trans-Aconitic acid (BioDeep_00000400464)

Main id: BioDeep_00000014389

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


1-Propene-1,2,3-tricarboxylic acid

化学式: C6H6O6 (174.01643760000002)
中文名称: 反式乌头酸, 乌头酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(=C(\CC(=O)O)/C(=O)O)\C(=O)O
InChI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/b3-1+

描述信息

The trans-isomer of aconitic acid.
trans-Aconitic acid is present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase.
trans-Aconitic acid is present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase.

同义名列表

4 个代谢物同义名

1-Propene-1,2,3-tricarboxylic acid; trans-Aconitic acid; (E)-Aconitic Acid; trans-Aconitate



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

82 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alyssa C Baugh, Justin B Defalco, Chantel V Duscent-Maitland, Melissa P Tumen-Velasquez, Nicole S Laniohan, Kayla Figatner, Timothy R Hoover, Anna C Karls, Kathryn T Elliott, Ellen L Neidle. Regulation of tricarboxylate transport and metabolism in Acinetobacter baylyi ADP1. Applied and environmental microbiology. 2024 Jan; ?(?):e0211123. doi: 10.1128/aem.02111-23. [PMID: 38289138]
  • Zhaojun Nie, Linglu Wang, Peng Zhao, Zhenbo Wang, Qiuzhe Shi, Hongen Liu. Metabolomics reveals the impact of nitrogen combined with the zinc supply on zinc availability in calcareous soil via root exudates of winter wheat (Triticum aestivum). Plant physiology and biochemistry : PPB. 2023 Nov; 204(?):108069. doi: 10.1016/j.plaphy.2023.108069. [PMID: 37852066]
  • Ce Geng, Zhigang Jin, Meng Gu, Jibin Li, Shen Tang, Qiang Guo, Yunpeng Zhang, Wei Zhang, Yuezhong Li, Xuenian Huang, Xuefeng Lu. Microbial production of trans-aconitic acid. Metabolic engineering. 2023 Jun; ?(?):. doi: 10.1016/j.ymben.2023.06.007. [PMID: 37315711]
  • Waeil Al Youssef, Regina Feil, Maureen Saint-Sorny, Xenie Johnson, John E Lunn, Bernhard Grimm, Pawel Brzezowski. Singlet oxygen-induced signalling depends on the metabolic status of the Chlamydomonas reinhardtii cell. Communications biology. 2023 May; 6(1):529. doi: 10.1038/s42003-023-04872-5. [PMID: 37193883]
  • Congcong Chen, Junshen Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou. An integrated strategy to study the combination mechanisms of Bupleurum chinense DC and Paeonia lactiflora Pall for treating depression based on correlation analysis between serum chemical components profiles and endogenous metabolites profiles. Journal of ethnopharmacology. 2023 Apr; 305(?):116068. doi: 10.1016/j.jep.2022.116068. [PMID: 36574791]
  • Somruthai Chaowongdee, Srihunsa Malichan, Pornkanok Pongpamorn, Atchara Paemanee, Wanwisa Siriwan. Metabolic profiles of Sri Lankan cassava mosaic virus-infected and healthy cassava (Manihot esculenta Crantz) cultivars with tolerance and susceptibility phenotypes. BMC plant biology. 2023 Apr; 23(1):178. doi: 10.1186/s12870-023-04181-3. [PMID: 37020181]
  • Sandeep Kumar, Anmol, Upendra Sharma, Sg Eswara Reddy. Insecticidal potential of extracts, fractions, and molecules of Aconitum heterophyllum Wall ex. Royle against aphid Aphis craccivora Koch (Hemiptera: Aphididae). Pest management science. 2022 Dec; ?(?):. doi: 10.1002/ps.7324. [PMID: 36519419]
