Miquelianin (BioDeep_00000230319)

Main id: BioDeep_00000398145

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2S,3S,4S,5R,6S)-6-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

化学式: C21H18O13 (478.0747378)
中文名称: 槲皮素-3-O-葡萄糖醛酸苷, 槲皮素-3-葡萄糖醛酸苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=C(O)C(O)=CC=3)=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(=O)O)O3)C(=O)C=2C(O)=C1
InChI: InChI=1S/C21H18O13/c22-7-4-10(25)12-11(5-7)32-17(6-1-2-8(23)9(24)3-6)18(13(12)26)33-21-16(29)14(27)15(28)19(34-21)20(30)31/h1-5,14-16,19,21-25,27-29H,(H,30,31)/t14-,15-,16+,19-,21+/m0/s1

描述信息

Miquelianin is a quercetin O-glycoside that consists of quercetin attached to a beta-D-glucuronopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from Salvia and Phaseolus vulgaris, it exhibits antioxidant and antidepressant activities. It has a role as a metabolite, an antioxidant and an antidepressant. It is a beta-D-glucosiduronic acid and a quercetin O-glycoside.
quercetin 3-O-glucuronide is a natural product found in Theobroma grandiflorum, Eucalyptus cypellocarpa, and other organisms with data available.
See also: Bilberry (part of); Theobroma grandiflorum seed (part of).
A quercetin O-glycoside that consists of quercetin attached to a beta-D-glucuronopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from Salvia and Phaseolus vulgaris, it exhibits antioxidant and antidepressant activities.
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.

同义名列表

49 个代谢物同义名

(2S,3S,4S,5R,6S)-6-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R)-6-(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yloxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-chromen-3-yl]oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; GLUCOPYRANOSIDURONIC ACID, 2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4-OXO-4H-1-BENZOPYRAN-3-YL, .BETA.-D-; .beta.-D-Glucopyranosiduronic acid, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl; GLUCOPYRANOSIDURONIC ACID, 2-(3,4-DIHYDROXYPHENYL)-5,7-DIHYDROXY-4-OXO-4H-1-BENZOPYRAN-3-YL, beta-D-; beta-D-Glucopyranosiduronic acid, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(.beta.-D-glucopyranuronosyloxy)-5,7-dihydroxy-; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl beta-D-glucopyranosiduronic acid; Quercetin 3-glucuronide, primary pharmaceutical reference standard; Quercetin 3-glucuronideQuercetin 3-O-glucuronide; Quercetin 3-glucuronide, >=95\\% (LC/MS-ELSD); Quercetin 3-glucuronide, analytical standard; 3,3,4,5,7-Pentahydroxyflavone 3-glucuronide; QUERCETIN 3-O-.BETA.-D-GLUCURONOPYRANOSIDE; quercetin-3-O-beta-D-glucuronopyranoside; QUERCETIN 3-O-beta-D-GLUCURONOPYRANOSIDE; QUERCETIN-3-O-.BETA.-D-GLUCURONIDE; quercetin 3-O-beta-glucopyranoside; Quercetin 3-O-.beta.-D-glucuronide; Quercetin-3-O-beta-D-glucuronide; quercetin 3-O-beta-D-glucuronide; QUERCETIN-3-.BETA.-D-GLUCURONIDE; Quercetin-3-glucosiduronic acid; Quercetein-3-O-beta-glucuronide; QUERCETIN 3-.BETA.-GLUCURONIDE; QUERCETIN-3-beta-D-GLUCURONIDE; Quercetin 3-O-|A-D-glucuronide; Quercetin 3-O-β-D-glucuronide; QUERCETIN 3-beta-GLUCURONIDE; QUERCETIN .BETA.-GLUCURONIDE; quercetin-3-O-glucoronoside; QUERCETIN beta-GLUCURONIDE; quercetin 3-O-glucuronide; QUERCETIN-3-O-GLUCURONIDE; quercetin-3-glucuronide; Quercetin 3-glucuronide; QUERCETIN GLUCURONIDE; UNII-RY36PD0CQ2; MEGxp0_000321; Querciturone; ACon1_000029; Quercituron; Miquelianin; Mikwelianin; RY36PD0CQ2; Quercetin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

373 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhenyu Wang, Tian Yang, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He. Mitophagy suppression by miquelianin-rich lotus leaf extract induces 'beiging' of white fat via AMPK/DRP1-PINK1/PARKIN signaling axis. Journal of the science of food and agriculture. 2023 Nov; ?(?):. doi: 10.1002/jsfa.13143. [PMID: 37991930]
  • Zhenyu Wang, Tian Yang, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He. Miquelianin in Folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Oct; 181(?):114089. doi: 10.1016/j.fct.2023.114089. [PMID: 37804915]
