Exact Mass: 414.13799720000003

Exact Mass Matches: 414.13799720000003

Found 187 metabolites which its exact mass value is equals to given mass value 414.13799720000003, within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error 0.001 dalton.

Lignans

(10R,11S,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one

C22H22O8 (414.1314612)


Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas. Lignans is found in arrowroot and flaxseed. Lignans is found in arrowroot. Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podofilox is used to remove certain types of warts on the outside skin of the genital areas Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

   

Flecainide

N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

C17H20F6N2O3 (414.1378042)


A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial arrhythmias and tachycardias. Paradoxically, however, in myocardial infarct patients with either symptomatic or asymptomatic arrhythmia, flecainide exacerbates the arrhythmia and is not recommended for use in these patients. [PubChem] C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BC - Antiarrhythmics, class ic D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents CONFIDENCE standard compound; EAWAG_UCHEM_ID 3020 CONFIDENCE standard compound; INTERNAL_ID 2276 D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker

   

Clavamycin A

Antibiotic CA 31

C16H22N4O9 (414.1386722)


   

1,5-a-L-Arabinotriose

alpha-L-Araf-(1->5)-alpha-L-Araf-(1->5)-L-Araf

C15H26O13 (414.13733460000003)


   

Podofilox

FURO(3,4:6,7)NAPHTHO(2,3-D)-1,3-DIOXOL-6(5AH)-ONE, 5,8,8A,9-TETRAHYDRO-9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-, (5R-(5.ALPHA.,5A.BETA.,8A.ALPHA.,9.ALPHA.))-

C22H22O8 (414.1314612)


Podophyllotoxin is an organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. It has a role as an antineoplastic agent, a keratolytic drug, a tubulin modulator, a microtubule-destabilising agent, an antimitotic and a plant metabolite. It is a furonaphthodioxole, a lignan and an organic heterotetracyclic compound. ["Podofilox is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of external genital warts and perianal warts. Podofilox gel and solution are for topicalcutaneous use only.","External genital and perianal warts are caused by the human papillomavirus (HPV). HPV can be an opportunistic infection (OI) of HIV."] A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. The physiologic effect of podofilox is by means of Decreased Mitosis. Podofilox is a natural product found in Juniperus, Hernandia ovigera, and other organisms with data available. Podofilox is a pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04) A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. [PubChem] An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents D003879 - Dermatologic Agents > D007641 - Keratolytic Agents C1907 - Drug, Natural Product Same as: D05529 Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

   

a-L-Arabinofuranosyl-(1->3)-b-D-xylopyranosyl-(1->4)-D-xylose

5-[(4-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]oxane-2,3,4-triol

C15H26O13 (414.13733460000003)


a-L-Arabinofuranosyl-(1->3)-b-D-xylopyranosyl-(1->4)-D-xylose is produced of partial enzymic hydrolysis of xylans found in foods, e.g. rye flour. Production of partial enzymic hydrolysis of xylans found in foods, e.g. rye flour

   

Dulxanthone G

5-hydroxy-7,9,10,12-tetramethoxy-2,2-dimethyl-2,6-dihydro-1,11-dioxatetracen-6-one

C22H22O8 (414.1314612)


Dulxanthone G is found in fruits. Dulxanthone G is a constituent of Garcinia dulcis (mundu) Constituent of Garcinia dulcis (mundu). Dulxanthone G is found in fruits.

   

beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->5)-L-arabinose

2-({3,4-dihydroxy-5-[(3,4,5-trihydroxyoxolan-2-yl)methoxy]oxolan-2-yl}methoxy)oxane-3,4,5-triol

C15H26O13 (414.13733460000003)


beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->5)-L-arabinose is found in fruits. beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->5)-L-arabinose is isolated from the mucilage of Opuntia ficus-indica (Indian fig). Isolated from the mucilage of Opuntia ficus-indica (Indian fig). beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->5)-L-arabinose is found in fruits.

   

beta-D-Xylopyranosyl-(1->3)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose

4-{[3-hydroxy-5-(hydroxymethyl)-4-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxolan-2-yl]oxy}oxane-2,3,5-triol

C15H26O13 (414.13733460000003)


beta-D-Xylopyranosyl-(1->3)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose is found in fruits. beta-D-Xylopyranosyl-(1->3)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose is isolated from the mucilage of Opuntia ficus-indica (Indian fig). Isolated from the mucilage of Opuntia ficus-indica (Indian fig). beta-D-Xylopyranosyl-(1->3)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose is found in fruits.

   

beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose

4-[(3,4-dihydroxy-5-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxolan-2-yl)oxy]oxane-2,3,5-triol

C15H26O13 (414.13733460000003)


beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose is found in fruits. beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose is isolated from the mucilage of Opuntia ficus-indica (Indian fig). Isolated from the mucilage of Opuntia ficus-indica (Indian fig). beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose is found in fruits.

   

Dulxanthone H

7-hydroxy-5,9,10,12-tetramethoxy-2,2-dimethyl-2,6-dihydro-1,11-dioxatetracen-6-one

C22H22O8 (414.1314612)


Dulxanthone H is found in fruits. Dulxanthone H is a constituent of Garcinia dulcis (mundu) Constituent of Garcinia dulcis (mundu). Dulxanthone H is found in fruits.