  • Diego Pinto de Oliveira, Eliana de Faria Garcia, Mariana Assíria de Oliveira, Luiza C M Candido, Fernanda M Coelho, Vivian Vasconcelos Costa, Nathália Vieira Batista, Celso Martins Queiroz-Junior, Larissa Froede Brito, Lirlândia Pires Sousa, Daniele G Souza, Flávio Almeida Amaral, Rodrigo Maia de Pádua, Mauro Martins Teixeira, Fernão Castro Braga. cis-Aconitic Acid, a Constituent of Echinodorus grandiflorus Leaves, Inhibits Antigen-Induced Arthritis and Gout in Mice. Planta medica. 2022 Oct; 88(13):1123-1131. doi: 10.1055/a-1676-4371. [PMID: 34763354]
  • Ru-Ping Hong, Yue-Ying Hou, Xin-Jie Xu, Ji-Dong Lang, Yun-Feng Jin, Xiao-Feng Zeng, Xuan Zhang, Geng Tian, Xin You. The Difference of Gut Microbiota and Their Correlations With Urinary Organic Acids Between Autistic Children With and Without Atopic Dermatitis. Frontiers in cellular and infection microbiology. 2022; 12(?):886196. doi: 10.3389/fcimb.2022.886196. [PMID: 35800387]
  • Mònica Bulló, Christopher Papandreou, Jesus García-Gavilán, Miguel Ruiz-Canela, Jun Li, Marta Guasch-Ferré, Estefanía Toledo, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Chih-Hao Lee, Kerry Pierce, Cristina Razquin, Fernando Arós, Lluís Serra-Majem, Liming Liang, Miguel A Martínez-González, Frank B Hu, Jordi Salas-Salvadó. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure. Metabolism: clinical and experimental. 2021 12; 125(?):154915. doi: 10.1016/j.metabol.2021.154915. [PMID: 34678258]
  • Alexander T Eprintsev, Dmitry N Fedorin, Maria A Dobychina, Abir U Igamberdiev. Aconitate isomerase from maize leaves: Light-dependent expression and kinetic properties. Journal of plant physiology. 2021 Feb; 257(?):153350. doi: 10.1016/j.jplph.2020.153350. [PMID: 33360493]
  • Wen-Fa Zhang, Ze-Hao Gong, Meng-Bo Wu, Helen Chan, Yu-Jin Yuan, Ning Tang, Qiang Zhang, Ming-Jun Miao, Wei Chang, Zhi Li, Zheng-Guo Li, Liang Jin, Wei Deng. Integrative comparative analyses of metabolite and transcript profiles uncovers complex regulatory network in tomato (Solanum lycopersicum L.) fruit undergoing chilling injury. Scientific reports. 2019 03; 9(1):4470. doi: 10.1038/s41598-019-41065-9. [PMID: 30872788]
  • Tiara da Silva Coelho Bortolo, Rogério Marchiosi, Joselaine Viganó, Rita de Cássia Siqueira-Soares, Ana Paula Ferro, Gabriela Elen Barreto, Graciene de Souza Bido, Josielle Abrahão, Wanderley Dantas Dos Santos, Osvaldo Ferrarese-Filho. Trans-aconitic acid inhibits the growth and photosynthesis of Glycine max. Plant physiology and biochemistry : PPB. 2018 Nov; 132(?):490-496. doi: 10.1016/j.plaphy.2018.09.036. [PMID: 30292981]
  • Diego Pinto de Oliveira, Gabriela Guimarães Augusto, Nathália Vieira Batista, Vivian Louise S de Oliveira, Diêgo Santos Ferreira, Mateus Araújo Castro E Souza, Christian Fernandes, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Mônica Cristina Oliveira, Fernão Castro Braga. Encapsulation of trans-aconitic acid in mucoadhesive microspheres prolongs the anti-inflammatory effect in LPS-induced acute arthritis. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2018 Jul; 119(?):112-120. doi: 10.1016/j.ejps.2018.04.010. [PMID: 29627623]
