Exact Mass: 425.15215280000007
Exact Mass Matches: 425.15215280000007
Found 270 metabolites which its exact mass value is equals to given mass value 425.15215280000007,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
domperidone
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent D005765 - Gastrointestinal Agents > D000932 - Antiemetics D002491 - Central Nervous System Agents CONFIDENCE standard compound; INTERNAL_ID 2739 CONFIDENCE standard compound; INTERNAL_ID 8517 Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
Ketotifen fumarate
C23H23NO5S (425.12968680000006)
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist D003879 - Dermatologic Agents > D000982 - Antipruritics D018926 - Anti-Allergic Agents Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention[1][2][3][4].
Domperidone
Domperidone is only found in individuals that have used or taken this drug. It is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. [PubChem]Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent D005765 - Gastrointestinal Agents > D000932 - Antiemetics D002491 - Central Nervous System Agents Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
((4-(3-(4-Fluoro-alpha-hydroxybenzyl)-4-hydroxyphenoxy)-3,5-dimethylphenyl)amino)oxoacetate
C23H20FNO6 (425.12745920000003)
4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid
C25H19N3O4 (425.13754940000007)
Filgotinib
C21H23N5O3S (425.15215280000007)
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AA - Selective immunosuppressants C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
Mecinarone
C24H27NO6 (425.18382820000005)
Skepinone-L
Tulopafant
C25H19N3O2S (425.11979140000005)
Cepharanone A N-beta-D-glucoside
C22H19NO8 (425.11106140000004)
3alpha,6beta-bis(4-methoxybenzoyloxy)tropane|merredissine
C24H27NO6 (425.18382820000005)
2-(4-hydroxy-3-methoxybenzoyloxymethyl)-4-O-beta-D-glucopyranosyloxy-2(E)-butenenitrile|nigrumin-4-hydroxy-3-methoxybenzoate
Alfuzosin hydrochloride (Uroxatral)
C19H28ClN5O4 (425.1829718000001)
(S)-N-[[3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide
C22H20FN3O5 (425.13869220000004)
Cys Cys Asn Ser
Cys Cys Ser Asn
Cys Asn Cys Ser
Cys Asn Ser Cys
Cys Ser Cys Asn
Cys Ser Asn Cys
desmethylnortriptyline glucuronide
C24H27NO6 (425.18382820000005)
Asn Cys Cys Ser
Asn Cys Ser Cys
Asn Ser Cys Cys
Ser Cys Cys Asn
Ser Cys Asn Cys
Ser Asn Cys Cys
2-(Tributylstannyl)-1,3-benzothiazole
C19H31NSSn (425.11990760000003)
N-{2-[(E)-(2-Cyano-4,6-dinitrophenyl)diazenyl]-5-(diethylamino)ph enyl}acetamide
1-O-tert-butyl 4-O-ethyl 4-[(4-bromophenyl)methyl]piperidine-1,4-dicarboxylate
C20H28BrNO4 (425.12015880000007)
(S)-2-((TERT-BUTOXYCARBONYL)AMINO)-6-((((4-NITROBENZYL)OXY)CARBONYL)AMINO)HEXANOIC ACID
1,3-Benzodioxole-5-carboxamide, N-(((2-(1-(phenylmethyl)-4-piperdinyl) ethyl)amino)thioxomethyl)-
C23H27N3O3S (425.1773032000001)
z-l-phenylalanine 2-naphthyl ester
C27H23NO4 (425.16269980000004)
Benzyl 4,5-bis(benzyloxy)picolinate
C27H23NO4 (425.16269980000004)
tert-butyl 4-((3-fluoro-5-(trifluoromethyl)phenylsulfonyl)Methyl)piperidine-1-carboxylate
C18H23F4NO4S (425.12838460000006)
4-AMINOPHENYL 2,3,4-TRI-O-ACETYL-β-D-GLUCURONIDE METHYL ESTER
1-(2-nitro-1-imidazolyl)-2-o-tetrahydropyranyl-3-o-toluenesulfonyl-propanediol
C18H23N3O7S (425.12566480000004)
(2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)-methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane
C23H27N3O3S (425.1773032000001)
2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl Acetate
C23H27N3O3S (425.1773032000001)
Fmoc-N-(tert-butyloxycarbonylethyl)-glycine
C24H27NO6 (425.18382820000005)
Alfuzosin hydrochloride
C19H28ClN5O4 (425.1829718000001)
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists D000089162 - Genitourinary Agents > D064804 - Urological Agents Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH)[1][2].
