ST 21:4;O4 (BioDeep_00000637544)
代谢物信息卡片
21-Hydroxypregn-4-ene-3,11,20-trione
化学式: C21H28O4 (344.19874880000003)
中文名称: 17α-羟基孕甾-4-烯-3,11,20-三酮, 11-去氢皮质甾酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1(CCC2C1(CC(=O)C3C2CCC4=CC(=O)CCC34C)C)O
InChI: InChI=1S/C21H28O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-16,18,25H,4-9,11H2,1-3H3/t15-,16-,18+,19-,20-,21-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:34308
- ChEBI: CHEBI:78600
- PubChem: 102178
- PubChem: 5311364
- ChEMBL: CHEMBL3244489
- LipidMAPS: LMST02030289
- LipidMAPS: LMST02030284
- LipidMAPS: LMST02030192
- CAS: 1882-82-2
- CAS: 72-23-1
- RefMet: ST 21:4;O4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vadim Tseilikman, Maria Komelkova, Marina V Kondashevskaya, Eugenia Manukhina, H Fred Downey, Valerii Chereshnev, Margarita Chereshneva, Pavel Platkovskii, Anna Goryacheva, Anton Pashkov, Julia Fedotova, Olga Tseilikman, Natalya Maltseva, Olga Cherkasova, Charlotte Steenblock, Stefan R Bornstein, Barbara Ettrich, George P Chrousos, Enrico Ullmann. A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413235. [PMID: 34948031] - David J Morris, Andrew S Brem, Alex Odermatt. Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis.
The Journal of steroid biochemistry and molecular biology.
2021 11; 214(?):105988. doi:
10.1016/j.jsbmb.2021.105988. [PMID: 34464733] - Manu Verma, Karen Sooy, George Just, Mark Nixon, Ruth Morgan, Ruth Andrew, Karen E Chapman, Natalie Z M Homer. Quantitative analysis of 11-dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography/triple quadrupole mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2020 Sep; 34 Suppl 4(?):e8610. doi:
10.1002/rcm.8610. [PMID: 31677354] - Catharine J Wheaton, Natalie D Mylniczenko, John M Rimoldi, Rama S V S Gadepalli, R Hart, Bobbi R O'Hara, Andrew N Evans. Challenges, pitfalls and surprises: development and validation of a monoclonal antibody for enzyme immunoassay of the steroid 1α-hydroxycorticosterone in elasmobranch species.
General and comparative endocrinology.
2018 09; 265(?):83-89. doi:
10.1016/j.ygcen.2018.01.028. [PMID: 29409969] - Rachael C Crew, Peter J Mark, Michael W Clarke, Brendan J Waddell. Obesity Disrupts the Rhythmic Profiles of Maternal and Fetal Progesterone in Rat Pregnancy.
Biology of reproduction.
2016 09; 95(3):55. doi:
10.1095/biolreprod.116.139451. [PMID: 27465137] - Xiaoheng Li, Baiping Mao, Yaoyao Dong, Yuan Li, Meizheng Zhan, Yanfang Bai, Qingquan Lian, Ren-Shan Ge, Leping Ye. Effects of Ziram on Rat and Human 11β-Hydroxysteroid Dehydrogenase Isoforms.
Chemical research in toxicology.
2016 Mar; 29(3):398-405. doi:
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Journal of neuroendocrinology.
2016 Mar; 28(3):12374. doi:
10.1111/jne.12374. [PMID: 26849997] - Michaela D Wharfe, Peter J Mark, Caitlin S Wyrwoll, Jeremy T Smith, Cassandra Yap, Michael W Clarke, Brendan J Waddell. Pregnancy-induced adaptations of the central circadian clock and maternal glucocorticoids.
The Journal of endocrinology.
2016 Mar; 228(3):135-47. doi:
10.1530/joe-15-0405. [PMID: 26883207] - Yegor V Antonov, Yuriy V Alexandrovich, Olga E Redina, Michael A Gilinsky, Arcady L Markel. Stress and hypertensive disease: adrenals as a link. Experimental study on hypertensive ISIAH rat strain.
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Hypertension (Dallas, Tex. : 1979).
2015 Sep; 66(3):667-73. doi:
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Molecular metabolism.
2014 Aug; 3(5):554-64. doi:
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Steroids.
2013 Mar; 78(3):347-55. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Oct; 25(10):3195-203. doi:
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2008 Dec; 146(6):708-10. doi:
10.1007/s10517-009-0393-6. [PMID: 19513361] - Yong Liu, Frank Park, Jennifer L Pietrusz, Guangfu Jia, Ravinder J Singh, Brian C Netzel, Mingyu Liang. Suppression of 11beta-hydroxysteroid dehydrogenase type 1 with RNA interference substantially attenuates 3T3-L1 adipogenesis.
Physiological genomics.
2008 Feb; 32(3):343-51. doi:
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American journal of physiology. Renal physiology.
2007 Jul; 293(1):F186-92. doi:
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Biological & pharmaceutical bulletin.
2007 Mar; 30(3):403-9. doi:
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Biomeditsinskaia khimiia.
2006 Nov; 52(6):568-75. doi:
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Cardiovascular research.
2006 Jun; 70(3):555-65. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2005 Jul; 37(7):402-7. doi:
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Endocrine journal.
