Hidermart (BioDeep_00000863472)

Main id: BioDeep_00000000368

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-13-keto-2,4a,6a,6b,9,9,12a-heptamethyl-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

化学式: C30H46O4 (470.3395916)
中文名称: 甘草次酸(β型), 甘草次酸(α型)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]([C@@](CC[C@]3(C)[C@]4([H])C[C@@](C)(C(O)=O)CC3)(C)C4=C5)(C)[C@]2([H])C5=O
InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1

描述信息

D - Dermatologicals > D03 - Preparations for treatment of wounds and ulcers > D03A - Cicatrizants
C471 - Enzyme Inhibitor > C54678 - Hydroxysteroid Dehydrogenase Inhibitor
D000893 - Anti-Inflammatory Agents
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[1][2].
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhiza uralensis and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

同义名列表

57 个代谢物同义名

(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-13-keto-2,4a,6a,6b,9,9,12a-heptamethyl-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid; (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid; Enoxolone; 18beta-Glycyrrhetinic acid; 3?-Hydroxy-11-oxo-18?,20?-olean-12-en-29-oic acid; Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-; 3beta-Hydroxy-11-oxo-18beta,20beta-olean-12-en-29-oic acid; (3beta,20beta)-3-Hydroxy-11-oxo-olean-12-en-29-oic acid; Olean-12-en-30-oic acid, 3beta-hydroxy-11-oxo- (8CI); (3beta)-3-hydroxy-11-oxoolean-12-en-30-oic acid; Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-; 3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid; 4-10-00-03775 (Beilstein Handbook Reference); 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid; 18-beta-Glycyrrhetinic acid; 18beta-Glycyrrhetinic acid; 18-beta-Glycyrrhetic acid; Glycyrrhetinic acid (JAN); alpha-Glycyrrhetinic acid; 18beta-Glycyrrhetic acid; Enoxolona [INN-Spanish]; Enoxolone [BAN:DCF:INN]; Enoxolonum [INN-Latin]; Glycyrrhetinic Acid; Glycyrrhetic acid; EINECS 207-444-6; Enoxolone (INN); NCGC00142473-03; Hidermart (TN); G10105_ALDRICH; Uralenic acid; MLS000028748; Glycyrrhetin; SMR000058239; BRN 2229654; 50510_FLUKA; 202522-39-2; CHEBI:30853; 107420-91-7; BB_NC-0599; 15301-63-0; CCRIS 3962; Arthrodont; NSC 35347; NSC-35347; 8055-71-8; Hidermart; Enoxolone; Enoloxone; SBB006496; 471-53-4; STX-352; GM-1658; C02283; S00284; D00156; BX-1; 18α-Glycyrrhetinic acid; 18β-Glycyrrhetinic acid