  • Ana M Gil, Daniela Duarte, Joana Pinto, António S Barros. Assessing Exposome Effects on Pregnancy through Urine Metabolomics of a Portuguese (Estarreja) Cohort. Journal of proteome research. 2018 03; 17(3):1278-1289. doi: 10.1021/acs.jproteome.7b00878. [PMID: 29424227]
  • Diego Pinto de Oliveira, Thales do Valle Moreira, Nathália Vieira Batista, José Dias de Souza Filho, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Fernão Castro Braga. Esterification of trans-aconitic acid improves its anti-inflammatory activity in LPS-induced acute arthritis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Mar; 99(?):87-95. doi: 10.1016/j.biopha.2018.01.009. [PMID: 29329035]
  • Stein Hallan, Maryam Afkarian, Leila R Zelnick, Bryan Kestenbaum, Shoba Sharma, Rintaro Saito, Manjula Darshi, Gregory Barding, Daniel Raftery, Wenjun Ju, Matthias Kretzler, Kumar Sharma, Ian H de Boer. Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients. EBioMedicine. 2017 Dec; 26(?):68-77. doi: 10.1016/j.ebiom.2017.10.027. [PMID: 29128444]
  • Ammar Hassanzadeh Keshteli, Floris F van den Brand, Karen L Madsen, Rupasri Mandal, Rosica Valcheva, Karen I Kroeker, Beomsoo Han, Rhonda C Bell, Janis Cole, Thomas Hoevers, David S Wishart, Richard N Fedorak, Levinus A Dieleman. Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study. World journal of gastroenterology. 2017 Jun; 23(21):3890-3899. doi: 10.3748/wjg.v23.i21.3890. [PMID: 28638229]
  • Cuiying Du, Shiyun Cao, Xiangyu Shi, Xiangtao Nie, Jinshui Zheng, Yun Deng, Lifang Ruan, Donghai Peng, Ming Sun. Genetic and Biochemical Characterization of a Gene Operon for trans-Aconitic Acid, a Novel Nematicide from Bacillus thuringiensis. The Journal of biological chemistry. 2017 02; 292(8):3517-3530. doi: 10.1074/jbc.m116.762666. [PMID: 28087696]
  • Lucia Abela, Ronen Spiegel, Lisa M Crowther, Andrea Klein, Katharina Steindl, Sorina Mihaela Papuc, Pascal Joset, Yoav Zehavi, Anita Rauch, Barbara Plecko, Thomas Luke Simmons. Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency. PloS one. 2017; 12(5):e0176363. doi: 10.1371/journal.pone.0176363. [PMID: 28463998]
  • Chun Zhang, Cheng-Li Ling, Liang Pang, Qi Wang, Jing-Xin Liu, Bing-Shan Wang, Jian-Ming Liang, Yi-Zhen Guo, Jing Qin, Jian-Xin Wang. Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles. Theranostics. 2017; 7(13):3260-3275. doi: 10.7150/thno.19979. [PMID: 28900508]
  • William Piang-Siong, Pascale de Caro, Arnaud Marvilliers, Xavier Chasseray, Bertrand Payet, Alain Shum Cheong Sing, Bertrand Illien. Contribution of trans-aconitic acid to DPPH scavenging ability in different media. Food chemistry. 2017 Jan; 214(?):447-452. doi: 10.1016/j.foodchem.2016.07.083. [PMID: 27507497]
  • Gantumur Battogtokh, Young Tag Ko. Graphene oxide-incorporated pH-responsive folate-albumin-photosensitizer nanocomplex as image-guided dual therapeutics. Journal of controlled release : official journal of the Controlled Release Society. 2016 07; 234(?):10-20. doi: 10.1016/j.jconrel.2016.05.007. [PMID: 27164545]
