Ketotifen fumarate (BioDeep_00000015066)
natural product
代谢物信息卡片
Ketotifen fumarate (Zaditor)
化学式: C23H23NO5S (425.12968680000006)
中文名称: 酮替芬延胡索酸
谱图信息:
最多检出来源 Escherichia coli(natural_products) 28.57%
分子结构信息
SMILES: C12(C(CC3=C(C(C=1C=CS2)=C4CCN(CC4)C)C=CC=C3)=O).C(/C=C/C(O)=O)(O)=O
InChI: 2-1+
描述信息
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention[1][2][3][4].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31750
- KEGG: C74779
- KEGGdrug: D01332
- PubChem: 5282408
- ChEMBL: CHEMBL1633
- MeSH: Ketotifen
- CAS: 34580-14-8
- MoNA: CCMSLIB00000078392
- medchemexpress: HY-B0157A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jia-Zi Dong, Pei-Jing Rong, Tie-Ming Ma, Dan Wang, Xiao-Tong Wang, Ye Qiao. [Influence of electroacupuncture of"Zusanli"(ST36)on mast cells/TRPV1 signaling pathway in visceral hypersensitivity rats with functional dyspepsia].
Zhen ci yan jiu = Acupuncture research.
2022 Jul; 47(7):592-7. doi:
10.13702/j.1000-0607.20210937. [PMID: 35880275] - Ziye Huang, Guang Wang, Bowei Yang, Pei Li, Tongxin Yang, Yuyun Wu, Xing Yang, Jianhe Liu, Jiongming Li. Mechanism of ketotifen fumarate inhibiting renal calcium oxalate stone formation in SD rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jul; 151(?):113147. doi:
10.1016/j.biopha.2022.113147. [PMID: 35643070] - Huanan Li, Wei Zhang, Fei Ma, Xiaofan Zhang, Yuyan Wang, Jingui Wang. Abdominal Massage Improves the Symptoms of Irritable Bowel Syndrome by Regulating Mast Cells via the Trypase-PAR2-PKCε Pathway in Rats.
Pain research & management.
2022; 2022(?):8331439. doi:
10.1155/2022/8331439. [PMID: 36213180] - Tomohiro Nizawa, Imran A Bhutto, Anupama Tiwari, Rhonda R Grebe, Jesse Alt, Rana Rais, Malia M Edwards, Gerard A Lutty. Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy.
Translational vision science & technology.
2021 12; 10(14):37. doi:
10.1167/tvst.10.14.37. [PMID: 34967831] - Pantea Kiani, Andrew Scholey, Thomas A Dahl, Lauren McMann, Jacqueline M Iversen, Joris C Verster. In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2.
Viruses.
2021 03; 13(4):. doi:
10.3390/v13040558. [PMID: 33810356] - Nur Zahirah Abd Rani, Kok Wai Lam, Juriyati Jalil, Hazni Falina Mohamad, Mohd Shukri Mat Ali, Khairana Husain. Mechanistic Studies of the Antiallergic Activity of Phyllanthus amarus Schum. & Thonn. and Its Compounds.
Molecules (Basel, Switzerland).
2021 Jan; 26(3):. doi:
10.3390/molecules26030695. [PMID: 33525733] - Walaa Yehia Abdelzaher, Abdel Hamid Sayed AboBakr Ali, Nashwa Fathy Gamal El-Tahawy. Mast cell stabilizer modulates Sirt1/Nrf2/TNF pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of cyclophosphamide hepatotoxicity.
Immunopharmacology and immunotoxicology.
2020 Apr; 42(2):101-109. doi:
10.1080/08923973.2020.1727499. [PMID: 32066295] - Feifei Feng, J Paul Fawcett, Hu Zhang, Ian G Tucker. Cell-based, animal and H1 receptor binding studies relative to the sedative effects of ketotifen and norketotifen atropisomers.
The Journal of pharmacy and pharmacology.
2020 Apr; 72(4):507-518. doi:
10.1111/jphp.13220. [PMID: 32030755] - Dalia El Baihary, Rihab Osman, Hend Mohamed Abdel-Bar, Omaima A Sammour. Pharmacokinetic/pulmokinetic analysis of optimized lung targeted spray dried ketotifen-dextran core shell nanocomplexes-in-microparticles.
International journal of biological macromolecules.
2019 Oct; 139(?):678-687. doi:
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Biochimica et biophysica acta. Molecular basis of disease.
2019 06; 1865(6):1690-1700. doi:
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Endocrine journal.
2017 Apr; 64(4):411-416. doi:
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Drug metabolism and pharmacokinetics.
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(1):15-27. doi:
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Luminescence : the journal of biological and chemical luminescence.
2015 Nov; 30(7):1094-100. doi:
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Drug design, development and therapy.
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The Chinese journal of physiology.
2014 Oct; 57(5):271-8. doi:
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International immunopharmacology.
2013 Jun; 16(2):254-60. doi:
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PloS one.
2013; 8(10):e75262. doi:
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2012 Jun; 685(1-3):180-5. doi:
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2012 Mar; 37(1):17-22. doi:
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2011 Nov; 27(8):919-24. doi:
10.1002/dmrr.1272. [PMID: 22069285] - Min Zhou, Yu-Jie Li, Yong-Jun Ma, Wei-Feng Wang, Juan Mi, Hui Chen. Determination of ketotifen fumarate by capillary electrophoresis with tris(2,2'-bipyridyl) ruthenium(II) electrochemiluminescence detection.
Luminescence : the journal of biological and chemical luminescence.
2011 Sep; 26(5):319-23. doi:
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2011 Aug; 4(8):642-4. doi:
10.1016/s1995-7645(11)60163-6. [PMID: 21914543] - Jinku Xu, Xinsong Li, Fuqian Sun. In vitro and in vivo evaluation of ketotifen fumarate-loaded silicone hydrogel contact lenses for ocular drug delivery.
Drug delivery.
2011 Feb; 18(2):150-8. doi:
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Developmental and comparative immunology.
2011 Jan; 35(1):125-34. doi:
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2010 Dec; 199(3):254-60. doi:
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Chemical & pharmaceutical bulletin.
2009 Feb; 57(2):117-21. doi:
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BMC gastroenterology.
2008 Sep; 8(?):42. doi:
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Hepatobiliary & pancreatic diseases international : HBPD INT.
2008 Aug; 7(4):383-94. doi:
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Journal of pharmaceutical sciences.
2008 Aug; 97(8):3153-69. doi:
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American journal of physiology. Heart and circulatory physiology.
2008 Jun; 294(6):H2456-64. doi:
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Journal of cardiovascular pharmacology.
2008 Jun; 51(6):596-604. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
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Pulmonary pharmacology & therapeutics.
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