N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)amino]propyl]-N-methyloxolane-2-carboxamide,hydrochloride
C19H28ClN5O4 (425.1829718000001)
Ethyl-2-ethoxy-1-[[(2-cyanobiphenyl-4-yl)methyl]benzimidazole]-7-carboxylate
Fananserin
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist Fananserin (RP 62203) is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor[1].
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-aspartic acid 4-(1,1-dimethylethyl) ester
C24H27NO6 (425.18382820000005)
(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid
C24H27NO6 (425.18382820000005)
(3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
GlutaMic acid, N-[[(4-Methoxyphenyl)thio]carbonyl]-, bis(1,1-diMethylethyl) ester
C21H31NO6S (425.18719860000004)
Ethylbenzhydramine methyl iodide
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AB - Synthetic anticholinergics, quaternary ammonium compounds
[5-Chloro-1H-indol-2-carbonyl-phenylalaninyl]-azetidine-3-carboxylic acid
C22H20ClN3O4 (425.1142270000001)
5-[1-(3,4-Dimethoxy-benzoyl)-1,2,3,4-tetrahydro-quinolin-6-YL]-6-methyl-3,6-dihydro-[1,3,4]thiadiazin-2-one
C22H23N3O4S (425.14091980000006)
Reproterol hydrochloride
C18H24ClN5O5 (425.14658840000004)
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents C78273 - Agent Affecting Respiratory System > C29712 - Anti-asthmatic Agent > C319 - Bronchodilator C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
Deudomperidone
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Platencin
C24H27NO6 (425.18382820000005)
A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.
N-(1-((5-Cyanopyridin-2-yl)methyl)-1H-pyrazol-3-yl)-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)acetamide
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators
N-[4-[(8-ethoxy-4,4-dimethyl-5H-dithiolo[3,4-c]quinolin-1-ylidene)amino]phenyl]acetamide
1-[2-[[(3-Chloro-4-methoxyanilino)-oxomethyl]amino]-2-methyl-1-oxopropyl]-4-piperidinecarboxylic acid ethyl ester
C20H28ClN3O5 (425.17173880000007)
5-(3-{3-[3-Hydroxy-2-(methoxycarbonyl)phenoxy]propenyl}phenyl)-4-(hydroxymethyl)isoxazole-3-carboxylic acid
C22H19NO8 (425.11106140000004)
N-(5-Chloro-1,3-Benzodioxol-4-Yl)-N-(3-Morpholin-4-Ylphenyl)pyrimidine-2,4-Diamine
C21H20ClN5O3 (425.1254600000001)
Filgotinib
C21H23N5O3S (425.15215280000007)
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AA - Selective immunosuppressants C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
Paroxetine Mesylate
C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
(2S,4R)-N-[2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidin-1-ium-2-carboxamide
(Z)-1-[6-[2-(dimethylamino)ethoxy]-4,7-dimethoxy-1-benzofuran-5-yl]-3-(4-methoxyphenyl)prop-2-en-1-one
C24H27NO6 (425.18382820000005)
ALIMTA
C20H19N5O6-2 (425.13352740000005)
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists D000970 - Antineoplastic Agents
4-[(2E)-2-{2-[6-hydroxy-3-methyl-2-oxo-8-(piperidin-1-yl)-2,3-dihydro-7H-purin-7-yl]ethylidene}hydrazinyl]benzoic acid
C20H23N7O4 (425.18114380000003)
