Isopsoralen (BioDeep_00002055735)

   

Volatile Flavor Compounds natural product


代谢物信息卡片


2H-furo[2,3-h]chromen-2-one

化学式: C11H6O3 (186.0316926)
中文名称: 异补骨脂素, 当归素
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-10-24.

Cite this Page

Isopsoralen. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/isopsoralen (retrieved 2024-11-22) (BioDeep RN: BioDeep_00002055735). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: O=c1ccc2ccc3occc3c2o1
InChI:

描述信息

Isopsoralen is a natural organic compound belonging to the family of furocoumarins, which are well-known for their phototoxic and photochemical properties. It is found in various plants, including species of the genus Psoralea, from which it derives its name. Isopsoralen is structurally similar to psoralen, another furocoumarin, but with a distinct arrangement of functional groups.
Chemically, isopsoralen consists of a furan ring fused to a coumarin moiety. This structure imparts the compound with its unique photobiological activities. When exposed to ultraviolet (UV) light, particularly UVA radiation, isopsoralen intercalates into the DNA strands, forming covalent bonds with the DNA bases. This interaction can lead to the formation of DNA crosslinks, which can be mutagenic and cytotoxic, and can also interfere with DNA replication and transcription processes.
Due to these properties, isopsoralen and other psoralen derivatives have been used in photodynamic therapy (PDT), particularly in the treatment of skin disorders such as psoriasis and vitiligo. In PDT, the psoralen compound is applied or administered orally, followed by exposure to UV light. The activated psoralen induces therapeutic effects by damaging the hyperproliferative skin cells.
Isopsoralen also has applications in research, where it is used as a tool to study DNA damage and repair mechanisms. However, the use of isopsoralen and related compounds requires careful consideration due to their potential risks, including skin irritation and an increased risk of skin cancer with prolonged or excessive UV exposure.
In summary, isopsoralen is a furocoumarin with significant photobiological activities, primarily used in photodynamic therapy and as a research tool in the study of DNA. Its use is associated with potential risks, highlighting the importance of careful application and monitoring when utilizing this compound.

同义名列表

2 个代谢物同义名

Angelicin; Angelicin



数据库引用编号

6 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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121 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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