   

a-L-Arabinofuranosyl-(1->3)-[a-L-arabinofuranosyl-(1r5)]-L-arabinose

2-[(3-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-4,5-dihydroxyoxolan-2-yl)methoxy]-5-(hydroxymethyl)oxolane-3,4-diol

C15H26O13 (414.13733460000003)


a-L-Arabinofuranosyl-(1->3)-[a-L-arabinofuranosyl-(1r5)]-L-arabinose is found in green vegetables. a-L-Arabinofuranosyl-(1->3)-[a-L-arabinofuranosyl-(1r5)]-L-arabinose is a constituent of the anti-complementary arabinogalactan (AG IIb-1), isolated from the roots of Angelica acutiloba (Dong Dang Gui). Constituent of the anti-complementary arabinogalactan (AG IIb-1), isolated from the roots of Angelica acutiloba (Dong Dang Gui). a-L-Arabinofuranosyl-(1->3)-[a-L-arabinofuranosyl-(1r5)]-L-arabinose is found in green vegetables.

   

Edulone A

2-{3,4,6-trihydroxy-1,12-dimethyl-8,11-dioxo-10-oxatetracyclo[7.6.1.0²,⁷.0¹³,¹⁶]hexadeca-2(7),3,5,9(16),12-pentaen-5-yl}propyl acetic acid

C22H22O8 (414.1314612)


Edulone A is found in root vegetables. Edulone A is a constituent of Plectranthus edulis (oromo dinich) Constituent of Plectranthus edulis (oromo dinich). Edulone A is found in root vegetables.

   

N-desalkyl delavirdine

N-{2-[4-(3-aminopyridin-2-yl)piperazine-1-carbonyl]-1H-indol-5-yl}methanesulfonamide

C19H22N6O3S (414.1474022)


N-desalkyl delavirdine is a metabolite of delavirdine. Delavirdine (DLV) (brand name Rescriptor) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) marketed by ViiV Healthcare. It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1. It is presented as the mesylate. The recommended dosage is 400 mg, three times a day. Although delavirdine was approved by the U.S. (Wikipedia)

   

5-Hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0³,⁷.0¹¹,¹⁵]hexadeca-1,3(7),8-trien-12-one

C22H22O8 (414.1314612)


   

Xylotriose

(2S,3R,4S,5R)-2-[(3R,4R,5R,6S)-4,5-dihydroxy-6-[(3R,4R,5R)-4,5,6-trihydroxyoxan-3-yl]oxyoxan-3-yl]oxyoxane-3,4,5-triol

C15H26O13 (414.13733460000003)


Beta-D-Xylp-(1->4)-beta-D-Xylp-(1->4)-D-Xylp is a xylotriose consisting of three D-xylose units connected via beta-(1->4)-linkages. Xylotriose is a natural product found in Streptomyces rameus with data available. Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor[1].

   

0F35AOI227

Furo(3,4:6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))-

C22H22O8 (414.1314612)


Picropodophyllotoxin is an organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an insulin-like growth factor receptor 1 antagonist and a plant metabolite. It is a lignan, a furonaphthodioxole and an organic heterotetracyclic compound. Picropodophyllin has been investigated for the treatment of Non Small Cell Lung Cancer. Picropodophyllin is a natural product found in Juniperus, Juniperus thurifera, and other organisms with data available. Picropodophyllin is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells. An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents. C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor C1907 - Drug, Natural Product Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

   

Piscerisoflavone F

5,7-Dihydroxy-4,5-dimethoxy-5-(1-hydroxy-1-methylethyl)-4,5-dihydrofurano[2,3:2,3]isoflavone

C22H22O8 (414.1314612)


   

1,4-Bis(7-methoxybenzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan

1,4-Bis(7-methoxybenzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan

C22H22O8 (414.1314612)


   

6,4-Dihydroxy-7-methylaurone 6-rhamnoside

6,4-Dihydroxy-7-methylaurone 6-rhamnoside

C22H22O8 (414.1314612)


   
   

Aciculatin

8- [ (2S,4S,5S,6R) -4,5-dihydroxy-6-methyloxan-2-yl ] -5-hydroxy-2- (4-hydroxyphenyl) -7-methoxychromen-4-one

C22H22O8 (414.1314612)


   

(2,3-trans-3,4-trans)-3,4-Methylenedioxy-3,4,5,8-tetramethoxy-[2,3:7,6]-furanoflavan

(2,3-trans-3,4-trans)-3,4-Methylenedioxy-3,4,5,8-tetramethoxy-[2,3:7,6]-furanoflavan

C22H22O8 (414.1314612)


   
   
   

(2,3-trans-3,4-cis)-3,4-Methylenedioxy-3,4,5,6-tetramethoxy-[2,3:7,8]-furanoflavan

(2,3-trans-3,4-cis)-3,4-Methylenedioxy-3,4,5,6-tetramethoxy-[2,3:7,8]-furanoflavan

C22H22O8 (414.1314612)


   
   
   
   

Antibiotic CL 1565B

Antibiotic CL 1565B

C19H27O8P (414.1443472)


   

Piscerisoflavone G

5,7,5-Trihydroxy-4,5-dimethoxy-6,6-dimethyl-4,5-dihydropyrano[2,3:2,3]isoflavone

C22H22O8 (414.1314612)


   

Quercetin 3,3-dimethyl ether 4-(2-methylbutyrate)

5,7,4-Trihydroxy-3,3-dimethoxyflavone 4- (2-methylbutyrate)

C22H22O8 (414.1314612)


   

Daidzein G 3

7,4-Dihydroxyisoflavone 7-O-(2-O-methylrhamnoside)

C22H22O8 (414.1314612)


   

2beta-Hydroxysalvigenolide

(-)-2beta-Hydroxysalvigenolide

C22H22O8 (414.1314612)


   

Cylindroxanthone A

Cylindroxanthone A

C22H22O8 (414.1314612)


   

yahyaxanthone

yahyaxanthone

C22H22O8 (414.1314612)


A member of the class of pyranoxanthones that is 3H,7H-pyrano[2,3-c]xanthen-7-one substituted by a hydroxy group at position 6, methoxy groups at positions 5, 8, 10 and 11 and geminal methyl groups at position 3. Isolated from Garcinia rigida, it exhibits cytotoxic activity.

