D-(-)-Lactic acid (BioDeep_00000229706)

Main id: BioDeep_00000014411

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


D-(−)-Lactic acid

化学式: C3H6O3 (90.0317)
中文名称: D-乳酸
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-08-05.

Cite this Page

D-(-)-Lactic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/d-(-)-lactic_acid (retrieved 2024-12-24) (BioDeep RN: BioDeep_00000229706). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C(=O)O)O
InChI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1

描述信息

Lactic acid, also known as lactate, plays several important biological roles in living organisms. Here are some of its key functions:

Energy Production: Lactic acid is a crucial intermediate in the process of anaerobic glycolysis, which occurs in cells when oxygen is limited. During intense exercise, for example, muscle cells produce lactic acid as a byproduct of breaking down glucose for energy without using oxygen. This process helps sustain muscle activity when oxygen supply is insufficient.
pH Regulation: Lactic acid serves as a pH buffer in the blood and other bodily fluids. It helps maintain the acid-base balance by accepting or donating hydrogen ions (H+), thereby preventing large fluctuations in pH that could be harmful to cellular processes.
Hemoglobin Oxygen Release: Lactic acid can also influence the affinity of hemoglobin for oxygen. In tissues with high lactic acid concentrations (like exercising muscles), lactic acid binds to hemoglobin, causing a conformational change that promotes the release of oxygen. This is known as the Bohr effect.
Cell Signaling: Lactate can act as a signaling molecule in various physiological processes. It has been shown to play a role in cell proliferation, inflammation, and immune response. Lactate can modulate the activity of immune cells and may contribute to the regulation of inflammation.
Metabolic Regulation: Lactic acid is an important component in the metabolic network. It can be converted back into glucose in the liver through a process called gluconeogenesis, providing a source of energy for other tissues, including the brain, when carbohydrates are scarce.
Antioxidant Properties: Lactic acid can function as an antioxidant, helping to protect cells from oxidative stress and damage caused by reactive oxygen species (ROS).
Preservation of Foods: In food industry, lactic acid is used as a preservative due to its antimicrobial properties. It can inhibit the growth of bacteria and extend the shelf life of various food products.