  • Chen Yuan, Clary B Clish, Chen Wu, Jared R Mayers, Peter Kraft, Mary K Townsend, Mingfeng Zhang, Shelley S Tworoger, Ying Bao, Zhi Rong Qian, Douglas A Rubinson, Kimmie Ng, Edward L Giovannucci, Shuji Ogino, Meir J Stampfer, John Michael Gaziano, Jing Ma, Howard D Sesso, Garnet L Anderson, Barbara B Cochrane, JoAnn E Manson, Margaret E Torrence, Alec C Kimmelman, Laufey T Amundadottir, Matthew G Vander Heiden, Charles S Fuchs, Brian M Wolpin. Circulating Metabolites and Survival Among Patients With Pancreatic Cancer. Journal of the National Cancer Institute. 2016 Jun; 108(6):djv409. doi: 10.1093/jnci/djv409. [PMID: 26755275]
  • Tingting Wei, Liangcai Zhao, Jianmin Jia, Huanhuan Xia, Yao Du, Qiuting Lin, Xiaodong Lin, Xinjian Ye, Zhihan Yan, Hongchang Gao. Metabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice. Scientific reports. 2015 Jul; 5(?):11998. doi: 10.1038/srep11998. [PMID: 26149603]
  • Donald F Stec, Suwan Wang, Cody Stothers, Josh Avance, Deon Denson, Raymond Harris, Paul Voziyan. Alterations of urinary metabolite profile in model diabetic nephropathy. Biochemical and biophysical research communications. 2015 Jan; 456(2):610-4. doi: 10.1016/j.bbrc.2014.12.003. [PMID: 25499815]
  • Haldis H Lillefosse, Morten R Clausen, Christian C Yde, Ditte B Ditlev, Xumin Zhang, Zhen-Yu Du, Hanne C Bertram, Lise Madsen, Karsten Kristiansen, Bjørn Liaset. Urinary loss of tricarboxylic acid cycle intermediates as revealed by metabolomics studies: an underlying mechanism to reduce lipid accretion by whey protein ingestion?. Journal of proteome research. 2014 May; 13(5):2560-70. doi: 10.1021/pr500039t. [PMID: 24702026]
  • Ming Wang, Kyle Alberti, Shuo Sun, Carlos Luis Arellano, Qiaobing Xu. Combinatorially designed lipid-like nanoparticles for intracellular delivery of cytotoxic protein for cancer therapy. Angewandte Chemie (International ed. in English). 2014 Mar; 53(11):2893-8. doi: 10.1002/anie.201311245. [PMID: 24519972]
  • Guozhu Ye, Bin Zhu, Zhenzhen Yao, Peiyuan Yin, Xin Lu, Hongwei Kong, Fei Fan, Binghua Jiao, Guowang Xu. Analysis of urinary metabolic signatures of early hepatocellular carcinoma recurrence after surgical removal using gas chromatography-mass spectrometry. Journal of proteome research. 2012 Aug; 11(8):4361-72. doi: 10.1021/pr300502v. [PMID: 22768978]
  • Takafumi Toyohara, Takehiro Suzuki, Yasutoshi Akiyama, Daisuke Yoshihara, Yoichi Takeuchi, Eikan Mishima, Koichi Kikuchi, Chitose Suzuki, Masayuki Tanemoto, Sadayoshi Ito, Shizuko Nagao, Tomoyoshi Soga, Takaaki Abe. Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model. Clinical and experimental nephrology. 2011 Oct; 15(5):676-687. doi: 10.1007/s10157-011-0467-4. [PMID: 21695416]
  • Takafumi Toyohara, Takaaki Abe. [Analysis of transporter function and development to clinical application]. Seikagaku. The Journal of Japanese Biochemical Society. 2011 Apr; 83(4):323-8. doi: NULL. [PMID: 21626887]
  • Eliana de Faria Garcia, Mariana Assíria de Oliveira, Adriana Martins Godin, Wallace Carvalho Ferreira, Leandro Francisco Silva Bastos, Márcio de Matos Coelho, Fernão Castro Braga. Antiedematogenic activity and phytochemical composition of preparations from Echinodorus grandiflorus leaves. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Dec; 18(1):80-6. doi: 10.1016/j.phymed.2010.05.008. [PMID: 20637578]
  • A Almodares, M Ranjbar, M R Hadi. Effects of nitrogen treatments and harvesting stages on the aconitic acid, invert sugar and fiber in sweet sorghum cultivars. Journal of environmental biology. 2010 Nov; 31(6):1001-5. doi: . [PMID: 21506489]