   

3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-8-methoxy-7-[(3-methyl-2-butenyl)oxy]-4H-1-benzopyran-4-one

3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-8-methoxy-7-[(3-methyl-2-butenyl)oxy]-4H-1-benzopyran-4-one

C22H22O8 (414.1314612)


   

beta-Peltatin

(-)-beta-peltatin

C22H22O8 (414.1314612)


relative retention time with respect to 9-anthracene Carboxylic Acid is 1.014 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.018 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.994 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.000

   

Quercetin 3,3-dimethyl ether 4-isovalerate

Quercetin 3,3-dimethyl ether 4-isovalerate

C22H22O8 (414.1314612)


   

3,5,8,4-Tetrahydroxy-7,3-dimethoxy-6-(3-methylbut-2-enyl)flavone

3,5,8,4-Tetrahydroxy-7,3-dimethoxy-6-(3-methylbut-2-enyl)flavone

C22H22O8 (414.1314612)


   

Kanzonol S

5,7,3,4-Tetrahydroxy-8- [ 4- (acetyloxy) -3-methyl-2-butenyl ] flavanone

C22H22O8 (414.1314612)


   

3,5,8,4-Tetrahydroxy-7,3-dimethoxy-6- (3-methylbut-2'-enyl) flavone

3,5,8,4-Tetrahydroxy-7,3-dimethoxy-6- (3-methylbut-2"-enyl) flavone

C22H22O8 (414.1314612)


   

Podophyllotoxin

5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

C22H22O8 (414.1314612)


Origin: Plant, Organic chemicals, Polycyclic compounds, Naphthalenes relative retention time with respect to 9-anthracene Carboxylic Acid is 0.992 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.994 Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

   
   

1-O-feruloyl-3-O-p-coumaroylglycerol

1-O-feruloyl-3-O-p-coumaroylglycerol

C22H22O8 (414.1314612)


   

salvianduline B acetate

salvianduline B acetate

C22H22O8 (414.1314612)


   

beta-D-Xylp-(1-4)-beta-D-Xylp-(1-4)-D-Xyl|xylotriose

beta-D-Xylp-(1-4)-beta-D-Xylp-(1-4)-D-Xyl|xylotriose

C15H26O13 (414.13733460000003)


   

9,10-Dihydro-6,7-dimethoxy-2,3,5-phenanthrenetriol triacetate

9,10-Dihydro-6,7-dimethoxy-2,3,5-phenanthrenetriol triacetate

C22H22O8 (414.1314612)


   
   

3-O-L-quinovosyl saphenate

3-O-L-quinovosyl saphenate

C21H22N2O7 (414.1426942)


   

2-O-Ethyl-arboreol

2-O-Ethyl-arboreol

C22H22O8 (414.1314612)


   
   

alpha-L-Araf-(1 -> 2)-alpha-L-Araf-(1 -> 4)-L-Arap

alpha-L-Araf-(1 -> 2)-alpha-L-Araf-(1 -> 4)-L-Arap

C15H26O13 (414.13733460000003)


   
   

(2xi,3R)-7-(2-Acetoxy-1-methylethyl)-6,9-dihydroxy-3,4-dimethyl-3-(2-propenyl)naphthol<2,3-b>furan-2(3H),5,8-trion|(2xi,3R)-7-(2-Acetoxy-1-methylethyl)-6,9-dihydroxy-3,4-dimethyl-3-(2-propenyl)naphthol[2,3-b]furan-2(3H),5,8-trion

(2xi,3R)-7-(2-Acetoxy-1-methylethyl)-6,9-dihydroxy-3,4-dimethyl-3-(2-propenyl)naphthol<2,3-b>furan-2(3H),5,8-trion|(2xi,3R)-7-(2-Acetoxy-1-methylethyl)-6,9-dihydroxy-3,4-dimethyl-3-(2-propenyl)naphthol[2,3-b]furan-2(3H),5,8-trion

C22H22O8 (414.1314612)


   
   

4,5,4,5-bismethylendioxypolemannone

4,5,4,5-bismethylendioxypolemannone

C22H22O8 (414.1314612)


   

7-Hydroxyanhydropodorhizol

7-Hydroxyanhydropodorhizol

C22H22O8 (414.1314612)


   

3,3-dimetoxysesamin

3,3-dimetoxysesamin

C22H22O8 (414.1314612)


   

5,7,4-trihydroxy-3,3-dimethoxyflavone-4-O-(2-methylisobutyrate)|5,7,4-trihydroxy-3,3-dimethoxyflavone-4-O-<2-methylisobutyrate>

5,7,4-trihydroxy-3,3-dimethoxyflavone-4-O-(2-methylisobutyrate)|5,7,4-trihydroxy-3,3-dimethoxyflavone-4-O-<2-methylisobutyrate>

C22H22O8 (414.1314612)


   
   

3-hydroxy-N-methylwelwitindolinone C formamide

3-hydroxy-N-methylwelwitindolinone C formamide

C22H23ClN2O4 (414.13462680000004)


