yuxi Liu, Xu Li, Zhou Zhou, Xiang Huang, Xiaohua Wang, Quansheng Zhou, Zhe Zhao. Lycorine inhibits pancreatic cancer cell growth and neovascularization by inducing Notch1 degradation and downregulating key vasculogenic genes. Biochemical pharmacology. 2023 Sep; 217(?):115833. doi: 10.1016/j.bcp.2023.115833. [PMID: 37769714]
  • Xinming Liang, Wenli Fu, YuHui Peng, Juanjuan Duan, Ting Zhang, Daogui Fan, Wei Hong, Xiaolan Qi, ChangXue Wu, Yan He, Wenfeng Yu, Jing Zhou, Pengxiang Guo, Hua Bai, Qifang Zhang. Lycorine induces apoptosis of acute myeloid leukemia cells and inhibits triglyceride production via binding and targeting FABP5. Annals of hematology. 2023 Mar; ?(?):. doi: 10.1007/s00277-023-05169-7. [PMID: 36943465]
  • Xia Jiang, Xiaomin Lu, Jiuxin Tang, Yang Xia, Zijian Zhao, Miaohua Quan, Xiaoliang Xiang. Lycorine inhibits the proliferation of neuroblastoma neuro-2a cells by inducing G2/M phase cell cycle arrest and apoptosis. Pakistan journal of pharmaceutical sciences. 2023 Mar; 36(2):379-385. doi: . [PMID: 37530144]
  • Siwei Qiao, Jingyuan Yao, Qizhi Wang, Linwei Li, Bi Wang, Xu Feng, Zhong Wang, Min Yin, Yu Chen, Shu Xu. Anti-fungal effects of amaryllidaceous alkaloids from bulbs of Lycoris spp. against Magnaporthe oryzae. Pest management science. 2023 Feb; ?(?):. doi: 10.1002/ps.7420. [PMID: 36810871]
  • Veronique Mathieu, Breana Laguera, Marco Masi, Sara Adriana Dulanto, Tanner W Bingham, Lucas W Hernandez, David Sarlah, Antonio Evidente, Denis L J Lafontaine, Alexander Kornienko, Michelle A Lane. Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells. Biomolecules. 2022 09; 12(9):. doi: 10.3390/biom12091267. [PMID: 36139106]
  • Lorene Coelho Silva, Amabel Fernandes Correia, João Victor Dutra Gomes, Wanderson Romão, Larissa Campos Motta, Christopher William Fagg, Pérola Oliveira Magalhães, Dâmaris Silveira, Yris Maria Fonseca-Bazzo. Lycorine Alkaloid and Crinum americanum L. (Amaryllidaceae) Extracts Display Antifungal Activity on Clinically Relevant Candida Species. Molecules (Basel, Switzerland). 2022 May; 27(9):. doi: 10.3390/molecules27092976. [PMID: 35566325]
  • Sneha Singh, Nandini Pathak, Eram Fatima, Arvind Singh Negi. Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine. European journal of medicinal chemistry. 2021 Dec; 226(?):113839. doi: 10.1016/j.ejmech.2021.113839. [PMID: 34536668]
  • Shuangshuang Yin, Shenshen Yang, Yanming Luo, Jia Lu, Gaoyong Hu, Kailong Wang, Yingying Shao, Shiyue Zhou, Sangho Koo, Yuling Qiu, Tao Wang, Haiyang Yu. Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma. Biochemical pharmacology. 2021 11; 193(?):114806. doi: 10.1016/j.bcp.2021.114806. [PMID: 34673013]
  • Rong Wang, Yantong Liu, Sheng Xu, Jie Li, Jiayu Zhou, Ren Wang. An ATP-Binding Cassette Transporter, LaABCB11, Contributes to Alkaloid Transport in Lycoris aurea. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111458. [PMID: 34768889]
  • Hui Shang, Xuena Jang, Lingyun Shi, Yifei Ma. Lycorine inhibits cell proliferation and induced oxidative stress-mediated apoptosis via regulation of the JAK/STAT3 signaling pathway in HT-3 cells. Journal of biochemical and molecular toxicology. 2021 Oct; 35(10):e22882. doi: 10.1002/jbt.22882. [PMID: 34558146]
  • Hongzhi Hu, Wenbo Yang, Zihui Liang, Zezhu Zhou, Qingcheng Song, Weijian Liu, Xiangtian Deng, Jian Zhu, Xin Xing, Binglong Zhong, Baichuan Wang, Shangyu Wang, Zengwu Shao, Yingze Zhang. Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy. Journal of nanobiotechnology. 2021 Jul; 19(1):221. doi: 10.1186/s12951-021-00933-1. [PMID: 34315494]