  • Muxin Zheng, Shenghao Chen, Yi Liu, Yang He. α-Glucosidase inhibitory activities of constituents from Psidium guajava leaves. Natural product research. 2023 Jul; ?(?):1-4. doi: 10.1080/14786419.2023.2238113. [PMID: 37506309]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Zhenyu Wang, Chaoyi Xue, Xuan Wang, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He. Quercetin 3-O-glucuronide-rich lotus leaf extract promotes a Brown-fat-phenotype in C3H10T1/2 mesenchymal stem cells. Food research international (Ottawa, Ont.). 2023 01; 163(?):112198. doi: 10.1016/j.foodres.2022.112198. [PMID: 36596137]
  • Daniel Muñoz-Reyes, Alfredo G Casanova, Ana María González-Paramás, Ángel Martín, Celestino Santos-Buelga, Ana I Morales, Francisco J López-Hernández, Marta Prieto. Protective Effect of Quercetin 3-O-Glucuronide against Cisplatin Cytotoxicity in Renal Tubular Cells. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041319. [PMID: 35209106]
  • Małgorzata Domżalska, Wiesław Wiczkowski, Aleksandra Szczepkowska, Sylwia Chojnowska, Tomasz Misztal, Fruzsina R Walter, Maria A Deli, Hiroshi Ishikawa, Horst Schroten, Christian Schwerk, Janina Skipor. Effect of Lipopolysaccharide-Induced Inflammatory Challenge on β-Glucuronidase Activity and the Concentration of Quercetin and Its Metabolites in the Choroid Plexus, Blood Plasma and Cerebrospinal Fluid. International journal of molecular sciences. 2021 Jul; 22(13):. doi: 10.3390/ijms22137122. [PMID: 34281178]
  • Singeun Kim, Ki-Bae Hong, Kyungae Jo, Hyung Joo Suh. Quercetin-3-O-glucuronide in the Ethanol Extract of Lotus Leaf (Nelumbo nucifera) Enhances Sleep Quantity and Quality in a Rodent Model via a GABAergic Mechanism. Molecules (Basel, Switzerland). 2021 May; 26(10):. doi: 10.3390/molecules26103023. [PMID: 34069439]
  • Tae Heon Kim, Hyun Young Shin, Soon Yeong Park, Hoon Kim, Dae Kyun Chung. Development and Validation of a Method for Determining the Quercetin-3-O-glucuronide and Ellagic Acid Content of Common Evening Primrose (Oenothera biennis) by HPLC-UVD. Molecules (Basel, Switzerland). 2021 Jan; 26(2):. doi: 10.3390/molecules26020267. [PMID: 33430409]
  • Enkhtaivan Gansukh, Arti Nile, Doo Hwan Kim, Jae Wook Oh, Shivraj Hariram Nile. New insights into antiviral and cytotoxic potential of quercetin and its derivatives - A biochemical perspective. Food chemistry. 2021 Jan; 334(?):127508. doi: 10.1016/j.foodchem.2020.127508. [PMID: 32711265]
  • Kirsten Berger, Johanna Josefine Ostberg-Potthoff, Tamara Bakuradze, Peter Winterhalter, Elke Richling. Carbohydrate Hydrolase-Inhibitory Activity of Juice-Based Phenolic Extracts in Correlation to Their Anthocyanin/Copigment Profile. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225224. [PMID: 33182561]
  • Sakina Bouderias, Péter Teszlák, Gábor Jakab, László Kőrösi. Age- and season-dependent pattern of flavonol glycosides in Cabernet Sauvignon grapevine leaves. Scientific reports. 2020 08; 10(1):14241. doi: 10.1038/s41598-020-70706-7. [PMID: 32859977]
  • Marí C Santos, Mariana Koetz, Andreas S L Mendez, Amélia T Henriques. Ultrasound-assisted extraction optimization and validation of ultra-performance liquid chromatographic method for the quantification of miquelianin in Cuphea glutinosa leaves. Talanta. 2020 Aug; 216(?):120988. doi: 10.1016/j.talanta.2020.120988. [PMID: 32456919]
  • Jeffrey P Davis, Mihoko Koyanagi, Robert R Maronpot, Leslie Recio, Shim-Mo Hayashi. Identification of compound causing yellow bone discoloration following alpha-glycosyl isoquercitrin exposure in Sprague-Dawley rats. Archives of toxicology. 2020 07; 94(7):2413-2421. doi: 10.1007/s00204-020-02760-z. [PMID: 32388820]
  • Diahann J Perdicaro, Cecilia Rodriguez Lanzi, Julián Gambarte Tudela, Roberto M Miatello, Patricia I Oteiza, Marcela A Vazquez Prieto. Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet. The Journal of nutritional biochemistry. 2020 05; 79(?):108352. doi: 10.1016/j.jnutbio.2020.108352. [PMID: 32145471]
  • Yumi Kitahiro, Hiroshi Ikeda, Hyoung-Tak Im, Eiichi Kodaira, Makio Shibano. Phytochemical characterization of Rosa multiflora Thunb. (Rosaceae) in Japan and South Korea, with a focus on the bioactive flavonol glycoside 'multiflorin A'. Journal of natural medicines. 2019 Jun; 73(3):555-565. doi: 10.1007/s11418-019-01302-x. [PMID: 30949951]
