betulic acid (BioDeep_00000395799)

PANOMIX_OTCML-2023 Volatile Flavor Compounds

代谢物信息卡片

(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

化学式: C30H48O3 (456.36032579999994)
中文名称: 表白桦脂酸, 白桦脂酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C(=O)O
InChI: InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)

描述信息

Lup-20(29)-en-28-oic acid, 3beta-hydroxy- is a natural product found in Euphorbia polygonifolia, Ternstroemia gymnanthera, and other organisms with data available.
A lupane-type triterpene derivative of betulin which was originally isolated from BETULA or birch tree. It has anti-inflammatory, anti-HIV and antineoplastic activities.
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties[1][2][3][4].
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties[1][2][3][4].
Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity[1].

同义名列表

18 个代谢物同义名

(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid; 9-Hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid; 1H-Cyclopenta[a]chrysene, lup-20(29)-en-28-oic acid deriv.; Lup-20(29)-en-28-oic acid, 3-hydroxy-, (3.beta.)-; Lup-20(29)-en-28-oic acid, 3.beta.-hydroxy-; 3-Hydroxylup-20(29)-en-28-oic acid #; 3-Hydroxy-lup-20(29)-en-28-oic Acid; 3-hydroxylup-20(29)-en-28-oic acid; acs.jmedchem.1c00409_ST.478; QGJZLNKBHJESQX-UHFFFAOYSA-N; 3-epi-betulinic acid; 3 Epi betulinic Acid; Epibetulinic acid; betulinic acid; betulic acid; NCI60_000293; Lupatic acid; Betulinic acid

数据库引用编号

9 个数据库交叉引用编号

PubChem: 2371
MeSH: Betulinic Acid
CAS: 38736-77-5
CAS: 472-15-1
medchemexpress: HY-N0223
medchemexpress: HY-10529
KEGG: C08619
PubChem: 10812
KNApSAcK: 3087

分类词条

萜类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

75 个相关的物种来源信息

178749 - Acacia acuminata: 10.1016/J.PHYTOCHEM.2004.03.002
479624 - Acacia salicina: 10.1016/J.PHYTOCHEM.2004.03.002
115911 - Achatinella: 10.1016/J.PHYTOCHEM.2006.03.005
2068726 - Ajania nubigena: 10.1002/PCA.995
109061 - Alnus hirsuta: 10.1055/S-2005-916178
432372 - Alphitonia incana: 10.1002/JCCS.200400124
2358445 - Alphitonia philippinensis: 10.1002/JCCS.200400124
1502681 - Alphitonia zizyphoides: 10.1071/CH9722209
216988 - Betula platyphylla var. japonica: 10.1248/CPB.44.1033
228163 - Betula utilis: 10.1038/2121364B0
4058 - Catharanthus roseus: 10.1021/NP800378Q
36622 - Chaenomeles Sinensis (Thouin) Koehne: -
34329 - Corymbia citriodora: 10.1016/S0031-9422(00)00058-3
2708779 - Cussonia bancoensis: 10.1007/BF02976660
240001 - Diospyros ferrea: 10.1016/J.PHYTOCHEM.2004.03.010
413758 - Diospyros maritima: 10.1021/NP980217V
2026877 - Eria robusta:
34316 - Eucalyptus camaldulensis:
1711301 - Eucalyptus flocktoniae: 10.1016/S0031-9422(00)00058-3
260132 - Eugenia myrcianthes: 10.1016/S0031-9422(01)00180-7
334667 - Euphorbia burmanni: 10.1021/NP900305J
1046501 - Euphorbia polygonifolia: 10.1021/NP900305J
756632 - Euphorbia rigida: 10.1021/NP900305J
38847 - Euphorbia segetalis: 10.1021/NP900305J
469923 - Garcinia celebica:
231905 - Garcinia dulcis: 10.1248/CPB.54.301
231906 - Garcinia hanburyi:
180107 - Garcinia hombroniana:
1692142 - Hypericum chinense: 10.1021/NP1004483
282542 - Hypericum japonicum: 10.1021/NP1004483
684760 - Hypericum monogynum: 10.1021/NP1004483
124772 - Illicium Difengpi K. L. B. Et K. I. M.: -
425908 - Isodon japonicus: 10.1021/NP030165W
389181 - Jasminum grandiflorum: 10.1248/CPB.55.474
164936 - Melaleuca leucadendra: 10.1016/S0031-9422(00)88978-5
210380 - Mesua ferrea: 10.3390/MOLECULES16075647
499990 - Mimosa invisa: 10.1021/NP200307R
63461 - Nerium: 10.1021/NP040072U
4146 - Olea europaea:
1938192 - Oxytropis altaica: 10.1007/S10600-009-9377-Z
62886 - Paeonia rockii:
673036 - Peganum nigellastrum: 10.1016/S0031-9422(99)00440-9
542674 - Phyla dulcis: 10.1021/NP068010M
33090 - Plants: -
2651278 - Pongamia pinnata var. pinnata: 10.1021/NP030207G
3755 - Prunus dulcis:
714493 - Pulsatilla chinensis (Bge.) Regel: -
176258 - Rhododendron arboreum: 10.1016/0031-9422(83)80161-7
49622 - Rhododendron ferrugineum: 10.1016/0031-9422(83)80161-7
191528 - Rhododendron maximum: 10.1016/0031-9422(83)80161-7
66907 - Rhododendron metternichii: 10.1248/YAKUSHI1947.94.6_756
74645 - Rosa rugosa:
452792 - Ruta microcarpa: 10.1016/0031-9422(86)80093-0
2886701 - Salvia coulteri: 10.1021/NP50044A005
226208 - Salvia miltiorrhiza: 10.1021/NP50044A005
268919 - Salvia nubicola: 10.1021/NP50044A005
588964 - Salvia prionitis: 10.1021/NP50044A005
39367 - Salvia rosmarinus: 10.1021/NP50044A005
324593 - Saussurea costus: 10.3390/MOLECULES14010266
108362 - Sida cordifolia:
765745 - Sorbus decora: 10.1021/NP1003005
219860 - Syzygium claviflorum:
260142 - Syzygium cumini: 10.1021/NP980313W
1609897 - Syzygium formosanum: 10.1016/S2221-1691(12)60050-1
334497 - Syzygium sandwicense:
714511 - Tadehagi triquetrum: 10.1021/JF0483117
1085512 - Ternstroemia cherryi: 10.1021/NP030069V
107827 - Ternstroemia gymnanthera: 10.1071/CH9650591
318066 - Tridax procumbens: 10.3390/MOLECULES15096357
3972 - Viscum album: 10.1248/CPB.54.1063
999598 - Vismia guianensis: 10.1016/S0031-9422(00)95279-8
999599 - Vismia guineensis: 10.1021/NP990226J
326968 - Ziziphus jujuba: 10.1248/CPB.54.535
326968 - Ziziphus jujuba Mill.: -
714518 - Ziziphus jujuba var. spinosa: 10.1248/CPB.54.535

