Rhoifolin (BioDeep_00000018139)

Main id: BioDeep_00000002498

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


7-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

化学式: C27H30O14 (578.1635)
中文名称: 野漆树苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O
InChI: InChI=1S/C27H30O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-8,10,18,20-30,32-36H,9H2,1H3

描述信息

Isolated from Citrus aurantium (Seville orange). Rhoifolin is found in many foods, some of which are citrus, grapefruit/pummelo hybrid, german camomile, and lemon.
Rhoifolin is found in citrus. Rhoifolin is isolated from Citrus aurantium (Seville orange).
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines[1][2][3].
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines[1][2][3].
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines[1][2][3].

同义名列表

7 个代谢物同义名

7-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Apigenin 7-O-neohesperidoside; Apigenin 7-neohesperidoside; (-)-Rhoifolin; Rhoifoloside; Rhoifolin; Apigenin 7-O-neohesperidoside



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

19 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(19)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

180 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Dinesh Singh Moirangthem, Narayan Chandra Talukdar, Naresh Kasoju, Utpal Bora. Antioxidant, antibacterial, cytotoxic, and apoptotic activity of stem bark extracts of Cephalotaxus griffithii Hook. f. BMC complementary and alternative medicine. 2012 Apr; 12(?):30. doi: 10.1186/1472-6882-12-30. [PMID: 22469333]
  • Ansarullah, Bhavna Bharucha, Mitesh Dwivedi, Naresh C Laddha, Rasheedunnisa Begum, Anandwardhan A Hardikar, A V Ramachandran. Antioxidant rich flavonoids from Oreocnide integrifolia enhance glucose uptake and insulin secretion and protects pancreatic β-cells from streptozotocin insult. BMC complementary and alternative medicine. 2011 Dec; 11(?):126. doi: 10.1186/1472-6882-11-126. [PMID: 22169757]
  • Yerra Koteswara Rao, Meng-Jen Lee, Keru Chen, Yi-Ching Lee, Wen-Shi Wu, Yew-Min Tzeng. Insulin-Mimetic Action of Rhoifolin and Cosmosiin Isolated from Citrus grandis (L.) Osbeck Leaves: Enhanced Adiponectin Secretion and Insulin Receptor Phosphorylation in 3T3-L1 Cells. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):624375. doi: 10.1093/ecam/nep204. [PMID: 20008903]
  • Van Kiem Phan, Thi Mai Nguyen, Chau Van Minh, Huu Khoi Nguyen, Hai Dang Nguyen, Phuong Thao Nguyen, Xuan Cuong Nguyen, Hoai Nam Nguyen, Xuan Nhiem Nguyen, Yvan Vander Heyden, Joëlle Quetin-Leclercq, Gyo Nam Kim, Hae Dong Jang, Young Ho Kim. Two new C-glucosyl benzoic acids and flavonoids from Mallotus nanus and their antioxidant activity. Archives of pharmacal research. 2010 Feb; 33(2):203-8. doi: 10.1007/s12272-010-0203-8. [PMID: 20195819]
  • Cong Zhang, Zhiqi Yin, Wencai Ye, Yuzhen Guan, Lian Guo, Jian Zhang, Wenbin Shen. [Chemical constituents from stems of Lonicera japonica]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Dec; 34(23):3051-3. doi: . [PMID: 20222422]
  • Claudio Gardana, Federico Nalin, Paolo Simonetti. Evaluation of flavonoids and furanocoumarins from Citrus bergamia (Bergamot) juice and identification of new compounds. Molecules (Basel, Switzerland). 2008 Sep; 13(9):2220-8. doi: 10.3390/molecules13092220. [PMID: 18830151]
  • Zhen-Dan He, Kit-Man Lau, Paul Pui-Hay But, Ren-Wang Jiang, Hui Dong, Shuang-Cheng Ma, Kwok-Pui Fung, Wen-Cai Ye, Han-Dong Sun. Antioxidative glycosides from the leaves of Ligustrum robustum. Journal of natural products. 2003 Jun; 66(6):851-4. doi: 10.1021/np020568g. [PMID: 12828473]