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jianan Wei, Junhong Zhang, Fengju Hu, Wenjuan Zhang, Yunshan Wu, Bo Liu, Yue Lu, Li Li, Ling Han, Chuanjian Lu. Anti-psoriasis effect of 18β-glycyrrhetinic acid by breaking CCL20/CCR6 axis through its vital active group targeting GUSB/ATF2 signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155524. doi: 10.1016/j.phymed.2024.155524. [PMID: 38552435]
  • Bin Zou, Shuang Zhang, Fengling Li, Fengyi Weng, Jing Zhao, Jingyi Jin, Dongming Yan, Xiaoqing Xu, Gaofeng Chen, Chenghai Liu, Chengzeng Yao, Yue Li, Furong Qiu. Gancao decoction attenuates hepatic necroptosis via activating caspase 8 in cholestatic liver injury. Journal of ethnopharmacology. 2024 May; 326(?):117909. doi: 10.1016/j.jep.2024.117909. [PMID: 38350503]
  • Ibrahim Bayav, Ekrem Darendelioğlu, Cuneyt Caglayan. 18β-Glycyrrhetinic acid exerts cardioprotective effects against BPA-induced cardiotoxicity through antiapoptotic and antioxidant mechanisms. Journal of biochemical and molecular toxicology. 2024 Feb; 38(2):e23655. doi: 10.1002/jbt.23655. [PMID: 38348715]
  • Jinrong Kong, Qingzhen Xiang, Wanyue Ge, Yunlai Wang, Fan Xu, Gaoxiang Shi. Network pharmacology mechanisms and experimental verification of licorice in the treatment of ulcerative colitis. Journal of ethnopharmacology. 2024 Jan; 324(?):117691. doi: 10.1016/j.jep.2023.117691. [PMID: 38176667]
  • Xiao Mi, Yang Lou, Yutian Wang, Mingran Dong, Hongwei Xue, Shuyang Li, Juan Lu, Xi Chen. Glycyrrhetinic Acid Receptor-Mediated Zeolitic Imidazolate Framework-8 Loaded Doxorubicin as a Nanotherapeutic System for Liver Cancer Treatment. Molecules (Basel, Switzerland). 2023 Dec; 28(24):. doi: 10.3390/molecules28248131. [PMID: 38138618]
  • Bin Zou, Shuang Zhang, Jing Zhao, Guochao Song, Fengyi Weng, Xiaoqing Xu, Fengling Li, Jingyi Jin, Dongming Yan, Kai Huang, Chenghai Liu, Yue Li, Furong Qiu. Glycyrrhetinic acid attenuates endoplasmic reticulum stress-induced hepatocyte apoptosis via CHOP/DR5/Caspase 8 pathway in cholestasis. European journal of pharmacology. 2023 Dec; 961(?):176193. doi: 10.1016/j.ejphar.2023.176193. [PMID: 37981257]
  • Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Rohit Sharma. Revisiting Licorice as a functional food in the management of neurological disorders: bench to trend. Neuroscience and biobehavioral reviews. 2023 Nov; ?(?):105452. doi: 10.1016/j.neubiorev.2023.105452. [PMID: 37925093]
  • Xiu-Li Wang, Hui-da Guan, Shu-Xian Qu, Bo-Wen Xue, Geng Li, Xing-Yu Liu, Li-Sha Chen, Heng Gu. [Liver targeting of compound liposomes mediated by glycyrrhetinic acid derivative receptor and its effect on hepatic stellate cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Oct; 48(19):5195-5204. doi: 10.19540/j.cnki.cjcmm.20230605.301. [PMID: 38114109]
  • Kangchen Li, Xinguang Liu, Runsu Hou, Hulei Zhao, Peng Zhao, Yange Tian, Jiansheng Li. Uncovering mechanisms of Baojin Chenfei formula treatment for silicosis by inhibiting inflammation and fibrosis based on serum pharmacochemistry and network analysis. Ecotoxicology and environmental safety. 2023 May; 260(?):115082. doi: 10.1016/j.ecoenv.2023.115082. [PMID: 37257350]
  • Xia Li, Yuhua Du, Shicong Huang, Yi Yang, Doudou Lu, Junfei Zhang, Yan Chen, Lei Zhang, Yi Nan, Ling Yuan. Exploring the molecular mechanism of glycyrrhetinic acid in the treatment of gastric cancer based on network pharmacology and experimental validation. Aging. 2023 May; 15(9):3839-3856. doi: 10.18632/aging.204718. [PMID: 37171392]
  • Xuejiao Yuan, Yanfeng Zhou, Jinli Sun, Shanshan Wang, Xingjie Hu, Jiyu Li, Jing Huang, Nan Chen. Preventing acute liver injury via hepatocyte-targeting nano-antioxidants. Cell proliferation. 2023 May; ?(?):e13494. doi: 10.1111/cpr.13494. [PMID: 37139662]
  • Liu Cui, Xi Wang, Zhaoyun Liu, Ziqi Li, Ziwei Bai, Kui Lin, Jian Yang, Yuanlu Cui, Fei Tian. Metal-organic framework decorated with glycyrrhetinic acid conjugated chitosan as a pH-responsive nanocarrier for targeted drug delivery. International journal of biological macromolecules. 2023 Apr; 240(?):124370. doi: 10.1016/j.ijbiomac.2023.124370. [PMID: 37044320]