  • Qing Huang, Yi-Hong Lu, Guang-Ji Wang, Xin-Wen Wang, Nan Meng, Jie Gao, Di Lu, Xin Yan, Ying Zhang, Lin-Sheng Liu, Gang Hao, Bei Yan, Sheng-Hua Gu, Ji-Ye A. [Metabonomic profiling of plasma metabolites in Wistar rats to study the effect of aging by means of GC/TOFMS-based techniques]. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Oct; 44(10):1095-101. doi: NULL. [PMID: 20055130]
  • Wilfried Rémus-Borel, James G Menzies, Richard R Bélanger. Aconitate and methyl aconitate are modulated by silicon in powdery mildew-infected wheat plants. Journal of plant physiology. 2009 Sep; 166(13):1413-22. doi: 10.1016/j.jplph.2009.02.011. [PMID: 19345440]
  • Wilfried Rémus-Borel, Nancy Shallow, David J McNally, Caroline Labbé, Richard R Bélanger. High-speed counter-current chromatography for the study of defense metabolites in wheat. Characterization of 5,6-O-methyl trans-aconitic acid. Journal of chromatography. A. 2006 Jul; 1121(2):200-8. doi: 10.1016/j.chroma.2006.04.004. [PMID: 16650851]
  • Elemar Voll, Cristiano Elemar Voll, Ricardo Victória Filho. Allelopathic effects of aconitic acid on wild poinsettia (Euphorbia heterophylla) and morningglory (Ipomoea grandifolia). Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2005; 40(1):69-75. doi: 10.1081/pfc-200034226. [PMID: 15656164]
  • Markus Engstler, Michael Boshart. Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei. Genes & development. 2004 Nov; 18(22):2798-811. doi: 10.1101/gad.323404. [PMID: 15545633]
  • Elemar Voll, Júlio Cezar Franchini, Roberto Tomazoni Da Cruz, Dionízio Luis Pisa Gazziero, Alexandre Magno Brighenti, Fernando Storniolo Adegas. Chemical interactions of Brachiaria plantaginea with Commelina bengalensis and Acanthospermum hispidum in soybean cropping systems. Journal of chemical ecology. 2004 Jul; 30(7):1467-75. doi: 10.1023/b:joec.0000037752.57907.fb. [PMID: 15503532]
  • Hartmut Hentschel, Birgitta C Burckhardt, Beate Schölermann, Lars Kühne, Gerhard Burckhardt, Jürgen Steffgen. Basolateral localization of flounder Na+-dicarboxylate cotransporter (fNaDC-3) in the kidney of Pleuronectes americanus. Pflugers Archiv : European journal of physiology. 2003 Aug; 446(5):578-84. doi: 10.1007/s00424-003-1081-4. [PMID: 12759753]
  • Yasuomi Yamasaki, Jin Hisazumi, Kiyoshi Yamaoka, Yoshinobu Takakura. Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: the influence of charge density and size of the proteins molecules. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2003 Apr; 18(5):305-12. doi: 10.1016/s0928-0987(03)00021-6. [PMID: 12694882]
  • Leonie Beljaars, René Floris, Ben Berkhout, Catharina Smit, Dirk K F Meijer, Grietje Molema. The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins. Biochemical pharmacology. 2002 May; 63(9):1663-73. doi: 10.1016/s0006-2952(02)00912-7. [PMID: 12007569]
  • Martin Bartsch, Alida H Weeke-Klimp, Dirk K F Meijer, Gerrit L Scherphof, Jan A A M Kamps. Massive and selective delivery of lipid-coated cationic lipoplexes of oligonucleotides targeted in vivo to hepatic endothelial cells. Pharmaceutical research. 2002 May; 19(5):676-80. doi: 10.1023/a:1015318415705. [PMID: 12069172]
