Epipodophyllotoxin (BioDeep_00000397016)
PANOMIX_OTCML-2023 Toxin
代谢物信息卡片
(5R)-5beta-(3,4,5-Trimethoxyphenyl)-7alpha-(hydroxymethyl)-8alpha-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6beta-carboxylic acid 6,7-lactone
化学式: C22H22O8 (414.1314612)
中文名称: 表鬼臼毒素, 表鬼臼毒素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
InChI: InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20+/m0/s1
描述信息
Epipodophyllotoxin is a natural product found in Juniperus sabina and Podophyllum peltatum with data available.
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D003879 - Dermatologic Agents > D007641 - Keratolytic Agents
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
(-)-Epipodophyllotoxin (2) is an antiproliferative agent against cancer cells isolated from American mayapple Podophyllum peltatum, with GI50s of 0.36 and 0.24 μM in HeLa cells and MCF-7 cells, respectively. (-)-Epipodophyllotoxin can inhibit mitotic spindle assembly in vitro[1].
同义名列表
22 个代谢物同义名
(5R)-5beta-(3,4,5-Trimethoxyphenyl)-7alpha-(hydroxymethyl)-8alpha-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6beta-carboxylic acid 6,7-lactone; Furo(3,4:6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R-(5-alpha,5a-beta,8a-alpha,9-beta))-; (10R,11R,15R,16S)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one; (10R,11R,15R,16S)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1(9),2,7-trien-12-one; Furo(3,4:6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)-; Furo[3,4:6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,(5r,5ar,8ar,9s)-; (5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one; Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer; Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer; Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer; Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer; (-)-Epipodophyllotoxin; Epipodophyllotoxin; Podophyllotoxin; Podocon-25; Condyline; Podofilox; Warticon; Podofilm; Condylox; Wartec; CPH86
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 105111
- ChEMBL: CHEMBL282256
- Wikipedia: Epipodophyllotoxin
- MeSH: Podophyllotoxin
- ChemIDplus: 0004375079
- CAS: 4375-07-9
- CAS: 7/9/4375
- medchemexpress: HY-N7654
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 93611 - Dysosma versipellis [Syn. Podophyllum versipelle ]: -
- 224740 - Juniperus sabina: 10.1016/0031-9422(90)85460-W
- 33090 - Plants: -
- 35933 - Podophyllum peltatum: 10.1021/NP960155D
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yujin Guo, Beibei Chen, Jinxiu Guo, Pei Jiang, Jianhua Wang, Wenxue Sun. Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents.
Pharmaceutical biology.
2024 Dec; 62(1):233-249. doi:
10.1080/13880209.2024.2318350. [PMID: 38393642] - Meng Hao, Hui Xu. Chemistry and Biology of Podophyllotoxins: An Update.
Chemistry (Weinheim an der Bergstrasse, Germany).
2024 Jan; 30(4):e202302595. doi:
10.1002/chem.202302595. [PMID: 37814110] - Jiajia Duan, Jiaxing Sun, Tao Jiang, Xiao Ma, Xuejiao Li, Yuming Wang, Fangfang Zhang, Chuanxin Liu. Podophyllotoxin-mediated neurotoxicity via the microbiota-gut-brain axis in SD rats based on the toxicological evidence chain (TEC) concept.
The Science of the total environment.
2024 Jan; 907(?):168106. doi:
10.1016/j.scitotenv.2023.168106. [PMID: 37884145] - Mona Soltani, Reza Fotovat, Mohsen Sharifi, Najmeh Ahmadian Chashmi, Mehrdad Behmanesh. In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells.
Iranian journal of medical sciences.
2024 Jan; 49(1):30-39. doi:
10.30476/ijms.2023.94805.2611. [PMID: 38322161] - Hyun-Ju Yu, Ji-Ae Shin, Su-Jung Choi, Sung-Dae Cho. Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia‑1.
International journal of molecular medicine.
2023 Nov; 52(5):. doi:
10.3892/ijmm.2023.5306. [PMID: 37711052] - Keisuke Kobayashi, Masaomi Yamamura, Bunzo Mikami, Akira Shiraishi, Masato Kumatani, Honoo Satake, Eiichiro Ono, Toshiaki Umezawa. Anthriscus sylvestris Deoxypodophyllotoxin Synthase Involved in Podophyllotoxin Biosynthesis.
Plant & cell physiology.
2023 Oct; ?(?):. doi:
10.1093/pcp/pcad103. [PMID: 37948767] - Jiao Kong, Hongqian Kui, Yue Tian, Xianbin Kong, Tao He, Qingbo Li, Chunyu Gu, Jinhe Guo, Chuanxin Liu. Nephrotoxicity assessment of podophyllotoxin-induced rats by regulating PI3K/Akt/mTOR-Nrf2/HO1 pathway in view of toxicological evidence chain (TEC) concept.