同义名列表

4 个代谢物同义名

D-(−)-Lactic acid; D-Lactic acid; lactic acid; (R)-Lactate



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Haifeng Li, Siyuan Chen, Mengyu Wang, Shuoshuo Shi, Wenjian Zhao, Guoyang Xiong, Jia Zhou, Jianhang Qu. Phosphate solubilization and plant growth properties are promoted by a lactic acid bacterium in calcareous soil. Applied microbiology and biotechnology. 2024 Dec; 108(1):24. doi: 10.1007/s00253-023-12850-4. [PMID: 38159115]
  • Isaac A Chávez-Guevara, Everardo González-Rodríguez, Verónica Moreno-Brito, Jorge A Pérez-León, Francisco J Amaro-Gahete, Marina Trejo-Trejo, Arnulfo Ramos-Jiménez. The polymorphism T1470A of the SLC16A1 gene is associated with the lactate and ventilatory thresholds but not with fat oxidation capacity in young men. European journal of applied physiology. 2024 Jun; 124(6):1835-1843. doi: 10.1007/s00421-023-05407-w. [PMID: 38216723]
  • Zhenyuan Qian, Fang Wu, Guoqing Feng, Wenfa Lin, Xufan Cai, Jianzhang Wu, Kun Ke, Zaiyuan Ye, Guoxi Xu. A prognostic risk model based on lactate metabolism and transport-related lncRNAs for gastric adenocarcinoma. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2024 Jun; 29(4):211-221. doi: 10.1080/1354750x.2024.2341411. [PMID: 38629165]
  • Weijuan Zou, Feng Gao, Zheying Meng, Xiaojun Cai, Wu Chen, Yuanyi Zheng, Tao Ying, Longchen Wang, Jianrong Wu. Lactic acid responsive sequential production of hydrogen peroxide and consumption of glutathione for enhanced ferroptosis tumor therapy. Journal of colloid and interface science. 2024 Jun; 663(?):787-800. doi: 10.1016/j.jcis.2024.03.001. [PMID: 38442520]
  • Anam Layla, Qamar Abbas Syed, Tahir Zahoor, Muhammad Shahid. Investigating the role of Lactiplantibacillus plantarum vs. spontaneous fermentation in improving nutritional and consumer safety of the fermented white cabbage sprouts. International microbiology : the official journal of the Spanish Society for Microbiology. 2024 Jun; 27(3):753-764. doi: 10.1007/s10123-023-00426-1. [PMID: 37700156]
  • Alexander S Shashkov, Natalia V Potekhina, Elena M Tul'skaya, Andrey S Dmitrenok, Sof'ya N Senchenkova, Vladimir I Torgov, Lubov V Dorofeeva, Lyudmila I Evtushenko. New lactate- and pyruvate-containing polysaccharide and rhamnomannan with xylose residues from the cell wall of Rathayibacter oskolensis VKM Ac-2121T. Carbohydrate research. 2024 Jun; 540(?):109145. doi: 10.1016/j.carres.2024.109145. [PMID: 38759341]
  • Mariannys Chavez, Sharon Viscardi, María José Ruiz, Eulàlia Sans-Serramitjana, Paola Durán. CLI: A new protocol for the isolation of Lactic Acid Bacteria from complex plant samples. Journal of microbiological methods. 2024 Jun; 221(?):106937. doi: 10.1016/j.mimet.2024.106937. [PMID: 38648958]
  • Francesco Martelli, Valentina Bernini, Erasmo Neviani, Vitor Vasconcelos, Ralph Urbatzka. Lactic acid fermented microalgae and cyanobacteria as a new source of lipid reducing compounds: assessment through zebrafish Nile red fat metabolism assay and untargeted metabolomics. Food & function. 2024 May; 15(10):5554-5565. doi: 10.1039/d4fo00699b. [PMID: 38712867]
  • Yuanqing Gu, Björn M Reinhard. Membrane fluidity properties of lipid-coated polylactic acid nanoparticles. Nanoscale. 2024 May; 16(17):8533-8545. doi: 10.1039/d3nr06464f. [PMID: 38595322]
  • Nopparuj Soomherun, Narumol Kreua-Ongarjnukool, Saowapa Thumsing Niyomthai, Sorayouth Chumnanvej. Lipid-Polymer Hybrid Nanoparticles Synthesized via Lipid-Based Surface Engineering for a robust drug delivery platform. Colloids and surfaces. B, Biointerfaces. 2024 May; 237(?):113858. doi: 10.1016/j.colsurfb.2024.113858. [PMID: 38547797]