   

methyl rel-(1R,2S,3S)-2,2-bis-(7-methoxy-1,3-benzodioxol-5-yl)cyclobutanecarboxylate|peperotetrapin

methyl rel-(1R,2S,3S)-2,2-bis-(7-methoxy-1,3-benzodioxol-5-yl)cyclobutanecarboxylate|peperotetrapin

C22H22O8 (414.1314612)


   
   
   

(-)-teubrevin G|teubrevin G

(-)-teubrevin G|teubrevin G

C22H22O8 (414.1314612)


   

mearnsetin 3-rhamnoside

mearnsetin 3-rhamnoside

C22H22O8 (414.1314612)


   

(2S,3S)-2,3-Bis(5-methoxy-3,4-methylenedioxybenzyl)-butyrolactone|(2S,3S)-2,3-bis(5-methoxy-3,4-methylenedioxybenzyl)butyrolactone

(2S,3S)-2,3-Bis(5-methoxy-3,4-methylenedioxybenzyl)-butyrolactone|(2S,3S)-2,3-bis(5-methoxy-3,4-methylenedioxybenzyl)butyrolactone

C22H22O8 (414.1314612)


   
   

2-methylene-3-[(5-methoxy-3,4-methylenedioxyphenyl)(4-hydroxy-3,5-dimethoxyphenyl)methyl]butyrolactone

2-methylene-3-[(5-methoxy-3,4-methylenedioxyphenyl)(4-hydroxy-3,5-dimethoxyphenyl)methyl]butyrolactone

C22H22O8 (414.1314612)


   

1-O-feruloy-l2-O-p-coumaroylglycerol|1-O-feruloyl-2-O-p-coumaroylglycerol

1-O-feruloy-l2-O-p-coumaroylglycerol|1-O-feruloyl-2-O-p-coumaroylglycerol

C22H22O8 (414.1314612)


   

alpha-L-Araf-(1 -> 2)-alpha-L-Araf-(1 -> 5)-L-Araf

alpha-L-Araf-(1 -> 2)-alpha-L-Araf-(1 -> 5)-L-Araf

C15H26O13 (414.13733460000003)


   

3,6-dimethoxy-1,1-dimethylchromene-[2,3:7,8]-flavone

3,6-dimethoxy-1,1-dimethylchromene-[2,3:7,8]-flavone

C26H22O5 (414.1467162)


   

5-demethoxy-6-methoxypodophyllotoxin

5-demethoxy-6-methoxypodophyllotoxin

C22H22O8 (414.1314612)


   
   

1-O-p-coumaroyl-2-O-feruloylglycerol

1-O-p-coumaroyl-2-O-feruloylglycerol

C22H22O8 (414.1314612)


   

(3S,4R,4aR,4bS,5R,7aR,10aS)-3-(furan-3-yl)-3,4,4a,4b,5,7a,8,11-octahydro-4-hydroxy-4a-methyl-1,8-dioxo-1H-[2]benzofuro[4,3a-f]isochromene-5-yl acetate|15,16-epoxy-1beta-O-acetyl-11beta-hydroxy-12betaH-cleroda-2,7,13(16),14-tetraene-17,12:18,19-diolide|splendidin B

(3S,4R,4aR,4bS,5R,7aR,10aS)-3-(furan-3-yl)-3,4,4a,4b,5,7a,8,11-octahydro-4-hydroxy-4a-methyl-1,8-dioxo-1H-[2]benzofuro[4,3a-f]isochromene-5-yl acetate|15,16-epoxy-1beta-O-acetyl-11beta-hydroxy-12betaH-cleroda-2,7,13(16),14-tetraene-17,12:18,19-diolide|splendidin B

C22H22O8 (414.1314612)


   

PELTATIN B

Furo[3,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-10-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5.alpha.,5a.beta.,8a.alpha.)]-

C22H22O8 (414.1314612)


Beta-peltatin is an organic heterotetracyclic compound that is alpha-peltatin in which the phenolic hydroxy group of the 4-hydroxy-3,5-dimethoxyphenyl substitutent had been converted into the corresponding methyl ether. It has a role as an antineoplastic agent and a plant metabolite. It is a furonaphthodioxole, a lignan, a member of phenols, a gamma-lactone and an organic heterotetracyclic compound. It is functionally related to an alpha-peltatin. beta-Peltatin is a natural product found in Libocedrus bidwillii, Eriope macrostachya, and other organisms with data available. An organic heterotetracyclic compound that is alpha-peltatin in which the phenolic hydroxy group of the 4-hydroxy-3,5-dimethoxyphenyl substitutent had been converted into the corresponding methyl ether.

   

Epipodophyllotoxin

(5R)-5beta-(3,4,5-Trimethoxyphenyl)-7alpha-(hydroxymethyl)-8alpha-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6beta-carboxylic acid 6,7-lactone

C22H22O8 (414.1314612)


Epipodophyllotoxin is a natural product found in Juniperus sabina and Podophyllum peltatum with data available. A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents D003879 - Dermatologic Agents > D007641 - Keratolytic Agents (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1]. (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1]. (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1]. (-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].