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Prativa Biswasroy, Deepak Pradhan, Dilip Kumar Pradhan, Goutam Ghosh, Goutam Rath. Development of Betulin-Loaded Nanostructured Lipid Carriers for the Management of Imiquimod-Induced Psoriasis. AAPS PharmSciTech. 2024 Mar; 25(3):57. doi: 10.1208/s12249-024-02774-1. [PMID: 38472545]
Yu-Hao Shi, Yi Nan, Wei Zheng, Lan Yao, Hai-Zhen Liang, Xiao-Juan Chen, Juan Song, Jie Zhang, De-Xian Jia, Qian Wang, Bai-Ping Ma. [Qualitative and semiquantitative analyses of the chemical components of the seed coat and kernel of Ziziphi Spinosae Semen]. Se pu = Chinese journal of chromatography. 2024 Mar; 42(3):234-244. doi: 10.3724/sp.j.1123.2023.09015. [PMID: 38503700]
Huanyu Zhang, Xiance Che, Hongyan Jing, Yaowu Su, Wenqi Yang, Rubing Wang, Guoqi Zhang, Jie Meng, Wei Yuan, Juan Wang, Wenyuan Gao. A New Potent Inhibitor against α-Glucosidase Based on an In Vitro Enzymatic Synthesis Approach. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040878. [PMID: 38398628]
Feyisayo O Adepoju, Ksenia V Sokolova, Irina F Gette, Irina G Danilova, Mikhail V Tsurkan, Alicia C Mondragon, Elena G Kovaleva, Jose Manuel Miranda. Protective Effect of Betulin on Streptozotocin-Nicotinamide-Induced Diabetes in Female Rats. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042166. [PMID: 38396842]
Sílvia Fernandes, Mariana Vieira, Cristina Prudêncio, Ricardo Ferraz. Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042108. [PMID: 38396785]
Hye-Yeon Lee, Kyung-Jin Min. Betulinic Acid Increases the Lifespan of Drosophila melanogaster via Sir2 and FoxO Activation. Nutrients. 2024 Feb; 16(3):. doi: 10.3390/nu16030441. [PMID: 38337725]
Yaowen Liu, Tianqing Nie, Jinjun Hou, Huali Long, Zijia Zhang, Min Lei, Yechun Xu, Wanying Wu. Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2. Steroids. 2024 Feb; 202(?):109351. doi: 10.1016/j.steroids.2023.109351. [PMID: 38101718]
Olexander M Semenenko, Victoria V Lipson, Alina O Sadchenko, Olga V Vashchenko, Natalia A Kasian, Liliia V Sviechnikova, Longin M Lisetski, Mykola L Babak, Volodymyr M Vakula, Oleksandr V Borysov, Yuliia V Holota, Sergey O Zozulya, Petro O Borysko, Olexander V Mazepa. Synthesis of methotrexate-betulonic acid hybrids and evaluation of their effect on artificial and Caco-2 cell membranes. Steroids. 2024 Jan; 201(?):109332. doi: 10.1016/j.steroids.2023.109332. [PMID: 37939980]
Martina Wimmerová, Uladzimir Bildziukevich, Zdeněk Wimmer. Selected Plant Triterpenoids and Their Derivatives as Antiviral Agents. Molecules (Basel, Switzerland). 2023 Nov; 28(23):. doi: 10.3390/molecules28237718. [PMID: 38067449]
Q Zhang, M Zhang, Y Liu, Y Wang, F Lv, Y Wang. [Exploring the therapeutic mechanism of Liuwei Suanzao decoction for perimenopausal insomnia based on network pharmacology and animal experiments]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 Sep; 43(9):1536-1547. doi: 10.12122/j.issn.1673-4254.2023.09.11. [PMID: 37814868]
Neeraj Kumari, Manoj Kumar, Nisha Chaudhary, Baohong Zhang, Radha, Deepak Chandran, Shourabh Joshi, Daljeet Singh, Abhijit Dey, Sureshkumar Rajalingam, Krishnaprabu Natarajan, Muthamilselvan Muthukumar, Pran Mohankumar, Vijay Sheri, Sangram Dhumal, Jose M Lorenzo. Exploring the Chemical and Biological Potential of Jamun (Syzygium cumini (L.) Skeels) Leaves: A Comprehensive Review. Chemistry & biodiversity. 2023 Sep; ?(?):e202300479. doi: 10.1002/cbdv.202300479. [PMID: 37667613]
Huijuan Mu, Yuli Sun, Bo Yuan, Ying Wang. Betulinic acid in the treatment of breast cancer: Application and mechanism progress. Fitoterapia. 2023 Jul; 169(?):105617. doi: 10.1016/j.fitote.2023.105617. [PMID: 37479118]
Reem S Alruhaimi. Betulinic acid protects against cardiotoxicity of the organophosphorus pesticide chlorpyrifos by suppressing oxidative stress, inflammation, and apoptosis in rats. Environmental science and pollution research international. 2023 Feb; ?(?):. doi: 10.1007/s11356-023-25917-6. [PMID: 36808036]
Li Tao, Kehui Zhou, Yang Zhao, Xiangyu Xia, Yajie Guo, Yang Gao, Guoping Peng, Yanqing Liu. Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation. Journal of ethnopharmacology. 2023 Feb; ?(?):116295. doi: 10.1016/j.jep.2023.116295. [PMID: 36813244]
Chenglin Yang, Yunqin Chen, Mengran Yang, Jiayan Li, You Wu, Hui Fan, Xiangyi Kong, Can Ning, Siqi Wang, Wenguang Xiao, Zhihang Yuan, Jine Yi, Jing Wu. Betulinic acid alleviates zearalenone-induced uterine injury in mice. Environmental pollution (Barking, Essex : 1987). 2023 Jan; 316(Pt 1):120435. doi: 10.1016/j.envpol.2022.120435. [PMID: 36257561]