Ecotoxicology and environmental safety.
2023 Oct; 264(?):115392. doi:
10.1016/j.ecoenv.2023.115392. [PMID: 37651795] - Giang Thu Nguyen, Ha Thi Hong Nguyen, Hoa Thi Tran, Huyen Thi Tran, Anh Ngoc Ho, Quang Ho Tran, Ngoc Bich Pham. Enhanced podophyllotoxin production of endophyte Fusarium proliferatum TQN5T by host extract and phenylalanine.
Applied microbiology and biotechnology.
2023 Sep; 107(17):5367-5378. doi:
10.1007/s00253-023-12659-1. [PMID: 37436482] - Di Hu, Xiaowei Luo, Yuxian Wang, Ming Gong, Zhurong Zou. [Gene cloning and enzymatic activity analysis of phenylalanine ammonia-lyase from Sinopodophyllum hexandrum (Royle) Ying].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2023 Jul; 39(7):2818-2838. doi:
10.13345/j.cjb.230076. [PMID: 37584134] - Zahra Danaeipour, Ghasemali Garoosi, Masoud Tohidfar, Mohammad Reza Bakhtiarizadeh, Mohammad Hossein Mirjalili. Comprehensive RNA-Seq-based study and metabolite profiling to identify genes involved in podophyllotoxin biosynthesis in Linum album Kotschy ex Boiss. (Linaceae).
Scientific reports.
2023 06; 13(1):9219. doi:
10.1038/s41598-023-36102-7. [PMID: 37286620] - Mostafa Sagharyan, Mohsen Sharifi, Elaheh Samari. Methyl jasmonate redirects the dynamics of carbohydrates and amino acids toward the lignans accumulation in Linum album cells.
Plant physiology and biochemistry : PPB.
2023 May; 198(?):107677. doi:
10.1016/j.plaphy.2023.107677. [PMID: 37086692] - Jing Hu, Jiali Wu, Qihuang Jin, Ling Zhang, Ning Shen, Yiyang Shu, Lu Cheng, Jian Zhang, Guangyi Hu, Kangjia Lv, Qizhi Jian, Hui Chen, Fang Zhang, Xiaodong Sun. Repurposing picropodophyllin as a potential thyroid eye disease treatment via delaying mitotic clonal expansion through a patient-derived preclinical platform.
Clinical and translational medicine.
2023 04; 13(4):e1218. doi:
10.1002/ctm2.1218. [PMID: 37012693] - Shenghu Guo, Yuchao Chen, Yongxing Zhu, Mei Tian. Transcriptome analysis reveals differentially expressed genes involved in somatic embryogenesis and podophyllotoxin biosynthesis of Sinopodophyllum hexandrum (Royle) T. S. Ying.
Protoplasma.
2023 Feb; ?(?):. doi:
10.1007/s00709-023-01843-9. [PMID: 36840780] - Sara Motyka, Karolina Jafernik, Halina Ekiert, Javad Sharifi-Rad, Daniela Calina, Basem Al-Omari, Agnieszka Szopa, William C Cho. Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 158(?):114145. doi:
10.1016/j.biopha.2022.114145. [PMID: 36586242] - Yi-Fong Chen, Bashir Lawal, Li-Jiau Huang, Sheng-Chu Kuo, Maryam Rachmawati Sumitra, Ntlotlang Mokgautsi, Hung-Yun Lin, Hsu-Shan Huang. In Vitro and In Silico Biological Studies of 4-Phenyl-2-quinolone (4-PQ) Derivatives as Anticancer Agents.
Molecules (Basel, Switzerland).
2023 Jan; 28(2):. doi:
10.3390/molecules28020555. [PMID: 36677621] - Lu Jin, Zhijun Song, Fang Cai, Lijun Ruan, Renwang Jiang. Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins.
Molecules (Basel, Switzerland).
2022 Dec; 28(1):. doi:
10.3390/molecules28010302. [PMID: 36615496] - Siyu Shen, Yuru Tong, Yunfeng Luo, Luqi Huang, Wei Gao. Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives.
Natural product reports.
