Isoginkgetin (BioDeep_00000017227)

 

Secondary id: BioDeep_00000311235

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-

化学式: C32H22O10 (566.1212912)
中文名称: 异银杏双黄酮, 异银杏素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 93.75%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=CC(OC)=C(C4=C(O)C=C(O)C5C(=O)C=C(C6=CC=C(OC)C=C6)OC4=5)C=3)=CC(=O)C=2C(O)=C1
InChI: InChI=1S/C32H22O10/c1-39-18-6-3-15(4-7-18)26-14-24(38)31-22(36)12-21(35)29(32(31)42-26)19-9-16(5-8-25(19)40-2)27-13-23(37)30-20(34)10-17(33)11-28(30)41-27/h3-14,33-36H,1-2H3

描述信息

Isoginkgetin is a biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4-methoxyflavone and the 3 position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metalloproteinase 9 (MMP-9). It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor, an antineoplastic agent and a plant metabolite. It is a biflavonoid and an aromatic ether. It is functionally related to a 5,7-dihydroxy-4-methoxyflavone.
Isoginkgetin is a natural product found in Podocarpus latifolius, Sciadopitys verticillata, and other organisms with data available.
A biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4-methoxyflavone and the 3 position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metalloproteinase 9 (MMP-9).
From leaves of Ginkgo biloba (ginkgo). Isoginkgetin is found in ginkgo nuts and fats and oils.
Isoginkgetin is found in fats and oils. Isoginkgetin is from leaves of Ginkgo biloba (ginkgo
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2].
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2].
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2].

同义名列表

23 个代谢物同义名

4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-; 2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5,7-dihydroxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one; 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one; 3,8-Biflavone, 5,5,7,7-tetrahydroxy-4,4-dimethoxy-; HUOOMAOYXQFIDQ-UHFFFAOYSA-N; 4,4-Dimethylamentoflavone; Spectrum4_001945; Spectrum3_001112; Spectrum2_000302; Spectrum5_000819; DivK1c_006529; Sciadopitysin; iso-ginkgetin; KBio2_000886; KBio2_003454; KBio2_006022; Isoginkgetin; KBio1_001473; KBio3_002064; IgG



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Siyu Zhang, Yujie Sun, Fengli Yao, Hongju Li, Yacong Yang, Xionghao Li, Zhongyue Bai, Yu Hu, Peng Wang, Ximing Xu. Ginkgo Biflavones Cause p53 Wild-Type Dependent Cell Death in a Transcription-Independent Manner of p53. Journal of natural products. 2023 Feb; 86(2):346-356. doi: 10.1021/acs.jnatprod.2c00959. [PMID: 36700552]
  • Nan Shao, Zhibo Feng, Nannan Li. Isoginkgetin inhibits inflammatory response in the fibroblast-like synoviocytes of rheumatoid arthritis by suppressing matrix metallopeptidase 9 expression. Chemical biology & drug design. 2022 06; 99(6):923-929. doi: 10.1111/cbdd.14049. [PMID: 35353950]
  • Cuimei Zhao, Song Han, Shengbao Yang, Weidong Xin. Validation and application of a novel LC/MS/MS method for the determination of isoginkgetin in rat plasma. Biomedical chromatography : BMC. 2019 Nov; 33(11):e4667. doi: 10.1002/bmc.4667. [PMID: 31353500]
  • Guohong Liu, Mirta Grifman, James Macdonald, Peter Moller, Flossie Wong-Staal, Qi-Xiang Li. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase. The Journal of endocrinology. 2007 Sep; 194(3):569-78. doi: 10.1677/joe-07-0200. [PMID: 17761896]
  • Wie-Jong Kwak, Chang Kyun Han, Kun Ho Son, Hyeun Wook Chang, Sam Sik Kang, Byoung Kyu Park, Hyun Pyo Kim. Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation. Planta medica. 2002 Apr; 68(4):316-21. doi: 10.1055/s-2002-26742. [PMID: 11988854]
  • Mario Dell'Agli, Enrica Bosisio. Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes. Planta medica. 2002 Jan; 68(1):76-9. doi: 10.1055/s-2002-19876. [PMID: 11842336]