Martina S Savova, Monika N Todorova, Apostol G Apostolov, Galina T Yahubyan, Milen I Georgiev. Betulinic acid counteracts the lipid accumulation in Caenorhabditis elegans by modulation of nhr-49 expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Dec; 156(?):113862. doi: 10.1016/j.biopha.2022.113862. [PMID: 36242845]
S J Sudharshan, Ananth Krishna Narayanan, Jemima Princilly, Madhu Dyavaiah, Dinesh A Nagegowda. Betulinic acid mitigates oxidative stress-mediated apoptosis and enhances longevity in the yeast Saccharomyces cerevisiae model. Free radical research. 2022 Nov; 56(11-12):699-712. doi: 10.1080/10715762.2023.2166505. [PMID: 36624963]
Chenlu Zhang, Yameng Liu, Ying Wang, Xiu Ge, Tingying Jiao, Jianpeng Yin, Kanglong Wang, Cuina Li, Shimeng Guo, Xin Xie, Cen Xie, Fajun Nan. Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis. Journal of medicinal chemistry. 2022 10; 65(19):13452-13472. doi: 10.1021/acs.jmedchem.2c01394. [PMID: 36107013]
Huizi Zhao, Lin Wu, Yuan Zhang, Shiqi Feng, Yuhao Ding, Xin Deng, Rui Feng, Jun Li, Taotao Ma, Cheng Huang. Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation. Journal of ethnopharmacology. 2022 Oct; 296(?):115459. doi: 10.1016/j.jep.2022.115459. [PMID: 35714879]
Gang Wang, Yu Yang, Du Yi, Lu Yuan, Pei-Hao Yin, Xu Ke, Wang Jun-Jie, Min-Fang Tao. Eudragit S100 prepared pH-responsive liposomes-loaded betulinic acid against colorectal cancer in vitro and in vivo. Journal of liposome research. 2022 Sep; 32(3):250-264. doi: 10.1080/08982104.2021.1999974. [PMID: 34895013]
You Huang, Zihan Zhu, Chenxi Luo, Chaoyang Ma, Lijuan Zhu, Li Kong, Rongfang Li, Jing Wu, Zhihang Yuan, Jine Yi. Betulinic acid attenuates cognitive dysfunction, oxidative stress, and inflammation in a model of T-2 toxin-induced brain damage. Environmental science and pollution research international. 2022 Jul; 29(34):52098-52110. doi: 10.1007/s11356-022-19498-z. [PMID: 35254615]
Sameh S Elhady, Elsayed A Ibrahim, Marwa S Goda, Mohamed S Nafie, Hanan Samir, Reem M Diri, Abdulrahman M Alahdal, Ama Kyeraa Thomford, Alaa El Gindy, Ghada M Hadad, Jihan M Badr, Reda F A Abdelhameed. GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea. Molecules (Basel, Switzerland). 2022 Jun; 27(13):. doi: 10.3390/molecules27134109. [PMID: 35807354]
Zhengqi Cheng, Yue Li, Ke Wang, Xue Zhu, Priyanka Tharkar, Wenying Shu, Ting Zhang, Shaoxue Zeng, Ling Zhu, Michael Murray, Wojciech Chrzanowski, Fanfan Zhou. Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Müller cells against oxidative injury. Experimental eye research. 2022 02; 215(?):108906. doi: 10.1016/j.exer.2021.108906. [PMID: 34953864]
Rassameepen Phonarknguen, Saksit Nobsathian, Kanjana Assawasuparerk. Effect of Betulinic acid Extraction from Guava (Psidium guajava Linn.) Leaves Against Human Cholangiocarcinoma Cells. Asian Pacific journal of cancer prevention : APJCP. 2022 Feb; 23(2):583-590. doi: 10.31557/apjcp.2022.23.2.583. [PMID: 35225471]
Hao Sun, Dan Wang, Mengjin Xu, Yi Gao, Fan Li. Methodological Verification-based Screening of the Representative Ingredients for Traditional Chinese Medicine: Taking Astragalus as an Example for Interfering with Cervical Cancer. Current computer-aided drug design. 2022; 18(5):347-362. doi: 10.2174/1573409918666220823120304. [PMID: 36017857]
Aboli Girme, Prajkta Bhoj, Ganesh Saste, Sandeep Pawar, Amit Mirgal, Dipak Raut, Machindra Chavan, Lal Hingorani. Development and Validation of RP-HPLC Method for Vicenin-2, Orientin, Cynaroside, Betulinic Acid, Genistein, and Major Eight Bioactive Constituents with LC-ESI-MS/MS Profiling in Ocimum Genus. Journal of AOAC International. 2021 Dec; 104(6):1634-1651. doi: 10.1093/jaoacint/qsab067. [PMID: 33930142]
Hongjuan Wang, Hongxia Wang, Ling Ge, Yanying Zhao, Kongxi Zhu, Zhaosheng Chen, Qiong Wu, Yu Xin, Jianqiang Guo. Betulinic acid targets drug-resistant human gastric cancer cells by inducing autophagic cell death, suppresses cell migration and invasion, and modulates the ERK/MEK signaling pathway. Acta biochimica Polonica. 2021 Dec; 69(1):25-30. doi: 10.18388/abp.2020_5530. [PMID: 34860480]
Gbadebo E Adeleke, Oluwatosin A Adaramoye. Betulinic acid abates N-nitrosodimethylamine-induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22901. doi: 10.1002/jbt.22901. [PMID: 34472159]
Hyun Kyung Kim, Yejee Park, Minhye Shin, Jun-Mo Kim, Gwang-Woong Go. Betulinic Acid Suppresses de novo Lipogenesis by Inhibiting Insulin and IGF1 Signaling as Upstream Effectors of the Nutrient-Sensing mTOR Pathway. Journal of agricultural and food chemistry. 2021 Oct; 69(42):12465-12473. doi: 10.1021/acs.jafc.1c04797. [PMID: 34645271]