  • Q Lin, Y Chen, H Chen, C Zheng. [Effect of organic acids on soil chemical behavior of lead and cadmium and their toxicity to plants]. Ying yong sheng tai xue bao = The journal of applied ecology. 2001 Aug; 12(4):619-22. doi: ". [PMID: 11758397]
  • O V Popova, T N Popova, S F Izmaĭlov. [Characteristics of NADP-dependent isocitrate dehydrogenase functioning in pea leaves during salt stress]. Izvestiia Akademii nauk. Seriia biologicheskaia. 2001 Mar; ?(2):174-9. doi: ". [PMID: 11357381]
  • P Olinga, I H Hof, M T Merema, M Smit, M H de Jager, P J Swart, M J Slooff, D K Meijer, G M Groothuis. The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake. Journal of pharmacological and toxicological methods. 2001 Jan; 45(1):55-63. doi: 10.1016/s1056-8719(01)00127-7. [PMID: 11489665]
  • P J Swart, M C Harmsen, M E Kuipers, A A Van Dijk, B W Van Der Strate, P H Van Berkel, J H Nuijens, C Smit, M Witvrouw, E De Clercq, M P de Béthune, R Pauwels, D K Meijer. Charge modification of plasma and milk proteins results in antiviral active compounds. Journal of peptide science : an official publication of the European Peptide Society. 1999 Dec; 5(12):563-76. doi: 10.1002/(sici)1099-1387(199912)5:12<563::aid-psc226>3.0.co;2-3. [PMID: 10628656]
  • C Cabrera, M Witvrouw, A Gutiérrez, B Clotet, M E Kuipers, P J Swart, D K Meijer, J Desmyter, E De Clercq, J A Esté. Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4. AIDS research and human retroviruses. 1999 Nov; 15(17):1535-43. doi: 10.1089/088922299309829. [PMID: 10580404]
  • Y Bousquet, P J Swart, N Schmitt-Colin, F Velge-Roussel, M E Kuipers, D K Meijer, N Bru, J Hoebeke, P Breton. Molecular mechanisms of the adsorption of a model protein (human serum albumin) on poly(methylidene malonate 2.1.2) nanoparticles. Pharmaceutical research. 1999 Jan; 16(1):141-7. doi: 10.1023/a:1018843401077. [PMID: 9950293]
  • M E Kuipers, P J Swart, M Witvrouw, J A Esté, D Reymen, E De Clercq, D K Meijer. Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT. Journal of drug targeting. 1999; 6(5):323-35. doi: 10.3109/10611869908996840. [PMID: 10342381]
  • J A Kamps, H W Morselt, P J Swart, D K Meijer, G L Scherphof. Massive targeting of liposomes, surface-modified with anionized albumins, to hepatic endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1997 Oct; 94(21):11681-5. doi: 10.1073/pnas.94.21.11681. [PMID: 9326670]
  • K Watanabe, M Katsuhara, H Nakao, M Sato. Detection and molecular analysis of plant- and insect-associated bacteria harboring aconitate isomerase involved in biosynthesis of trans-aconitic acid as antifeedant in brown planthoppers. Current microbiology. 1997 Aug; 35(2):97-102. doi: 10.1007/s002849900219. [PMID: 9216883]
  • J M Barry. Enzymes and symmetrical molecules. Trends in biochemical sciences. 1997 Jun; 22(6):228-30. doi: 10.1016/s0968-0004(97)01067-0. [PMID: 9204712]
  • N R McGregor, R H Dunstan, M Zerbes, H L Butt, T K Roberts, I J Klineberg. Preliminary determination of a molecular basis of chronic fatigue syndrome. Biochemical and molecular medicine. 1996 Apr; 57(2):73-80. doi: 10.1006/bmme.1996.0012. [PMID: 8733884]