6-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-N-ethyl-N-phenyl-3-pyridinesulfonamide
C22H23N3O4S (425.14091980000006)
4-(1H-benzimidazol-2-ylthio)-1-[4-(4-nitrophenyl)-1-piperazinyl]-1-butanone
C21H23N5O3S (425.15215280000007)
2-Cyclopentylacetic acid [2-[(3-chloro-9,10-dioxo-2-anthracenyl)amino]-2-oxoethyl] ester
C23H20ClNO5 (425.1029940000001)
5-amino-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-4-triazolecarboxamide
N-[3-cyano-1-(2-furanylmethyl)-10-methyl-5-oxo-2-dipyrido[3,4-c:1,2-f]pyrimidinylidene]-2-furancarboxamide
C23H15N5O4 (425.11239900000004)
l-Tyrosyl-l-prolyl-l-phenylalanine
C23H27N3O5 (425.19506120000005)
1-[2-(Diethylsulfamoyl)-4-nitroanilino]-3-(4-fluorophenyl)urea
C17H20FN5O5S (425.11691220000006)
N-(4-methoxyphenyl)-2-(3-methylphenoxy)-N-(4-methylphenyl)sulfonylacetamide
C23H23NO5S (425.12968680000006)
1,3-Dimethyl-5-[[2-[2-(4-nitrophenoxy)ethoxy]phenyl]methylidene]-1,3-diazinane-2,4,6-trione
C21H19N3O7 (425.12229440000004)
1-(1,3-Benzodioxol-5-yl)-3-[4-[(phenylmethyl)sulfamoyl]phenyl]urea
C21H19N3O5S (425.1045364000001)
4-Methoxy-3-[2-phenylethyl-(phenylmethyl)sulfamoyl]benzoic acid
C23H23NO5S (425.12968680000006)
2-[4-[2-(4-Chlorophenyl)ethylamino]-3-nitrophenyl]-3a,4,7,7a-tetrahydroisoindole-1,3-dione
C22H20ClN3O4 (425.1142270000001)
[2-[4-[4-(2-Methylbutan-2-yl)phenoxy]anilino]-2-oxoethyl] 2,3-dihydro-1,4-dioxine-5-carboxylate
C24H27NO6 (425.18382820000005)
Ethyl 4-[2-(2-ethoxy-2-oxoethyl)sulfanyl-4-oxothieno[3,2-d]pyrimidin-3-yl]piperidine-1-carboxylate
N-(3-{N-[(4-chloro-1-methyl-1H-pyrazol-5-yl)carbonyl]ethanehydrazonoyl}phenyl)-2-phenoxyacetamide
C21H20ClN5O3 (425.1254600000001)
2-[[[4-(Diethylsulfamoyl)phenyl]-oxomethyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester
1-[(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-1-(2-furanylmethyl)-3-(2-oxolanylmethyl)thiourea
C23H27N3O3S (425.1773032000001)
1-[3-[(6-Methoxy-2-naphthalenyl)-oxomethyl]-1-piperidinyl]-2-[(5-methyl-1,3,4-oxadiazol-2-yl)thio]ethanone
C22H23N3O4S (425.14091980000006)
(E)-1-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-3-quinolin-2-ylprop-2-en-1-one
C22H20FN3O3S (425.1209342000001)
3-[(2E)-2-[[3-Ethoxy-4-(2-oxo-2-piperidin-1-ylethoxy)phenyl]methylidene]hydrazinyl]benzoic acid
C23H27N3O5 (425.19506120000005)
N-[(E)-2,3-dihydro-1,4-benzodioxin-6-ylmethylideneamino]-N-(2-hydroxyphenyl)octanediamide
C23H27N3O5 (425.19506120000005)
Diphenyl-[1-(phenylmethyl)-3-imidazo[1,2-a]pyridin-4-iumyl]-sulfanylidenephosphorane
C26H22N2PS+ (425.12412420000004)
(E)-4-hydroxy-4-oxobut-2-enoate;2-(1-methylpiperidin-1-ium-4-ylidene)-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
C23H23NO5S (425.12968680000006)
N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide;hydron;chloride
C19H28ClN5O4 (425.1829718000001)
4-fluoro-N-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-[4-(2-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