   

PODOPHYLLOTOXIN

NCGC00022001-07!PODOPHYLLOTOXIN

C22H22O8 (414.1314612)


   

(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

NCGC00022001-15!(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

C22H22O8 (414.1314612)


   

4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

NCGC00095966-03!4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

C22H22O8 (414.1314612)


   
   
   

Podofilox

Podophyllotoxin

C22H22O8 (414.1314612)


D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents D003879 - Dermatologic Agents > D007641 - Keratolytic Agents C1907 - Drug, Natural Product Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

   

flecainide

flecainide

C17H20F6N2O3 (414.1378042)


C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BC - Antiarrhythmics, class ic D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker

   

(-)-Podophyllotoxin

(-)-Podophyllotoxin

C22H22O8 (414.1314612)


Annotation level-1

   

4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based on: CCMSLIB00000849060]

NCGC00095966-03!4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based on: CCMSLIB00000849060]

C22H22O8 (414.1314612)


   

(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based on: CCMSLIB00000845603]

NCGC00022001-15!(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based on: CCMSLIB00000845603]

C22H22O8 (414.1314612)


   

(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based: Match]

NCGC00022001-15!(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based: Match]

C22H22O8 (414.1314612)


   

[IIN-based: Match]

NCGC00381169-01! [IIN-based: Match]

C22H22O8 (414.1314612)


   

[IIN-based on: CCMSLIB00000847987]

NCGC00381169-01! [IIN-based on: CCMSLIB00000847987]

C22H22O8 (414.1314612)


   

4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based: Match]

NCGC00095966-03!4-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one [IIN-based: Match]

C22H22O8 (414.1314612)


   

Picropodophyllin_major

Picropodophyllin_major

C22H22O8 (414.1314612)


   
   

PODOFILOX_72.3\\%

PODOFILOX_72.3\\%

C22H22O8 (414.1314612)


   

Beta-Peltatin_43.4\\%

Beta-Peltatin_43.4\\%

C22H22O8 (414.1314612)


   

Beta-Peltatin_major

Beta-Peltatin_major

C22H22O8 (414.1314612)


   

PODOFILOX_60.1\\%

PODOFILOX_60.1\\%

C22H22O8 (414.1314612)


   

His-His-OH

(S)-2-(3-(2-(1H-imidazol-4-yl)ethoxy)-4-nitrobenzamido)-4-(1H-imidazol-4-yl)butanoic acid

C18H18N6O6 (414.1287768)


   

Lignans

(10R,11S,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-12-one

C22H22O8 (414.1314612)


   

Dulxanthone G

5-hydroxy-7,9,10,12-tetramethoxy-2,2-dimethyl-2,6-dihydro-1,11-dioxatetracen-6-one

C22H22O8 (414.1314612)


   

Dulxanthone H

7-hydroxy-5,9,10,12-tetramethoxy-2,2-dimethyl-2,6-dihydro-1,11-dioxatetracen-6-one

C22H22O8 (414.1314612)


   

Edulone A

2-{3,4,6-trihydroxy-1,12-dimethyl-8,11-dioxo-10-oxatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-2(7),3,5,9(16),12-pentaen-5-yl}propyl acetate

C22H22O8 (414.1314612)


   

beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose

4-[(3,4-dihydroxy-5-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxolan-2-yl)oxy]oxane-2,3,5-triol

C15H26O13 (414.13733460000003)


   

2,2-Dimethylthiazolidine

2-({3,4-dihydroxy-5-[(3,4,5-trihydroxyoxolan-2-yl)methoxy]oxolan-2-yl}methoxy)oxane-3,4,5-triol

C15H26O13 (414.13733460000003)


   

beta-D-Xylopyranosyl-(1->3)-alpha-L-arabinofuranosyl-(1->3)-L-arabinose

4-{[3-hydroxy-5-(hydroxymethyl)-4-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxolan-2-yl]oxy}oxane-2,3,5-triol

C15H26O13 (414.13733460000003)


   

a-L-Arabinofuranosyl-(1->3)-b-D-xylopyranosyl-(1->4)-D-xylose

5-[(4-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]oxane-2,3,4-triol

C15H26O13 (414.13733460000003)


   

a-L-Arabinofuranosyl-(1->3)-[a-L-arabinofuranosyl-(1r5)]-L-arabinose

4-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-5-({[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}methyl)oxolane-2,3-diol

C15H26O13 (414.13733460000003)


   

3-Hydroxy-7,8,14-trimethoxy-17-methyl-12,16,21-trioxapentacyclo[15.3.1.02,15.04,13.06,11]henicosa-2(15),3,6,8,10,13-hexaen-5-one

3-Hydroxy-7,8,14-trimethoxy-17-methyl-12,16,21-trioxapentacyclo[15.3.1.02,15.04,13.06,11]henicosa-2(15),3,6,8,10,13-hexaen-5-one

C22H22O8 (414.1314612)


   

(6R,7R)-3-methyl-8-oxo-7-[[2-[4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-methyl-8-oxo-7-[[2-[4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C20H22N4O4S (414.13616920000004)


   

Phosphonium,triphenyl(3-phenyl-2-propen-1-yl)-, chloride (1:1)

Phosphonium,triphenyl(3-phenyl-2-propen-1-yl)-, chloride (1:1)

C27H24ClP (414.1304064)


   

1,2-bis(diphenylphosphino)ethane monooxide

1,2-bis(diphenylphosphino)ethane monooxide

C26H24OP2 (414.13023139999996)


   

a-D-Galactopyranose,1,2:3,4-bis-O-(1-methylethylidene)-, 6-(4-methylbenzenesulfonate)

a-D-Galactopyranose,1,2:3,4-bis-O-(1-methylethylidene)-, 6-(4-methylbenzenesulfonate)

C19H26O8S (414.13483160000004)


   

N-[6,7-dichloro-3-(2-phenylethenyl)quinoxalin-2-yl]-N,N,N-trimethylpropane-1,3-diamine

N-[6,7-dichloro-3-(2-phenylethenyl)quinoxalin-2-yl]-N,N,N-trimethylpropane-1,3-diamine

