Stepholidine (BioDeep_00000229966)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(13aS)-3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol

化学式: C19H21NO4 (327.14705060000006)
中文名称: L-千金藤立定, 左旋千金藤啶碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O
InChI: InChI=1S/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1

描述信息

l-Stepholidine is a natural product found in Desmos cochinchinensis, Meiogyne monosperma, and other organisms with data available.

同义名列表

23 个代谢物同义名

(13aS)-3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol; (S)-3,9-Dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,10-diol; (S)-3,9-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline-2,10-diol; 6H-Dibenzo[a,g]quinolizine-2,10-diol, 5,8,13,13a-tetrahydro-3,9-dimethoxy-, (13aS)-; 6H-dibenzo(A,G)quinolizine-2,10-diol, 5,8,13,13A-tetrahydro-3,9-dimethoxy-, (13AS)-; 6H-Dibenzo(a,g)quinolizine-2,10-diol, 5,8,13,13a-tetrahydro-3,9-dimethoxy-, (S)-; (13AS)-5,8,13,13A-TETRAHYDRO-3,9-DIMETHOXY-6H-DIBENZO(A,G)QUINOLIZINE-2,10-DIOL; (12bS)-4,10-dimethoxy-7,8,12b,13-tetrahydro-5H-6-azatetraphene-3,11-diol; l-2,10-Dihydroxy-3,9-dimethyloxytetrahydropseudoberberine; 13A.ALPHA.-BERBINE-2,10-DIOL, 3,9-DIMETHOXY-; 13a-alpha-BERBINE-2,10-DIOL, 3,9-DIMETHOXY-; 3,9-Dimethoxy-13a-alpha-berbine-2,10-diol; STEPHOLIDINE [WHO-DD]; (S)-(-)-Stepholidine; STEPHOLIDINE, (-)-; L-(S)-Stepholidine; (-)-stepholidine; UNII-0UPX3E69W8; L-Stepholidine; S-Stepholidine; stepholidine; 0UPX3E69W8; l-SPD



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinhua Li, Ziqi Yan, Hongmei Li, Qiong Shi, Vidhula Ahire, Shenqiu Zhang, Naganna Nimishetti, Dun Yang, Thaddeus D Allen, Jing Zhang. The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects. Journal of natural products. 2021 08; 84(8):2312-2320. doi: 10.1021/acs.jnatprod.1c00429. [PMID: 34406008]
  • Yan Sun, Jieyu Dai, Zheyi Hu, Feifei Du, Wei Niu, Fengqing Wang, Fei Liu, Guozhang Jin, Chuan Li. Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D(1) and antagonist at D(2) receptors, in rats. British journal of pharmacology. 2009 Nov; 158(5):1302-12. doi: 10.1111/j.1476-5381.2009.00393.x. [PMID: 19788498]
  • En-Jun Wang, Yun-Bao Ma, Xue-Mei Zhang, Zhi-Yong Jiang, Ji-Jun Chen. [Five alkaloids from vine stems of Diploclisia affinis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Nov; 33(21):2503-5. doi: . [PMID: 19149259]
  • Wei Fu, Jianhua Shen, Xiaomin Luo, Weiliang Zhu, Jiagao Cheng, Kunqian Yu, James M Briggs, Guozhang Jin, Kaixian Chen, Hualiang Jiang. Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations. Biophysical journal. 2007 Sep; 93(5):1431-41. doi: 10.1529/biophysj.106.088500. [PMID: 17468175]
  • Wei-hua Gu, Shen Yang, Wei-xing Shi, Xue-chu Zhen, Guo-zhang Jin. Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine. Acta pharmacologica Sinica. 2007 Jul; 28(7):953-8. doi: 10.1111/j.1745-7254.2007.00581.x. [PMID: 17588330]
  • John Odontiadis, Erin M MacKenzie, Sridhar Natesan, David Mamo, Shitij Kapur, Glen B Baker. Quantification of l-stepholidine in rat brain and plasma by high performance liquid chromatography combined with fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 May; 850(1-2):544-7. doi: 10.1016/j.jchromb.2006.11.039. [PMID: 17161981]
  • C Y Chen, F R Chang, Y C Shih, T J Hsieh, Y C Chia, H Y Tseng, H C Chen, S J Chen, M C Hsu, Y C Wu. Cytotoxic constituents of Polyalthia longifolia var. pendula. Journal of natural products. 2000 Nov; 63(11):1475-8. doi: 10.1021/np000176e. [PMID: 11087586]
  • X L Jin, Y Shao, M J Wang, L J Chen, G Z Jin. Tetrahydroprotoberberines inhibit lipid peroxidation and scavenge hydroxyl free radicals. Acta pharmacologica Sinica. 2000 May; 21(5):477-80. doi: ". [PMID: 11324451]
  • J Huang, J Guo, G Duan. [Determination of 7 bio-active alkaloids in Stephania plants by RP-HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 1998 Jul; 33(7):528-33. doi: . [PMID: 12016887]
  • L L Zou, Y Chen, Y Y Song, G Z Jin. Effect of (-)-stepholidine on serum prolactin level of female rats. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1996 Jul; 17(4):311-4. doi: NULL. [PMID: 9812710]
  • C L You, Z F Han, Y S Qu, Y M Wang, L J Chen, G Z Jin. [Antagonism of l-stepholidine against bromocriptine-inhibition on prolactin level in lactational rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1996 Jul; 17(4):382-4. doi: ". [PMID: 9812731]
  • B Xuan, D X Li, W Wang. [Protective effects of tetrahydroprotoberberines on experimental myocardial infarction in rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1992 Mar; 13(2):167-71. doi: . [PMID: 1598835]
  • T H Gu, Z Y Zhang, K R Zhou. [Hypotensive action of l-stepholidine in relation of dopamine receptors]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1990 Sep; 11(5):445-9. doi: NULL. [PMID: 2130601]
  • Z D Zhang, C M Zhou, G Z Jin, X Zhang, L Yang. Pharmacokinetics and autoradiography of [3H] or [14C]stepholidine. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1990 Jul; 11(4):289-92. doi: NULL. [PMID: 2104478]