  • Mingxing Qiu, Jiong Wang, Jiaojiao Bai, Xiaoxu Li, Cuiqing Tian, Zhi Liu, Chaoran Zheng, Andrew R Clark, Xinwei Cheng, Xiaoyan Liao, Song Wu, Robert J Lee, Xiaoju Zhou. Dual-Ligand-Functionalized Liposomes Based on Glycyrrhetinic Acid and cRGD for Hepatocellular Carcinoma Targeting and Therapy. Molecular pharmaceutics. 2023 Apr; 20(4):1951-1963. doi: 10.1021/acs.molpharmaceut.2c00842. [PMID: 36952242]
  • W Caré, G Grenet, C Schmitt, S Michel, J Langrand, G Le Roux, D Vodovar. [Adverse effects of licorice consumed as food: An update]. La Revue de medecine interne. 2023 Mar; ?(?):. doi: 10.1016/j.revmed.2023.03.004. [PMID: 37005098]
  • Dongju Lin, Jie Liu, Xiaojin Chang, Bufan Yang, Xiaofei Gu, Weiwei Li. Glycyrrhetinic acid ameliorates diosbulbin B-induced hepatotoxicity in mice by modulating metabolic activation of diosbulbin B. Journal of applied toxicology : JAT. 2023 Feb; ?(?):. doi: 10.1002/jat.4450. [PMID: 36807597]
  • Shasha Kong, Pengyue Li, Robert Verpoorte, Mingqian Li, Yuntao Dai. Chemical and pharmacological difference between honey-fried licorice and fried licorice. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115841. doi: 10.1016/j.jep.2022.115841. [PMID: 36270557]
  • Hany Khalil, Alaa H Nada, Hoda Mahrous, Amr Hassan, Patricia Rijo, Ibrahim A Ibrahim, Dalia D Mohamed, Fawziah A Al-Salmi, Doaa D Mohamed, Ahmed I Abd Elmaksoud. Amelioration effect of 18β-Glycyrrhetinic acid on methylation inhibitors in hepatocarcinogenesis -induced by diethylnitrosamine. Frontiers in immunology. 2023; 14(?):1206990. doi: 10.3389/fimmu.2023.1206990. [PMID: 38322013]
  • Ulises Zendejas-Hernandez, Nemi Alcántara-Martínez, Diana Tovar Vivar, Fermín Valenzuela, Alejandro Sosa Espinoza, Eduardo Emir Cervera Ceballos. Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial. Frontiers in immunology. 2023; 14(?):1282280. doi: 10.3389/fimmu.2023.1282280. [PMID: 38283346]
  • Min He, Siyuan Guo, Yan Yin, Chi Zhang, Xianan Zhang. A novel sterol glycosyltransferase catalyses steroidal sapogenin 3-O glucosylation from Paris polyphylla var. yunnanensis. Molecular biology reports. 2022 Dec; ?(?):. doi: 10.1007/s11033-022-08199-y. [PMID: 36562935]
  • Linjun Zou, Qinglong Li, Yong Hou, Meiying Chen, Xudong Xu, Haifeng Wu, Zhaocui Sun, Guoxu Ma. Self-assembled glycyrrhetinic acid derivatives for functional applications: a review. Food & function. 2022 Dec; 13(24):12487-12509. doi: 10.1039/d2fo02472a. [PMID: 36413139]
  • Lihong Sang, Ji Li, Faxing Zhang, Jiajia Jia, Jian Zhang, Pingtian Ding, Ting Sun, Dongkai Wang. Glycyrrhetinic acid modified chlorambucil prodrug for hepatocellular carcinoma treatment based on DNA replication and tumor microenvironment. Colloids and surfaces. B, Biointerfaces. 2022 Dec; 220(?):112864. doi: 10.1016/j.colsurfb.2022.112864. [PMID: 36272286]
  • Yamei Jiang, Chengzhe Cai, Pingbao Zhang, Yongsheng Luo, Jingjing Guo, Jiawei Li, Ruiming Rong, Yi Zhang, Tongyu Zhu. Transcriptional profile changes after treatment of ischemia reperfusion injury-induced kidney fibrosis with 18β-glycyrrhetinic acid. Renal failure. 2022 Dec; 44(1):660-671. doi: 10.1080/0886022x.2022.2061998. [PMID: 35699239]
  • Yanfen Cheng, Xiaoping Wu, Xin Nie, Yihan Wu, Chen Zhang, Simon Ming-Yuen Lee, Kongpeng Lv, George Pak-Heng Leung, Chaomei Fu, Jinming Zhang, Jingjing Li. Natural compound glycyrrhetinic acid protects against doxorubicin-induced cardiotoxicity by activating the Nrf2/HO-1 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154407. doi: 10.1016/j.phymed.2022.154407. [PMID: 36070662]
  • Rui Fan, Yanxiang Gao. Maillard and Hydrolytic Reactions in Subcritical Water Extraction of Bioactive Compounds from Licorice. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206851. [PMID: 36296445]