  • Kristóf Csepregi, Péter Teszlák, László Kőrösi, Éva Hideg. Changes in grapevine leaf phenolic profiles during the day are temperature rather than irradiance driven. Plant physiology and biochemistry : PPB. 2019 Apr; 137(?):169-178. doi: 10.1016/j.plaphy.2019.02.012. [PMID: 30797184]
  • Itziar Eseberri, Jonatan Miranda, Arrate Lasa, Andrea Mosqueda-Solís, Susana González-Manzano, Celestino Santos-Buelga, Maria P Portillo. Effects of Quercetin Metabolites on Triglyceride Metabolism of 3T3-L1 Preadipocytes and Mature Adipocytes. International journal of molecular sciences. 2019 Jan; 20(2):. doi: 10.3390/ijms20020264. [PMID: 30641871]
  • Manuela Mandrone, Aline Coqueiro, Ferruccio Poli, Fabiana Antognoni, Young Hae Choi. Identification of a Collagenase-Inhibiting Flavonoid from Alchemilla vulgaris Using NMR-Based Metabolomics. Planta medica. 2018 Aug; 84(12-13):941-946. doi: 10.1055/a-0630-2079. [PMID: 29797306]
  • Yang Liu, Yanni Cao, Shengzuo Fang, Tongli Wang, Zhiqi Yin, Xulan Shang, Wanxia Yang, Xiangxiang Fu. Antidiabetic Effect of Cyclocarya paliurus Leaves Depends on the Contents of Antihyperglycemic Flavonoids and Antihyperlipidemic Triterpenoids. Molecules (Basel, Switzerland). 2018 Apr; 23(5):. doi: 10.3390/molecules23051042. [PMID: 29710841]
  • A Garbetta, L Nicassio, I D'Antuono, A Cardinali, V Linsalata, G Attolico, F Minervini. Influence of in vitro digestion process on polyphenolic profile of skin grape (cv. Italia) and on antioxidant activity in basal or stressed conditions of human intestinal cell line (HT-29). Food research international (Ottawa, Ont.). 2018 04; 106(?):878-884. doi: 10.1016/j.foodres.2018.01.072. [PMID: 29579999]
  • Roger Remy Dresch, Maria Terezinha Kreinecker Dresch, Renata Biegelmeyer, Débora Fretes Argenta, Ricardo Fagundes da Rocha, Helder Ferreira Teixeira, José Cláudio Fonseca Moreira, Amélia Teresinha Henriques. Potential use of secondary products of the agri-food industry for topical formulations and comparative analysis of antioxidant activity of grape leaf polyphenols. Natural product research. 2018 Feb; 32(4):486-492. doi: 10.1080/14786419.2017.1315573. [PMID: 28403634]
  • Cristina Sgherri, Usue Pérez-López, Francesco Micaelli, Jon Miranda-Apodaca, Amaia Mena-Petite, Alberto Muñoz-Rueda, Mike Frank Quartacci. Elevated CO2 and salinity are responsible for phenolics-enrichment in two differently pigmented lettuces. Plant physiology and biochemistry : PPB. 2017 Jun; 115(?):269-278. doi: 10.1016/j.plaphy.2017.04.006. [PMID: 28411511]
  • Sameh R Hussein, Mona M Marzouk, Mona E S Kassem, Rasha R Abdel Latif, Reda S Mohammed. Chemosystematic significance of flavonoids isolated from Diplotaxis acris (Brassicaceae) and related taxa. Natural product research. 2017 Feb; 31(3):347-350. doi: 10.1080/14786419.2016.1226831. [PMID: 27589908]
  • Hyun Soo Jang, Seung In Um, Sung Hee Lee, Wan Kyunn Whang, Young Sil Min, Sun Young Park, Uy Dong Sohn. The protective mechanism of QGC in feline esophageal epithelial cells by interleukin-1β treatment. Archives of pharmacal research. 2017 Feb; 40(2):204-213. doi: 10.1007/s12272-016-0858-x. [PMID: 28012047]
  • Fei Li, Xiao-Yue Sun, Xiao-Wei Li, Tong Yang, Lian-Wen Qi. Enrichment and separation of quercetin-3-O-β-d-glucuronide from lotus leaves (nelumbo nucifera gaertn.) and evaluation of its anti-inflammatory effect. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jan; 1040(?):186-191. doi: 10.1016/j.jchromb.2016.12.017. [PMID: 27987489]
  • Le-Le Yang, Na Xiao, Xiao-Wei Li, Yong Fan, Raphael N Alolga, Xiao-Yue Sun, Shi-Lei Wang, Ping Li, Lian-Wen Qi. Pharmacokinetic comparison between quercetin and quercetin 3-O-β-glucuronide in rats by UHPLC-MS/MS. Scientific reports. 2016 10; 6(?):35460. doi: 10.1038/srep35460. [PMID: 27775094]
  • Cheng-Hung Chuang, Chiao-Lin Yeh, Shu-Lan Yeh, En-Shyh Lin, Li-Yu Wang, Ying-Hsuna Wang. Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms. The Journal of nutritional biochemistry. 2016 07; 33(?):45-53. doi: 10.1016/j.jnutbio.2016.03.011. [PMID: 27260467]
  • Yu Geon Lee, Jeong-Yong Cho, Young-Min Kim, Jae-Hak Moon. Change in Flavonoid Composition and Antioxidative Activity during Fermentation of Onion (Allium cepa L.) by Leuconostoc mesenteroides with Different Salt Concentrations. Journal of food science. 2016 Jun; 81(6):C1385-93. doi: 10.1111/1750-3841.13329. [PMID: 27175820]
