NCBI Taxonomy: 140950
Templetonia (ncbi_taxid: 140950)
found 81 associated metabolites at genus taxonomy rank level.
Ancestor: Brongniartieae
Child Taxonomies: Templetonia egena, Templetonia retusa, Templetonia sulcata, Templetonia hookeri, Templetonia aculeata, Templetonia neglecta, Templetonia stenophylla
Anagyrine
Anagyrine is an alkaloid. Anagyrine is a natural product found in Daphniphyllum oldhamii, Ormosia fordiana, and other organisms with data available. Thermospine is a natural product found in Platycelyphium voense, Thermopsis mongolica, and other organisms with data available. Thermopsine is a quinolizidine alkaloid isolated from the fruits and pods and stem bark of Sophora velutina subsp. Thermopsine has antibacterial activity[1].
Angustifoline
Angustifoline is a member of quinolizidines and a cyclic ketone. 4-(Prop-2-en-1-yl)decahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one is a natural product found in Haplophyllum thesioides, Lupinus hintonii, and other organisms with data available. CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 54 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 18 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 33 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 40 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 25 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 10 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 3
Cytisine
N - Nervous system > N07 - Other nervous system drugs > N07B - Drugs used in addictive disorders > N07BA - Drugs used in nicotine dependence C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist > C73579 - Nicotinic Agonist relative retention time with respect to 9-anthracene Carboxylic Acid is 0.054 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.052 Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3]. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3]. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3].
Sparteine
Sparteine is a quinolizidine alkaloid and a quinolizidine alkaloid fundamental parent. Sparteine is a plant alkaloid derived from Cytisus scoparius and Lupinus mutabilis which may chelate calcium and magnesium. It is a sodium channel blocker, so it falls in the category of class 1a antiarrhythmic agents. Sparteine is not currently FDA-approved for human use, and its salt, sparteine sulfate, is one of the products that have been withdrawn or removed from the market for reasons of safety or effectiveness. Sparteine is a natural product found in Ormosia coarctata, Thermopsis chinensis, and other organisms with data available. A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype. See also: Cytisus scoparius flowering top (part of). C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BA - Antiarrhythmics, class ia C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents D012102 - Reproductive Control Agents > D010120 - Oxytocics Annotation level-1 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 53 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 39 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 32 INTERNAL_ID 24; CONFIDENCE Reference Standard (Level 1) CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 24 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 17 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 9 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.395 beta-Isosparteine is a natural product found in Ulex airensis, Ulex densus, and other organisms with data available. A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype. (+)-Sparteine is a natural product found in Baptisia australis, Dermatophyllum secundiflorum, and other organisms with data available. A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti-arrhythmia agent. It has also been of interest as an indicator of CYP2D6 genotype. (-)-Sparteine is a natural alkaloid isolated from beans. (-)-Sparteine is a natural alkaloid isolated from beans. (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.
lupanine
C15H24N2O (248.18885339999997)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 56 INTERNAL_ID 56; CONFIDENCE Reference Standard (Level 1) CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 42 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 35 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 27 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 20 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 12 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 5 alpha-Isolupanine is a natural product found in Listia bainesii, Thermopsis chinensis, and other organisms with data available.
Ammodendrine
A piperidine alkaloid that is piperidine substituted by a 1-acetyl-1,4,5,6-tetrahydropyridin-3-yl group at position 2 (the 2R-stereoisomer). relative retention time with respect to 9-anthracene Carboxylic Acid is 0.321 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.317
Aloperine
Aloperine is a natural product found in Thinicola incana, Sophora alopecuroides, and other organisms with data available. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1]. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties[1]. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China[2]. Aloperine induces apoptosis and autophagy in HL-60 cells[1].
Baptifoline
Baptifoline is found in coffee and coffee products. Baptifoline is an alkaloid from Caulophyllum thalictroides (blue cohosh). Alkaloid from Caulophyllum thalictroides (blue cohosh). Baptifoline is found in coffee and coffee products.
Rhombifoline
Rhombifoline is a natural product found in Plagiocarpus axillaris, Cristonia biloba, and other organisms with data available. Rhombifoline is an alkaloid isolated for the first time from the leaves and stems of A. foetida L.[1]. Rhombifoline is an alkaloid isolated for the first time from the leaves and stems of A. foetida L.[1].
Cytisinicline
Cytisine is an organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking. It has a role as a nicotinic acetylcholine receptor agonist, a phytotoxin and a plant metabolite. It is an alkaloid, an organic heterotricyclic compound, a secondary amino compound, a lactam and a bridged compound. Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Tabex (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost. Cytisine is a natural product found in Viscum cruciatum, Thermopsis chinensis, and other organisms with data available. See also: Cytisus scoparius flowering top (part of); Thermopsis lanceolata whole (part of). An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking. N - Nervous system > N07 - Other nervous system drugs > N07B - Drugs used in addictive disorders > N07BA - Drugs used in nicotine dependence C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist > C73579 - Nicotinic Agonist Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3]. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3]. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3].
