Ermanin (BioDeep_00000266208)

   

PANOMIX_OTCML-2023 Chemicals and Drugs natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-

化学式: C17H14O6 (314.079)
中文名称: 堪非醇 3,4-二-O-甲醚, 堪非醇3,4-二-O-甲醚, ERMANIN
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)OC)c1ccc(cc1)OC)O)O
InChI: InChI=1S/C17H14O6/c1-21-11-5-3-9(4-6-11)16-17(22-2)15(20)14-12(19)7-10(18)8-13(14)23-16/h3-8,18-19H,1-2H3

描述信息

3,4-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4 have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. It has a role as an anti-inflammatory agent, an antimycobacterial drug, an apoptosis inducer, an antineoplastic agent and a plant metabolite. It is a dihydroxyflavone and a dimethoxyflavone. It is functionally related to a kaempferol.
Ermanin is a natural product found in Grindelia glutinosa, Grindelia hirsutula, and other organisms with data available.
A dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4 have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum.

同义名列表

36 个代谢物同义名

4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-; 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one #; 5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-3-methoxy-2-(4-methoxy-phenyl)-chromen-4-one; 5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-3-methoxy-2-(4-methoxy-phenyl)chromen-4-one; 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)chromen-4-one; 3,4-dimethoxy-5,7-dihydroxyflavone; 5,6-dihydroxy-3,4-dimethoxyflavone; 5,7-dihydroxy-3,4-dimethoxyflavone; 5,7-Dihydroxy-3,4-dimethoxyflavone; Kaempferol 3,4-di-O-methyl ether; kaempferol-3,4-di-O-methyl ether; Kaempferol 3,4-dimethyl ether; Kaempferol-3,4-dimethyl ether; Kaempferol-3,4-dimethylether; 3,4-O-dimethylkaempferol; 3,4-dimethoxykaempferol; Chrysin, 3,4-dimethoxy-; 3,4-dimethylkaempferol; Chrysin,4-dimethoxy-; 3,4-Dimethoxychrysin; MEGxp0_000250; NCI60_002742; Ermanin; 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4-chromenone; 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)chromone; EINECS 244-093-8; ZINC01664047; AIDS-001405; 20869-95-8; AIDS001405; NSC 31882; NSC31882; 5,7-Dihydroxy-3-methoxy-2- (4-methoxyphenyl) -4H-1-benzopyran-4-one



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

133 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Qiong Ding, Lin Luo, Lan Yu, Si-Lu Huang, Xiao-Qin Wang, Bo Zhang. The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis. Free radical biology & medicine. 2021 11; 176(?):392-405. doi: 10.1016/j.freeradbiomed.2021.09.017. [PMID: 34560247]
  • Li-Yan Song, Fang Huang, Yan Wang, Zu-Jian Wu, Ming-An Ouyang. New Alkaloid and Aromatic Glucoside from the Flowers of Cymbidium Lunagrad Eternal Green. Molecules (Basel, Switzerland). 2018 Jan; 23(1):. doi: 10.3390/molecules23010099. [PMID: 29301372]
  • Siriporn Saepou, Manat Pohmakotr, Vichai Reutrakul, Chalobon Yoosook, Jitra Kasisit, Chanita Napaswad, Patoomratana Tuchinda. Anti-HIV-1 diterpenoids from leaves and twigs of Polyalthia sclerophylla. Planta medica. 2010 May; 76(7):721-5. doi: 10.1055/s-0029-1240683. [PMID: 20013639]
  • A A da Silva Filho, D O Resende, M J Fukui, F F Santos, P M Pauletti, W R Cunha, M L A Silva, L E Gregório, J K Bastos, N P D Nanayakkara. In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae). Fitoterapia. 2009 Dec; 80(8):478-82. doi: 10.1016/j.fitote.2009.06.007. [PMID: 19540316]
  • Samir Kumar Sadhu, Emi Okuyama, Haruhiro Fujimoto, Masami Ishibashi, Erdem Yesilada. Prostaglandin inhibitory and antioxidant components of Cistus laurifolius, a Turkish medicinal plant. Journal of ethnopharmacology. 2006 Dec; 108(3):371-8. doi: 10.1016/j.jep.2006.05.024. [PMID: 16814498]
  • José Antonio Guerra, María Francisca Molina, María José Abad, Angel María Villar, Bermejo Paulina. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum. International immunopharmacology. 2006 Nov; 6(11):1723-8. doi: 10.1016/j.intimp.2006.07.012. [PMID: 16979127]
  • Isabel Rivero-Cruz, Laura Acevedo, José A Guerrero, Sergio Martínez, Robert Bye, Rogelio Pereda-Miranda, Scott Franzblau, Barbara N Timmermann, Rachel Mata. Antimycobacterial agents from selected Mexican medicinal plants. The Journal of pharmacy and pharmacology. 2005 Sep; 57(9):1117-26. doi: 10.1211/jpp.57.9.0007. [PMID: 16105233]
  • Dae Sik Jang, Ah-Reum Han, Gowooni Park, Gil-Ja Jhon, Eun-Kyoung Seo. Flavonoids and aromatic compounds from the rhizomes of Zingiber zerumbet. Archives of pharmacal research. 2004 Apr; 27(4):386-9. doi: 10.1007/bf02980078. [PMID: 15180302]
  • María José Abad, Paulina Bermejo, María Alvarez, José Antonio Guerra, Ana María Silván, Angel Maria Villar. Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages. Planta medica. 2004 Jan; 70(1):34-8. doi: 10.1055/s-2004-815452. [PMID: 14765290]
  • Rachel Mata, Robert Bye, Edelmira Linares, Martha Macías, Isabel Rivero-Cruz, Olga Pérez, Barbara N Timmermann. Phytotoxic compounds from Flourensia cernua. Phytochemistry. 2003 Sep; 64(1):285-91. doi: 10.1016/s0031-9422(03)00217-6. [PMID: 12946427]
  • J I Murillo, R Encarnación-Dimayuga, J Malmstrøm, C Christophersen, S G Franzblau. Antimycobacterial flavones from Haplopappus sonorensis. Fitoterapia. 2003 Apr; 74(3):226-30. doi: 10.1016/s0367-326x(03)00033-9. [PMID: 12727485]
  • V Robin, A Irurzun, M Amoros, J Boustie, L Carrasco. Antipoliovirus flavonoids from Psiadia dentata. Antiviral chemistry & chemotherapy. 2001 Sep; 12(5):283-91. doi: 10.1177/095632020101200503. [PMID: 11900347]
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