2022 09; 39(9):1856-1875. doi:
10.1039/d2np00028h. [PMID: 35913409] - Shengnan Xu, Xinru Li, Shi Liu, Peilin Tian, Dengwu Li. Juniperus sabina L. as a Source of Podophyllotoxins: Extraction Optimization and Anticholinesterase Activities.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810205. [PMID: 36142118] - Ying-Lian Song, Shuai-Shuai Liu, Jie Yang, Jiao Xie, Xiang Zhou, Zhi-Bing Wu, Li-Wei Liu, Pei-Yi Wang, Song Yang. Discovery of Epipodophyllotoxin-Derived B2 as Promising XooFtsZ Inhibitor for Controlling Bacterial Cell Division: Structure-Based Virtual Screening, Synthesis, and SAR Study.
International journal of molecular sciences.
2022 Aug; 23(16):. doi:
10.3390/ijms23169119. [PMID: 36012385] - Xin Zhang, Tingting Yang, Xin Jin, Kaige Lin, Xiling Dai, Ting Gao, Guozheng Huang, Minghui Fan, Liang Ma, Zi Liu, Jianguo Cao. Synthesis and biological evaluation of cytotoxic activity of novel podophyllotoxin derivatives incorporating piperazinyl-cinnamic amide moieties.
Bioorganic chemistry.
2022 06; 123(?):105761. doi:
10.1016/j.bioorg.2022.105761. [PMID: 35358823] - Kishor Mazumder, Asma Aktar, Priyanka Roy, Biswajit Biswas, Md Emran Hossain, Kishore Kumar Sarkar, Sitesh Chandra Bachar, Firoj Ahmed, A S M Monjur-Al-Hossain, Koichi Fukase. A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship.
Molecules (Basel, Switzerland).
2022 May; 27(9):. doi:
10.3390/molecules27093036. [PMID: 35566385] - Rui Wang, Yinan Zhao, Zhenlong Huang, Yaxin Zhou, Wei Wang, Yang Xuan, Yuhong Zhen, Benzhi Ju, Shutao Guo, Shubiao Zhang. Self-Assembly of Podophyllotoxin-Loaded Lipid Bilayer Nanoparticles for Highly Effective Chemotherapy and Immunotherapy via Downregulation of Programmed Cell Death Ligand 1 Production.
ACS nano.
2022 03; 16(3):3943-3954. doi:
10.1021/acsnano.1c09391. [PMID: 35166522] - Jiao Kong, Tao He, Chuanxin Liu, Jianmei Huang. Multi modular toxicity assessment of nephrotoxicity in podophyllotoxin exposure rats on account of toxicological evidence chain (TEC) concept.
Ecotoxicology and environmental safety.
2022 Feb; 231(?):113157. doi:
10.1016/j.ecoenv.2021.113157. [PMID: 35026582] - Qianqian Zhang, Xuemei Li, Xiaoxin Gao, Chunran Cao, Yuchi Hu, Hongzhu Guo. Total saponins from stems and leaves of Panax quinquefolius L. ameliorate podophyllotoxin-induced myelosuppression and gastrointestinal toxicity.
Biomedical chromatography : BMC.
2022 Feb; 36(2):e5266. doi:
10.1002/bmc.5266. [PMID: 34648200] - Haoyu Tang, Min-Hao Wu, Hsiao-Yu Lin, Meng-Ru Han, Yueh-Hua Tu, Zhi-Jie Yang, Tun-Cheng Chien, Nei-Li Chan, Wei-Chen Chang. Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase.
Proceedings of the National Academy of Sciences of the United States of America.
2022 01; 119(1):. doi:
10.1073/pnas.2113770119. [PMID: 34969844] - Akihito Yokosuka, Chiaki Yamada, Makoto Saito, Shohei Yokogawa, Yoshihiro Mimaki. Chemical Constituents of the Leaves of Thujopsis dolabrata and Their Cytotoxicity.
Chemical & pharmaceutical bulletin.
2022; 70(10):720-725. doi:
10.1248/cpb.c22-00286. [PMID: 36184455] - Xuejie Zhu, Xiaojie Chen, Guoli Wang, Dan Lei, Xiaoyu Chen, Kehao Lin, Minjing Li, Haiyan Lin, Defang Li, Qiusheng Zheng. Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition.
Biological & pharmaceutical bulletin.
2022; 45(8):1027-1035. doi:
10.1248/bpb.b21-01006. [PMID: 35908886] - Dejan Orčić, Sanja Berežni, Dušan Škorić, Neda Mimica-Dukić. Comprehensive study of Anthriscus sylvestris lignans.
Phytochemistry.
2021 Dec; 192(?):112958. doi:
10.1016/j.phytochem.2021.112958. [PMID: 34560578] - Verónica Rodríguez-López, César Millán-Pacheco, Judith González-Christen, Maricruz Anaya-Ruíz, Omar Aristeo Peña-Morán. In Vitro Anti-Tubulin Activity on MCF10A Cell Line and In Silico Rigid/Semiflexible-Residues Docking, of Two Lignans from Bursera Fagaroides var. Fagaroides.
