11-Keto β-Boswellic Acid (BioDeep_00000620632)
Main id: BioDeep_00000017378
PANOMIX_OTCML-2023
代谢物信息卡片
(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid
化学式: C30H46O4 (470.3395916)
中文名称: 11-酮基-beta-乳香酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(CCC3(C(=CC(=O)C4C3(CCC5C4(CCC(C5(C)C(=O)O)O)C)C)C2C1C)C)C
InChI: InChI=1S/C30H46O4/c1-17-8-11-26(3)14-15-28(5)19(23(26)18(17)2)16-20(31)24-27(4)12-10-22(32)30(7,25(33)34)21(27)9-13-29(24,28)6/h16-18,21-24,32H,8-15H2,1-7H3,(H,33,34)/t17-,18+,21-,22-,23+,24-,26-,27+,28-,29-,30-/m1/s1
描述信息
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1].
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1].
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1].
同义名列表
11 个代谢物同义名
(3R,4R,6aR,6bS,8aR,11R,12S,14bS)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4a,5,6,7,8,9,10,11,12,12a,14a-tetradecahydropicene-4-carboxylic acid; 11-Keto β-Boswellic Acid; (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid; 3-Hydroxy-11-oxo-(3alpha,4beta)-Urs-12-en-23-oic acid; Urs-12-en-24-oic acid, 3alpha-hydroxy-11-oxo- (8CI); 3a-Hydroxy-11-oxo-12-ursen-24-oic acid; 11-Keto-beta-boswellic acid; 11-Keto-b-boswellic acid; 11-Oxo-b-boswellic acid; 11-Keto-β-boswellic acid; 11-?Keto-?beta-?boswellic acid
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:168160
- PubChem: 6918114
- PubChem: 9847548
- Metlin: METLIN91712
- ChEMBL: CHEMBL437964
- CAS: 17019-92-0
- medchemexpress: HY-N2056
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 1461607 - Boswellia papyrifera: 10.1021/NP040142X
- 173701 - Boswellia sacra:
- 613112 - Boswellia serrata: 10.1016/0031-9422(95)99386-3
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194. [PMID: 37200814] - Huiqiang Wei, Jianghong Guo, Xiao Sun, Wenfeng Gou, Hongxin Ning, Haihua Shang, Qiang Liu, Wenbin Hou, Yiliang Li. Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study.
Journal of natural products.
2022 05; 85(5):1248-1255. doi:
10.1021/acs.jnatprod.1c01166. [PMID: 35500202] - Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Najeeb Ur Rehman, Nasiara Karim, Waqar Ahmad, Majid Khan, Rene Csuk, Ahmed Al-Harrasi. Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112669. doi:
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Molecules (Basel, Switzerland).
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Natural product research.
2021 Mar; 35(5):707-716. doi:
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Combinatorial chemistry & high throughput screening.
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10.2174/1386207323666200914091733. [PMID: 32928084] - Umair Shamraiz, Hidayat Hussain, Najeeb Ur Rehman, Sulaiman Al-Shidhani, Aasim Saeed, Husain Yar Khan, Ajmal Khan, Lucie Fischer, René Csuk, Amin Badshah, Ahmed Al-Rawahi, Javid Hussain, Ahmed Al-Harrasi. Synthesis of new boswellic acid derivatives as potential antiproliferative agents.
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10.1080/14786419.2018.1564295. [PMID: 30691289] - Cheng Wei Lu, Tzu Yu Lin, Su Jane Wang. 11-Keto-β-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus.
Planta medica.
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
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Pharmaceutical biology.
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
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Biomedical chromatography : BMC.
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Journal of natural products.
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Phytochemistry.
2013 Dec; 96(?):330-6. doi:
10.1016/j.phytochem.2013.07.018. [PMID: 23962801] - Shimaa M Elshazly, Dalia M Abd El Motteleb, Noha N Nassar. The selective 5-LOX inhibitor 11-keto-β-boswellic acid protects against myocardial ischemia reperfusion injury in rats: involvement of redox and inflammatory cascades.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Sep; 386(9):823-33. doi:
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Journal of natural products.
2012 Oct; 75(10):1675-82. doi:
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Journal of clinical pharmacology.
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Bioorganic & medicinal chemistry.
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Cancer research.
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