  • Chiemi Kamada, Rie Mukai, Akari Kondo, Shinya Sato, Junji Terao. Effect of quercetin and its metabolite on caveolin-1 expression induced by oxidized LDL and lysophosphatidylcholine in endothelial cells. Journal of clinical biochemistry and nutrition. 2016 May; 58(3):193-201. doi: 10.3164/jcbn.16-2. [PMID: 27257344]
  • Shu-Lan Yeh, Yi-Chin Lin, Yi-Ling Lin, Chien-Chun Li, Cheng-Hung Chuang. Comparing the metabolism of quercetin in rats, mice and gerbils. European journal of nutrition. 2016 Feb; 55(1):413-22. doi: 10.1007/s00394-015-0862-9. [PMID: 25691233]
  • Lu Lu Wang, Zhi Chao Zhang, Waseem Hassan, Yu Li, Jun Liu, Jing Shang. Amelioration of free fatty acid-induced fatty liver by quercetin-3-O-β-D-glucuronide through modulation of peroxisome proliferator-activated receptor-alpha/sterol regulatory element-binding protein-1c signaling. Hepatology research : the official journal of the Japan Society of Hepatology. 2016 Feb; 46(2):225-38. doi: 10.1111/hepr.12557. [PMID: 26190035]
  • Alessandro Venditti, Laura Guarcini, Armandodoriano Bianco, Sergio Rosselli, Maurizio Bruno, Felice Senatore. Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands). Natural product research. 2016; 30(8):912-9. doi: 10.1080/14786419.2015.1079188. [PMID: 26327332]
  • Rungnapa Boonpawa, Nooshin Moradi, Albertus Spenkelink, Ivonne M C M Rietjens, Ans Punt. Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites. Biochemical pharmacology. 2015 Dec; 98(4):690-702. doi: 10.1016/j.bcp.2015.09.022. [PMID: 26441251]
  • Shujing Jiang, Qi Liu, Yixi Xie, Hualiang Zeng, Li Zhang, Xinyu Jiang, Xiaoqing Chen. Separation of five flavonoids from tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) grains via off-line two dimensional high-speed counter-current chromatography. Food chemistry. 2015 Nov; 186(?):153-9. doi: 10.1016/j.foodchem.2014.08.120. [PMID: 25976805]
  • Jonathan G Messer, Robin G Hopkins, Deborah E Kipp. Quercetin Metabolites Up-Regulate the Antioxidant Response in Osteoblasts Isolated From Fetal Rat Calvaria. Journal of cellular biochemistry. 2015 Sep; 116(9):1857-66. doi: 10.1002/jcb.25141. [PMID: 25716194]
  • Flora Tolentino, Priscila Alves de Araújo, Eduardo de Souza Marques, Marcel Petreanu, Sérgio Faloni de Andrade, Rivaldo Niero, Fábio F Perazzo, Paulo César Pires Rosa, Edson Luis Maistro. In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage. Journal of ethnopharmacology. 2015 Apr; 164(?):89-95. doi: 10.1016/j.jep.2015.02.013. [PMID: 25681544]
  • Karsten Beekmann, Laura Rubió, Laura H J de Haan, Lucas Actis-Goretta, Bart van der Burg, Peter J van Bladeren, Ivonne M C M Rietjens. The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-γ). Food & function. 2015 Apr; 6(4):1098-107. doi: 10.1039/c5fo00076a. [PMID: 25765892]
  • R Jimenez, R Lopez-Sepulveda, M Romero, M Toral, A Cogolludo, F Perez-Vizcaino, J Duarte. Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats. Food & function. 2015 Feb; 6(2):409-14. doi: 10.1039/c4fo00818a. [PMID: 25562607]
  • James Daubney, Philip L Bonner, Alan J Hargreaves, John M Dickenson. Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated h9c2 cardiomyocytes. Basic & clinical pharmacology & toxicology. 2015 Feb; 116(2):96-109. doi: 10.1111/bcpt.12319. [PMID: 25203460]
  • Almudena Perez, Susana Gonzalez-Manzano, Rosario Jimenez, Rocío Perez-Abud, Jose M Haro, Antonio Osuna, Celestino Santos-Buelga, Juan Duarte, Francisco Perez-Vizcaino. The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity. Pharmacological research. 2014 Nov; 89(?):11-8. doi: 10.1016/j.phrs.2014.07.005. [PMID: 25076013]
  • Shu-Ting Chan, Yi-Chin Lin, Cheng-Hung Chuang, Rong-Jen Shiau, Jiunn-Wang Liao, Shu-Lan Yeh. Oral and intraperitoneal administration of quercetin decreased lymphocyte DNA damage and plasma lipid peroxidation induced by TSA in vivo. BioMed research international. 2014; 2014(?):580626. doi: 10.1155/2014/580626. [PMID: 24868531]
  • Chao-Zhan Lin, Zhong-Xiang Zhao, Si-Min Xie, Ju-Hua Mao, Chen-Chen Zhu, Xiao-Hui Li, Bairi Zeren-dawa, Kangsa Suolang-qimei, Dun Zhu, Tian-Qin Xiong, Ai-Zhi Wu. Diterpenoid alkaloids and flavonoids from Delphinium trichophorum. Phytochemistry. 2014 Jan; 97(?):88-95. doi: 10.1016/j.phytochem.2013.10.011. [PMID: 24256579]
