Moracin M (BioDeep_00000017431)

 

Secondary id: BioDeep_00000618357

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1/C14H10O4/c15-10-2-1-8-5-13(18-14(8)7-10)9-3-11(16)6-12(17)4-9/h1-7,15-17

化学式: C14H10O4 (242.057906)
中文名称: 桑辛素M, 桑辛素M
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 38.2%

分子结构信息

SMILES: C1=CC2=C(C=C1O)OC(=C2)C3=CC(=CC(=C3)O)O
InChI: InChI=1S/C14H10O4/c15-10-2-1-8-5-13(18-14(8)7-10)9-3-11(16)6-12(17)4-9/h1-7,15-17H

描述信息

Moracin M is a member of benzofurans.
Moracin M is a natural product found in Morus insignis, Morus mesozygia, and other organisms with data available.
Moracin M is found in fruits. Moracin M is isolated from Morus alba (white mulberry) infected with Fusarium solani.
Isolated from Morus alba (white mulberry) infected with Fusarium solani. Moracin M is found in fruits.
Moracin M, a phenolic component in the skin of Morus alba Linn., is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity[1].
Moracin M, a phenolic component in the skin of Morus alba Linn., is a potent phosphodiesterase-4 (PDE4) inhibitor with IC50 values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity[1].

同义名列表

18 个代谢物同义名

InChI=1/C14H10O4/c15-10-2-1-8-5-13(18-14(8)7-10)9-3-11(16)6-12(17)4-9/h1-7,15-17; 5-(6-Hydroxy-2-benzofuranyl)-1,3-benzenediol, 9CI; 5-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol; 5-(6-hydroxy-1-benzofuran-2-yl)-1,3-benzenediol; 5-(6-Hydroxy-benzofuran-2-yl)-benzene-1,3-diol; 5-(6-hydroxy-1-benzouran-2-yl)benzene-1,3-diol; 1,3-benzenediol, 5-(6-hydroxy-2-benzofuranyl)-; 5-(6-Hydroxy-2-benzofuranyl)-1,3-Benzenediol; 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol; 2-(3,5-Dihydroxyphenyl)-6-hydroxybenzofuran; 3,5,6-trihydroxy-2-phenylbenzofuran; 6,3,5-Trihydroxy-2-phenylbenzofuran; LHPRYOJTASOZGJ-UHFFFAOYSA-N; UNII-L9FI83128D; L9FI83128D; Veraphenol; Moracin M; MoracinM



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

35 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Luce M Mattio, Giorgia Catinella, Andrea Pinto, Sabrina Dallavalle. Natural and nature-inspired stilbenoids as antiviral agents. European journal of medicinal chemistry. 2020 Sep; 202(?):112541. doi: 10.1016/j.ejmech.2020.112541. [PMID: 32652408]
  • Fang Guo, Yong Zou, Yongjiang Zheng. Moracin M inhibits lipopolysaccharide-induced inflammatory responses in nucleus pulposus cells via regulating PI3K/Akt/mTOR phosphorylation. International immunopharmacology. 2018 May; 58(?):80-86. doi: 10.1016/j.intimp.2018.03.015. [PMID: 29558663]
  • Ji Yeon Jeong, Yang Hee Jo, Seon Beom Kim, Qing Liu, Jin Woo Lee, Eun Jin Mo, Ki Yong Lee, Bang Yeon Hwang, Mi Kyeong Lee. Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions. Bioorganic & medicinal chemistry letters. 2015 Jun; 25(11):2269-74. doi: 10.1016/j.bmcl.2015.04.045. [PMID: 25935644]
  • Ji-Hae Park, Ye-Jin Jung, Jae-Woo Jung, Sabina Shrestha, Daeseok Han, Dong Wook Lim, Nam-In Baek. Two new isoarylbenzofuran diglucosides from the root bark of Morus alba. Journal of Asian natural products research. 2015; 17(4):357-63. doi: 10.1080/10286020.2014.971775. [PMID: 25401999]
  • Peng Zhao, Shang-Ke Chen, Ying-Hong Cai, Xiao Lu, Zhe Li, Yuen-Kit Cheng, Cuixian Zhang, Xiaopeng Hu, Xixin He, Hai-Bin Luo. The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay. Biochimica et biophysica acta. 2013 Oct; 1834(10):2089-96. doi: 10.1016/j.bbapap.2013.07.004. [PMID: 23871879]
  • Qiu-Fen Hu, Bin Zhou, Jian-Ming Huang, Xue-Mei Gao, Li-Dan Shu, Guang-Yu Yang, Chun-Tao Che. Antiviral phenolic compounds from Arundina gramnifolia. Journal of natural products. 2013 Feb; 76(2):292-6. doi: 10.1021/np300727f. [PMID: 23368966]
  • Shang-Ke Chen, Peng Zhao, Yong-Xian Shao, Zhe Li, Cuixian Zhang, Peiqing Liu, Xixin He, Hai-Bin Luo, Xiaopeng Hu. Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor. Bioorganic & medicinal chemistry letters. 2012 May; 22(9):3261-4. doi: 10.1016/j.bmcl.2012.03.026. [PMID: 22483586]
  • Hyun Yong Lee, Ji Hyun Yum, Yang Kook Rho, Seong Jun Oh, Hyun Sik Choi, Hwan Bong Chang, Dong Hwa Choi, Moon-Jeong Leem, Eun Joo Choi, Jei Man Ryu, Soon Bong Hwang. Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis. Planta medica. 2007 Nov; 73(14):1481-5. doi: 10.1055/s-2007-990249. [PMID: 17948170]
  • Bao-Ning Su, Muriel Cuendet, Michael E Hawthorne, Leonardus B S Kardono, Soedarsono Riswan, Harry H S Fong, Rajendra G Mehta, John M Pezzuto, A Douglas Kinghorn. Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. Journal of natural products. 2002 Feb; 65(2):163-9. doi: 10.1021/np010451c. [PMID: 11858749]