Tomasz Kowalczyk, Przemysław Sitarek, Anna Merecz-Sadowska, Monika Szyposzyńska, Aleksandra Spławska, Leslaw Gorniak, Michał Bijak, Tomasz Śliwiński. Methyl Jasmonate Effect on Betulinic Acid Content and Biological Properties of Extract from Senna obtusifolia Transgenic Hairy Roots. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206208. [PMID: 34684788]
Ye Zhong, Nan Liang, Yang Liu, Mao-Sheng Cheng. Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review. Chinese journal of natural medicines. 2021 Sep; 19(9):641-647. doi: 10.1016/s1875-5364(21)60097-3. [PMID: 34561074]
Tomasz Kowalczyk, Przemysław Sitarek, Monika Toma, Patricia Rijo, Eva Domínguez-Martín, Irene Falcó, Gloria Sánchez, Tomasz Śliwiński. Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological Properties in Various Biological Models. Chemistry & biodiversity. 2021 Aug; 18(8):e2100455. doi: 10.1002/cbdv.202100455. [PMID: 34185351]
Dan-Hua He, Yu-Fei Chen, Yi-Le Zhou, Shi-Bing Zhang, Ming Hong, Xianjun Yu, Su-Fen Wei, Xiang-Zhen Fan, Si-Yi Li, Qi Wang, Yongzhi Lu, Yong-Qiang Liu. Phytochemical library screening reveals betulinic acid as a novel Skp2-SCF E3 ligase inhibitor in non-small cell lung cancer. Cancer science. 2021 Aug; 112(8):3218-3232. doi: 10.1111/cas.15005. [PMID: 34080260]
Haider N Sultani, Ibrahim Morgan, Hidayat Hussain, Andreas H Roos, Haleh H Haeri, Goran N Kaluđerović, Dariush Hinderberger, Bernhard Westermann. Access to New Cytotoxic Triterpene and Steroidal Acid-TEMPO Conjugates by Ugi Multicomponent-Reactions. International journal of molecular sciences. 2021 Jul; 22(13):. doi: 10.3390/ijms22137125. [PMID: 34281176]
Ahmed Wahab Obeng, Yaw Duah Boakye, Theresa Appiah Agana, Georgina Isabella Djameh, Daniel Boamah, Francis Adu. Anti-trypanosomal and anthelminthic properties of ethanol and aqueous extracts of Tetrapleura tetraptera Taub. Veterinary parasitology. 2021 Jun; 294(?):109449. doi: 10.1016/j.vetpar.2021.109449. [PMID: 33991727]
Veena S Patel, Usmangani K Chhalotiya, Sandip B Patel, Jivani Nuruddin. Simultaneous Quantification of Betulinic Acid, Lupeol, and β-Sitosterol in Madhuca longifolia Methanolic Extract of Bark by Liquid Chromatography-Tandem Mass Spectrometric Method. Journal of AOAC International. 2021 May; 104(2):498-505. doi: 10.1093/jaoacint/qsaa128. [PMID: 33615381]
Ching-Feng Chiu, Hsin-Yi Chang, Chun-Yine Huang, Chen-Zou Mau, Tzu-Ting Kuo, Hsiu-Chuan Lee, Shih-Yi Huang. Betulinic Acid Affects the Energy-Related Proteomic Profiling in Pancreatic Ductal Adenocarcinoma Cells. Molecules (Basel, Switzerland). 2021 Apr; 26(9):. doi: 10.3390/molecules26092482. [PMID: 33923185]
Luis Fernando Méndez-López, Pierluigi Caboni, Eder Arredondo-Espinoza, Juan J J Carrizales-Castillo, Isaías Balderas-Rentería, María Del Rayo Camacho-Corona. Bioassay-Guided Identification of the Antiproliferative Compounds of Cissus trifoliata and the Transcriptomic Effect of Resveratrol in Prostate Cancer Pc3 Cells. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082200. [PMID: 33920405]
Paul Thomas, Emmanuel Essien, Anwanabasi Udoh, Bright Archibong, Ofonasaha Akpan, Emediong Etukudo, Marinella De Leo, Olorunfemi Eseyin, Guido Flamini, Kola' Ajibesin. Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark. Journal of ethnopharmacology. 2021 Apr; 269(?):113737. doi: 10.1016/j.jep.2020.113737. [PMID: 33359855]
Kelly Oriakhi, Patrick O Uadia, Farzana Shaheen, Humera Jahan, Collins U Ibeji, Choudhary M Iqbal. Isolation, characterization, and hepatoprotective properties of betulinic acid and ricinine from Tetracarpidium conophorum seeds (Euphorbiaceae). Journal of food biochemistry. 2021 03; 45(3):e13288. doi: 10.1111/jfbc.13288. [PMID: 32529649]
André Barreto Cunha, Ronan Batista, María Ángeles Castro, Jorge Mauricio David. Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26041081. [PMID: 33670791]
Chen Chen, Kainan Song, Yongzhen Zhang, Chengjiao Chu, Boyi Fan, Yan Song, Huilian Huang, Guangtong Chen. Biotransformation of betulinic acid by Circinella muscae and Cunninghamella echinulata to discover anti-inflammatory derivatives. Phytochemistry. 2021 Feb; 182(?):112608. doi: 10.1016/j.phytochem.2020.112608. [PMID: 33310627]
Chenxi Luo, Chenglong Huang, Lijuan Zhu, Li Kong, Zhihang Yuan, Lixin Wen, Rongfang Li, Jing Wu, Jine Yi. Betulinic Acid Ameliorates the T-2 Toxin-Triggered Intestinal Impairment in Mice by Inhibiting Inflammation and Mucosal Barrier Dysfunction through the NF-κB Signaling Pathway. Toxins. 2020 12; 12(12):. doi: 10.3390/toxins12120794. [PMID: 33322178]
Marcus Wing Choy Loe, Erwei Hao, Meiling Chen, Cong Li, Regina Ching Hua Lee, Isabelle Xin Yu Zhu, Zi Yun Teo, Wei-Xin Chin, Xiaotao Hou, JiaGang Deng, Justin Jang Hann Chu. Betulinic acid exhibits antiviral effects against dengue virus infection. Antiviral research. 2020 12; 184(?):104954. doi: 10.1016/j.antiviral.2020.104954. [PMID: 33080251]
