Cortolone (BioDeep_00000005842)

 

Secondary id: BioDeep_00000637561

human metabolite Endogenous


代谢物信息卡片


(1S,2S,5R,7R,10S,11S,14R,15S)-14-[(1S)-1,2-dihydroxyethyl]-5,14-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-17-one

化学式: C21H34O5 (366.24061140000003)
中文名称: Β-皮甾酮四醇
谱图信息: 最多检出来源 Homo sapiens(feces) 0.18%

分子结构信息

SMILES: CC12CCC(CC1CCC3C2C(=O)CC4(C3CCC4(C(CO)O)O)C)O
InChI: InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12-,13-,14+,15+,17+,18-,19+,20+,21+/m1/s1

描述信息

It is one of the steriod metabolites. It is found in the urine of pregnant (36-40 weeks of gestation) and nonpregnant women and in amniotic fluid from nearly fullterm pregnant women.(PMID: 7419663) [HMDB]
It is one of the steriod metabolites. It is found in the urine of pregnant (36-40 weeks of gestation) and nonpregnant women and in amniotic fluid from nearly fullterm pregnant women.(PMID: 7419663).

同义名列表

12 个代谢物同义名

(1S,2S,5R,7R,10S,11S,14R,15S)-14-[(1S)-1,2-dihydroxyethyl]-5,14-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-17-one; Pregnan-11-one,3,17,20,21-tetrahydroxy-, (3a,5b,20S)-; Cortolone, (3alpha,5alpha,20S)-isomer; Cortolone, (3alpha,5beta,20R)-isomer; 5a,17,20a,21-Tetrol-11-one; 20alpha-Cortolone; .alpha.-Cortolone; alpha-Cortolone; α-cortolone; a-Cortolone; Cortolone; Cortolon



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Stéphanie Espiard, Johanna McQueen, Mark Sherlock, Oskar Ragnarsson, Ragnhildur Bergthorsdottir, Pia Burman, Per Dahlqvist, Bertil Ekman, Britt Edén Engström, Stanko Skrtic, Jeanette Wahlberg, Paul M Stewart, Gudmundur Johannsson. Improved Urinary Cortisol Metabolome in Addison Disease: A Prospective Trial of Dual-Release Hydrocortisone. The Journal of clinical endocrinology and metabolism. 2021 03; 106(3):814-825. doi: 10.1210/clinem/dgaa862. [PMID: 33236103]
  • Laura I Stirrat, James R O'Reilly, Sarah M Barr, Ruth Andrew, Simon C Riley, Alexander F Howie, Maria Bowman, Roger Smith, John G Lewis, Fiona C Denison, Shareen Forbes, Jonathan R Seckl, Brian R Walker, Jane E Norman, Rebecca M Reynolds. Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery. Psychoneuroendocrinology. 2016 Jan; 63(?):135-43. doi: 10.1016/j.psyneuen.2015.09.019. [PMID: 26444587]
  • Alexander P Scott, Tim Ellis, Helge Tveiten. Identification of cortisol metabolites in the bile of Atlantic cod Gadus morhua L. Steroids. 2014 Oct; 88(?):26-35. doi: 10.1016/j.steroids.2014.05.014. [PMID: 24928732]
  • Molly A H Webb, J Alan Allert, Kevin M Kappenman, Josep Marcos, Grant W Feist, Carl B Schreck, Cedric H Shackleton. Identification of plasma glucocorticoids in pallid sturgeon in response to stress. General and comparative endocrinology. 2007 Oct; 154(1-3):98-104. doi: 10.1016/j.ygcen.2007.06.002. [PMID: 17632105]
  • Walid K Jerjes, Norman F Taylor, Timothy J Peters, Simon Wessely, Anthony J Cleare. Urinary cortisol and cortisol metabolite excretion in chronic fatigue syndrome. Psychosomatic medicine. 2006 Jul; 68(4):578-82. doi: 10.1097/01.psy.0000222358.01096.54. [PMID: 16868267]
  • Viktória Poór, Susan Juricskay, Agnes Gáti, Péter Osváth, Tamás Tényi. Urinary steroid metabolites and 11beta-hydroxysteroid dehydrogenase activity in patients with unipolar recurrent major depression. Journal of affective disorders. 2004 Jul; 81(1):55-9. doi: 10.1016/s0165-0327(03)00199-x. [PMID: 15183600]
  • M Vogeser, G Fischer, K Jacob. Quantification of cortisol inactivation in cirrhosis of the liver. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 1998; 106(5):410-4. doi: 10.1055/s-0029-1212007. [PMID: 9831307]
  • A L Yergey, Y Teffera, N V Esteban, F P Abramson. Direct determination of human urinary cortisol metabolites by HPLC/CRIMS. Steroids. 1995 Mar; 60(3):295-8. doi: 10.1016/0039-128x(94)00071-j. [PMID: 7792835]
  • T Cronholm, S Borg, M Viestam-Rains, J Sjövall. Metabolic profiles of steroids in urine of alcoholics after withdrawal. The Journal of steroid biochemistry and molecular biology. 1994 May; 49(1):101-5. doi: 10.1016/0960-0760(94)90307-7. [PMID: 8003435]
  • Y Teffera, F P Abramson, M McLean, M Vestal. Development of an isotope-selective high-performance liquid chromatography detector using chemical-reaction-interface mass spectrometry: application to deuterated cortisol metabolites in urine. Journal of chromatography. 1993 Oct; 620(1):89-96. doi: 10.1016/0378-4347(93)80055-9. [PMID: 8106596]
  • T E Chapman, G P Kraan, N M Drayer, G T Nagel, B G Wolthers, B Colenbrander, M Fentener-van Vlissingen. Are (13C)cortisol and (3H)cortisol metabolized identically to natural cortisol in adrenalectomized piglets?. Biomedical & environmental mass spectrometry. 1988 Nov; 17(5):343-53. doi: 10.1002/bms.1200170502. [PMID: 3061511]
  • B S Thomas, R D Bulbrook, M J Russell, J L Hayward, R R Millis. Urinary androgen and 17-hydroxylated corticosteroid metabolites and their relation to recurrence rates in early breast cancer. Breast cancer research and treatment. 1984; 4(1):27-35. doi: 10.1007/bf01806985. [PMID: 6538102]
  • S B Pal. Urinary cortisol and cortisol metabolites in women with idiopathic hirsutism. Endokrinologie. 1979; 74(2):158-62. doi: . [PMID: 119635]
  • L P ROMANOFF, C W MORRIS, P WELCH, R M RODRIGUEZ, G PINCUS. The metabolism of cortisol-4-C14 in young and elderly men. I. Secretion rate of cortisol and daily excretion of tetrahydrocortisol, allotetrahydrocortisol, tetrahydrocortisone and cortolone (20alpha and 20beta). The Journal of clinical endocrinology and metabolism. 1961 Nov; 21(?):1413-25. doi: 10.1210/jcem-21-11-1413. [PMID: 14493561]
  • L P ROMANOFF, C PARENT, R M RODRIGUEZ, G PINCUS. Urinary excretion of beta-cortolone (3 alpha, 17 alpha, 20 beta, 21-tetrahydroxypregnane-11-one) in young and elderly men and women. The Journal of clinical endocrinology and metabolism. 1959 Jul; 19(7):819-26. doi: 10.1210/jcem-19-7-819. [PMID: 13664768]