Guanadrel (BioDeep_00000006405)
Secondary id: BioDeep_00001868565
human metabolite blood metabolite
代谢物信息卡片
化学式: C10H19N3O2 (213.1477)
中文名称: 胍那决尔
谱图信息:
最多检出来源 Homo sapiens(blood) 42.82%
分子结构信息
SMILES: C1CCC2(CC1)OCC(CNC(=N)N)O2
InChI: InChI=1S/C10H19N3O2/c11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10/h8H,1-7H2,(H4,11,12,13)
描述信息
Guanadrel is a postganglionic sympathetic adrenergic antagonist that is administered orally to treat hypertension (high blood pressure). It was used in the form of its sulfate (trade name: Hylorel) but has been largely superseded by other antihypertensive agents due to its unpleasant side effect of orthostatic hypotension (i.e. dizziness when standing) (PMID: 6143629). Guanadrel both prevents noradrenaline (norepinephrine) release and depletes noradrenaline stores which effectively creates a peripheral sympathetic blockade. This serves to reduce vasoconstriction which subsequently lowers blood pressure (PMID: 3896742).
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:5555
- KEGG: C07035
- KEGGdrug: D08029
- PubChem: 38521
- HMDB: HMDB0014371
- Metlin: METLIN4059
- DrugBank: DB00226
- ChEMBL: CHEMBL1037
- Wikipedia: Guanadrel
- chemspider: 35305
- CAS: 40580-59-4
- PMhub: MS000019441
- PubChem: 9247
- NIKKAJI: J16.514J
- RefMet: Guanadrel Sulfate
- medchemexpress: HY-W376701
- KNApSAcK: 5555
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- R V Hogikyan, M A Supiano. Arterial alpha-adrenergic responsiveness is decreased and SNS activity is increased in older humans.
The American journal of physiology.
1994 May; 266(5 Pt 1):E717-24. doi:
10.1152/ajpendo.1994.266.5.e717. [PMID: 8203510] - J J Opplt, E S Holzberg. Ultracentrifugal subclasses of low and intermediate density lipoproteins.
Journal of lipid research.
1994 Mar; 35(3):510-23. doi:
10.1016/s0022-2275(20)41202-7. [PMID: 8014586] - R V Hogikyan, M A Supiano. Homologous upregulation of human arterial alpha-adrenergic responses by guanadrel.
The Journal of clinical investigation.
1993 Apr; 91(4):1429-35. doi:
10.1172/jci116347. [PMID: 8473492] - M A Supiano, R V Hogikyan, L A Morrow, F J Ortiz-Alonso, W H Herman, R N Bergman, J B Halter. Hypertension and insulin resistance: role of sympathetic nervous system activity.
The American journal of physiology.
1992 Nov; 263(5 Pt 1):E935-42. doi:
10.1152/ajpendo.1992.263.5.e935. [PMID: 1443127] - M A Supiano, R V Hogikyan, A M Stoltz, N Orstan, J B Halter. Regulation of venous alpha-adrenergic responses in older humans.
The American journal of physiology.
1991 Apr; 260(4 Pt 1):E599-607. doi:
10.1152/ajpendo.1991.260.4.e599. [PMID: 1850202] - L L Darga, M J Hakim, C P Lucas, B A Franklin. Comparison of the effects of guanadrel sulfate and propranolol on blood pressure, functional capacity, serum lipoproteins and glucose in systemic hypertension.
The American journal of cardiology.
1991 Mar; 67(7):590-6. doi:
10.1016/0002-9149(91)90897-t. [PMID: 2000792] - M A Sekkarie, B M Egan, R R Neubig, M A Supiano. Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate.
Clinical pharmacology and therapeutics.
1990 Nov; 48(5):537-43. doi:
10.1038/clpt.1990.190. [PMID: 2171846] - C E Halstenson, J A Opsahl, P A Abraham, M H Schwenk, N A Andreadis, E J Antal, G R Matzke. Disposition of guanadrel in subjects with normal and impaired renal function.
Journal of clinical pharmacology.
1989 Feb; 29(2):128-32. doi:
10.1002/j.1552-4604.1989.tb03300.x. [PMID: 2715368] - D G Kaiser, G J Vangiessen, J A Shah, D J Weber. Gas chromatographic determination of guanadrel in plasma and urine.
Journal of chromatography.
1988 Dec; 434(1):135-43. doi:
10.1016/0378-4347(88)80068-9. [PMID: 3243808] - B Egan, R Neubig, S Julius. Pharmacologic reduction of sympathetic drive increases platelet alpha-2-receptor number.
Clinical pharmacology and therapeutics.
1985 Nov; 38(5):519-24. doi:
10.1038/clpt.1985.217. [PMID: 2996819] - J H Bauer. Adrenergic blocking agents and the kidney.
Journal of clinical hypertension.
1985 Sep; 1(3):199-221. doi:
. [PMID: 2872278] - V DeQuattro, A deGrau, A Foti, S J Kim, E DeQuattro, J Allen. Effects of exercise on blood pressure, plasma catecholamines, potassium and the electrocardiogram after diuretic and neural-blocking therapy for moderate hypertension.
The American journal of cardiology.
1985 Aug; 56(6):39D-45D. doi:
10.1016/0002-9149(85)91114-2. [PMID: 2412430] - B Egan, R Neubig, R H Schneider, S Julius. Methods for measuring vascular and nonvascular alpha-receptor sensitivity in humans.
Journal of cardiovascular pharmacology.
1985; 7 Suppl 6(?):S153-8. doi:
10.1097/00005344-198500076-00026. [PMID: 2414579]