C22H24Cl2N4 (414.13779239999997)


   

Sancycline

Sancycline

C21H22N2O7 (414.1426942)


C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic C254 - Anti-Infective Agent > C258 - Antibiotic

   

2-ACETAMIDO-9-VINYL-9H-PURIN-6-YL DIPHENYLCARBAMATE

2-ACETAMIDO-9-VINYL-9H-PURIN-6-YL DIPHENYLCARBAMATE

C22H18N6O3 (414.1440318)


   

Aluminum, tris[ethyl3-(oxo-kO)butanoato-kO]-

Aluminum, tris[ethyl3-(oxo-kO)butanoato-kO]-

C18H27AlO9 (414.1470402)


   
   

5-[(2-Methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide

5-[(2-Methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide

C21H17F3N4O2 (414.13035379999997)


   

beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose

beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose

C15H26O13 (414.13733460000003)


   

N-Desisopropyl delavirdine

N-Desisopropyl delavirdine

C19H22N6O3S (414.1474022)


   

alpha-L-Araf-(1->5)-alpha-L-Araf-(1->5)-alpha-L-Araf

alpha-L-Araf-(1->5)-alpha-L-Araf-(1->5)-alpha-L-Araf

C15H26O13 (414.13733460000003)


   

(5R,5aS,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one

(5R,5aS,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one

C22H22O8 (414.1314612)


   
   

4-Methyl-2-{[4-(toluene-4-sulfonyl)-thiomorpholine-3-carbonyl]-amino}-pentanoic acid

4-Methyl-2-{[4-(toluene-4-sulfonyl)-thiomorpholine-3-carbonyl]-amino}-pentanoic acid

C18H26N2O5S2 (414.12830660000003)


   

Derivative OF aklanonic acid methyl ester (aame)

Derivative OF aklanonic acid methyl ester (aame)

C22H22O8 (414.1314612)


   

477-47-4

Furo[3,4:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5.alpha.,5a.alpha.,8a.alpha.,9.alpha.)]-

C22H22O8 (414.1314612)


C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor C1907 - Drug, Natural Product Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

   

Wartec

Furo[3,4:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5.alpha.,5a.beta.,8a.alpha.,9.alpha.)]-

C22H22O8 (414.1314612)


D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents D003879 - Dermatologic Agents > D007641 - Keratolytic Agents C1907 - Drug, Natural Product Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.

   

2-(4-chloro-2-methyl-5-pyrrolidin-1-ylsulfonylphenoxy)-N-cyclohexylacetamide

2-(4-chloro-2-methyl-5-pyrrolidin-1-ylsulfonylphenoxy)-N-cyclohexylacetamide

C19H27ClN2O4S (414.13799720000003)


   

Sdccgsbi-0050902.P004

Sdccgsbi-0050902.P004

C22H22O8 (414.1314612)


   
   

8-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one

8-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one

C22H22O8 (414.1314612)


   

2-[[2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)thio]-1-oxoethyl]amino]-4-methylpentanoic acid methyl ester

2-[[2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)thio]-1-oxoethyl]amino]-4-methylpentanoic acid methyl ester

C20H22N4O4S (414.13616920000004)


   

3-Chloro-4-[2-(3,4-dimethoxyphenyl)ethylamino]-1-(2-phenylethyl)pyrrole-2,5-dione

3-Chloro-4-[2-(3,4-dimethoxyphenyl)ethylamino]-1-(2-phenylethyl)pyrrole-2,5-dione

C22H23ClN2O4 (414.13462680000004)


   

1-[4-(2-Methoxyphenyl)-1-piperazinyl]-2-[[5-(2-methyl-3-furanyl)-1,3,4-oxadiazol-2-yl]thio]ethanone

1-[4-(2-Methoxyphenyl)-1-piperazinyl]-2-[[5-(2-methyl-3-furanyl)-1,3,4-oxadiazol-2-yl]thio]ethanone

C20H22N4O4S (414.13616920000004)


   

[2-[4-(furan-2-carbonyl)piperazin-1-yl]-2-oxoethyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

[2-[4-(furan-2-carbonyl)piperazin-1-yl]-2-oxoethyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

C21H22N2O7 (414.1426942)


   

(5R)-3-(4-dibenzothiophenyl)-5-(3,4-dimethoxyphenyl)-1-cyclohex-2-enone

(5R)-3-(4-dibenzothiophenyl)-5-(3,4-dimethoxyphenyl)-1-cyclohex-2-enone

C26H22O3S (414.12895820000006)


   

Coumaroyl-feruloylglycerol

Coumaroyl-feruloylglycerol

C22H22O8 (414.1314612)


   

Ethyl [5-benzyloxy-4-(trifluoromethyl)biphenyl-3-yl]acetate

Ethyl [5-benzyloxy-4-(trifluoromethyl)biphenyl-3-yl]acetate

C24H21F3O3 (414.14427120000005)


   

2-[5-Phenoxy-4-(trifluoromethyl)biphenyl-3-yl]pentanoic acid

2-[5-Phenoxy-4-(trifluoromethyl)biphenyl-3-yl]pentanoic acid

C24H21F3O3 (414.14427120000005)


   

2-[(1S,3S,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1S,3S,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

2-[(1S,3R,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1S,3R,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

2-[(1R,3S,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1R,3S,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

2-[(1R,3R,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1R,3R,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

2-[(1R,3S,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1R,3S,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

2-[(1R,3R,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1R,3R,4aS,9aR)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

2-[(1S,3S,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1S,3S,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