  • J A Kamps, P J Swart, H W Morselt, R Pauwels, M P De Béthune, E De Clercq, D K Meijer, G L Scherphof. Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity. Biochimica et biophysica acta. 1996 Jan; 1278(2):183-90. doi: 10.1016/0005-2736(95)00218-9. [PMID: 8593275]
  • P J Swart, E Beljaars, C Smit, A Pasma, H Schuitemaker, D K Meijer. Comparative pharmacokinetic, immunologic and hematologic studies on the anti-HIV-1/2 compounds aconitylated and succinylated HSA. Journal of drug targeting. 1996; 4(2):109-16. doi: 10.3109/10611869609046269. [PMID: 8894971]
  • V Walker, G A Mills. Effects of birth asphyxia on urinary organic acid excretion. Biology of the neonate. 1992; 61(3):162-72. doi: 10.1159/000243739. [PMID: 1610944]
  • J Czichos, C Nonnengaesser, P Overath. Trypanosoma brucei: cis-aconitate and temperature reduction as triggers of synchronous transformation of bloodstream to procyclic trypomastigotes in vitro. Experimental parasitology. 1986 Oct; 62(2):283-91. doi: 10.1016/0014-4894(86)90033-0. [PMID: 3743718]
  • J B Russell, N Forsberg. Production of tricarballylic acid by rumen microorganisms and its potential toxicity in ruminant tissue metabolism. The British journal of nutrition. 1986 Jul; 56(1):153-62. doi: 10.1079/bjn19860095. [PMID: 3676191]
  • L Huang. [Pharmacological effect of the organic acid of Achillea alpina]. Zhong yao tong bao (Beijing, China : 1981). 1985 Nov; 10(11):38-40. doi: ". [PMID: 2938791]
  • B Meixner-Monori, C P Kubicek, A Habison, E M Kubicek-Pranz, M Röhr. Presence and regulation of the alpha-ketoglutarate dehydrogenase multienzyme complex in the filamentous fungus Aspergillus niger. Journal of bacteriology. 1985 Jan; 161(1):265-71. doi: 10.1128/jb.161.1.265-271.1985. [PMID: 3968029]
  • G Steen, L Ransnäs. Organic acids or urine in multiple sclerosis. Acta neurologica Scandinavica. 1983 Oct; 68(4):231-40. doi: 10.1111/j.1600-0404.1983.tb04831.x. [PMID: 6659864]
  • W Harrington, A S Liu, D Lonsdale, D Igou. Urinary organic acid profiles of Reye's syndrome patients. Clinica chimica acta; international journal of clinical chemistry. 1977 Feb; 74(3):247-54. doi: 10.1016/0009-8981(77)90291-1. [PMID: 832426]
  • A Aksu, G Morrow, L A Barness. Urinary excretion of non-nitrogenous organic acids by healthy infants and children. Clinical chemistry. 1974 May; 20(5):603-5. doi: 10.1093/clinchem/20.5.603. [PMID: 4826956]
  • R L Prior, W J Visek. Effects of modifying urea hydrolysis in acute nephrectomy on survival, ammonia in cecal contents and blood metabolites. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1973 Oct; 144(1):184-8. doi: 10.3181/00379727-144-37553. [PMID: 4771557]
  • R L Prior, W J Visek. Effects of urea in rats deprived of arginine. The Journal of nutrition. 1973 Aug; 103(8):1107-11. doi: 10.1093/jn/103.8.1107. [PMID: 4719721]
  • S LASCOMBES, A LATTES, R MIQUEL, R PULOU. [Formation of an ester of aconitic acid during the stabilization of plant material and during the extraction of organic acids by ethyl alcohol]. Bulletin de la Societe de chimie biologique. 1959; 41(?):1055-8. doi: ". [PMID: 14414339]
  • M SAFFRAN, J L PRADO. Oxidation of members of the Krebs cycle by liver and kidney; inhibition by trans-aconitate. Federation proceedings. 1948 Mar; 7(1 Pt):182. doi: NULL. [PMID: 18938450]