Velutin (BioDeep_00000229936)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methyoxyphenyl)-7-methoxy-

化学式: C17H14O6 (314.079)
中文名称: 毡毛美洲茶素
谱图信息: 最多检出来源 Viridiplantae(plant) 76.61%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(cc2=O)c1ccc(c(c1)OC)O)O)OC
InChI: InChI=1S/C17H14O6/c1-21-10-6-12(19)17-13(20)8-14(23-16(17)7-10)9-3-4-11(18)15(5-9)22-2/h3-8,18-19H,1-2H3

描述信息

Velutin is a dimethoxyflavone that is luteolin in which the hydroxy groups at positions 7 and 3 are replaced by methoxy groups. It has a role as an anti-inflammatory agent, a plant metabolite, a melanin synthesis inhibitor, an antibacterial agent, an antioxidant and an anti-allergic agent. It is a dimethoxyflavone and a dihydroxyflavone. It is functionally related to a 4,5,7-trihydroxy-3-methoxyflavone.
Velutin is a natural product found in Avicennia officinalis, Lantana montevidensis, and other organisms with data available.
See also: Acai (part of).
A dimethoxyflavone that is luteolin in which the hydroxy groups at positions 7 and 3 are replaced by methoxy groups.
[Raw Data] CB095_Velutin_neg_50eV_000026.txt
[Raw Data] CB095_Velutin_neg_40eV_000026.txt
[Raw Data] CB095_Velutin_neg_30eV_000026.txt
[Raw Data] CB095_Velutin_neg_20eV_000026.txt
[Raw Data] CB095_Velutin_neg_10eV_000026.txt
[Raw Data] CB095_Velutin_pos_50eV_CB000040.txt
[Raw Data] CB095_Velutin_pos_40eV_CB000040.txt
[Raw Data] CB095_Velutin_pos_30eV_CB000040.txt
[Raw Data] CB095_Velutin_pos_20eV_CB000040.txt
[Raw Data] CB095_Velutin_pos_10eV_CB000040.txt
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway[1][2].
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway[1][2].
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway[1][2].

同义名列表

18 个代谢物同义名

4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methyoxyphenyl)-7-methoxy-; 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-; 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one; 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-chromen-4-one; 5-hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-chromen-4-one; 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one; FLAVONE, 4,5-DIHYDROXY-3,7-DIMETHOXY-; 4,5-dihydroxy-3,7-dimethoxyflavone; 5,4-dihydroxy-7,3-dimethoxyflavone; Luteolin 7,3-dimethyl ether; LUTEOLIN 3,7-DIMETHYL ETHER; CHRYSOERIOL 7-METHYL ETHER; 3,7-DIMETHYLLUTEOLIN; Flavoyadorigenin B; UNII-CT1Q4E0I0W; CT1Q4E0I0W; Velutin; 5-Hydroxy-2- (4-hydroxy-3-methoxyphenyl) -7-methoxy-4H-1-benzopyran-4-one