  • Yilin Xu, Min Wang, Shuangcheng Ning, Zhonglan Yang, Lili Zhou, Xinhua Xia. Development of Glycyrrhetinic Acid and Folate Modified Cantharidin Loaded Solid Lipid Nanoparticles for Targeting Hepatocellular Carcinoma. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27206786. [PMID: 36296377]
  • Fei Liu, Xin Tang, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Shumao Cui, Wei Chen. Ethanol Extract of Licorice Alleviates HFD-Induced Liver Fat Accumulation in Association with Modulation of Gut Microbiota and Intestinal Metabolites in Obesity Mice. Nutrients. 2022 Oct; 14(19):. doi: 10.3390/nu14194180. [PMID: 36235833]
  • Yi Hu, Li Liu, Zhuxian Wang, Cui Ping Jiang, Zhaoming Zhu, Hui Li, Quanfu Zeng, Yaqi Xue, Yufan Wu, Yuan Wang, Yankui Yi, Hongxia Zhu, Chunyan Shen, Qiang Liu. Network pharmacology, molecular docking and in vivo and in vitro experiments to explore the molecular mechanism of licorice green tea beverage to scavenge oxygen free radicals. Journal of food biochemistry. 2022 10; 46(10):e14315. doi: 10.1111/jfbc.14315. [PMID: 35855584]
  • Huanyu Guan, Pengfei Li, Qian Wang, Fanli Zeng, Jiashuo Wu, Fangqing Zhang, Shanggao Liao, Yue Shi. Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultrahigh-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resistance-associated protein 2 in the vesicular transport assay. Journal of separation science. 2022 Sep; 45(18):3459-3479. doi: 10.1002/jssc.202200370. [PMID: 35838583]
  • Xiu-Rong Zhang, Tao Lin, Xiu-Li Wang, Xiao-Jie Wang, Heng Gu. [Preparation of salvianolic acid B, tanshinone Ⅱ_A, and glycyrrhetinic acid lipid emulsion and its protective effect against acute liver injury induced by acetaminophen]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4634-4642. doi: 10.19540/j.cnki.cjcmm.20220705.302. [PMID: 36164869]
  • Cai Zhang, Chenxu Li, Qi Shao, Sudan Meng, Xueying Wang, Tao Kong, Yu Li. Antioxidant monoammonium glycyrrhizinate alleviates damage from oxidative stress in perinatal cows. Journal of animal physiology and animal nutrition. 2022 Aug; ?(?):. doi: 10.1111/jpn.13764. [PMID: 35989475]
  • Cong Wang, Jun Yang, Enliang Li, Shuaiwu Luo, Chi Sun, Yuting Liao, Min Li, Jin Ge, Jun Lei, Fan Zhou, Linquan Wu, Wenjun Liao. Metabolic signatures of hepatolithiasis using ultra-high performance liquid chromatography-tandem mass spectrometry. Metabolomics : Official journal of the Metabolomic Society. 2022 08; 18(9):69. doi: 10.1007/s11306-022-01927-2. [PMID: 35976530]
  • Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Cihan Gür, Sefa Küçükler, Ekrem Darendelioğlu. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway. Metabolic brain disease. 2022 08; 37(6):1931-1940. doi: 10.1007/s11011-022-01027-z. [PMID: 35699857]
  • Zhangting Wang, Jiang Ma, Yisheng He, Kai-Kei Miu, Sheng Yao, Chunping Tang, Yang Ye, Ge Lin. Nrf2-mediated liver protection by 18β-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3β pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154162. doi: 10.1016/j.phymed.2022.154162. [PMID: 35598524]
  • Huawei Li, Jia You, Xi Yang, Yuanfeng Wei, Lingnan Zheng, Yaqin Zhao, Ying Huang, Zhao Jin, Cheng Yi. Glycyrrhetinic acid: A potential drug for the treatment of COVID-19 cytokine storm. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154153. doi: 10.1016/j.phymed.2022.154153. [PMID: 35636166]
  • Jia-Ling Wang, Hui Liu, Zhi-Cheng Jing, Fang Zhao, Ru Zhou. 18β-Glycyrrhetinic acid ameliorates endoplasmic reticulum stress-induced inflammation in pulmonary arterial hypertension through PERK/eIF2α/NF-κB signaling. The Chinese journal of physiology. 2022 Jul; 65(4):187-198. doi: 10.4103/0304-4920.354801. [PMID: 36073567]
  • Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu, Mingfeng Xiong. Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats. BMC complementary medicine and therapies. 2022 Jun; 22(1):160. doi: 10.1186/s12906-022-03632-y. [PMID: 35710396]