Baptifoline
Unii-27F71M186X is a natural product found in Thermopsis chinensis, Thermopsis lanceolata, and other organisms with data available. See also: Caulophyllum thalictroides Root (part of).
(+)-Lupanine
C15H24N2O (248.18885339999997)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 29
Cytisin
N - Nervous system > N07 - Other nervous system drugs > N07B - Drugs used in addictive disorders > N07BA - Drugs used in nicotine dependence C78272 - Agent Affecting Nervous System > C47796 - Cholinergic Agonist > C73579 - Nicotinic Agonist CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2241 Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3]. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3]. Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3].
Baptifoline
(9r)-7,11-diazatricyclo[7.3.1.0²,⁷]trideca-2,4-dien-6-one
(1r,9r)-11-methyl-7,11-diazatricyclo[7.3.1.0²,⁷]trideca-2,4-dien-6-one
C12H16N2O (204.12625659999998)
anagyrine
{"Ingredient_id": "HBIN015975","Ingredient_name": "anagyrine","Alias": "FYU1U980Q9; 5-24-03-00410 (Beilstein Handbook Reference); (1R,9R,10R)-7,15-DIAZATETRACYCLO[7.7.1.0(2),?.0(1)?,(1)?]HEPTADECA-2,4-DIEN-6-ONE; BRN 0086776; ANAGYRINE; (-)-Anagyrine; UNII-FYU1U980Q9; 7,7a,8,9,10,11,13,14-Octahydro-7,14-memethano-4H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocin-4-one; 3,4,5,6-Tetradehydrospartein-2-one; (7alpha)-11,12,13,14-tetradehydrospartein-15-one; (-)-anagyrine; CHEMBL509692; Rhombinine; Anagyrine; AC1LE9O5; NSC76019; ZINC900282; Monolupine; 486-89-5","Ingredient_formula": "C15H20N2O","Ingredient_Smile": "C1CCN2CC3CC(C2C1)CN4C3=CC=CC4=O","Ingredient_weight": "244.33 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "SMIT01268;SMIT05719","TCMID_id": "1134","TCMSP_id": "MOL003687;MOL006571","TCM_ID_id": "6815;17611","PubChem_id": "71056954","DrugBank_id": "NA"}
baptifoline
{"Ingredient_id": "HBIN017585","Ingredient_name": "baptifoline","Alias": "Epibaptifoline","Ingredient_formula": "C15H20N2O2","Ingredient_Smile": "C1CN2CC3CC(C2CC1O)CN4C3=CC=CC4=O","Ingredient_weight": "260.33 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "SMIT14437","TCMID_id": "2145","TCMSP_id": "NA","TCM_ID_id": "6429","PubChem_id": "131676079","DrugBank_id": "NA"}
1-(piperidin-2-yl)-3,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadecane
(9r,10s)-7,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadeca-2,4-dien-6-one
(1s)-7,11-diazatricyclo[7.3.1.0²,⁷]trideca-2,4-dien-6-one
(1s,9r)-7,11-diazatricyclo[7.3.1.0²,⁷]trideca-2,4-dien-6-one
(1s,2r,9r)-11-(but-3-en-1-yl)-7,11-diazatricyclo[7.3.1.0²,⁷]tridecan-6-one
C15H24N2O (248.18885339999997)
(1s,2r,9s,10s)-3,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadec-7-ene
n-[(1e,9ar)-octahydroquinolizin-1-ylidenemethyl]ethanimidic acid
6-oxo-7,11-diazatricyclo[7.3.1.0²,⁷]trideca-2,4-diene-11-carbaldehyde
(1r,2r,9s,10s)-7,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadecan-6-one
C15H24N2O (248.18885339999997)
(1s,2r,7r,9r,10r)-1-[(2s)-piperidin-2-yl]-3,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadecane
11-acetyl-7,11-diazatricyclo[7.3.1.0²,⁷]trideca-2,4-dien-6-one
(1r,9s,10r,12s)-12-hydroxy-7,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadeca-2,4-dien-6-one
(1s,2s,7r,9r,10r)-1-[(2s)-piperidin-2-yl]-3,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadecane
(1r,2r,9s,10s)-10-(prop-2-en-1-yl)-7,11-diazatricyclo[7.3.1.0²,⁷]tridecan-6-one
(1r,2r,9s,10r)-7,15-diazatetracyclo[7.7.1.0²,⁷.0¹⁰,¹⁵]heptadecan-6-one
C15H24N2O (248.18885339999997)