Gang Wang, Yang Yu, Yu-Zhu Wang, Zhi-Min Zhu, Pei-Hao Yin, Ke Xu. Effects and mechanisms of fatty acid metabolism‑mediated glycolysis regulated by betulinic acid‑loaded nanoliposomes in colorectal cancer. Oncology reports. 2020 12; 44(6):2595-2609. doi: 10.3892/or.2020.7787. [PMID: 33125108]
Jiaming Wang, Mei Jin, Chunshi Jin, Chao Ye, Yi Zhou, Rongshen Wang, Huanhuan Cui, Wei Zhou, Gao Li. A new pentacyclic triterpenoid from the leaves of Rhododendron dauricum L. with inhibition of NO production in LPS-induced RAW 264.7 cells. Natural product research. 2020 Dec; 34(23):3313-3319. doi: 10.1080/14786419.2019.1566822. [PMID: 30810367]
Feng Zhang, Jian Huang, Rong-Jing He, Lu Wang, Peng-Chao Huo, Xiao-Qing Guan, Sheng-Quan Fang, Yan-Wei Xiang, Shou-Ning Jia, Guang-Bo Ge. Herb-drug interaction between Styrax and warfarin: Molecular basis and mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Oct; 77(?):153287. doi: 10.1016/j.phymed.2020.153287. [PMID: 32739573]
Ebrahim Azadniya, Luca Goldoni, Tiziano Bandiera, Gertrud E Morlock. Same analytical method for both (bio)assay and zone isolation to identify/quantify bioactive compounds by quantitative nuclear magnetic resonance spectroscopy. Journal of chromatography. A. 2020 Sep; 1628(?):461434. doi: 10.1016/j.chroma.2020.461434. [PMID: 32822974]
Shao-Hua Xu, Hai-Lan Chen, Ze-Lin Yang, Li-Wei Lyu, Yong Fan, Mei Sha, Jian Zhang, Wei Xu, Yu Lin. New 30-norlupane derivatives through chemical-microbial semi-synthesis of betulinic acid and their neuroprotective effect. Bioorganic & medicinal chemistry letters. 2020 09; 30(17):127407. doi: 10.1016/j.bmcl.2020.127407. [PMID: 32738992]
Qian Mu, Hui Wang, Lei Tong, Qianhua Fang, Minqi Xiang, Luyu Han, Lina Jin, Jian Yang, Zhen Qian, Guang Ning, Yifei Zhang, Zhiguo Zhang. Betulinic acid improves nonalcoholic fatty liver disease through YY1/FAS signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 09; 34(9):13033-13048. doi: 10.1096/fj.202000546r. [PMID: 32777136]
Lijuan Zhu, Xianglian Yi, Chaoyang Ma, Chenxi Luo, Li Kong, Xing Lin, Xinyu Gao, Zhihang Yuan, Lixin Wen, Rongfang Li, Jing Wu, Jine Yi. Betulinic Acid Attenuates Oxidative Stress in the Thymus Induced by Acute Exposure to T-2 Toxin via Regulation of the MAPK/Nrf2 Signaling Pathway. Toxins. 2020 08; 12(9):. doi: 10.3390/toxins12090540. [PMID: 32842569]
Jing Yin, Lu Sun, Ying Li, Jialei Xiao, Siyao Wang, Jie Yang, Ziyue Qu, Yaguang Zhan. Functional identification of BpMYB21 and BpMYB61 transcription factors responding to MeJA and SA in birch triterpenoid synthesis. BMC plant biology. 2020 Aug; 20(1):374. doi: 10.1186/s12870-020-02521-1. [PMID: 32787836]
Ângela R Guerra, Ana F Paulino, Maria M Castro, Helena Oliveira, Maria F Duarte, Iola F Duarte. Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids. Biomolecules. 2020 08; 10(8):. doi: 10.3390/biom10081163. [PMID: 32784479]
Yun Chen, Xiongjian Wu, Chi Liu, Yun Zhou. Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress. Cell biochemistry and function. 2020 Aug; 38(6):702-709. doi: 10.1002/cbf.3537. [PMID: 32283563]
Michał Sulik, Ewa Maj, Joanna Wietrzyk, Adam Huczyński, Michał Antoszczak. Synthesis and Anticancer Activity of Dimeric Polyether Ionophores. Biomolecules. 2020 07; 10(7):. doi: 10.3390/biom10071039. [PMID: 32664671]
Yingying Chen, Xinchen Wang, Yinbiao Zhu, Longlong Si, Bo Zhang, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao. Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor. Molecular pharmaceutics. 2020 07; 17(7):2546-2554. doi: 10.1021/acs.molpharmaceut.0c00244. [PMID: 32426985]
Jing Yin, Jie Yang, Hongsi Ma, Tian Liang, Ying Li, Jialei Xiao, Hongmei Tian, Zhiqiang Xu, Yaguang Zhan. Expression characteristics and function of CAS and a new beta-amyrin synthase in triterpenoid synthesis in birch (Betula platyphylla Suk.). Plant science : an international journal of experimental plant biology. 2020 May; 294(?):110433. doi: 10.1016/j.plantsci.2020.110433. [PMID: 32234222]
R A Ajala-Lawal, N O Aliyu, T O Ajiboye. Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation and oxidative stress in metabolic syndrome rats via PI3K/Akt pathways. Archives of physiology and biochemistry. 2020 May; 126(2):107-115. doi: 10.1080/13813455.2018.1498901. [PMID: 30288995]
Da Hye Jeong, Sung Chul Kwak, Myeung Su Lee, Kwon-Ha Yoon, Ju-Young Kim, Chang Hoon Lee. Betulinic Acid Inhibits RANKL-Induced Osteoclastogenesis via Attenuating Akt, NF-κB, and PLCγ2-Ca2+ Signaling and Prevents Inflammatory Bone Loss. Journal of natural products. 2020 04; 83(4):1174-1182. doi: 10.1021/acs.jnatprod.9b01212. [PMID: 32237724]