2003 Dec; 50(6):783-92. doi:
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American journal of physiology. Endocrinology and metabolism.
2003 Aug; 285(2):E272-9. doi:
10.1152/ajpendo.00409.2002. [PMID: 12700160] - Marie-Edith Rafestin-Oblin, Anny Souque, Brigitte Bocchi, Gregory Pinon, Jerome Fagart, Alain Vandewalle. The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related.
Endocrinology.
2003 Feb; 144(2):528-33. doi:
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The Journal of steroid biochemistry and molecular biology.
2003 Feb; 84(2-3):239-44. doi:
10.1016/s0960-0760(03)00036-0. [PMID: 12711009] - Sophie Combet, Nancy Geffroy, Véronique Berthonaud, Bernhard Dick, Laurent Teillet, Jean-Marc Verbavatz, Bruno Corman, Marie-Marcelle Trinh-Trang-Tan. Correction of age-related polyuria by dDAVP: molecular analysis of aquaporins and urea transporters.
American journal of physiology. Renal physiology.
2003 Jan; 284(1):F199-208. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2002 Oct; 34(10):545-9. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2002 Oct; 34(10):537-44. doi:
10.1055/s-2002-35424. [PMID: 12439780] - Bruno Vogt, Bernhard Dick, Hans-Peter Marti, Felix J Frey, Brigitte M Frey. Reduced 11beta-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2002 May; 17(5):753-8. doi:
10.1093/ndt/17.5.753. [PMID: 11981059] - O P Cherkasova, V I Fedorov. [Influence of diet without added bran on the contents of corticosteroid hormones in adrenal gland and blood plasma of rats].
Voprosy pitaniia.
2002; 71(4):6-8. doi:
NULL. [PMID: 12462946] - Karen E Sheppard, Dominic J Autelitano. 11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart.
Endocrinology.
2002 Jan; 143(1):198-204. doi:
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Life sciences.
2001 Oct; 69(20):2429-38. doi:
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Endocrinology.
2001 Mar; 142(3):1341-8. doi:
10.1210/endo.142.3.8044. [PMID: 11181553] - P M Jamieson, B R Walker, K E Chapman, R Andrew, S Rossiter, J R Seckl. 11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver.
The Journal of endocrinology.
2000 Jun; 165(3):685-92. doi:
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2000 Feb; 141(2):560-3. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2000 Jan; 32(1):20-5. doi:
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The Journal of steroid biochemistry and molecular biology.
1999 Apr; 69(1-6):391-401. doi:
10.1016/s0960-0760(99)00074-6. [PMID: 10419017] - O A Ajilore, R M Sapolsky. In vivo characterization of 11beta-hydroxysteroid dehydrogenase in rat hippocampus using glucocorticoid neuroendangerment as an endpoint.
Neuroendocrinology.
1999 Feb; 69(2):138-44. doi:
10.1159/000054412. [PMID: 9986927] - C M Leckie, L A Welberg, J R Seckl. 11beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells.
The Journal of endocrinology.
1998 Nov; 159(2):233-8. doi:
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Kidney international.
1998 Aug; 54(2):492-508. doi:
10.1046/j.1523-1755.1998.00033.x. [PMID: 9690216] - M Vylitová, I Miksík, J Pácha. Metabolism of corticosterone in mammalian and avian intestine.
General and comparative endocrinology.
1998 Mar; 109(3):315-24. doi:
10.1006/gcen.1997.7035. [PMID: 9480739] - A S Brem, R B Bina, T C King, D J Morris. Localization of 2 11beta-OH steroid dehydrogenase isoforms in aortic endothelial cells.
Hypertension (Dallas, Tex. : 1979).
1998 Jan; 31(1 Pt 2):459-62. doi:
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Life sciences.
1998; 62(13):1195-201. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
1997 Nov; 702(1-2):33-9. doi:
10.1016/s0378-4347(97)00361-7. [PMID: 9449553] - V L Nacharaju, O Muneyyirci-Delale, N Khan. Presence of 11 beta-hydroxysteroid dehydrogenase in human semen: evidence of correlation with semen characteristics.
Steroids.
1997 Mar; 62(3):311-4. doi:
10.1016/s0039-128x(96)00225-5. [PMID: 9071740] - H Morita, M Zhou, M F Foecking, E P Gomez-Sanchez, E N Cozza, C E Gomez-Sanchez. 11 beta-Hydroxysteroid dehydrogenase type 2 complementary deoxyribonucleic acid stably transfected into Chinese hamster ovary cells: specific inhibition by 11 alpha-hydroxyprogesterone.
Endocrinology.
1996 Jun; 137(6):2308-14. doi:
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Steroids.
1996 Mar; 61(3):110-5. doi:
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Steroids.
1995 Nov; 60(11):773-9. doi:
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Biochimica et biophysica acta.
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Endocrinology.
1995 Apr; 136(4):1759-65. doi:
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Journal of molecular endocrinology.
1994 Oct; 13(2):167-74. doi:
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Kidney international.
1994 Mar; 45(3):679-83. doi:
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Steroids.
1994 Feb; 59(2):142-7. doi:
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1994 Jan; 12(1):33-9. doi:
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The American journal of physiology.
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Endocrinology.
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Mineral and electrolyte metabolism.
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Steroids.
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The Journal of steroid biochemistry and molecular biology.
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Kidney international.
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