(-)-dehydrocostus lactone (BioDeep_00000000027)

PANOMIX_OTCML-2023 Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

Azuleno(4,5-b)furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3aS-(3a.alpha.,6a.alpha.,9a.alpha.,9b.beta.))-

化学式: C15H18O2 (230.1306728)
中文名称: 去氢木香内酯, 去氢木香烃内酯
谱图信息: 最多检出来源 Viridiplantae(plant) 1.06%

Reviewed

Last reviewed on 2024-07-03.

Cite this Page

(-)-dehydrocostus lactone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/(-)-dehydrocostus_lactone (retrieved 2024-11-24) (BioDeep RN: BioDeep_00000000027). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C=C1C(=O)OC2C1CCC(=C)C1CCC(=C)C12
InChI: InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2

描述信息

Dehydrocostus lactone is an organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone. It has a role as a metabolite, a trypanocidal drug, an antineoplastic agent, a cyclooxygenase 2 inhibitor, an antimycobacterial drug and an apoptosis inducer. It is a sesquiterpene lactone, a guaiane sesquiterpenoid, an organic heterotricyclic compound and a gamma-lactone.
Dehydrocostus lactone is a natural product found in Marshallia obovata, Cirsium carolinianum, and other organisms with data available.
See also: Arctium lappa Root (part of).
An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.
CONFIDENCE standard compound; ML_ID 36
Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea costus. IC50 value: Target: In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. In vivo: Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo [3].
Dehydrocostus Lactone is a major sesquiterpene lactone isolated from the roots of Saussurea costus. IC50 value: Target: In vitro: Dehydrocostus Lactone promoted apoptosis with increased activation of caspases 8, 9, 7, 3, enhanced PARP cleavage, decreased Bcl-xL expression and increased levels of Bax, Bak, Bok, Bik, Bmf, and t-Bid. We have demonstrated that Dehydrocostus Lactone inhibits cell growth and induce apoptosis in DU145 cells [1]. Dehydrocostus Lactone inhibits NF-kappaB activation by preventing TNF-alpha-induced degradation and phosphorylation of its inhibitory protein I-kappaB alpha in human leukemia HL-60 cells and that dehydrocostus lactone renders HL-60 cells susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 activities [2]. Dehydrocostus Lactone inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. In vivo: Dehydrocostus Lactone decreased the TNF-alpha level in LPS-activated systems in vivo [3].

同义名列表

32 个代谢物同义名

Azuleno(4,5-b)furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3aS-(3a.alpha.,6a.alpha.,9a.alpha.,9b.beta.))-; Azuleno(4,5-b)furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3aS-(3aalpha,6aalpha,9aalpha,9bbeta))-; (3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one; (3aS,6aR,9aR,9bS)-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one; (3aR,6aS,9aS,9bR)-3,6,9-tris(methylidene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione; (3aR,6aS,9aS,9bR)-3,6,9-tris(methylene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione; AZULENO(4,5-B)FURAN-2(3H)-ONE, DECAHYDRO-3,6,9-TRIS(METHYLENE)-, (3AS,6AR,9AR,9BS)-; GUAIA-4(15),10(14),11(13)-TRIEN-12-OIC ACID, 6.ALPHA.-HYDROXY-, .GAMMA.-LACTONE; (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one; (3as,6ar,9ar,9bs)-3,6,9-trimethylidenedecahydroazuleno[4,5-b]furan-2(3h)-one; (3aS,6aR,9aR,9bS)-3,6,9-Trimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one; Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone; (3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one; Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-tris(methylene)-; Dehydrocostus lactone, analytical standard; (-)-Dehydrocostus lactone; Dehydrocostus lactone, >=98\\% (HPLC); Dehydrocostus lactone, (-)-; (-)-dehydrocostus lactone; (-)-dehydrocostuslactone; COSTUS LACTONE, DEHYDRO-; Dehydrocostus-Lactone; dehydrocostus lactone; dehydrocostuslactone; Epiligulyl oxide; UNII-71TRF5K040; Dehydrocostus; 71TRF5K040; 3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one; Epiligulyl oxide; Dehydrocostus lactone; Dehydrocostus lactone