Victor Constante Oliveira, Maria Paula Carvalho Naves, Cássio Resende de Morais, Sarah Alves Rodrigues Constante, Priscila Capelari Orsolin, Bianca Silva Alves, Francisco Rinaldi Neto, Lucas Henrique Domingos da Silva, Lucas Teixeira Souza de Oliveira, Natália Helen Ferreira, Tábata Rodrigues Esperandim, Wilson Roberto Cunha, Denise Crispim Tavares, Mário Antônio Spanó. Betulinic acid modulates urethane-induced genotoxicity and mutagenicity in mice and Drosophila melanogaster. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Apr; 138(?):111228. doi: 10.1016/j.fct.2020.111228. [PMID: 32112866]
Tomasz Kowalczyk, Przemysław Sitarek, Monika Toma, Laurent Picot, Marzena Wielanek, Ewa Skała, Tomasz Śliwiński. An Extract of Transgenic Senna obtusifolia L. Hairy Roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line. Biomolecules. 2020 03; 10(4):. doi: 10.3390/biom10040510. [PMID: 32230928]
C Emade Kwene, Anastasie E Tih, Bintou Abderamane, Rapheal T Ghogomu. Two new phenolic glycosides from the leaves of Garcinia epunctata Stapf. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2020 Jan; 75(1-2):51-56. doi: 10.1515/znc-2018-0217. [PMID: 32053496]
Xin Jin, Qing Yang, Ning Cai, Zhenhai Zhang. A cocktail of betulinic acid, parthenolide, honokiol and ginsenoside Rh2 in liposome systems for lung cancer treatment. Nanomedicine (London, England). 2020 01; 15(1):41-54. doi: 10.2217/nnm-2018-0479. [PMID: 31868113]
Kun-Liu, Jian-Ying Wang, Lei Zhang, Ying-Yi Pan, Xiao-Yun Chen, Ying Yuan. Effects of betulinic acid on synovial inflammation in rats with collagen-induced arthritis. International journal of immunopathology and pharmacology. 2020 Jan; 34(?):2058738420945078. doi: 10.1177/2058738420945078. [PMID: 32718263]
Dongfang Xiang, Min Zhao, Xiaofan Cai, Yongxia Wang, Lei Zhang, Helen Yao, Min Liu, Huan Yang, Mingtao Xu, Huilin Li, Huijuan Peng, Min Wang, Xuefang Liang, Ling Li, Paul Yao. Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor β Signaling Pathway. Frontiers in endocrinology. 2020; 11(?):604648. doi: 10.3389/fendo.2020.604648. [PMID: 33362719]
Gang Wang, Yu-Zhu Wang, Yang Yu, Jun-Jie Wang, Pei-Hao Yin, Ke Xu. Triterpenoids Extracted from Rhus chinensis Mill Act Against Colorectal Cancer by Inhibiting Enzymes in Glycolysis and Glutaminolysis: Network Analysis and Experimental Validation. Nutrition and cancer. 2020; 72(2):293-319. doi: 10.1080/01635581.2019.1631858. [PMID: 31267795]
Tatyana S Khlebnicova, Yuri A Piven, Fedor A Lakhvich, Iryna V Sorokina, Tatiana S Frolova, Dmitry S Baev, Tatyana G Tolstikova. Betulinic Acid-Azaprostanoid Hybrids: Synthesis and Pharmacological Evaluation as Anti-inflammatory Agents. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2020; 19(3):254-267. doi: 10.2174/1871523018666190426152049. [PMID: 33001006]
Ran Tao, Chengzhang Wang, Yin Lu, Changwei Zhang, Hao Zhou, Hongxia Chen, WenJun Li. Characterization and Cytotoxicity of Polyprenol Lipid and Vitamin E-TPGS Hybrid Nanoparticles for Betulinic Acid and Low-Substituted Hydroxyl Fullerenol in MHCC97H and L02 Cells. International journal of nanomedicine. 2020; 15(?):2733-2749. doi: 10.2147/ijn.s249773. [PMID: 32368052]
Birendra Nath Karan, Tapan Kumar Maity, Bikash Chandra Pal, Tanushree Singha, Snehasis Jana. Betulinic Acid, the first lupane-type triterpenoid isolated via bioactivity-guided fractionation, and identified by spectroscopic analysis from leaves of Nyctanthes arbor-tristis: its potential biological activities in vitro assays. Natural product research. 2019 Nov; 33(22):3287-3292. doi: 10.1080/14786419.2018.1470171. [PMID: 29724132]
Qin Shu, Jianan Wu, Qihe Chen. Synthesis, Characterization of Liposomes Modified with Biosurfactant MEL-A Loading Betulinic Acid and Its Anticancer Effect in HepG2 Cell. Molecules (Basel, Switzerland). 2019 Oct; 24(21):. doi: 10.3390/molecules24213939. [PMID: 31683639]
Xihong Wang, Zhihang Yuan, Lijuan Zhu, Xianglian Yi, Zhaoping Ou, Rongfang Li, Zhuliang Tan, Blazej Pozniak, Bozena Obminska-Mrukowicz, Jing Wu, Jine Yi. Protective effects of betulinic acid on intestinal mucosal injury induced by cyclophosphamide in mice. Pharmacological reports : PR. 2019 Oct; 71(5):929-939. doi: 10.1016/j.pharep.2019.05.004. [PMID: 31450028]
Jiajian Huang, Wenlong Zha, Tianyue An, Hua Dong, Ying Huang, Dong Wang, Rongmin Yu, Lixin Duan, Xueli Zhang, Reuben J Peters, Zhubo Dai, Jiachen Zi. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid. Applied microbiology and biotechnology. 2019 Sep; 103(17):7029-7039. doi: 10.1007/s00253-019-10004-z. [PMID: 31309269]
