2-Acetolactate (BioDeep_00000004511)

Main id: BioDeep_00000628747

 

human metabolite Endogenous


代谢物信息卡片


2-hydroxy-2-methyl-3-oxobutanoic acid

化学式: C5H8O4 (132.0422568)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C(C)(C(=O)O)O
InChI: InChI=1S/C5H8O4/c1-3(6)5(2,9)4(7)8/h9H,1-2H3,(H,7,8)

描述信息

2-Acetolactate is involved in the butanoate metabolism and pantothenate and CoA biosynthesis pathways. In the butanoate metabolism pathway, 2-Acetolactate is created from 2-(alpha-Hydroxyethyl)thiamine diphosphate by acetolactate synthase [EC:2.2.1.6]. 2-Acetolactate is then converted to (R)-Acetoin by acetolactate decarboxylase [EC:4.1.1.5]. In the pantothenate and CoA pathway, 2-Acetolactate is irreversibly created from pyruvate by acetolactate synthase [EC:2.2.1.6]. 2-Acetolactate is then irreversibly converted to 2,3-Dihydroxy-3-methylbutanoate by ketol-acid reductoisomerase [EC:1.1.1.86].
2-Acetolactate is involved in the butanoate metabolism and pantothenate and CoA biosynthesis pathways.

同义名列表

4 个代谢物同义名

2-hydroxy-2-methyl-3-oxobutanoic acid; 2-acetyllactic acid; 2-Acetolactic acid; 2-Acetolactate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jerry M Green, Micheal D K Owen. Herbicide-resistant crops: utilities and limitations for herbicide-resistant weed management. Journal of agricultural and food chemistry. 2011 Jun; 59(11):5819-29. doi: 10.1021/jf101286h. [PMID: 20586458]
  • Eric T McDowell, Jeremy Kapteyn, Adam Schmidt, Chao Li, Jin-Ho Kang, Anne Descour, Feng Shi, Matthew Larson, Anthony Schilmiller, Lingling An, A Daniel Jones, Eran Pichersky, Carol A Soderlund, David R Gang. Comparative functional genomic analysis of Solanum glandular trichome types. Plant physiology. 2011 Jan; 155(1):524-39. doi: 10.1104/pp.110.167114. [PMID: 21098679]
  • Qin Yu, Heping Han, Martin M Vila-Aiub, Stephen B Powles. AHAS herbicide resistance endowing mutations: effect on AHAS functionality and plant growth. Journal of experimental botany. 2010 Sep; 61(14):3925-34. doi: 10.1093/jxb/erq205. [PMID: 20627897]
  • Safiyh Taghavi, Daniel van der Lelie, Adam Hoffman, Yian-Biao Zhang, Michael D Walla, Jaco Vangronsveld, Lee Newman, Sébastien Monchy. Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638. PLoS genetics. 2010 May; 6(5):e1000943. doi: 10.1371/journal.pgen.1000943. [PMID: 20485560]
  • Hiromoto Yamakawa, Makoto Hakata. Atlas of rice grain filling-related metabolism under high temperature: joint analysis of metabolome and transcriptome demonstrated inhibition of starch accumulation and induction of amino acid accumulation. Plant & cell physiology. 2010 May; 51(5):795-809. doi: 10.1093/pcp/pcq034. [PMID: 20304786]
  • Ralph Kissen, Per Winge, Diem Hong Thi Tran, Tommy S Jørstad, Trond R Størseth, Tone Christensen, Atle M Bones. Transcriptional profiling of an Fd-GOGAT1/GLU1 mutant in Arabidopsis thaliana reveals a multiple stress response and extensive reprogramming of the transcriptome. BMC genomics. 2010 Mar; 11(?):190. doi: 10.1186/1471-2164-11-190. [PMID: 20307264]
  • Tanja Knill, Michael Reichelt, Christian Paetz, Jonathan Gershenzon, Stefan Binder. Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation. Plant molecular biology. 2009 Oct; 71(3):227-39. doi: 10.1007/s11103-009-9519-5. [PMID: 19597944]
  • Marcelo Bertalan, Rodolpho Albano, Vânia de Pádua, Luc Rouws, Cristian Rojas, Adriana Hemerly, Kátia Teixeira, Stefan Schwab, Jean Araujo, André Oliveira, Leonardo França, Viviane Magalhães, Sylvia Alquéres, Alexander Cardoso, Wellington Almeida, Marcio Martins Loureiro, Eduardo Nogueira, Daniela Cidade, Denise Oliveira, Tatiana Simão, Jacyara Macedo, Ana Valadão, Marcela Dreschsel, Flávia Freitas, Marcia Vidal, Helma Guedes, Elisete Rodrigues, Carlos Meneses, Paulo Brioso, Luciana Pozzer, Daniel Figueiredo, Helena Montano, Jadier Junior, Gonçalo de Souza Filho, Victor Martin Quintana Flores, Beatriz Ferreira, Alan Branco, Paula Gonzalez, Heloisa Guillobel, Melissa Lemos, Luiz Seibel, José Macedo, Marcio Alves-Ferreira, Gilberto Sachetto-Martins, Ana Coelho, Eidy Santos, Gilda Amaral, Anna Neves, Ana Beatriz Pacheco, Daniela Carvalho, Letícia Lery, Paulo Bisch, Shaila C Rössle, Turán Urményi, Alessandra Rael Pereira, Rosane Silva, Edson Rondinelli, Wanda von Krüger, Orlando Martins, José Ivo Baldani, Paulo C G Ferreira. Complete genome sequence of the sugarcane nitrogen-fixing endophyte Gluconacetobacter diazotrophicus Pal5. BMC genomics. 2009 Sep; 10(?):450. doi: 10.1186/1471-2164-10-450. [PMID: 19775431]
  • Eleanor W W Leung, Luke W Guddat. Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures. Journal of molecular biology. 2009 May; 389(1):167-82. doi: 10.1016/j.jmb.2009.04.012. [PMID: 19362563]
  • Ivi C Tsantili, M Nazmul Karim, Maria I Klapa. Quantifying the metabolic capabilities of engineered Zymomonas mobilis using linear programming analysis. Microbial cell factories. 2007 Mar; 6(?):8. doi: 10.1186/1475-2859-6-8. [PMID: 17349037]
  • Ana Zabalza, Esther M González, Cesar Arrese-Igor, Mercedes Royuela. Fermentative metabolism is induced by inhibiting different enzymes of the branched-chain amino acid biosynthesis pathway in pea plants. Journal of agricultural and food chemistry. 2005 Sep; 53(19):7486-93. doi: 10.1021/jf050654x. [PMID: 16159177]
  • S S Pang, L W Guddat, R G Duggleby. Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl. Acta crystallographica. Section D, Biological crystallography. 2004 Jan; 60(Pt 1):153-5. doi: 10.1107/s0907444903025423. [PMID: 14684914]
  • E A Sergienko, F Jordan. Catalytic acid-base groups in yeast pyruvate decarboxylase. 2. Insights into the specific roles of D28 and E477 from the rates and stereospecificity of formation of carboligase side products. Biochemistry. 2001 Jun; 40(25):7369-81. doi: 10.1021/bi002856m. [PMID: 11412091]
  • A Carmel, E Kessler, A Yaron. Intramolecularly-quenched fluorescent peptides as fluorogenic substrates ofleucine aminopeptidase and inhibitors of clostridial aminopeptidase. European journal of biochemistry. 1977 Mar; 73(2):617-25. doi: 10.1111/j.1432-1033.1977.tb11357.x. [PMID: 14833]