DMDP (BioDeep_00001883218)

Main id: BioDeep_00000007905

 

Volatile Flavor Compounds natural product


代谢物信息卡片


2R,5R-Dihydroxymethyl-3R,4R-dihydroxy-pyrrolidine

化学式: C6H13NO4 (163.0844538)
中文名称: Α-葡萄糖苷酶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C(C(C(N1)CO)O)O)O
InChI: InChI=1S/C6H13NO4/c8-1-3-5(10)6(11)4(2-9)7-3/h3-11H,1-2H2/t3-,4-,5-,6-/m1/s1

描述信息

同义名列表

6 个代谢物同义名

2R,5R-Dihydroxymethyl-3R,4R-dihydroxy-pyrrolidine; 2,5-Dihydroxymethyl-3,4-dihydroxypyrrolidine; (+)-2,5-Dideoxy-2,5-imino-D-mannitol; 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL; DMDP; DMDP



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • G- B Zhang, B Zhang, X- X Zhang, F- H Bing. Homonojirimycin, an alkaloid from dayflower inhibits the growth of influenza A virus in vitro. Acta virologica. 2013; 57(1):85-6. doi: 10.4149/av_2013_01_85. [PMID: 23530829]
  • Makio Shibano, Koji Kakutani, Masahiko Taniguchi, Masahide Yasuda, Kimiye Baba. Antioxidant constituents in the dayflower (Commelina communis L.) and their alpha-glucosidase-inhibitory activity. Journal of natural medicines. 2008 Jul; 62(3):349-53. doi: 10.1007/s11418-008-0244-1. [PMID: 18409066]
  • Atsushi Kato, Noriko Kato, Saori Miyauchi, Yuka Minoshima, Isao Adachi, Kyoko Ikeda, Naoki Asano, Alison A Watson, Robert J Nash. Iminosugars from Baphia nitida Lodd. Phytochemistry. 2008 Mar; 69(5):1261-5. doi: 10.1016/j.phytochem.2007.11.018. [PMID: 18191969]
  • Maureen Verhaest, Willem Lammens, Katrien Le Roy, Camiel J De Ranter, André Van Laere, Anja Rabijns, Wim Van den Ende. Insights into the fine architecture of the active site of chicory fructan 1-exohydrolase: 1-kestose as substrate vs sucrose as inhibitor. The New phytologist. 2007; 174(1):90-100. doi: 10.1111/j.1469-8137.2007.01988.x. [PMID: 17335500]
  • Chu-Yi Yu, Naoki Asano, Kyoko Ikeda, Mei-Xiang Wang, Terry D Butters, Mark R Wormald, Raymond A Dwek, Ana L Winters, Robert J Nash, George W J Fleet. Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP. Chemical communications (Cambridge, England). 2004 Sep; ?(17):1936-7. doi: 10.1039/b406035k. [PMID: 15340609]
  • Aderbal F Magalhães, Celira C Santos, Eva G Magalhães, Marisa A Nogueira. Detection of polyhydroxyalkaloids in Lonchocarpus extracts by GC-MS of acetylated derivatives. Phytochemical analysis : PCA. 2002 Jul; 13(4):215-21. doi: 10.1002/pca.645. [PMID: 12184175]
  • Kayo Yasuda, Haruhisa Kizu, Toru Yamashita, Yukihiko Kameda, Atsushi Kato, Robert J Nash, George W J Fleet, Russell J Molyneux, Naoki Asano. New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. Journal of natural products. 2002 Feb; 65(2):198-202. doi: 10.1021/np010360f. [PMID: 11858756]
  • H Nojima, I Kimura, F J Chen, Y Sugihara, M Haruno, A Kato, N Asano. Antihyperglycemic effects of N-containing sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in streptozotocin-diabetic mice. Journal of natural products. 1998 Mar; 61(3):397-400. doi: 10.1021/np970277l. [PMID: 9544568]
  • Y Le Merrer, L Poitout, J C Depezay, I Dosbaa, S Geoffroy, M J Foglietti. Synthesis of azasugars as potent inhibitors of glycosidases. Bioorganic & medicinal chemistry. 1997 Mar; 5(3):519-33. doi: 10.1016/s0968-0896(96)00266-0. [PMID: 9113331]
  • H Imamura, S Laberge, A Brault, J Coté, P M Huet. Immunogenic role of Kupffer cells in a rat model of acute liver allograft rejection. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 1995 Nov; 1(6):389-94. doi: 10.1002/lt.500010610. [PMID: 9346618]
  • N Asano, K Oseki, H Kizu, K Matsui. Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. Journal of medicinal chemistry. 1994 Oct; 37(22):3701-6. doi: 10.1021/jm00048a006. [PMID: 7966130]
  • G W Fleet, A Karpas, R A Dwek, L E Fellows, A S Tyms, S Petursson, S K Namgoong, N G Ramsden, P W Smith, J C Son. Inhibition of HIV replication by amino-sugar derivatives. FEBS letters. 1988 Sep; 237(1-2):128-32. doi: 10.1016/0014-5793(88)80185-6. [PMID: 3169233]
  • A S Tyms, E M Berrie, T A Ryder, R J Nash, M P Hegarty, D L Taylor, M A Mobberley, J M Davis, E A Bell, D J Jeffries. Castanospermine and other plant alkaloid inhibitors of glucosidase activity block the growth of HIV. Lancet (London, England). 1987 Oct; 2(8566):1025-6. doi: 10.1016/s0140-6736(87)92588-8. [PMID: 2889932]
  • C G Barker, W F Blakemore, A Dell, A C Palmer, P R Tiller, B G Winchester. GM1 gangliosidosis (type 1) in a cat. The Biochemical journal. 1986 Apr; 235(1):151-8. doi: 10.1042/bj2350151. [PMID: 3091002]
  • A D Elbein, M Mitchell, B A Sanford, L E Fellows, S V Evans. The pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine, inhibits glycoprotein processing. The Journal of biological chemistry. 1984 Oct; 259(20):12409-13. doi: 10.1016/s0021-9258(18)90761-1. [PMID: 6548472]