2-[(1S,3R,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

2-[(1S,3R,4aR,9aS)-1-(hydroxymethyl)-6-(methanesulfonamido)-3,4,4a,9a-tetrahydro-1H-pyrano[3,4-b]benzofuran-3-yl]-N-(2-methoxyethyl)acetamide

C18H26N2O7S (414.14606460000005)


   

3-Hydroxy-7,8,14-trimethoxy-17-methyl-12,16,21-trioxapentacyclo[15.3.1.02,15.04,13.06,11]henicosa-2(15),3,6(11),7,9,13-hexaen-5-one

3-Hydroxy-7,8,14-trimethoxy-17-methyl-12,16,21-trioxapentacyclo[15.3.1.02,15.04,13.06,11]henicosa-2(15),3,6(11),7,9,13-hexaen-5-one

C22H22O8 (414.1314612)


   

alpha-L-Araf-(1->5)-alpha-L-Araf-(1->5)-L-Araf

alpha-L-Araf-(1->5)-alpha-L-Araf-(1->5)-L-Araf

C15H26O13 (414.13733460000003)


   

beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->5)-L-arabinose

beta-D-Xylopyranosyl-(1->5)-alpha-L-arabinofuranosyl-(1->5)-L-arabinose

C15H26O13 (414.13733460000003)


   
   

(1e,6e)-4-(1,2-dihydroxyethyl)-4-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

(1e,6e)-4-(1,2-dihydroxyethyl)-4-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

C22H22O8 (414.1314612)


   

(12s,13r,14s)-14-hydroxy-3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclo[13.7.0.0²,¹⁰.0⁴,⁸.0¹⁷,²¹]docosa-1(15),2(10),3,8,16,21-hexaen-11-one

(12s,13r,14s)-14-hydroxy-3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclo[13.7.0.0²,¹⁰.0⁴,⁸.0¹⁷,²¹]docosa-1(15),2(10),3,8,16,21-hexaen-11-one

C22H22O8 (414.1314612)


   

5,7-dihydroxy-3-[(3s)-3-hydroxy-5,6-dimethoxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-8-yl]chromen-4-one

5,7-dihydroxy-3-[(3s)-3-hydroxy-5,6-dimethoxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-8-yl]chromen-4-one

C22H22O8 (414.1314612)


   

n-[(2s,3s,6r,8s)-4-chloro-3-ethenyl-8-hydroxy-3,7,7,10-tetramethyl-9,16-dioxo-10-azatetracyclo[6.6.1.1²,⁶.0¹¹,¹⁵]hexadeca-1(14),4,11(15),12-tetraen-2-yl]carboximidic acid

n-[(2s,3s,6r,8s)-4-chloro-3-ethenyl-8-hydroxy-3,7,7,10-tetramethyl-9,16-dioxo-10-azatetracyclo[6.6.1.1²,⁶.0¹¹,¹⁵]hexadeca-1(14),4,11(15),12-tetraen-2-yl]carboximidic acid

C22H23ClN2O4 (414.13462680000004)


   

(2z)-2-[(4-hydroxyphenyl)methylidene]-7-methyl-6-{[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-1-benzofuran-3-one

(2z)-2-[(4-hydroxyphenyl)methylidene]-7-methyl-6-{[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}-1-benzofuran-3-one

C22H22O8 (414.1314612)


   

(1s,3as,4s,6ar)-1,4-bis(2h-1,3-benzodioxol-5-yl)-4-ethoxy-tetrahydrofuro[3,4-c]furan-3a-ol

(1s,3as,4s,6ar)-1,4-bis(2h-1,3-benzodioxol-5-yl)-4-ethoxy-tetrahydrofuro[3,4-c]furan-3a-ol

C22H22O8 (414.1314612)


   

(3s,4s)-3,4-bis[(7-methoxy-2h-1,3-benzodioxol-5-yl)methyl]oxolan-2-one

(3s,4s)-3,4-bis[(7-methoxy-2h-1,3-benzodioxol-5-yl)methyl]oxolan-2-one

C22H22O8 (414.1314612)


   

(1r,2r,3s,4r,5s,9r)-5-acetyl-3,4,5-trihydroxy-8,8,16-trimethyl-19-oxa-7,16-diazahexacyclo[9.6.1.1¹,⁴.0²,⁹.0³,⁷.0¹⁵,¹⁸]nonadeca-11,13,15(18)-triene-6,17-dione

(1r,2r,3s,4r,5s,9r)-5-acetyl-3,4,5-trihydroxy-8,8,16-trimethyl-19-oxa-7,16-diazahexacyclo[9.6.1.1¹,⁴.0²,⁹.0³,⁷.0¹⁵,¹⁸]nonadeca-11,13,15(18)-triene-6,17-dione

C21H22N2O7 (414.1426942)


   

[(5s)-5-[(2e)-4-[(8-methoxy-2-oxochromen-7-yl)oxy]-2-methylbut-2-en-1-yl]-2-oxo-5h-furan-3-yl]methyl acetate

[(5s)-5-[(2e)-4-[(8-methoxy-2-oxochromen-7-yl)oxy]-2-methylbut-2-en-1-yl]-2-oxo-5h-furan-3-yl]methyl acetate

C22H22O8 (414.1314612)


   

4-[7-(acetyloxy)-5-hydroxy-6,8-dimethyl-4-oxo-2,3-dihydro-1-benzopyran-2-yl]-2-methoxyphenyl acetate

4-[7-(acetyloxy)-5-hydroxy-6,8-dimethyl-4-oxo-2,3-dihydro-1-benzopyran-2-yl]-2-methoxyphenyl acetate