  • Fan Yan, Junchi Ma, Manjiang Peng, Congfang Xi, Sheng Chang, Ying Yang, Suohui Tian, Bo Zhou, Tao Liu. Lactic acid induced defense responses in tobacco against Phytophthora nicotianae. Scientific reports. 2024 04; 14(1):9338. doi: 10.1038/s41598-024-60037-2. [PMID: 38654120]
  • Jie Li, Yi Liu, Ru-Ting Li, Yan Liu, Feng Li. The Effect of Anti-fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model. Journal of visualized experiments : JoVE. 2024 Apr; ?(206):. doi: 10.3791/66481. [PMID: 38682926]
  • Xueyan Gu, Heng Wang, Lei Wang, Kang Zhang, Yuhu Tian, Xiaoya Wang, Guowei Xu, Zhiting Guo, Saad Ahmad, Hanyurwumutima Egide, Jiahui Liu, Jianxi Li, Huub F J Savelkoul, Jingyan Zhang, Xuezhi Wang. The antioxidant activity and metabolomic analysis of the supernatant of Streptococcus alactolyticus strain FGM. Scientific reports. 2024 04; 14(1):8413. doi: 10.1038/s41598-024-58933-8. [PMID: 38600137]
  • Wenbo Sun, Dan Xu, YanXing Yang, Linfei Wen, Hanjiang Yu, Yaowen Xing, Xiaopeng Song, Huan Li, Haibo Xu. Improved Detection of Target Metabolites in Brain Tumors with Intermediate TE, High SNR, and High Bandwidth Spin-Echo Sequence at 5T. AJNR. American journal of neuroradiology. 2024 Apr; 45(4):461-467. doi: 10.3174/ajnr.a8150. [PMID: 38453417]
  • Yueling Chen, Wenchao Yang, Zikang Hu, Xiaoyan Gao, Jingbiao Ye, Xiangqian Song, Baoshu Chen, Zhengqiu Li. Bionic structure and biocompatibilities of long chain branched poly(L-lactic acid) oriented microcellular foaming material. International journal of biological macromolecules. 2024 Apr; 263(Pt 2):130467. doi: 10.1016/j.ijbiomac.2024.130467. [PMID: 38423433]
  • Mette G B Pedersen, Nikolaj Rittig, Maj Bangshaab, Kristoffer Berg-Hansen, Nigopan Gopalasingam, Lars C Gormsen, Esben Søndergaard, Niels Møller. Effects of exogenous lactate on lipid, protein, and glucose metabolism-a randomized crossover trial in healthy males. American journal of physiology. Endocrinology and metabolism. 2024 Apr; 326(4):E443-E453. doi: 10.1152/ajpendo.00301.2023. [PMID: 38324259]
  • Yuying Chen, Qingwei He, Huangjie Lu, Jie Yang, Jiongming Han, Ying Zhu, Ping Hu. Visualization and correlation of drug release of risperidone/clozapine microspheres in vitro and in vivo based on FRET mechanism. International journal of pharmaceutics. 2024 Mar; 653(?):123885. doi: 10.1016/j.ijpharm.2024.123885. [PMID: 38325621]
  • Jiarong Song, Xue Dong, Yue Lan, Yunwei Lu, Xu Liu, Xuena Kang, Zhonglu Huang, Bisong Yue, Yu Liu, Wenjin Ma, Libo Zhang, Haijun Yan, Miao He, Zhenxin Fan, Tao Guo. Interpretation of vaginal metagenomic characteristics in different types of vaginitis. mSystems. 2024 Mar; 9(3):e0137723. doi: 10.1128/msystems.01377-23. [PMID: 38364107]
  • Elton T Montrazi, Keren Sasson, Lilach Agemy, Avigdor Scherz, Lucio Frydman. Molecular imaging of tumor metabolism: Insight from pyruvate- and glucose-based deuterium MRI studies. Science advances. 2024 Mar; 10(11):eadm8600. doi: 10.1126/sciadv.adm8600. [PMID: 38478615]
  • Peiyan Yang, Hui Li, Mingjun Sun, Xinxin Guo, Yinghao Liao, Mohan Hu, Ping Ye, Ran Liu. Zinc deficiency drives ferroptosis resistance by lactate production in esophageal squamous cell carcinoma. Free radical biology & medicine. 2024 03; 213(?):512-522. doi: 10.1016/j.freeradbiomed.2024.01.041. [PMID: 38301975]
  • Jiaojiao Liao, Chenyuan Qin, Zongyu Wang, Ling Gao, Shimo Zhang, Yuting Feng, Jue Liu, Liyuan Tao. Effect of shenfu injection in patients with septic shock: A systemic review and meta-analysis for randomized clinical trials. Journal of ethnopharmacology. 2024 Feb; 320(?):117431. doi: 10.1016/j.jep.2023.117431. [PMID: 37981120]
  • Wenhui Duan, Lingxi Zhou, Yilin Ren, Fei Liu, Yuzheng Xue, Fang-Zhou Wang, Ran Lu, Xiao-Juan Zhang, Jin-Song Shi, Zheng-Hong Xu, Yan Geng. Lactic acid fermentation of goji berries (Lycium barbarum) prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice. Food & function. 2024 Feb; 15(3):1612-1626. doi: 10.1039/d3fo03324d. [PMID: 38240339]
