E-4031 (BioDeep_00000405810)

Main id: BioDeep_00000003121

 


代谢物信息卡片


N-[4-[1-[2-(6-Methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide

化学式: C21H27N3O3S (401.1773032000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C
InChI: InChI=1S/C21H27N3O3S/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27/h3-9,18,23H,10-15H2,1-2H3

描述信息

D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents

同义名列表

3 个代谢物同义名

N-[4-[1-[2-(6-Methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide; E-4031; E-4031



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mohammed I El-Gamal, Hanan S Anbar, Hamadeh Tarazi, Chang-Hyun Oh. Discovery of a potent p38α/MAPK14 kinase inhibitor: Synthesis, in vitro/in vivo biological evaluation, and docking studies. European journal of medicinal chemistry. 2019 Dec; 183(?):111684. doi: 10.1016/j.ejmech.2019.111684. [PMID: 31520926]
  • Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T Naito, Atsushi Sugiyama. Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects. Journal of pharmacological sciences. 2018 Jun; 137(2):237-240. doi: 10.1016/j.jphs.2018.06.005. [PMID: 29980434]
  • Daisuke Fukumoto, Wei-Guang Ding, Yuko Wada, Yusuke Fujii, Mari Ichikawa, Koichiro Takayama, Megumi Fukuyama, Koichi Kato, Hideki Itoh, Takeru Makiyama, Mariko Omatsu-Kanbe, Hiroshi Matsuura, Minoru Horie, Seiko Ohno. Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome. Journal of cardiology. 2018 04; 71(4):401-408. doi: 10.1016/j.jjcc.2017.10.004. [PMID: 29146210]
  • Suchitra Matsukura, Yuji Nakamura, Xin Cao, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Hiroshi Yamazaki, Atsushi Sugiyama. Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology. Journal of pharmacological sciences. 2017 Feb; 133(2):103-109. doi: 10.1016/j.jphs.2017.02.002. [PMID: 28245963]
  • Mikhail Krasavin, Alexey Lukin, Nikolay Zhurilo, Alexey Kovalenko, Ihor Zahanich, Sergey Zozulya, Daniel Moore, Irina G Tikhonova. Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold. Bioorganic & medicinal chemistry. 2016 07; 24(13):2954-2963. doi: 10.1016/j.bmc.2016.04.065. [PMID: 27229618]
  • Viksita Vijayvergiya, Shiv Acharya, Jason Poulos, Jacob Schmidt. Single channel and ensemble hERG conductance measured in droplet bilayers. Biomedical microdevices. 2015 Feb; 17(1):12. doi: 10.1007/s10544-014-9919-4. [PMID: 25653065]
  • Nobuo Aikawa, Yui Suzuki, Katsumi Takaba. A Simple Protocol for the Myocardial Differentiation of Human iPS Cells. Biological & pharmaceutical bulletin. 2015; 38(7):1070-5. doi: 10.1248/bpb.b14-00761. [PMID: 26133717]
  • Hiroko Izumi-Nakaseko, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Yukiko Yamazaki, Naoya Ueda, Kentaro Ando, Atsushi Sugiyama. Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs. European journal of pharmacology. 2014 Oct; 740(?):263-70. doi: 10.1016/j.ejphar.2014.06.064. [PMID: 25038475]
  • Xaver Koenig, Michael Kovar, Lena Rubi, Agnes K Mike, Peter Lukacs, Vaibhavkumar S Gawali, Hannes Todt, Karlheinz Hilber, Walter Sandtner. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile. Toxicology and applied pharmacology. 2013 Dec; 273(2):259-68. doi: 10.1016/j.taap.2013.05.012. [PMID: 23707769]
  • Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):581-94. doi: 10.1093/toxsci/kft205. [PMID: 24052561]