数据库引用编号

20 个数据库交叉引用编号

ChEBI: CHEBI:244418
ChEBI: CHEBI:181589
KEGG: C09387
PubChem: 73174
Metlin: METLIN67654
ChEMBL: CHEMBL88985
ChEMBL: CHEMBL1939730
MeSH: dehydrocostus lactone
ChemIDplus: 0000477430
chemspider: 65938
CAS: 477-43-0
MoNA: ML003601
medchemexpress: HY-N0591
PMhub: MS000009760
MetaboLights: MTBLC244418
PubChem: 11578
KNApSAcK: C00003245
3DMET: B02921
NIKKAJI: J12.433H
KNApSAcK: 244418

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

418280 - Ainsliaea uniflora: 10.1248/CPB.35.1479
4217 - Arctium lappa: 10.1271/NOGEIKAGAKU1924.59.389
1472730 - Aristolochia griffithii: 10.1016/0031-9422(89)80315-2
1907487 - Aristolochia yunnanensis: 10.1016/0031-9422(89)80315-2
1308047 - Cirsium carolinianum: 10.1016/0031-9422(81)85199-0
41555 - Cosmos: 10.1021/NP010615P
4631 - Costus: 10.1021/NP970333I
4265 - Cynara cardunculus: 10.1016/S0960-894X(02)00889-2
454324 - Dolomiaea souliei: 10.1016/0031-9422(90)85430-N
434655 - Eremanthus erythropappus: 10.1021/NP50042A020
3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
160037 - Fitchia speciosa: 10.1016/0031-9422(80)83071-8
1542350 - Gochnatia vernonioides: 10.1016/S0031-9422(00)84955-9
2676169 - Gymnanthemum myrianthum: 10.1016/0031-9422(94)85023-2
268054 - Hieracium intybaceum: 10.1002/CBDV.200490031
55635 - Inula helenium: 10.1002/MRC.2297
190079 - Laurobasidium lauri: 10.1016/S0031-9422(97)00435-4
85223 - Laurus nobilis:
1519680 - Laurus novocanariensis:
207887 - Liabum bourgeaui: 10.1016/S0031-9422(00)83499-8
545644 - Lindera aggregata: 10.1055/S-0030-1270922
82756 - Linzia glabra: 10.1016/0031-9422(83)80212-X
1548356 - Lychnophora candelabrum: 10.1016/0305-1978(91)90062-5
194324 - Maclura cochinchinensis: 10.1016/0031-9422(88)84133-5
85868 - Magnolia sieboldii: 10.1016/0031-9422(96)00082-9
128741 - Marshallia obovata: 10.1016/S0031-9422(00)83819-4
1542361 - Moquiniastrum paniculatum: 10.1016/S0031-9422(00)80086-2
2576591 - Nahuatlea hypoleuca: 10.1016/S0031-9422(00)81575-7
1569432 - Paralychnophora bicolor: 10.1016/S0031-9422(00)83940-0
320624 - Picris altissima: 10.1016/0031-9422(91)83066-T
379641 - Picris rhagadioloides: 10.1016/0031-9422(91)83066-T
33090 - Plants: -
324593 - Saussurea costus:
324593 - Saussurea costus: 10.3390/MOLECULES14010266
200489 - Saussurea involucrata:
261619 - Takhtajaniantha austriaca: 10.1021/NP900378C
2813300 - Targionia lorbeeriana: 10.1016/S0031-9422(98)00648-7
2067404 - Vernonia leopoldi: 10.1016/0031-9422(94)85023-2
33090 - 木香: -
33090 - 芦荟: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Miaomiao Sun, Honghong Zhan, Xiaoliang Long, Ali M Alsayed, Zhe Wang, Fancheng Meng, Guowei Wang, Jingxin Mao, Zhihua Liao, Min Chen. Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4/MD2 complex formation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155371. doi: 10.1016/j.phymed.2024.155371. [PMID: 38518649]
Chunyi Xu, Linxian Zhao, Weiling Zhou, Yanyan Li, Huiling Hu, Zhanguo Wang. Synergistic effect of berberine hydrochloride and dehydrocostus lactone in the treatment of ulcerative colitis: Take gut microbiota as the target. International immunopharmacology. 2023 Oct; 124(Pt B):111009. doi: 10.1016/j.intimp.2023.111009. [PMID: 37820424]