4-fluoro-N-[(2R,3S,6S)-2-(hydroxymethyl)-6-[2-[4-(2-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-fluoro-N-[(2S,3R,6R)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-fluoro-N-[(2R,3S,6S)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-fluoro-N-[(2S,3S,6S)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
4-fluoro-N-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-[4-(2-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
4-fluoro-N-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-[4-(2-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
4-fluoro-N-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-[4-(2-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
4-fluoro-N-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-[4-(2-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
(2R,3S,4R)-3-[4-[2-(4-fluorophenyl)ethynyl]phenyl]-4-(hydroxymethyl)-1-(1-oxo-2-pyridin-4-ylethyl)-2-azetidinecarbonitrile
(2S,3S,3aR,9bR)-3-(hydroxymethyl)-7-(4-methoxyphenyl)-2-[4-morpholinyl(oxo)methyl]-1,2,3,3a,4,9b-hexahydropyrrolo[2,3-a]indolizin-6-one
C23H27N3O5 (425.19506120000005)
(2R,3R,3aS,9bS)-3-(hydroxymethyl)-7-(4-methoxyphenyl)-2-(morpholine-4-carbonyl)-1,2,3,3a,4,9b-hexahydropyrrolo[2,3-a]indolizin-6-one
C23H27N3O5 (425.19506120000005)
(2S,3R)-8-bromo-2-[[cyclopropylmethyl(methyl)amino]methyl]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-6-one
C19H28BrN3O3 (425.1313918000001)
2-fluoro-N-[(2R,3R,6R)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-fluoro-N-[(2S,3S,6R)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-[(1S,3S,4aR,9aS)-1-(hydroxymethyl)-6-[(1-oxo-2-pyridin-4-ylethyl)amino]-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide
C23H27N3O5 (425.19506120000005)
2-fluoro-N-[(2S,3R,6S)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-fluoro-N-[(2R,3S,6R)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-fluoro-N-[(2R,3R,6S)-2-(hydroxymethyl)-6-[2-[4-(3-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
4-fluoro-N-[(2S,3R,6S)-2-(hydroxymethyl)-6-[2-[4-(2-pyridinyl)-1-triazolyl]ethyl]-3-oxanyl]benzamide
C22H24FN5O3 (425.18630859999996)
2-[(1R,3R,4aS,9aR)-1-(hydroxymethyl)-6-[(1-oxo-2-pyridin-4-ylethyl)amino]-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N,N-dimethylacetamide
C23H27N3O5 (425.19506120000005)
3-[4-[(8R,9R,10R)-10-(hydroxymethyl)-6-methylsulfonyl-1,6-diazabicyclo[6.2.0]decan-9-yl]phenyl]benzonitrile
C23H27N3O3S (425.1773032000001)
9-benzyl-2-butyl-1-(2-chlorophenyl)-9H-beta-carbolin-2-ium
C28H26ClN2+ (425.17844060000004)
N-[(Z)-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enylidene]amino]-N-(2-hydroxyphenyl)heptanediamide
C23H27N3O5 (425.19506120000005)
(R)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide
C22H20FN3O5 (425.13869220000004)
Antiviral agent 24
Antiviral agent 24 is a potent antiviral agent with EC50 values of 0.101, 19.9, 91.2 μM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner[1].
H-Val-Pro-Pro-OH (TFA)
H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.
JNJ-55308942
JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain[1][2].