  • Khem Raj Joshi, Hari Prasad Devkota, Takashi Watanabe, Shoji Yahara. Phenolic compounds from the flowers of Nepalese medicinal plant Aconogonon molle and their DPPH free radical-scavenging activities. Natural product research. 2014; 28(23):2208-10. doi: 10.1080/14786419.2014.915829. [PMID: 24825068]
  • Hideto Kimura, Tomoe Ishihara, Mahoko Michida, Satoshi Ogawa, Takashi Akihiro, Kazushige Yokota. Identification and quantitative analysis of polyphenolic compounds from the indigo plant (Polygonum tinctorium Lour). Natural product research. 2014; 28(7):492-5. doi: 10.1080/14786419.2013.871719. [PMID: 24437998]
  • R S Mohammed, A H Abou Zeid, E A El-Kashoury, A A Sleem, D A Waly. A new flavonol glycoside and biological activities of Adenanthera pavonina L. leaves. Natural product research. 2014; 28(5):282-9. doi: 10.1080/14786419.2013.856903. [PMID: 24289202]
  • Mariela Beatriz Vera Saltos, Blanca Fabiola Naranjo Puente, Nicola Malafronte, Alessandra Braca. A new monoterpene glycoside from Siparuna thecaphora. Natural product research. 2014; 28(1):57-60. doi: 10.1080/14786419.2013.843179. [PMID: 24087860]
  • Hyo Hyun Yang, Kyoung Hwangbo, Ming Shan Zheng, Jung Hee Cho, Jong-Keun Son, Hwa Young Kim, Suk Hwan Baek, Hyung Chul Choi, So Young Park, Jae-Ryong Kim. Quercetin-3-O-β-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells. Archives of pharmacal research. 2014; 37(9):1219-33. doi: 10.1007/s12272-014-0344-2. [PMID: 24638927]
  • Magdalena Stolarczyk, Jakub P Piwowarski, Sebastian Granica, Joanna Stefańska, Marek Naruszewicz, Anna K Kiss. Extracts from Epilobium sp. herbs, their components and gut microbiota metabolites of Epilobium ellagitannins, urolithins, inhibit hormone-dependent prostate cancer cells-(LNCaP) proliferation and PSA secretion. Phytotherapy research : PTR. 2013 Dec; 27(12):1842-8. doi: 10.1002/ptr.4941. [PMID: 23436427]
  • Kazuaki Ohara, Hideyuki Wakabayashi, Yoshimasa Taniguchi, Kazutoshi Shindo, Hiroaki Yajima, Aruto Yoshida. Quercetin-3-O-glucuronide induces ABCA1 expression by LXRα activation in murine macrophages. Biochemical and biophysical research communications. 2013 Nov; 441(4):929-34. doi: 10.1016/j.bbrc.2013.10.168. [PMID: 24216107]
  • Esma Kozan, Serap Arabaci Anul, I Irem Tatli. In vitro anthelmintic effect of Vicia pannonica var. purpurascens on trichostrongylosis in sheep. Experimental parasitology. 2013 Jul; 134(3):299-303. doi: 10.1016/j.exppara.2013.03.018. [PMID: 23562885]
  • Xin Yao, Guisheng Zhou, Yuping Tang, Zhenhao Li, Shulan Su, Dawei Qian, Jin-Ao Duan. A UPLC-MS/MS method for qualification of quercetin-3-O-β-D-glucopyranoside-(4→1)-α-L-rhamnoside in rat plasma and application to pharmacokinetic studies. Molecules (Basel, Switzerland). 2013 Mar; 18(3):3050-9. doi: 10.3390/molecules18033050. [PMID: 23470334]
  • Erdenechimeg Selenge, Toshihiro Murata, Kyoko Kobayashi, Javzan Batkhuu, Fumihiko Yoshizaki. Flavone tetraglycosides and benzyl alcohol glycosides from the Mongolian medicinal plant Dracocephalum ruyschiana. Journal of natural products. 2013 Feb; 76(2):186-93. doi: 10.1021/np300609u. [PMID: 23356964]
  • Kui-Wu Wang, Jun-Ru Zhu, Lian-Qing Shen. A new lignan with anti-tumour activity from Polygonum perfoliatum L. Natural product research. 2013; 27(6):568-73. doi: 10.1080/14786419.2012.682993. [PMID: 22533633]
  • Yong Zeng, Jian-Jun Luo, Chong Li. [Chemical constituents from aerial part of Rumex patientia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Jan; 36(1):57-60. doi: . [PMID: 23750410]
  • Tho Chau Minh Vinh Do, Tuan Duc Nguyen, Hung Tran, Hermann Stuppner, Markus Ganzera. Quantitative determination of phenolic compounds in lotus (Nelumbo nucifera) leaves by capillary zone electrophoresis. Planta medica. 2012 Nov; 78(16):1796-9. doi: 10.1055/s-0032-1315258. [PMID: 22923198]
  • Anh Pham, Anthony Bortolazzo, J Brandon White. Rapid dimerization of quercetin through an oxidative mechanism in the presence of serum albumin decreases its ability to induce cytotoxicity in MDA-MB-231 cells. Biochemical and biophysical research communications. 2012 Oct; 427(2):415-20. doi: 10.1016/j.bbrc.2012.09.080. [PMID: 23000408]