Anil Bhushan, Dixhya Rani, Misbah Tabassum, Saajan Kumar, Prem N Gupta, Sumeet Gairola, Ajai P Gupta, Prasoon Gupta. HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124815. [PMID: 37375368]
Lei Yu, Luyao Sun, Qian Yu, Fang Xiong, Daibo Wang, Lin Pu, Fu Peng, Xiaofang Xie, Cheng Peng. Bioactive compounds and mechanism of Xianglian pill in the treatment of gastric cancer: Network pharmacology analysis and experimental validation. Journal of ethnopharmacology. 2023 May; ?(?):116573. doi: 10.1016/j.jep.2023.116573. [PMID: 37142148]
Wenlong Wu, Hongjuan Huang, Jietian Su, Xiaopeng Yun, Yixiao Zhang, Shouhui Wei, Zhaofeng Huang, Chaoxian Zhang, Quanjiang Bai. Dynamics of germination stimulants dehydrocostus lactone and costunolide in the root exudates and extracts of sunflower. Plant signaling & behavior. 2022 12; 17(1):2025669. doi: 10.1080/15592324.2022.2025669. [PMID: 35060434]
Yingying Tian, Beibei Ma, Chuang Liu, Xinyue Zhao, Shangyue Yu, Yilin Li, Shiqiu Tian, Hailuan Pei, Zijian Wang, Zeping Zuo, Zhibin Wang. Integrated Solid-Phase Extraction, Ultra-High-Performance Liquid Chromatography-Quadrupole-Orbitrap High-Resolution Mass Spectrometry, and Multidimensional Data-Mining Techniques to Unravel the Metabolic Network of Dehydrocostus Lactone in Rats. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27227688. [PMID: 36431789]
Ya-Xian Wu, Feng-Juan Jiang, Gang Liu, Ying-Ying Wang, Zhi-Qi Gao, Si-Hao Jin, Yun-Juan Nie, Dan Chen, Jun-Liang Chen, Qing-Feng Pang. Dehydrocostus Lactone Attenuates Methicillin-Resistant Staphylococcus aureus-Induced Inflammation and Acute Lung Injury via Modulating Macrophage Polarization. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms22189754. [PMID: 34575918]
FanCheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, GuoWei Wang, ZhiHua Liao, Min Chen. Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 87(?):153588. doi: 10.1016/j.phymed.2021.153588. [PMID: 34091148]
Shinya Okubo, Tomoe Ohta, Hideaki Fujita, Yukihiro Shoyama, Takuhiro Uto. Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells. Journal of natural medicines. 2021 Jan; 75(1):240-245. doi: 10.1007/s11418-020-01462-1. [PMID: 33159250]
Carlos Rial, Sonia Tomé, Rosa M Varela, José M G Molinillo, Francisco A Macías. Phytochemical Study of Safflower Roots (Carthamus tinctorius) on the Induction of Parasitic Plant Germination and Weed Control. Journal of chemical ecology. 2020 Sep; 46(9):871-880. doi: 10.1007/s10886-020-01200-7. [PMID: 32691372]
Qijuan Li, Zhanguo Wang, Yu Xie, Huiling Hu. Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):109955. doi: 10.1016/j.biopha.2020.109955. [PMID: 32014691]
Yuanyuan Chen, Ruisheng Li, Zhilei Wang, Xiaorong Hou, Chunyu Wang, Yongqiang Ai, Wei Shi, Xiaoyan Zhan, Jia-Bo Wang, Xiaohe Xiao, Zhaofang Bai, Hongsheng Sun, Guang Xu. Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo. Cellular immunology. 2020 03; 349(?):104046. doi: 10.1016/j.cellimm.2020.104046. [PMID: 32057354]