  • Sydney Stanley, Xin Wang, Qingyun Liu, Young Yon Kwon, Abigail M Frey, Nathan D Hicks, Andrew J Vickers, Sheng Hui, Sarah M Fortune. Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure. PLoS pathogens. 2024 Feb; 20(2):e1012050. doi: 10.1371/journal.ppat.1012050. [PMID: 38422159]
  • Wei Bo, Ning Yu, Xiaokai Wang, Chun Wang, Chunying Liu. Lactate promoted cisplatin resistance in NSCLC by modulating the m6A modification-mediated FOXO3/MAGI1-IT1/miR-664b-3p/IL-6R axis. Neoplasia (New York, N.Y.). 2024 Feb; 48(?):100960. doi: 10.1016/j.neo.2023.100960. [PMID: 38184887]
  • Natalia Hernández-Herreros, Virginia Rivero-Buceta, Isabel Pardo, M Auxiliadora Prieto. Production of poly(3-hydroxybutyrate)/poly(lactic acid) from industrial wastewater by wild-type Cupriavidus necator H16. Water research. 2024 Feb; 249(?):120892. doi: 10.1016/j.watres.2023.120892. [PMID: 38007895]
  • Yihan Ni, Xiangdeng Lai, Lin Li, Jingquan Sun, Yaqian Qu, Siyu Chen, Hao Zhang. Role of GPR81 in regulating intramuscular triglyceride storage during aerobic exercise in rats. Physiology international. 2024 Jan; ?(?):. doi: 10.1556/2060.2023.00238. [PMID: 38294536]
  • Yanhui Zhao, Min Zhao, Yumeng Zhang, Zixuan Fu, Tong Jin, Jiaxi Song, Yihe Huang, Chunjie Zhao, Miao Wang. Bile acids metabolism involved in the beneficial effects of Danggui Shaoyao San via gut microbiota in the treatment of CCl4 induced hepatic fibrosis. Journal of ethnopharmacology. 2024 Jan; 319(Pt 3):117383. doi: 10.1016/j.jep.2023.117383. [PMID: 37925004]
  • Jing Yang, Glenn R Gourley, Adam Gilbertsen, Chi Chen, Lei Wang, Karen Smith, Marion Namenwirth, Libang Yang. High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81. Cells. 2024 Jan; 13(3):. doi: 10.3390/cells13030236. [PMID: 38334628]
  • Gorka Prieto-Bellver, Javier Diaz-Lara, David J Bishop, José Fernández-Sáez, Javier Abián-Vicén, Iñigo San-Millan, Jordan Santos-Concejero. A Five-Week Periodized Carbohydrate Diet Does Not Improve Maximal Lactate Steady-State Exercise Capacity and Substrate Oxidation in Well-Trained Cyclists compared to a High-Carbohydrate Diet. Nutrients. 2024 Jan; 16(2):. doi: 10.3390/nu16020318. [PMID: 38276556]
  • Yongzhan Zhu, Yinghao Li, Xiaosong Zhou, Haoxuan Li, Min Guo, Peibiao Zhang. Glucose microenvironment sensitive degradation of arginine modified calcium sulfate reinforced poly(lactide-co-glycolide) composite scaffolds. Journal of materials chemistry. B. 2024 Jan; 12(2):508-524. doi: 10.1039/d3tb01595e. [PMID: 38108579]
  • Fei Tang, Dong Liu, Feng Wan, Li Zhang, Li-Yue Xu, Jing-Nan Zhang, Xiao-Lan Zhao, Hui Ao, Cheng Peng. Ameliorative effect of anisodamine (654-1/654-2) against myocardial dysfunction induced by septic shock via the NF-κB/NLRP-3 or the PI3K-AKT/NF-κB pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155277. doi: 10.1016/j.phymed.2023.155277. [PMID: 38128396]
  • Devendra Paudel, Divek V T Nair, Sangshan Tian, Fuhua Hao, Umesh K Goand, Grace Joseph, Eleni Prodes, Zhi Chai, Chloé E M Robert, Benoit Chassaing, Andrew D Patterson, Vishal Singh. Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation. Gut microbes. 2024 Jan; 16(1):2341457. doi: 10.1080/19490976.2024.2341457. [PMID: 38630030]
  • Cui Wang, Xiaoting Wang, Hongmin Zhang, Dawei Liu, Chengyuan Zhang. Effect of Norepinephrine on Peripheral Perfusion Index and Its Association With the Prognosis of Patients With Sepsis. Journal of intensive care medicine. 2024 Jan; 39(1):21-27. doi: 10.1177/08850666231187333. [PMID: 37431214]