  • Chi Chun Wong, Yasutoshi Akiyama, Takaaki Abe, Jonathan D Lippiat, Caroline Orfila, Gary Williamson. Carrier-mediated transport of quercetin conjugates: involvement of organic anion transporters and organic anion transporting polypeptides. Biochemical pharmacology. 2012 Aug; 84(4):564-70. doi: 10.1016/j.bcp.2012.05.011. [PMID: 22634047]
  • Rie Mukai, Kyuichi Kawabata, Seiko Otsuka, Akari Ishisaka, Yoshichika Kawai, Zai-Si Ji, Hiroshi Tsuboi, Junji Terao. Effect of quercetin and its glucuronide metabolite upon 6-hydroxydopamine-induced oxidative damage in Neuro-2a cells. Free radical research. 2012 Aug; 46(8):1019-28. doi: 10.3109/10715762.2012.673720. [PMID: 22404304]
  • Massimiliano Cuccioloni, Laura Bonfili, Matteo Mozzicafreddo, Valentina Cecarini, Anna Maria Eleuteri, Mauro Angeletti. Sanguisorba minor extract suppresses plasmin-mediated mechanisms of cancer cell migration. Biochimica et biophysica acta. 2012 Jul; 1820(7):1027-34. doi: 10.1016/j.bbagen.2012.02.002. [PMID: 22348918]
  • Jun-Song Xiao, Bi-Jun Xie, Yan-Ping Cao, Hua Wu, Zhi-Da Sun, Di Xiao. Characterization of oligomeric procyanidins and identification of quercetin glucuronide from lotus ( Nelumbo nucifera Gaertn.) seedpod. Journal of agricultural and food chemistry. 2012 Mar; 60(11):2825-9. doi: 10.1021/jf205331e. [PMID: 22369273]
  • Fei Li, Lin-Dong Zhang, Bao-Cai Li, Jian Yang, Hua Yu, Jian-Bo Wan, Yi-Tao Wang, Peng Li. Screening of free radical scavengers from Erigeron breviscapus using on-line HPLC-ABTS/DPPH based assay and mass spectrometer detection. Free radical research. 2012 Mar; 46(3):286-94. doi: 10.3109/10715762.2011.652628. [PMID: 22239535]
  • W Nantitanon, S Okonogi. Comparison of antioxidant activity of compounds isolated from guava leaves and a stability study of the most active compound. Drug discoveries & therapeutics. 2012 Feb; 6(1):38-43. doi: 10.5582/ddt.2012.v6.1.38. [PMID: 22460427]
  • Pilar Galindo, Isabel Rodriguez-Gómez, Susana González-Manzano, Montserrat Dueñas, Rosario Jiménez, Carmen Menéndez, Félix Vargas, Juan Tamargo, Celestino Santos-Buelga, Francisco Pérez-Vizcaíno, Juan Duarte. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PloS one. 2012; 7(3):e32673. doi: 10.1371/journal.pone.0032673. [PMID: 22427863]
  • Hyun Soo Kwak, Sun Young Park, Thao Thanh Nguyen, Chung Hyo Kim, Jong Mi Lee, Jung Sook Suh, Wan Kyunn Whang, Uy Dong Sohn. Protective effect of extract from Rumex aquaticus herba on ethanol-induced gastric damage in rats. Pharmacology. 2012; 90(5-6):288-97. doi: 10.1159/000342767. [PMID: 23037147]
  • Elise F Hoek-van den Hil, Karsten Beekmann, Jaap Keijer, Peter C H Hollman, Ivonne M C M Rietjens, Evert M van Schothorst. Interference of flavonoids with enzymatic assays for the determination of free fatty acid and triglyceride levels. Analytical and bioanalytical chemistry. 2012 Jan; 402(3):1389-92. doi: 10.1007/s00216-011-5563-5. [PMID: 22119999]
  • Cassandra L Quave, Miriam Estévez-Carmona, Cesar M Compadre, Gerren Hobby, Howard Hendrickson, Karen E Beenken, Mark S Smeltzer. Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PloS one. 2012; 7(1):e28737. doi: 10.1371/journal.pone.0028737. [PMID: 22242149]
  • Quanzhen Wang, Bao Xie, Chunhui Wu, Guo Chen, Zhengwei Wang, Jian Cui, Tianming Hu, Pawel Wiatrak. Models analyses for allelopathic effects of chicory at equivalent coupling of nitrogen supply and pH level on F. arundinacea, T. repens and M. sativa. PloS one. 2012; 7(2):e31670. doi: 10.1371/journal.pone.0031670. [PMID: 22384054]
  • Carmen Menendez, Montserrat Dueñas, Pilar Galindo, Susana González-Manzano, Rosario Jimenez, Laura Moreno, Maria José Zarzuelo, Isabel Rodríguez-Gómez, Juan Duarte, Celestino Santos-Buelga, Francisco Perez-Vizcaino. Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed?. Molecular nutrition & food research. 2011 Dec; 55(12):1780-90. doi: 10.1002/mnfr.201100378. [PMID: 22144045]
  • Hiroshi Shimoda, Seiko Nakamura, Makoto Morioka, Junji Tanaka, Hisashi Matsuda, Masayuki Yoshikawa. Effect of cinnamoyl and flavonol glucosides derived from cherry blossom flowers on the production of advanced glycation end products (AGEs) and AGE-induced fibroblast apoptosis. Phytotherapy research : PTR. 2011 Sep; 25(9):1328-35. doi: 10.1002/ptr.3423. [PMID: 21308824]