Al-Mutary Mohsen G, Gasem Mohammad Abu-Taweel, Rajakrishnan Rajagopal, Kim Sun-Ju, Hak-Jae Kim, Young Ock Kim, Ramzi A Mothana, Shine Kadaikunnan, Jamal M Khaled, Nasir A Siddiqui, Adnan J Al-Rehaily. Betulinic acid lowers lipid accumulation in adipocytes through enhanced NCoA1-PPARγ interaction. Journal of infection and public health. 2019 Sep; 12(5):726-732. doi: 10.1016/j.jiph.2019.05.011. [PMID: 31133421]
Herong Cui, Wenbo Guo, Beibei Zhang, Guoping Li, Tong Li, Yanyan Yuan, Na Zhang, Yuwei Yang, Wuwen Feng, Fuhao Chu, Shenglan Wang, Bing Xu, Penglong Wang, Haimin Lei. BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation. International journal of molecular sciences. 2019 Aug; 20(16):. doi: 10.3390/ijms20164062. [PMID: 31434286]
Debasmita Dutta, Brahamacharry Paul, Biswajit Mukherjee, Laboni Mondal, Suparna Sen, Chinmay Chowdhury, Mita Chatterjee Debnath. Nanoencapsulated betulinic acid analogue distinctively improves colorectal carcinoma in vitro and in vivo. Scientific reports. 2019 08; 9(1):11506. doi: 10.1038/s41598-019-47743-y. [PMID: 31395908]
Cuihua Liu, Yuchao Chen, Chuanjian Lu, Haiming Chen, Jingwen Deng, Yuhong Yan, Yong-Yue Xu, Huazhen Liu, Haiding Huang, Jianan Wei, Ling Han, Zhenhua Dai. Betulinic acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation. International immunopharmacology. 2019 Aug; 73(?):343-352. doi: 10.1016/j.intimp.2019.05.030. [PMID: 31129421]
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Yuri Ko, Changhyun Pang, Noriko Yamabe, Ki Hyun Kim. Betulinic Acid Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis. Biomolecules. 2019 07; 9(7):. doi: 10.3390/biom9070257. [PMID: 31277238]
Anqi Zeng, Hua Hua, Li Liu, Junning Zhao. Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo. Bioorganic & medicinal chemistry. 2019 06; 27(12):2546-2552. doi: 10.1016/j.bmc.2019.03.033. [PMID: 30910472]
Alexsander Rodrigues Carvalho Junior, Arthur Lima de Berredo Martins, Brenda da Silva Cutrim, Deivid Martins Santos, Hermerson Sousa Maia, Mari Silma Maia da Silva, Adrielle Zagmignan, Maria Raimunda Chagas Silva, Cristina de Andrade Monteiro, Giselle Maria Skelding Pinheiro Guilhon, Antônio José Cantanhede Filho, Luís Cláudio Nascimento da Silva. Betulinic Acid Prevents the Acquisition of Ciprofloxacin-Mediated Mutagenesis in Staphylococcus aureus. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091757. [PMID: 31067626]
Shicheng Zhao, Chang Ha Park, Jingli Yang, Hyeon Ji Yeo, Tae Jin Kim, Jae Kwang Kim, Sang Un Park. Molecular characterization of anthocyanin and betulinic acid biosynthesis in red and white mulberry fruits using high-throughput sequencing. Food chemistry. 2019 May; 279(?):364-372. doi: 10.1016/j.foodchem.2018.11.101. [PMID: 30611502]
Ming Gu, Ping Zhao, Shiying Zhang, Shengjie Fan, Li Yang, Qingchun Tong, Guang Ji, Cheng Huang. Betulinic acid alleviates endoplasmic reticulum stress-mediated nonalcoholic fatty liver disease through activation of farnesoid X receptors in mice. British journal of pharmacology. 2019 04; 176(7):847-863. doi: 10.1111/bph.14570. [PMID: 30635917]
K-D Kim, H-Y Jung, H G Ryu, B Kim, J Jeon, H Y Yoo, C H Park, B-H Choi, C-K Hyun, K-T Kim, S Fang, S H Yang, J-B Kim. Betulinic acid inhibits high-fat diet-induced obesity and improves energy balance by activating AMPK. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2019 04; 29(4):409-420. doi: 10.1016/j.numecd.2018.12.001. [PMID: 30799179]
Nan Yao, Chenran Wang, Nan Hu, Yingjie Li, Mingqun Liu, Yuhe Lei, Minfeng Chen, Liping Chen, Chen Chen, Ping Lan, Weimin Chen, Zhesheng Chen, Dengrui Fu, Wencai Ye, Dongmei Zhang. Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog. Cell death & disease. 2019 03; 10(3):232. doi: 10.1038/s41419-019-1470-z. [PMID: 30850585]
Rui Liu, Corrine C Dobson, Brian C Foster, Tony Durst, Pablo Sanchez, John T Arnason, Cory S Harris. Effect of an anxiolytic botanical containing Souroubea sympetala and Platanus occidentalis on in-vitro diazepam human cytochrome P450-mediated metabolism. The Journal of pharmacy and pharmacology. 2019 Mar; 71(3):429-437. doi: 10.1111/jphp.13045. [PMID: 30467864]
Lee Kee Chua, Chooi Ling Lim, Anna Pick Kiong Ling, Soi Moi Chye, Rhun Yian Koh. Anticancer Potential of Syzygium Species: a Review. Plant foods for human nutrition (Dordrecht, Netherlands). 2019 Mar; 74(1):18-27. doi: 10.1007/s11130-018-0704-z. [PMID: 30535971]
Lin Jiao, Shengqi Wang, Yifeng Zheng, Neng Wang, Bowen Yang, Dongmei Wang, Depo Yang, Wenjie Mei, Zhimin Zhao, Zhiyu Wang. Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway. Biochemical pharmacology. 2019 03; 161(?):149-162. doi: 10.1016/j.bcp.2019.01.016. [PMID: 30684465]