Jeong-Hwa Woo, Ji-Hye Ahn, Dae Sik Jang, Jung-Hye Choi. Effect of Dehydrocostus Lactone Isolated from the Roots of Aucklandia lappa on the Apoptosis of Endometriotic Cells and the Alternative Activation of Endometriosis-Associated Macrophages. The American journal of Chinese medicine. 2019; 47(6):1289-1305. doi: 10.1142/s0192415x19500666. [PMID: 31488032]
Shu Dong, Li-Yan Ma, Yue-Tao Liu, Meng Yu, Hong-Mei Jia, Hong-Wu Zhang, Chang-Yuan Yu, Zhong-Mei Zou. Pharmacokinetics of costunolide and dehydrocostuslactone after oral administration of Radix aucklandiae extract in normal and gastric ulcer rats. Journal of Asian natural products research. 2018 Nov; 20(11):1055-1063. doi: 10.1080/10286020.2018.1489379. [PMID: 30130142]
Jingkun Liu, Min Xie, Xiuzhuang Li, Hui Jin, Xiaoyan Yang, Zhiqiang Yan, Anxiang Su, Bo Qin. Main Allelochemicals from the Rhizosphere Soil of Saussurea lappa (Decne.) Sch. Bip. and Their Effects on Plants' Antioxidase Systems. Molecules (Basel, Switzerland). 2018 Sep; 23(10):. doi: 10.3390/molecules23102506. [PMID: 30274332]
Wei Li, Yi Bing Ma, Ying Qiu Mao, Tong Lin. Dehydrocostus lactone suppresses cell growth and induces apoptosis in recombinant human papilloma virus‑18 HaCaT cells via the PI3K/Akt signaling pathway. Molecular medicine reports. 2018 Jun; 17(6):7925-7930. doi: 10.3892/mmr.2018.8805. [PMID: 29620208]
Yoshinori Asakawa, Agnieszka Ludwiczuk. Chemical Constituents of Bryophytes: Structures and Biological Activity. Journal of natural products. 2018 03; 81(3):641-660. doi: 10.1021/acs.jnatprod.6b01046. [PMID: 29019405]
Bo-Kyung Lee, Soo-Jin Park, So-Yeon Nam, Saeromi Kang, Jin Hwang, Seung-Jin Lee, Dong-Soon Im. Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments. Journal of ethnopharmacology. 2018 Mar; 213(?):256-261. doi: 10.1016/j.jep.2017.11.018. [PMID: 29158156]
Siwattra Choodej, Khanitha Pudhom, Tohru Mitsunaga. Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues. Planta medica. 2018 Mar; 84(5):329-335. doi: 10.1055/s-0043-120115. [PMID: 28962049]
Soma Shiva Nageswara Rao Singireesu, Sujan Kumar Mondal, Sunil Misra, Suresh Yerramsetty, Suresh Babu K. Dehydrocostus lactone induces prominent apoptosis in kidney distal tubular epithelial cells and interstitial fibroblasts along with cell cycle arrest in ovarian epithelial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Mar; 99(?):956-969. doi: 10.1016/j.biopha.2018.01.099. [PMID: 29710496]
Hong Cai, Xiaosong Qin, Chunhui Yang. Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways. Journal of cellular biochemistry. 2017 10; 118(10):3381-3390. doi: 10.1002/jcb.25994. [PMID: 28300289]
Antonio Cala, José M G Molinillo, Mónica Fernández-Aparicio, Jesús Ayuso, José A Álvarez, Diego Rubiales, Francisco A Macías. Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds. Organic & biomolecular chemistry. 2017 Aug; 15(31):6500-6510. doi: 10.1039/c7ob01394a. [PMID: 28745382]
Ch Pavan Kumar, A Devi, P Ashok Yadav, R Rao Vadaparthi, G Shankaraiah, P Sowjanya, Nishant Jain, K Suresh Babu. 'Click' reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity. Journal of Asian natural products research. 2016 Nov; 18(11):1063-78. doi: 10.1080/10286020.2016.1193012. [PMID: 27329166]