  • Xiang Mei Yan, Min Jae Joo, Jae Chun Lim, Wan Kyun Whang, Sang Soo Sim, Chaeuk Im, Hak Rim Kim, Seok Yong Lee, In Kyeom Kim, Uy Dong Sohn. The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression. Archives of pharmacal research. 2011 Sep; 34(9):1527-34. doi: 10.1007/s12272-011-0915-4. [PMID: 21975815]
  • Shu-Lan Yeh, Chiao-Lin Yeh, Shu-Ting Chan, Cheng-Hung Chuang. Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-γ expression in human A549 lung cancer cells. Planta medica. 2011 Jul; 77(10):992-8. doi: 10.1055/s-0030-1250735. [PMID: 21267808]
  • Anna K Kiss, Agnieszka Bazylko, Agnieszka Filipek, Sebastian Granica, Edyta Jaszewska, Urszula Kiarszys, Anita Kośmider, Jakub Piwowarski. Oenothein B's contribution to the anti-inflammatory and antioxidant activity of Epilobium sp. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 May; 18(7):557-60. doi: 10.1016/j.phymed.2010.10.016. [PMID: 21112753]
  • Hong-Li Liu, Bai-Lian Liu, Guo-Cai Wang, Yi Dai, Wen-Cai Ye, Yao-Lan Li. [Studies on the chemical constituents from Conyza canadensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 May; 34(5):718-20. doi: . [PMID: 21954558]
  • Yan Yi, Xin Wu, Ying Wang, Wen-Cai Ye, Qing-Wen Zhang. [Studies on the flavonoids from the flowers of Hylocereus undatus]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 May; 34(5):712-6. doi: ". [PMID: 21954556]
  • Chi Chun Wong, Nigel P Botting, Caroline Orfila, Nawaf Al-Maharik, Gary Williamson. Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochemical pharmacology. 2011 Apr; 81(7):942-9. doi: 10.1016/j.bcp.2011.01.004. [PMID: 21244849]
  • Keisuke Ishizawa, Masanori Yoshizumi, Yoshichika Kawai, Junji Terao, Yoshitaka Kihira, Yasumasa Ikeda, Shuhei Tomita, Kazuo Minakuchi, Koichiro Tsuchiya, Toshiaki Tamaki. Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis. Journal of pharmacological sciences. 2011; 115(4):466-70. doi: 10.1254/jphs.10r38fm. [PMID: 21436601]
  • Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris Bernstein. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clinical and experimental gastroenterology. 2011; 4(?):75-119. doi: 10.2147/ceg.s17114. [PMID: 21753893]
  • Joo Hee Kwon, Jee Hun Kim, Sun Eun Choi, Kwan Hee Park, Min Won Lee. Inhibitory effects of phenolic compounds from needles of Pinus densiflora on nitric oxide and PGE2 production. Archives of pharmacal research. 2010 Dec; 33(12):2011-6. doi: 10.1007/s12272-010-1217-y. [PMID: 21191767]
  • Linga R Gutha, Luis F Casassa, James F Harbertson, Rayapati A Naidu. Modulation of flavonoid biosynthetic pathway genes and anthocyanins due to virus infection in grapevine (Vitis vinifera L.) leaves. BMC plant biology. 2010 Aug; 10(?):187. doi: 10.1186/1471-2229-10-187. [PMID: 20731850]
  • J S Negi, P Singh, G P Joshi, M S Rawat, V K Bisht. Chemical constituents of Asparagus. Pharmacognosy reviews. 2010 Jul; 4(8):215-20. doi: 10.4103/0973-7847.70921. [PMID: 22228964]
  • Daizhi An, Qi Zhang, Shengmin Wu, Jingyu Wei, Jijun Yang, Fangting Dong, Xianzhong Yan, Changjiang Guo. Changes of metabolic profiles in urine after oral administration of quercetin in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Jun; 48(6):1521-7. doi: 10.1016/j.fct.2010.03.019. [PMID: 20304023]
  • Bernice Wright, Trevor Gibson, Jeremy Spencer, Julie A Lovegrove, Jonathan M Gibbins. Platelet-mediated metabolism of the common dietary flavonoid, quercetin. PloS one. 2010 Mar; 5(3):e9673. doi: 10.1371/journal.pone.0009673. [PMID: 20300638]
  • Bernice Wright, Leonardo A Moraes, Charles F Kemp, William Mullen, Alan Crozier, Julie A Lovegrove, Jonathan M Gibbins. A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. British journal of pharmacology. 2010 Mar; 159(6):1312-25. doi: 10.1111/j.1476-5381.2009.00632.x. [PMID: 20148891]
  • Ji Soo Kim, Hyun Ju Song, Sung Kwon Ko, Wan Kyunn Whang, Uy Dong Sohn. Quercetin-3-O-beta-d-glucuronopyranoside (QGC)-induced HO-1 expression through ERK and PI3K activation in cultured feline esophageal epithelial cells. Fitoterapia. 2010 Mar; 81(2):85-92. doi: 10.1016/j.fitote.2009.08.008. [PMID: 19686811]