  • Ling Yuan, Yi Yang, Xia Li, Xin Zhou, Yu-Hua Du, Wen-Jing Liu, Lei Zhang, Lei Yu, Ting-Ting Ma, Jia-Xin Li, Yan Chen, Yi Nan. 18β-glycyrrhetinic acid regulates mitochondrial ribosomal protein L35-associated apoptosis signaling pathways to inhibit proliferation of gastric carcinoma cells. World journal of gastroenterology. 2022 Jun; 28(22):2437-2456. doi: 10.3748/wjg.v28.i22.2437. [PMID: 35979263]
  • Adham M Alkhadrawi, Haijie Xue, Nadeem Ahmad, Muhammad Akram, Ying Wang, Chun Li. Molecular study on the role of vacuolar transporters in glycyrrhetinic acid production in engineered Saccharomyces cerevisiae. Biochimica et biophysica acta. Biomembranes. 2022 06; 1864(6):183890. doi: 10.1016/j.bbamem.2022.183890. [PMID: 35181296]
  • Qing Li, Rui Su, Xin Bao, Kunxia Cao, Yangyang Du, Nanya Wang, Jianfeng Wang, Fan Xing, Fei Yan, Keke Huang, Shouhua Feng. Glycyrrhetinic acid nanoparticles combined with ferrotherapy for improved cancer immunotherapy. Acta biomaterialia. 2022 05; 144(?):109-120. doi: 10.1016/j.actbio.2022.03.030. [PMID: 35314366]
  • Fang-Ning Chen, Xiu-Li Wang, Rui-Rui Xu, Xiao-Jie Wang, Jing-Hua Ruan. [Preparation of tanshinone Ⅱ_A-glycyrrhetinic acid solid lipid nanoparticles and its inhibitory effect on acne]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(9):2449-2456. doi: 10.19540/j.cnki.cjcmm.20210323.303. [PMID: 35531692]
  • K Buvanesvaragurunathan, J Ganesh, S Nagul Kumar, V Porchezhiyan, A Radha, P Azhahianambi, P Pandikumar, S Ignacimuthu. In vitro growth inhibitory effect of selected 18β-glycyrrhetinic acid esters on Theileriaannulata. Experimental parasitology. 2022 May; 236-237(?):108258. doi: 10.1016/j.exppara.2022.108258. [PMID: 35421387]
  • YaQi Zhang, Rong Liang, Chunhuan Liu, Cheng Yang. Improved stability and skin penetration through glycethosomes loaded with glycyrrhetinic acid. International journal of cosmetic science. 2022 Apr; 44(2):249-261. doi: 10.1111/ics.12771. [PMID: 35303372]
  • Mo Jie, Zhao-Qi Zhang, Ning Deng, Qiu-Meng Liu, Chao Wang, Qian-Yun Ge, Peng-Chen Du, Sha-Sha Song, Xue-Wu Zhang, Long-Xin, Hui-Fang Liang, Liang Chu, Lei Zhang, Xiao-Ping Chen, Jin Chen, Han-Hua Dong, Bi-Xiang Zhang. 18[Formula: see text]-Glycyrrhetinic Acid Inhibits TGF-[Formula: see text]-Induced Epithelial-to-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma by Targeting STAT3. The American journal of Chinese medicine. 2022; 50(1):313-332. doi: 10.1142/s0192415x22500124. [PMID: 34963428]
  • Yuan Feng, Yanwu Li, Di Zhou, Bingxin Li, Gang Chen, Ning Li. Glycyrrhetinic acid reverses antibiotic-induced intestinal epithelial injury through RNA-binding protein human antigen R (HuR). Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 94(?):153836. doi: 10.1016/j.phymed.2021.153836. [PMID: 34775357]
  • Yadong Fan, Wenjin Dong, Ying Wang, Shan Zhu, Rundong Chai, Zhe Xu, Xiaoyu Zhang, Yiqi Yan, Long Yang, Yuhong Bian. Glycyrrhetinic acid regulates impaired macrophage autophagic flux in the treatment of non-alcoholic fatty liver disease. Frontiers in immunology. 2022; 13(?):959495. doi: 10.3389/fimmu.2022.959495. [PMID: 35967372]
  • Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin, Chien-Ming Hsieh. CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas. Drug delivery. 2021 Dec; 28(1):2205-2217. doi: 10.1080/10717544.2021.1989087. [PMID: 34662257]
  • Hidayat Hussain, Iftikhar Ali, Daijie Wang, Faruck L Hakkim, Bernhard Westermann, Ishtiaq Ahmed, Ahmed M Ashour, Amjad Khan, Amjad Hussain, Ivan R Green, Syed Tasadaque Ali Shah. Glycyrrhetinic acid: a promising scaffold for the discovery of anticancer agents. Expert opinion on drug discovery. 2021 12; 16(12):1497-1516. doi: 10.1080/17460441.2021.1956901. [PMID: 34294017]
  • Xiaoyan Wang, Fang Xie, Xiaofeng Zhou, Ting Chen, Ye Xue, Wei Wang. 18β-Glycyrrhetinic acid inhibits the apoptosis of cells infected with rotavirus SA11 via the Fas/FasL pathway. Pharmaceutical biology. 2021 Dec; 59(1):1098-1105. doi: 10.1080/13880209.2021.1961821. [PMID: 34411493]
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