  • Tine Van den Bossche, Karen Goossens, Geert Haesaert, Eva Wambacq, Leen Vandaele, Johan L De Boever. Autumn grass treated with a hydrolysable tannin extract versus lactic acid bacteria inoculant: Effects on silage fermentation characteristics and nutritional value and on performance of lactating dairy cows. Journal of animal physiology and animal nutrition. 2024 Jan; 108(1):111-125. doi: 10.1111/jpn.13871. [PMID: 37602531]
  • Lang Bai, Qibin Han, Zeyu Han, Xiaoyu Zhang, Jingwen Zhao, Huitong Ruan, Junliang Wang, Feng Lin, Wenguo Cui, Xing Yang, Yuefeng Hao. Stem Cells Expansion Vector via Bioadhesive Porous Microspheres for Accelerating Articular Cartilage Regeneration. Advanced healthcare materials. 2024 Jan; 13(3):e2302327. doi: 10.1002/adhm.202302327. [PMID: 37947298]
  • Wei Zhou Teo, Jie Yang See, Sheena Ramazanu, James Chun Yip Chan, Xi Vivien Wu. Effect of lactic acid fermented foods on glycemic control in diabetic adults: a systemic review and meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition. 2024; 64(10):2863-2878. doi: 10.1080/10408398.2022.2128032. [PMID: 36178255]
  • Yirivinti Hayagreeva Dinakar, Naveen Rajana, Nalla Usha Kumari, Vikas Jain, Neelesh Kumar Mehra. Recent Advances of Multifunctional PLGA Nanocarriers in the Management of Triple-Negative Breast Cancer. AAPS PharmSciTech. 2023 Dec; 24(8):258. doi: 10.1208/s12249-023-02712-7. [PMID: 38097825]
  • Jing Wu, Panchaonan Huang, Yunzi Feng, Chun Cui, Jucai Xu, Laihao Li. Enhancing Kokumi Sensation and Reducing Bitterness in Acid-Hydrolyzed Vegetable Proteins through Lactate and Thermal Processing. Journal of agricultural and food chemistry. 2023 Dec; 71(49):19694-19704. doi: 10.1021/acs.jafc.3c04282. [PMID: 38016698]
  • Roland Eghoghosoa Akhigbe, Bayo-Olugbami Adedamola Aminat, Tunmise Maryanne Akhigbe, Moses Agbomhere Hamed. Glutamine Alleviates I/R-Induced Intestinal Injury and Dysmotility Via the Downregulation of Xanthine Oxidase/Uric Acid Signaling and Lactate Generation in Wistar Rats. The Journal of surgical research. 2023 Dec; 295(?):431-441. doi: 10.1016/j.jss.2023.11.041. [PMID: 38070257]
  • Yansheng Zhao, Mei Xiao, Aya Samy Eweys, Juan Bai, Osama M Darwesh, Xiang Xiao. Cinnamaldehyde Alleviates the Oxidative Stress of Caenorhabditis elegans in the Presence of Lactic Acid. Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Dec; 78(4):683-690. doi: 10.1007/s11130-023-01094-2. [PMID: 37688685]
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  • Samantha L Moss, Edward Brindley, Kevin Enright, Jamie Highton, Richard Bott. The Effects of an Acute Dose of New Zealand Blackcurrant Extract on 5-km Running Performance. International journal of sport nutrition and exercise metabolism. 2023 Nov; 33(6):323-330. doi: 10.1123/ijsnem.2023-0029. [PMID: 37648248]
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  • Lele Jian, Xing Gao, Chao Wang, Xiao Sun, Yuqiao Xu, Ruili Han, Yuying Wang, Shenhui Xu, Lan Ding, Jingjun Zhou, Yu Gu, Yuanlin Zhao, Ying Yang, Yuan Yuan, Jing Ye, Lijun Zhang. Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice. Biology direct. 2023 Sep; 18(1):54. doi: 10.1186/s13062-023-00411-8. [PMID: 37667357]
  • Mingzhu Yu, Qiaoling Pan, Wenbiao Li, Tingting Du, Fei Huang, Hui Wu, Yixin He, Xiaojun Wu, Hailian Shi. Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α mediated energy metabolic collapse. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155045. doi: 10.1016/j.phymed.2023.155045. [PMID: 37742526]
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  • Marcin Feldo, Magdalena Wójciak, Sławomir Dresler, Paweł Sowa, Bartosz J Płachno, Dariusz Samborski, Ireneusz Sowa. Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. International journal of molecular sciences. 2023 Aug; 24(16):. doi: 10.3390/ijms241612917. [PMID: 37629098]
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