  • Shulan Su, Jianming Guo, Jin-ao Duan, Tuanjie Wang, Dawei Qian, Erxin Shang, Yuping Tang. Ultra-performance liquid chromatography-tandem mass spectrometry analysis of the bioactive components and their metabolites of Shaofu Zhuyu decoction active extract in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Feb; 878(3-4):355-62. doi: 10.1016/j.jchromb.2009.11.048. [PMID: 20022308]
  • Akiyuki Yokoyama, Hiroyuki Sakakibara, Alan Crozier, Yoshichika Kawai, Asako Matsui, Junji Terao, Shigenori Kumazawa, Kayoko Shimoi. Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free radical research. 2009 Oct; 43(10):913-21. doi: 10.1080/10715760903137010. [PMID: 19669999]
  • Nadjet Mezache, Séverine Derbré, Salah Akkal, Hocine Laouer, Denis Séraphin, Pascal Richomme. Fast counter current chromatography of n-butanolic fraction from Senecio giganteus (Asteraceae). Natural product communications. 2009 Oct; 4(10):1357-62. doi: ". [PMID: 19911571]
  • Christine Boesch-Saadatmandi, Renata Toedter Pospissil, Anne-Christin Graeser, Raffaella Canali, Inka Boomgaarden, Frank Doering, Siegfried Wolffram, Sarah Egert, Manfred James Mueller, Gerald Rimbach. Effect of quercetin on paraoxonase 2 levels in RAW264.7 macrophages and in human monocytes--role of quercetin metabolism. International journal of molecular sciences. 2009 Sep; 10(9):4168-77. doi: 10.3390/ijms10094168. [PMID: 19865538]
  • Hong-Yu Lin, Yueh-Hsiung Kuo, Yun-Lian Lin, Wenchang Chiang. Antioxidative effect and active components from leaves of Lotus ( Nelumbo nucifera ). Journal of agricultural and food chemistry. 2009 Aug; 57(15):6623-9. doi: 10.1021/jf900950z. [PMID: 19572539]
  • Daizhi An, Shengming Wu, Jingyu Wei, Jijun Yang. [HPLC-MS analysis of quercetin and its metabolites in portal vein after intragastrical administration of quercetin in rats]. Wei sheng yan jiu = Journal of hygiene research. 2009 Jul; 38(4):417-9. doi: NULL. [PMID: 19689070]
  • Federica Lodi, Rosario Jimenez, Laura Moreno, Paul A Kroon, Paul W Needs, David A Hughes, Celestino Santos-Buelga, Ana Gonzalez-Paramas, Angel Cogolludo, Rocío Lopez-Sepulveda, Juan Duarte, Francisco Perez-Vizcaino. Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis. 2009 May; 204(1):34-9. doi: 10.1016/j.atherosclerosis.2008.08.007. [PMID: 18801486]
  • Keisuke Ishizawa, Yuki Izawa-Ishizawa, Sachiyo Ohnishi, Yuki Motobayashi, Kazuyoshi Kawazoe, Shuichi Hamano, Koichiro Tsuchiya, Shuhei Tomita, Kazuo Minakuchi, Toshiaki Tamaki. Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells. Journal of pharmacological sciences. 2009 Feb; 109(2):257-64. doi: 10.1254/jphs.08236fp. [PMID: 19202317]
  • Mark S Winterbone, Sandra Tribolo, Paul W Needs, Paul A Kroon, David A Hughes. Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells. Atherosclerosis. 2009 Feb; 202(2):431-8. doi: 10.1016/j.atherosclerosis.2008.04.040. [PMID: 18489909]
  • Yong-hai Meng, Qiu-hong Wang, Hai Jiang, Bing-you Yang, Hai-xue Kuang. [Study on chemical constituents of Herba Cirsii]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009 Jan; 32(1):58-61. doi: . [PMID: 19445122]
  • Yoshichika Kawai, Akari Ishisaka, Satomi Saito, Koji Uchida, Noriyuki Shibata, Makio Kobayashi, Yoshiko Fukuchi, Michitaka Naito, Junji Terao. Immunochemical detection of flavonoid glycosides: development, specificity, and application of novel monoclonal antibodies. Archives of biochemistry and biophysics. 2008 Aug; 476(2):124-32. doi: 10.1016/j.abb.2008.01.022. [PMID: 18267102]
  • Xian-Zhi He, Wen-Sheng Li, Jack W Blount, Richard A Dixon. Regioselective synthesis of plant (iso)flavone glycosides in Escherichia coli. Applied microbiology and biotechnology. 2008 Aug; 80(2):253-60. doi: 10.1007/s00253-008-1554-7. [PMID: 18568307]
  • Li-Guang Zhou, Xue-Song Feng, Kai-Yi Huang, Le He, Xu-Ming Deng, Da-Cheng Wang. [Studies on chemical constituents of Syringa veutina]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2008 May; 31(5):679-81. doi: . [PMID: 18826143]
  • Yoshichika Kawai, Tomomi Nishikawa, Yuko Shiba, Satomi Saito, Kaeko Murota, Noriyuki Shibata, Makio Kobayashi, Masaya Kanayama, Koji Uchida, Junji Terao. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. The Journal of biological chemistry. 2008 Apr; 283(14):9424-34. doi: 10.1074/jbc.m706571200. [PMID: 18199750]