C22H22O8 (414.1314612)


   

(3r,4r,5r)-5-{[(2r,3s,4s)-3,4-dihydroxy-5-{[(3r,4s,5r)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}oxane-2,3,4-triol

(3r,4r,5r)-5-{[(2r,3s,4s)-3,4-dihydroxy-5-{[(3r,4s,5r)-3,4,5-trihydroxyoxan-2-yl]oxy}oxan-2-yl]oxy}oxane-2,3,4-triol

C15H26O13 (414.13733460000003)


   

2-[(2-{[4,5-dihydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl)oxy]-5-(hydroxymethyl)oxolane-3,4-diol

2-[(2-{[4,5-dihydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl)oxy]-5-(hydroxymethyl)oxolane-3,4-diol

C15H26O13 (414.13733460000003)


   

methyl (1r,2s,3s)-2,3-bis(7-methoxy-2h-1,3-benzodioxol-5-yl)cyclobutane-1-carboxylate

methyl (1r,2s,3s)-2,3-bis(7-methoxy-2h-1,3-benzodioxol-5-yl)cyclobutane-1-carboxylate

C22H22O8 (414.1314612)


   

4-methoxy-6-[4-(7-methoxy-2h-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-1-yl]-2h-1,3-benzodioxole

4-methoxy-6-[4-(7-methoxy-2h-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-1-yl]-2h-1,3-benzodioxole

C22H22O8 (414.1314612)


   

(5r,9s)-5'-(furan-3-yl)-2',6-dioxo-3-(2-oxopropyl)-4,7,8,9-tetrahydrospiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate

(5r,9s)-5'-(furan-3-yl)-2',6-dioxo-3-(2-oxopropyl)-4,7,8,9-tetrahydrospiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate

C22H22O8 (414.1314612)


   

13,17-dihydroxy-6-(1-hydroxypropan-2-yl)-16-methoxy-2,7,20-trioxapentacyclo[11.8.0.0³,¹¹.0⁴,⁸.0¹⁴,¹⁹]henicosa-3(11),4(8),9,14(19),15,17-hexaen-12-one

13,17-dihydroxy-6-(1-hydroxypropan-2-yl)-16-methoxy-2,7,20-trioxapentacyclo[11.8.0.0³,¹¹.0⁴,⁸.0¹⁴,¹⁹]henicosa-3(11),4(8),9,14(19),15,17-hexaen-12-one

C22H22O8 (414.1314612)


   

6-(1-bromo-2-hydroxyethyl)-6,8b-dimethyl-1h,2h,2bh,3h,4h,4ah,5h,7h,9h,10h,10ah-cyclobuta[a]phenanthrene-2a,4,10-triol

6-(1-bromo-2-hydroxyethyl)-6,8b-dimethyl-1h,2h,2bh,3h,4h,4ah,5h,7h,9h,10h,10ah-cyclobuta[a]phenanthrene-2a,4,10-triol

C20H31BrO4 (414.1405586)


   

5'-(furan-3-yl)-2',6-dioxo-3-(2-oxopropyl)-4,7,8,9-tetrahydrospiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate

5'-(furan-3-yl)-2',6-dioxo-3-(2-oxopropyl)-4,7,8,9-tetrahydrospiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate

C22H22O8 (414.1314612)


   

methyl 1-(7-amino-5,8-dioxoquinolin-2-yl)-4-methyl-3h,4h,9h-pyrido[3,4-b]indole-3-carboxylate

methyl 1-(7-amino-5,8-dioxoquinolin-2-yl)-4-methyl-3h,4h,9h-pyrido[3,4-b]indole-3-carboxylate

C23H18N4O4 (414.1327988)


   

(10r,11r,12r)-12-(2h-1,3-benzodioxol-5-yl)-2,8,10,11-tetramethoxy-4,13-dioxatricyclo[7.4.0.0³,⁷]trideca-1(9),2,5,7-tetraene

(10r,11r,12r)-12-(2h-1,3-benzodioxol-5-yl)-2,8,10,11-tetramethoxy-4,13-dioxatricyclo[7.4.0.0³,⁷]trideca-1(9),2,5,7-tetraene

C22H22O8 (414.1314612)


   

(1r,2r,4s,6r,8s,9z,11s)-8-chloro-4,9-dimethyl-14-methylidene-13-oxo-5,12-dioxatricyclo[9.3.0.0⁴,⁶]tetradec-9-en-2-yl (2s,3s)-2,3-dihydroxy-2-methylbutanoate

(1r,2r,4s,6r,8s,9z,11s)-8-chloro-4,9-dimethyl-14-methylidene-13-oxo-5,12-dioxatricyclo[9.3.0.0⁴,⁶]tetradec-9-en-2-yl (2s,3s)-2,3-dihydroxy-2-methylbutanoate

C20H27ClO7 (414.14452220000004)


   

2-hydroxy-3-{[(2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}propyl (2e)-3-(4-hydroxyphenyl)prop-2-enoate

2-hydroxy-3-{[(2e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}propyl (2e)-3-(4-hydroxyphenyl)prop-2-enoate

C22H22O8 (414.1314612)


   

(5s,9s)-5'-(furan-3-yl)-2',6-dioxo-3-(2-oxopropyl)-4,7,8,9-tetrahydrospiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate

(5s,9s)-5'-(furan-3-yl)-2',6-dioxo-3-(2-oxopropyl)-4,7,8,9-tetrahydrospiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate

C22H22O8 (414.1314612)