  • Young-Hee Jin, Jung Sun Min, Sangeun Jeon, Jihye Lee, Seungtaek Kim, Tamina Park, Daeui Park, Min Seong Jang, Chul Min Park, Jong Hwan Song, Hyoung Rae Kim, Sunoh Kwon. Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jun; 86(?):153440. doi: 10.1016/j.phymed.2020.153440. [PMID: 33376043]
  • Motahareh Boozari, Hossein Hosseinzadeh. Natural products for COVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies. Phytotherapy research : PTR. 2021 Feb; 35(2):864-876. doi: 10.1002/ptr.6873. [PMID: 32985017]
  • Weina Zhang, Jiaqing Yang, Yu Chen, Renhao Xue, Zhiyong Mao, Wen Lu, Ying Jiang. Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells. Aging cell. 2021 02; 20(2):e13307. doi: 10.1111/acel.13307. [PMID: 33455051]
  • Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zifeng Yang, Jianxin Chen. Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Journal of medicinal chemistry. 2020 11; 63(22):13205-13227. doi: 10.1021/acs.jmedchem.0c00626. [PMID: 32845145]
  • Brenda Petró-Silveira, Graziela Vargas Rigo, Danielle da Silva Trentin, Alexandre José Macedo, Elisa Sauer, Elen de Oliveira Alves, Luciana Ruschel Tallini, Solange Cristina Garcia, Warley de Souza Borges, José Ângelo Silveira Zuanazzi, Tiana Tasca. Trichomonas vaginalis NTPDase inhibited by lycorine modulates the parasite-neutrophil interaction. Parasitology research. 2020 Aug; 119(8):2587-2595. doi: 10.1007/s00436-020-06739-8. [PMID: 32524267]
  • Jerald J Nair, Johannes van Staden. Insight to the antifungal properties of Amaryllidaceae constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Jul; 73(?):152753. doi: 10.1016/j.phymed.2018.11.013. [PMID: 30773353]
  • Deepali Katoch, Dharmesh Kumar, Yogendra S Padwad, Bikram Singh, Upendra Sharma. Pseudolycorine N-oxide, a new N-oxide from Narcissus tazetta. Natural product research. 2020 Jul; 34(14):2051-2058. doi: 10.1080/14786419.2019.1574785. [PMID: 30784301]
  • Martina Kolackova, Pavel Chaloupsky, Natalia Cernei, Borivoj Klejdus, Dalibor Huska, Vojtech Adam. Lycorine and UV-C stimulate phenolic secondary metabolites production and miRNA expression in Chlamydomonas reinhardtii. Journal of hazardous materials. 2020 06; 391(?):122088. doi: 10.1016/j.jhazmat.2020.122088. [PMID: 32045800]
  • Haiqin Wang, Yanfei Gong, Long Liang, Ling Xiao, Hui Yi, Mao Ye, Mridul Roy, Jiliang Xia, Wen Zhou, Chaoying Yang, Xiaokai Shen, Boxin Zhang, Zhenzhen Li, Jing Liu, Hui Zhou, Xiaojuan Xiao. Lycorine targets multiple myeloma stem cell-like cells by inhibition of Wnt/β-catenin pathway. British journal of haematology. 2020 06; 189(6):1151-1164. doi: 10.1111/bjh.16477. [PMID: 32167591]
  • Katharina Schimmel, Mira Jung, Ariana Foinquinos, Gorka San José, Javier Beaumont, Katharina Bock, Lea Grote-Levi, Ke Xiao, Christian Bär, Angelika Pfanne, Annette Just, Karina Zimmer, Soeun Ngoy, Begoña López, Susana Ravassa, Sabine Samolovac, Heike Janssen-Peters, Janet Remke, Kristian Scherf, Seema Dangwal, Maria-Teresa Piccoli, Felix Kleemiss, Fabian Philipp Kreutzer, Franziska Kenneweg, Julia Leonardy, Lisa Hobuß, Laura Santer, Quoc-Tuan Do, Robert Geffers, Jan Hinrich Braesen, Jessica Schmitz, Christina Brandenberger, Dominik N Müller, Nicola Wilck, Volkhard Kaever, Heike Bähre, Sandor Batkai, Jan Fiedler, Kevin M Alexander, Bradley M Wertheim, Sudeshna Fisch, Ronglih Liao, Javier Diez, Arantxa González, Thomas Thum. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation. 2020 03; 141(9):751-767. doi: 10.1161/circulationaha.119.042559. [PMID: 31948273]
