Drostanolone (BioDeep_00000010015)

 

Secondary id: BioDeep_00001871334

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,2S,4R,7S,10R,11S,14S,15S)-14-hydroxy-2,4,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one

化学式: C20H32O2 (304.24021719999996)
中文名称: 屈他雄酮
谱图信息: 最多检出来源 Homo sapiens(blood) 90.36%

分子结构信息

SMILES: CC1CC2(C(CCC3C2CCC4(C3CCC4O)C)CC1=O)C
InChI: InChI=1S/C20H32O2/c1-12-11-20(3)13(10-17(12)21)4-5-14-15-6-7-18(22)19(15,2)9-8-16(14)20/h12-16,18,22H,4-11H2,1-3H3/t12-,13+,14+,15+,16+,18+,19+,20+/m1/s1

描述信息

Drostanolone is only found in individuals that have used or taken this drug. It is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid

同义名列表

24 个代谢物同义名

(1S,2S,4R,7S,10R,11S,14S,15S)-14-hydroxy-2,4,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one; 17 beta-Hydroxy-2 alpha-methyl-5 alpha-androstan-3-one; 17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one; 17b-Hydroxy-2a-methyl-5a-androstan-3-one; 17Β-hydroxy-2α-methyl-5α-androstan-3-one; Dromostanolone, (5alpha,17beta)-isomer; 2.alpha.-Methyldihydrotestosterone; Dihydro-2alpha-methyltestosterone; 2alpha-Methyldihydrotestosterone; Dihydro-2a-methyltestosterone; Dihydro-2α-methyltestosterone; 2Α-methyldihydrotestosterone; 2a-Methyldihydrotestosterone; Dromostanolone; Drostanolonum; Drostanolone; Medrotestron; Drostanolona; Prometholone; Medrosteron; Drostanolon; Metholone; Methalone; Drolban



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aðalheiður Dóra Albertsdóttir, Wim Van Gansbeke, Gilles Coppieters, Kyzylkul Balgimbekova, Peter Van Eenoo, Michael Polet. Searching for new long-term urinary metabolites of metenolone and drostanolone using gas chromatography-mass spectrometry with a focus on non-hydrolysed sulfates. Drug testing and analysis. 2020 Aug; 12(8):1041-1053. doi: 10.1002/dta.2818. [PMID: 32386339]
  • Sabrina Lehmann, Andreas Thomas, Karl-Heinz Schiwy-Bochat, Hans Geyer, Mario Thevis, Frank Glenewinkel, Markus Alexander Rothschild, Hilke Andresen-Streichert, Martin Juebner. Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone). Forensic science international. 2019 Oct; 303(?):109925. doi: 10.1016/j.forsciint.2019.109925. [PMID: 31499423]
  • Jianli Zhang, Jianghai Lu, Yun Wu, Xiaobing Wang, Youxuan Xu, Yinong Zhang, Yan Wang. New Potential Biomarker for Methasterone Misuse in Human Urine by Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry. International journal of molecular sciences. 2016 Sep; 17(10):. doi: 10.3390/ijms17101628. [PMID: 27669235]
  • Yang Liu, Jianghai Lu, Sheng Yang, Qingying Zhang, Youxuan Xu. New drostanolone metabolites in human urine by liquid chromatography time-of-flight tandem mass spectrometry and their application for doping control. Steroids. 2016 Apr; 108(?):61-7. doi: 10.1016/j.steroids.2016.01.013. [PMID: 26826321]
  • Masato Takahashi, Yukitoshi Tatsugi, Toshihiko Kohno. Endocrinological and pathological effects of anabolic-androgenic steroid in male rats. Endocrine journal. 2004 Aug; 51(4):425-34. doi: 10.1507/endocrj.51.425. [PMID: 15351799]
  • M H Choi, B C Chung, M Kim, J Choi, Y Kim. Determination of four anabolic steroid metabolites by gas chromatography/mass spectrometry with negative ion chemical ionization and tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 1998; 12(22):1749-55. doi: 10.1002/(sici)1097-0231(19981130)12:22<1749::aid-rcm395>3.0.co;2-s. [PMID: 9853384]
  • D de Boer, E G de Jong, R A Maes, J M van Rossum. The methyl-5 alpha-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites. The Journal of steroid biochemistry and molecular biology. 1992 May; 42(3-4):411-9. doi: 10.1016/0960-0760(92)90146-a. [PMID: 1606052]
  • V Berta, M Perelli-Ercolini, G Beani. [Treatment of breast cancer in aged women]. Chirurgia italiana. 1980 Dec; 32(6):1543-51. doi: NULL. [PMID: 6894717]