Jianan Wu, Yongwu Niu, Yingchun Jiao, Qihe Chen. Fungal chitosan from Agaricus bisporus (Lange) Sing. Chaidam increased the stability and antioxidant activity of liposomes modified with biosurfactants and loading betulinic acid. International journal of biological macromolecules. 2019 Feb; 123(?):291-299. doi: 10.1016/j.ijbiomac.2018.11.062. [PMID: 30439434]
Maycow Marcos L de Azevedo, Márcia M Cascaes, Giselle Maria S P Guilhon, Eloisa Helena A Andrade, Maria das Graças B Zoghbi, Joyce Kelly R da Silva, Lourivaldo S Santos, Silvia Helena M da Silva. Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg. Natural product research. 2019 Feb; 33(4):506-515. doi: 10.1080/14786419.2017.1402311. [PMID: 29130365]
Nan Li, Zhaohui Gong, Xiaojuan Li, Qingyu Ma, Mansi Wu, Dongdong Liu, Lijuan Deng, Dongmei Pan, Qingping Liu, Zhenquan Wei, Qiang Wang, Longyin Han, Changsong Lin, Jiaxu Chen. Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis. International immunopharmacology. 2019 Feb; 67(?):186-193. doi: 10.1016/j.intimp.2018.11.042. [PMID: 30553912]
Wen-Dan Zhang, Miao-Miao Jin, Hong-Hong Jiang, Jian-Xi Yang, Qiao Wang, Ying-Feng Du, Liang Cao, Hui-Jun Xu. Study on the metabolites of betulinic acid in vivo and in vitro by ultra high performance liquid chromatography with time-of-flight mass spectrometry. Journal of separation science. 2019 Jan; 42(2):628-635. doi: 10.1002/jssc.201800960. [PMID: 30427118]
Yuan Liu, Yanmeng Bi, Chan Mo, Ting Zeng, Sha Huang, Lei Gao, Xuegang Sun, Zhiping Lv. Betulinic acid attenuates liver fibrosis by inducing autophagy via the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Journal of natural medicines. 2019 Jan; 73(1):179-189. doi: 10.1007/s11418-018-1262-2. [PMID: 30377904]
Flávia S Fernandes, Gustavo S da Silva, Alexandre S Hilel, Ana C Carvalho, Karina V T Remor, Aline D Schlindwein, Luiz A Kanis, Daniel F Martins, Maicon R Kviecinski. Study of the potential adverse effects caused by the dermal application of Dillenia indica L. fruit extract standardized to betulinic acid in rodents. PloS one. 2019; 14(5):e0217718. doi: 10.1371/journal.pone.0217718. [PMID: 31150479]
Yifeng Zheng, Pengxi Liu, Neng Wang, Shengqi Wang, Bowen Yang, Min Li, Jianping Chen, Honglin Situ, Meiqi Xie, Yi Lin, Zhiyu Wang. Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway. Oxidative medicine and cellular longevity. 2019; 2019(?):8781690. doi: 10.1155/2019/8781690. [PMID: 31531187]
Razieh Jafari Hajati, Vahide Payamnoor, Najmeh Ahmadian Chashmi. Effect of biotic and abiotic elicitors on production of betulin and betulinic acid in the hairy root culture of Betula pendula Roth. Preparative biochemistry & biotechnology. 2019; 49(10):1010-1019. doi: 10.1080/10826068.2019.1650372. [PMID: 31385749]
Shreya S Bellampalli, Yingshi Ji, Aubin Moutal, Song Cai, E M Kithsiri Wijeratne, Maria A Gandini, Jie Yu, Aude Chefdeville, Angie Dorame, Lindsey A Chew, Cynthia L Madura, Shizhen Luo, Gabriella Molnar, May Khanna, John M Streicher, Gerald W Zamponi, A A Leslie Gunatilaka, Rajesh Khanna. Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels. Pain. 2019 Jan; 160(1):117-135. doi: 10.1097/j.pain.0000000000001385. [PMID: 30169422]
Robert Ebeh Messanga, Ngono Bikobo Dominique Serge, Auguste Abouem A Zintchem, Mbabi Nyemeck Ii Norbert, Moni Ndedi Esther Del Florence, Betote Diboué Patrick Hervé, Nyegue Maximilienne Ascension, Atchadé Alex De Théodore, Pegnyemb Dieudonné Emmanuel, Bochet Christian G, Ulrich Koert. Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae). Natural product research. 2018 Aug; 32(16):1971-1976. doi: 10.1080/14786419.2017.1356832. [PMID: 28812370]
Yao Li, Sheng Guo, Quanjin Ren, Dandan Wei, Ming Zhao, Shulan Su, Zhishu Tang, Jin-Ao Duan. Pharmacokinetic Comparisons of Multiple Triterpenic Acids from Jujubae Fructus Extract Following Oral Delivery in Normal and Acute Liver Injury Rats. International journal of molecular sciences. 2018 07; 19(7):. doi: 10.3390/ijms19072047. [PMID: 30011885]
Ankit Saneja, Divya Arora, Robin Kumar, Ravindra Dhar Dubey, Amulya K Panda, Prem N Gupta. Therapeutic applications of betulinic acid nanoformulations. Annals of the New York Academy of Sciences. 2018 06; 1421(1):5-18. doi: 10.1111/nyas.13570. [PMID: 29377164]
Yunseok Oh, Yoo-Seong Jeong, Min-Soo Kim, Jee Sun Min, Gongmi Ryoo, Ji Eun Park, Yearin Jun, Yoo-Kyung Song, Se-Eun Chun, Songhee Han, Soo Kyung Bae, Suk-Jae Chung, Wooin Lee. Inhibition of Organic Anion Transporting Polypeptide 1B1 and 1B3 by Betulinic Acid: Effects of Preincubation and Albumin in the Media. Journal of pharmaceutical sciences. 2018 06; 107(6):1713-1723. doi: 10.1016/j.xphs.2018.02.010. [PMID: 29462635]