XEN723
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
(2e)-2-cyano-2-(2-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}ethylidene)ethyl 4-hydroxy-3-methoxybenzoate
n-[(2r,3s,4as,8r,8ar)-8-chloro-2,4a-dihydroxy-8a-methyl-5-oxo-2,3,4,8-tetrahydro-1-benzopyran-3-yl]dodeca-2,10-dienimidic acid
C22H32ClNO5 (425.19688920000004)
1-hydroxy-2,7-dimethoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4,6,8-tetraene-14,20-dione
C23H27N3O5 (425.19506120000005)
2-[(2-{[(1,3-dimethyl-2,4-dioxopteridin-6-yl)(hydroxy)methylidene]amino}-1-hydroxypropylidene)amino]benzenecarboximidic acid
n-[1-({4-chloro-6,6,9a-trimethyl-3-oxo-1h,4h,5h,5ah,7h,8h,9h-naphtho[1,2-c]furan-9-yl}oxy)-3-methyl-1-oxobutan-2-yl]ethanimidic acid
C22H32ClNO5 (425.19688920000004)
3-[2-(hydroxymethyl)-3-methoxyphenyl]-2-(3-methoxyphenyl)-10-methyl-2-azatricyclo[6.3.1.0⁴,¹²]dodeca-1(11),3,6,8(12),9-pentaen-5-one
C27H23NO4 (425.16269980000004)
(2s)-2-[(9ar)-3-hexanoyl-9a-methyl-2,9-dioxo-6-[(1e)-prop-1-en-1-yl]furo[3,2-g]isoquinolin-7-yl]propanoic acid
C24H27NO6 (425.18382820000005)
(2s,2'r,5r,5's,6's,8's)-5',6'-dihydroxy-n,4,4,5,10'-pentamethyl-3,12'-dioxo-11'-sulfanylidene-1',10'-diazaspiro[oxolane-2,4'-tricyclo[6.4.0.0²,⁶]dodecane]-8'-carboximidic acid
(1r,2r,12r,15s)-1-hydroxy-2,7-dimethoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4,6,8-tetraene-14,20-dione
C23H27N3O5 (425.19506120000005)
5',6'-dihydroxy-n,4,4,5,10'-pentamethyl-3,12'-dioxo-11'-sulfanylidene-1',10'-diazaspiro[oxolane-2,4'-tricyclo[6.4.0.0²,⁶]dodecane]-8'-carboximidic acid
(20s,21s)-21-hydroxy-5,6,10,11-tetramethoxy-16-azapentacyclo[12.7.0.0²,⁷.0⁸,¹³.0¹⁶,²⁰]henicosa-1(14),2(7),3,5,8(13),9,11-heptaen-16-ium-16-olate
C24H27NO6 (425.18382820000005)
3-(4-hydroxyphenyl)-6-(2-methylpropyl)-4-phenyl-7-oxa-2-azatricyclo[7.4.0.0²,⁶]trideca-1(13),3,9,11-tetraene-5,8-dione
C27H23NO4 (425.16269980000004)
2-[3-hexanoyl-9a-methyl-2,9-dioxo-6-(prop-1-en-1-yl)furo[3,2-g]isoquinolin-7-yl]propanoic acid
C24H27NO6 (425.18382820000005)
(4r)-4-[(1r,4z,8z,10s,13r,15r)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-3-(hydroxymethyl)-1,3-thiazolidin-2-one
C21H31NO6S (425.18719860000004)
3-(2,6-dimethyl-1,2,4a,5,8,8a-hexahydronaphthalene-1-carbonyl)-1,4-dihydroxy-5-{2-hydroxy-7-oxabicyclo[4.1.0]hept-2-en-3-yl}pyridin-2-one
C24H27NO6 (425.18382820000005)
(1r,3r,4r,5r,7r,9r,11s,12s,13s)-5-(6-aminopurin-9-yl)-1,4,12,13-tetrahydroxy-2,6,10-trioxatricyclo[7.4.0.0³,⁷]tridecane-11-carboxylic acid
4,6-dihydroxy-5-methoxy-3-propyl-7-[(3r)-2,3,4-trihydroxyindol-3-yl]naphthalene-1,2-dione
C22H19NO8 (425.11106140000004)
2,4-dihydroxy-3-({1-hydroxy-3-[(1s,5s,8s)-5-methyl-9-methylidene-4-oxotricyclo[6.2.2.0¹,⁶]dodec-2-en-5-yl]propylidene}amino)benzoic acid