  • Fang Zheng, Juanjuan Li, Wen Du, Ningfang Wang, Huiyu Li, Shiang Huang. Human ether-a-go-go-related gene K+ channels regulate shedding of leukemia cell-derived microvesicles. Leukemia & lymphoma. 2012 Aug; 53(8):1592-8. doi: 10.3109/10428194.2012.661855. [PMID: 22292854]
  • Zhi-Yuan Wu, De-Jie Yu, Tuck Wah Soong, Gavin S Dawe, Jin-Song Bian. Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis. The Journal of biological chemistry. 2011 Jun; 286(25):22186-94. doi: 10.1074/jbc.m110.198853. [PMID: 21525004]
  • Anton Mihic, Vijay S Chauhan, Xiaodong Gao, Gavin Y Oudit, Robert G Tsushima. Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation. PloS one. 2011 Mar; 6(3):e18273. doi: 10.1371/journal.pone.0018273. [PMID: 21483829]
  • Serena Pillozzi, Marika Masselli, Emanuele De Lorenzo, Benedetta Accordi, Emanuele Cilia, Olivia Crociani, Amedeo Amedei, Marinella Veltroni, Massimo D'Amico, Giuseppe Basso, Andrea Becchetti, Dario Campana, Annarosa Arcangeli. Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers. Blood. 2011 Jan; 117(3):902-14. doi: 10.1182/blood-2010-01-262691. [PMID: 21048156]
  • Lin Wu, Sridharan Rajamani, Hong Li, Craig T January, John C Shryock, Luiz Belardinelli. Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart. American journal of physiology. Heart and circulatory physiology. 2009 Sep; 297(3):H1048-57. doi: 10.1152/ajpheart.00467.2009. [PMID: 19592609]
  • Rachael M Hardman, Ian D Forsythe. Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neurons. The Journal of physiology. 2009 Jun; 587(Pt 11):2487-97. doi: 10.1113/jphysiol.2009.170548. [PMID: 19359372]
  • Herbert M Himmel. Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential. Journal of pharmacological and toxicological methods. 2007 Sep; 56(2):145-58. doi: 10.1016/j.vascn.2007.04.004. [PMID: 17590357]
  • Jun Guo, Hamid Massaeli, Wentao Li, Jianmin Xu, Tao Luo, James Shaw, Lorrie A Kirshenbaum, Shetuan Zhang. Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes. The Journal of pharmacology and experimental therapeutics. 2007 Jun; 321(3):911-20. doi: 10.1124/jpet.107.120931. [PMID: 17377062]
  • Thomas Vormberge, Michael Hoffmann, Herbert Himmel. Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve. Journal of pharmacological and toxicological methods. 2006 Sep; 54(2):130-40. doi: 10.1016/j.vascn.2006.03.011. [PMID: 16757186]
  • Qiuming Gong, Melanie A Jones, Zhengfeng Zhou. Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. The Journal of biological chemistry. 2006 Feb; 281(7):4069-74. doi: 10.1074/jbc.m511765200. [PMID: 16361248]
  • Rie Schultz Hansen, Thomas Goldin Diness, Torsten Christ, Joachim Demnitz, Ursula Ravens, Søren-Peter Olesen, Morten Grunnet. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Molecular pharmacology. 2006 Jan; 69(1):266-77. doi: 10.1124/mol.105.015859. [PMID: 16219910]
  • Motohiro Shiotani, Takuma Harada, Junko Abe, Yasufusa Sawada, Keitaro Hashimoto, Yoshimasa Hamada, Ikuo Horii. Practical application of guinea pig telemetry system for QT evaluation. The Journal of toxicological sciences. 2005 Aug; 30(3):239-47. doi: 10.2131/jts.30.239. [PMID: 16141657]
  • Tom Rossenbacker, Kanigula Mubagwa, Roselie J Jongbloed, Johan Vereecke, Koen Devriendt, Marc Gewillig, Edward Carmeliet, Désiré Collen, Hein Heidbüchel, Peter Carmeliet. Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome. Circulation. 2005 Mar; 111(8):961-8. doi: 10.1161/01.cir.0000156327.35255.d8. [PMID: 15699249]