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

134 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sarfaraz Ahmed, Mohammad K Parvez, Mohammed S Al-Dosari, Mazin A S Abdelwahid, Tawfeq A Alhowiriny, Adnan J Al-Rehaily. Novel anti‑hepatitis B virus flavonoids sakuranetin and velutin from Rhus retinorrhoea. Molecular medicine reports. 2023 Sep; 28(3):. doi: 10.3892/mmr.2023.13063. [PMID: 37539729]
  • Se Hyeop Cheon, Sang Yeob Park, Ji-Hun Sung, Jeong Gi Lee, Se-Hee Choi, Ji-Won Jang, Hee-Cheol Kim, Sung Tae Kim, Sehoon Jeong, Kooyeon Lee, Dong-Jin Jang. Preparation and Evaluation of Nanostructured Lipid Carrier for Topical Delivery of Velutin: Synthetic Tyrosinase Inhibitor. Journal of nanoscience and nanotechnology. 2021 07; 21(7):4093-4097. doi: 10.1166/jnn.2021.19173. [PMID: 33715752]
  • Richard Oriko Owor, Kibrom Gebreheiwot Bedane, Sebastian Zühlke, Solomon Derese, George Otieno Ong'amo, Albert Ndakala, Michael Spiteller. Anti-inflammatory Flavanones and Flavones from Tephrosia linearis. Journal of natural products. 2020 04; 83(4):996-1004. doi: 10.1021/acs.jnatprod.9b00922. [PMID: 32155073]
  • Se-Hui Jung, Jaehyun Kim, Juneyong Eum, Jung Won Choe, Hak Hyun Kim, Yun Kee, Kooyeon Lee. Velutin, an Aglycone Extracted from Korean Mistletoe, with Improved Inhibitory Activity against Melanin Biosynthesis. Molecules (Basel, Switzerland). 2019 Jul; 24(14):. doi: 10.3390/molecules24142549. [PMID: 31336931]
  • Hala I Al-Jaber, Khadeja K Abrouni, Mahmuod A Al-Qudah, Musa H Abu Zarga. New terpenes from Salvia palaestina Benth. and Salvia syriaca L. growing wild in Jordan. Journal of Asian natural products research. 2012; 14(7):618-25. doi: 10.1080/10286020.2012.682151. [PMID: 22574636]
  • Seru Ganapaty, Desaraju Venkata Rao, Steve Thomas Pannakal. A phenethyl bromo ester from Citharexylum fruticosum. Natural product communications. 2010 Mar; 5(3):399-402. doi: ". [PMID: 20420316]
  • Jian Sun, Hexiang Wang, Tzi Bun Ng. Trypsin isoinhibitors with antiproliferative activity toward leukemia cells from Phaseolus vulgaris cv "White Cloud Bean". Journal of biomedicine & biotechnology. 2010; 2010(?):219793. doi: 10.1155/2010/219793. [PMID: 20617140]
  • Juan Su, Zhijun Wu, Yunheng Shen, Runhui Liu, Chuan Zhang, Huiliang Li, Weidong Zhang. Flavonoids from Daphne giraldii Nitsche. Natural product research. 2008; 22(15):1355-8. doi: 10.1080/14786410701768196. [PMID: 19023794]
  • Bo-Young Park, Byung-Sun Min, Sei-Ryang Oh, Jung-Hee Kim, Ki-Hwan Bae, Hyeong-Kyu Lee. Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity. Phytotherapy research : PTR. 2006 Jul; 20(7):610-3. doi: 10.1002/ptr.1915. [PMID: 16685682]
  • Yan Feng, Xiao-Ming Li, Xiao-Juan Duan, Bin-Gui Wang. Iridoid glucosides and flavones from the aerial parts of Avicennia marina. Chemistry & biodiversity. 2006 Jul; 3(7):799-806. doi: 10.1002/cbdv.200690082. [PMID: 17193312]
  • Shugeng Cao, Rebecca Clare Guza, James S Miller, Rabodo Andriantsiferana, Vincent E Rasamison, David G I Kingston. Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. Journal of natural products. 2004 Jun; 67(6):986-9. doi: 10.1021/np040058h. [PMID: 15217279]
  • H X Wang, T B Ng. Isolation of pleuturegin, a novel ribosome-inactivating protein from fresh sclerotia of the edible mushroom Pleurotus tuber-regium. Biochemical and biophysical research communications. 2001 Nov; 288(3):718-21. doi: 10.1006/bbrc.2001.5816. [PMID: 11676502]
  • H Wang, T B Ng. Isolation and characterization of velutin, a novel low-molecular-weight ribosome-inactivating protein from winter mushroom (Flammulina velutipes) fruiting bodies. Life sciences. 2001 Mar; 68(18):2151-8. doi: 10.1016/s0024-3205(01)01023-2. [PMID: 11324720]
  • A Zahir, A Jossang, B Bodo, J Provost, J P Cosson, T Sévenet. Five new flavone 5-O-glycosides from Lethedon tannaensis: lethedosides and lethediosides. Journal of natural products. 1999 Feb; 62(2):241-3. doi: 10.1021/np980284p. [PMID: 10075750]
  • G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]