C24H27NO6 (425.18382820000005)
(1s,2s,12s,15s)-1-hydroxy-2,7-dimethoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4,6,8-tetraene-14,20-dione
C23H27N3O5 (425.19506120000005)
2-{[(2s)-2-{[(1,3-dimethyl-2,4-dioxopteridin-6-yl)(hydroxy)methylidene]amino}-1-hydroxypropylidene]amino}benzenecarboximidic acid
2-cyano-2-(2-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}ethylidene)ethyl 4-hydroxy-3-methoxybenzoate
2,4-dihydroxy-3-({1-hydroxy-3-[(1s,5s,6r,8s)-5-methyl-9-methylidene-4-oxotricyclo[6.2.2.0¹,⁶]dodec-2-en-5-yl]propylidene}amino)benzoic acid
C24H27NO6 (425.18382820000005)
(1r,2s,12r,15r)-1-hydroxy-2,7-dimethoxy-12-(2-methylprop-1-en-1-yl)-10,13,19-triazapentacyclo[11.7.0.0³,¹¹.0⁴,⁹.0¹⁵,¹⁹]icosa-3(11),4,6,8-tetraene-14,20-dione
C23H27N3O5 (425.19506120000005)
21-hydroxy-5,6,10,11-tetramethoxy-16-azapentacyclo[12.7.0.0²,⁷.0⁸,¹³.0¹⁶,²⁰]henicosa-1(14),2(7),3,5,8(13),9,11-heptaen-16-ium-16-olate
C24H27NO6 (425.18382820000005)
2,4-dihydroxy-3-({1-hydroxy-3-[(1s,5s)-5-methyl-9-methylidene-4-oxotricyclo[6.2.2.0¹,⁶]dodec-2-en-5-yl]propylidene}amino)benzoic acid
C24H27NO6 (425.18382820000005)
(2e,10e)-n-[(2r,3s,4as,8r,8ar)-8-chloro-2,4a-dihydroxy-8a-methyl-5-oxo-2,3,4,8-tetrahydro-1-benzopyran-3-yl]dodeca-2,10-dienimidic acid
C22H32ClNO5 (425.19688920000004)
7-[4-(5-cyclohexylpenta-2,4-dienamido)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-2-yl]hepta-2,4,6-trienoic acid
C24H27NO6 (425.18382820000005)
(2e,4e,6e)-7-[(1s,2r,6r)-4-{[(2e,4e)-5-cyclohexyl-1-hydroxypenta-2,4-dien-1-ylidene]amino}-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-2-yl]hepta-2,4,6-trienoic acid
C24H27NO6 (425.18382820000005)
n-[(2s)-1-{[(4r,5as,9s,9as)-4-chloro-6,6,9a-trimethyl-3-oxo-1h,4h,5h,5ah,7h,8h,9h-naphtho[1,2-c]furan-9-yl]oxy}-3-methyl-1-oxobutan-2-yl]ethanimidic acid
C22H32ClNO5 (425.19688920000004)
3-[2-(hydroxymethyl)-3-methoxyphenyl]-2-(4-methoxyphenyl)-10-methyl-2-azatricyclo[6.3.1.0⁴,¹²]dodeca-1(11),3,6,8(12),9-pentaen-5-one
C27H23NO4 (425.16269980000004)
3-[(1s,2s,4ar,8as)-2,6-dimethyl-1,2,4a,5,8,8a-hexahydronaphthalene-1-carbonyl]-1,4-dihydroxy-5-{2-hydroxy-7-oxabicyclo[4.1.0]hept-2-en-3-yl}pyridin-2-one
C24H27NO6 (425.18382820000005)
(2r)-2-[(9ar)-3-hexanoyl-9a-methyl-2,9-dioxo-6-[(1e)-prop-1-en-1-yl]furo[3,2-g]isoquinolin-7-yl]propanoic acid
C24H27NO6 (425.18382820000005)
10-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,5-dioxa-10-azapentacyclo[9.7.1.0²,⁶.0⁸,¹⁹.0¹³,¹⁸]nonadeca-1(19),2(6),7,11,13(18),14,16-heptaen-9-one
C22H19NO8 (425.11106140000004)
10-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,5-dioxa-10-azapentacyclo[9.7.1.0²,⁶.0⁸,¹⁹.0¹³,¹⁸]nonadeca-1(19),2(6),7,11,13(18),14,16-heptaen-9-one
C22H19NO8 (425.11106140000004)