  • Charles Antzelevitch, Luiz Belardinelli, Andrew C Zygmunt, Alexander Burashnikov, José M Di Diego, Jeffrey M Fish, Jonathan M Cordeiro, George Thomas. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation. 2004 Aug; 110(8):904-10. doi: 10.1161/01.cir.0000139333.83620.5d. [PMID: 15302796]
  • Hiroshi Mizuno, Hideyuki Adachi, Junko Kimura, Yoshio Sawa, Motoharu Kakiki, Kate Lansdell, Mamoru Saito, William David Kerns. Cardiovascular assessment of ER-118585, a selective phosphodiesterase 5 inhibitor. Biological & pharmaceutical bulletin. 2003 Dec; 26(12):1661-7. doi: 10.1248/bpb.26.1661. [PMID: 14646167]
  • Anthony A Fossa, Michael J DePasquale, David L Raunig, Michael J Avery, Derek J Leishman. The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment. The Journal of pharmacology and experimental therapeutics. 2002 Aug; 302(2):828-33. doi: 10.1124/jpet.102.035220. [PMID: 12130750]
  • Eckhard Ficker, Carlos A Obejero-Paz, Shuxia Zhao, Arthur M Brown. The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations. The Journal of biological chemistry. 2002 Feb; 277(7):4989-98. doi: 10.1074/jbc.m107345200. [PMID: 11741928]
  • S Kobayashi, Y Reien, T Ogura, T Saito, Y Masuda, H Nakaya. Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031. European journal of pharmacology. 2001 Nov; 430(2-3):149-57. doi: 10.1016/s0014-2999(01)01381-4. [PMID: 11711026]
  • R Webster, G Allan, K Anto-Awuakye, A Harrison, T Kidd, D Leishman, J Phipps, D Walker. Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog. Xenobiotica; the fate of foreign compounds in biological systems. 2001 Aug; 31(8-9):633-50. doi: 10.1080/00498250110054632. [PMID: 11569530]
  • A N Plotnikov, A Shvilkin, W Xiong, J R de Groot, L Rosenshtraukh, S Feinmark, R Gainullin, P Danilo, M R Rosen. Interactions between antiarrhythmic drugs and cardiac memory. Cardiovascular research. 2001 May; 50(2):335-44. doi: 10.1016/s0008-6363(01)00233-4. [PMID: 11334837]
  • Z Zhou, Q Gong, C T January. Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects. The Journal of biological chemistry. 1999 Oct; 274(44):31123-6. doi: 10.1074/jbc.274.44.31123. [PMID: 10531299]
  • Z Zhou, Q Gong, B Ye, Z Fan, J C Makielski, G A Robertson, C T January. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophysical journal. 1998 Jan; 74(1):230-41. doi: 10.1016/s0006-3495(98)77782-3. [PMID: 9449325]
  • K Takada, K Sumikawa, T Kamibayashi, Y Hayashi, A Yamatodani, K Kawabata, I Yoshiya. Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats. Anesthesiology. 1993 Sep; 79(3):563-70. doi: 10.1097/00000542-199309000-00021. [PMID: 8363083]
  • H Inoue, T Yamashita, M Usui, A Nozaki, T Sugimoto. Antiarrhythmic drugs preferentially produce conduction block at the area of slow conduction in the re-entrant circuit of canine atrial flutter: comparative study of disopyramide, flecainide, and E-4031. Cardiovascular research. 1991 Mar; 25(3):223-9. doi: 10.1093/cvr/25.3.223. [PMID: 1903082]
  • J G Ljunggren, B Persson. Preoperative treatment of thyrotoxicosis with a beta-adrenergic blocking agent. Acta chirurgica Scandinavica. 1975; 141(8):715-8. doi: NULL. [PMID: 3081]