  • Deepali Katoch, Dharmesh Kumar, Yogendra S Padwad, Bikram Singh, Upendra Sharma. Narciclasine-4-O-β-D-xylopyranoside, a new narciclasine glycoside from Zephyranthes minuta. Natural product research. 2020 Jan; 34(2):233-240. doi: 10.1080/14786419.2018.1527836. [PMID: 30636443]
  • Deepali Katoch, Upendra Sharma. Simultaneous quantification and identification of Amaryllidaceae alkaloids in Narcissus tazetta by ultra performance liquid chromatography-diode array detector-electrospray ionisation tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2019 Oct; 175(?):112750. doi: 10.1016/j.jpba.2019.06.047. [PMID: 31330284]
  • Jerald J Nair, Johannes van Staden. Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. Bioorganic & medicinal chemistry letters. 2019 10; 29(20):126642. doi: 10.1016/j.bmcl.2019.126642. [PMID: 31515186]
  • Li Li, Zao Zhang, Qian Yang, Meiying Ning. Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the miR-186/CDK1 axis. Life sciences. 2019 Aug; 231(?):116528. doi: 10.1016/j.lfs.2019.06.003. [PMID: 31176784]
  • Ameneh Tarakemeh, Majid Azizi, Vahid Rowshan, Hassan Salehi, Rosella Spina, François Dupire, Hossein Arouie, Dominique Laurain-Mattar. Screening of Amaryllidaceae alkaloids in bulbs and tissue cultures of Narcissus papyraceus and four varieties of N. tazetta. Journal of pharmaceutical and biomedical analysis. 2019 Aug; 172(?):230-237. doi: 10.1016/j.jpba.2019.04.043. [PMID: 31060036]
  • Aiqian Li, Zhifeng Du, Mei Liao, Yulin Feng, Hanli Ruan, Hongliang Jiang. Discovery and characterisation of lycorine-type alkaloids in Lycoris spp. (Amaryllidaceae) using UHPLC-QTOF-MS. Phytochemical analysis : PCA. 2019 May; 30(3):268-277. doi: 10.1002/pca.2811. [PMID: 30548356]
  • Hyun-Jung Park, Malihatosadat Gholam-Zadeh, Jae-Hee Suh, Hye-Seon Choi. Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss. Oxidative medicine and cellular longevity. 2019; 2019(?):8982147. doi: 10.1155/2019/8982147. [PMID: 31687088]
  • Wuyi Liu, Qian Zhang, Qin Tang, Changpeng Hu, Jingbin Huang, Yali Liu, Yanyi Lu, Qing Wang, Guobing Li, Rong Zhang. Lycorine inhibits cell proliferation and migration by inhibiting ROCK1/cofilin‑induced actin dynamics in HepG2 hepatoblastoma cells. Oncology reports. 2018 Oct; 40(4):2298-2306. doi: 10.3892/or.2018.6609. [PMID: 30066939]
  • Sarah S Takla, Eman Shawky, Hala M Hammoda, Fikria A Darwish. Green techniques in comparison to conventional ones in the extraction of Amaryllidaceae alkaloids: Best solvents selection and parameters optimization. Journal of chromatography. A. 2018 Sep; 1567(?):99-110. doi: 10.1016/j.chroma.2018.07.009. [PMID: 30033169]
  • H Bendaif, A Melhaoui, M Ramdani, H Elmsellem, C Douez, Y El Ouadi. Antibacterial activity and virtual screening by molecular docking of lycorine from Pancratium foetidum Pom (Moroccan endemic Amaryllidaceae). Microbial pathogenesis. 2018 Feb; 115(?):138-145. doi: 10.1016/j.micpath.2017.12.037. [PMID: 29253598]
  • Haiyang Yu, Yuling Qiu, Xu Pang, Jian Li, Song Wu, Shuangshuang Yin, Lifeng Han, Yi Zhang, Chengyun Jin, Xiumei Gao, Wenwei Hu, Tao Wang. Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma. Molecular cancer therapeutics. 2017 Dec; 16(12):2711-2723. doi: 10.1158/1535-7163.mct-17-0498. [PMID: 28974556]
  • Jerald J Nair, Anke Wilhelm, Susanna L Bonnet, Johannes van Staden. Antibacterial constituents of the plant family Amaryllidaceae. Bioorganic & medicinal chemistry letters. 2017 11; 27(22):4943-4951. doi: 10.1016/j.bmcl.2017.09.052. [PMID: 29033234]
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