Meili Yang, Junmin Zhang, Ya Li, Xiao Han, Kun Gao, Jianguo Fang. Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa: A new targeted cytosolic thioredoxin reductase anticancer agent. Archives of biochemistry and biophysics. 2016 10; 607(?):20-6. doi: 10.1016/j.abb.2016.08.008. [PMID: 27545438]
Kun Cao, Wei Qian, Yi Xu, Zhen Zhou, Qing Zhang, Xiaofeng Zhang. A new sesquiterpenoid from Saussurea lappa roots. Natural product research. 2016 Oct; 30(19):2160-3. doi: 10.1080/14786419.2016.1149708. [PMID: 26956664]
Hong Zheng, Yuling Chen, Jingze Zhang, Lei Wang, Zhaoxiang Jin, Hanhan Huang, Shuli Man, Wenyuan Gao. Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation. Chemico-biological interactions. 2016 Apr; 250(?):68-77. doi: 10.1016/j.cbi.2016.03.003. [PMID: 26970604]
Enping Jiang, Xiwen Sun, Haixian Kang, Liping Sun, Weifang An, Yunhong Yao, Xinrong Hu. Dehydrocostus Lactone Inhibits Proliferation, Antiapoptosis, and Invasion of Cervical Cancer Cells Through PI3K/Akt Signaling Pathway. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 2015 Sep; 25(7):1179-86. doi: 10.1097/igc.0000000000000474. [PMID: 26017248]
Hye-Sun Lim, Sung-Eun Jin, Ohn-Soon Kim, Hyeun-Kyoo Shin, Soo-Jin Jeong. Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells. Phytotherapy research : PTR. 2015 Jul; 29(7):1088-96. doi: 10.1002/ptr.5354. [PMID: 25881570]
Xiwen Sun, Haixian Kang, Yunhong Yao, Hongzhen Chen, Liping Sun, Weifang An, Enping Jiang, Sen Wang, Xinrong Hu. Dehydrocostus lactone suppressed the proliferation, migration, and invasion of colorectal carcinoma through the downregulation of eIF4E expression. Anti-cancer drugs. 2015 Jul; 26(6):641-8. doi: 10.1097/cad.0000000000000229. [PMID: 25850883]
Guang-Zhi Dong, Ah-Ram Shim, Jin Seong Hyeon, Hwa Jin Lee, Jae-Ha Ryu. Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells. Phytotherapy research : PTR. 2015 May; 29(5):680-6. doi: 10.1002/ptr.5299. [PMID: 25625870]
Jing-ze Zhang, Lei Wang, Zhao-xiang Jin, Zhuo Qu, Yu-ling Chen, Wen-yuan Gao. [Pharmacokinetics study on costunolide and dehydrocostuslactone after administration of traditional Chinese medicine Weichang'an pills]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Mar; 40(6):1173-8. doi: . [PMID: 26226766]
Eun Jung Park, Sang Won Park, Hye Jung Kim, Jong-Hwan Kwak, Dong-Ung Lee, Ki Churl Chang. Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo. International immunopharmacology. 2014 Oct; 22(2):332-40. doi: 10.1016/j.intimp.2014.07.012. [PMID: 25066549]
Zhangxiao Peng, Yan Wang, Xue Gu, Xiaojie Guo, Chao Yan. Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC-UV and UPLC-Q-TOF/MS. Biomedical chromatography : BMC. 2014 Oct; 28(10):1325-34. doi: 10.1002/bmc.3167. [PMID: 24889523]
Huimin Guo, Jingze Zhang, Wenyuan Gao, Zhuo Qu, Changxiao Liu. Gastrointestinal effect of methanol extract of Radix Aucklandiae and selected active substances on the transit activity of rat isolated intestinal strips. Pharmaceutical biology. 2014 Sep; 52(9):1141-9. doi: 10.3109/13880209.2013.879601. [PMID: 24649908]
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