Molecules (Basel, Switzerland).
2021 Oct; 26(20):. doi:
10.3390/molecules26206155. [PMID: 34684736] - Davide Decembrino, Alessandra Raffaele, Ronja Knöfel, Marco Girhard, Vlada B Urlacher. Synthesis of (-)-deoxypodophyllotoxin and (-)-epipodophyllotoxin via a multi-enzyme cascade in E. coli.
Microbial cell factories.
2021 Sep; 20(1):183. doi:
10.1186/s12934-021-01673-5. [PMID: 34544406] - Dongxue Sun, Xiaoxia Gao, Qiao Wang, Kristopher W Krausz, Zhongze Fang, Youbo Zhang, Cen Xie, Frank J Gonzalez. Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Sep; 51(9):1047-1059. doi:
10.1080/00498254.2021.1961920. [PMID: 34319859] - Michela Alfieri, Iride Mascheretti, Roméo A Dougué Kentsop, Roberto Consonni, Franca Locatelli, Monica Mattana, Gianluca Ottolina. Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures.
Molecules (Basel, Switzerland).
2021 Aug; 26(17):. doi:
10.3390/molecules26175189. [PMID: 34500623] - Diana I Ivanova, Paraskev T Nedialkov, Alexander N Tashev, Marta Olech, Renata Nowak, Yana E Ilieva, Zlatina K Kokanova-Nedialkova, Teodora N Atanasova, George Angelov, Hristo M Najdenski. Junipers of Various Origins as Potential Sources of the Anticancer Drug Precursor Podophyllotoxin.
Molecules (Basel, Switzerland).
2021 Aug; 26(17):. doi:
10.3390/molecules26175179. [PMID: 34500615] - Yuanyuan Zhang, Min Lv, Hui Xu. Insecticidal activity of twin compounds from podophyllotoxin and cytisine.
Bioorganic & medicinal chemistry letters.
2021 07; 43(?):128104. doi:
10.1016/j.bmcl.2021.128104. [PMID: 33984477] - Zhen Meng, Tingting Yao, Wei Zhao, Hongmei Li, Ya-Jie Tang. [Research progress in biosynthesis of podophyllotoxin and its derivatives].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2021 Jun; 37(6):2026-2038. doi:
10.13345/j.cjb.210258. [PMID: 34227292] - Valtcho D Zheljazkov, Charles L Cantrell, Ivanka Semerdjieva, Tzenka Radoukova, Albena Stoyanova, Vasilina Maneva, Miroslava Kačániová, Tess Astatkie, Daniela Borisova, Ivayla Dincheva, Ivan Salamon. Essential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia.
Molecules (Basel, Switzerland).
2021 Jun; 26(12):. doi:
10.3390/molecules26123659. [PMID: 34203980] - M Lv, H-Y Su, M-L Li, D-L Yang, R-Y Yao, M-F Li, J-H Wei. Effect of UV-B radiation on growth, flavonoid and podophyllotoxin accumulation, and related gene expression in Sinopodophyllum hexandrum.
Plant biology (Stuttgart, Germany).
2021 May; 23 Suppl 1(?):202-209. doi:
10.1111/plb.13226. [PMID: 33280221] - Zinnia Shah, Umar Farooq Gohar, Iffat Jamshed, Aamir Mushtaq, Hamid Mukhtar, Muhammad Zia-Ui-Haq, Sebastian Ionut Toma, Rosana Manea, Marius Moga, Bianca Popovici. Podophyllotoxin: History, Recent Advances and Future Prospects.
Biomolecules.
2021 04; 11(4):. doi:
10.3390/biom11040603. [PMID: 33921719] - Rajiv Ranjan, Bhargab Kalita, Abhinav Singh, M H Yashavarddhan, Hridayesh Prakash, Manju Lata Gupta. Prophylactic administration of podophyllotoxin and rutin combination assists the revival of radiation-induced hematopoietic suppression in lethally irradiated mice.
Biochemical and biophysical research communications.
2021 04; 549(?):214-220. doi:
10.1016/j.bbrc.2021.02.085. [PMID: 33706191] - Wei Ha, Xiao-Bo Zhao, Wei-Hua Zhao, Jiang-Jiang Tang, Yan-Ping Shi. A colon-targeted podophyllotoxin nanoprodrug: synthesis, characterization, and supramolecular hydrogel formation for the drug combination.
Journal of materials chemistry. B.
2021 04; 9(14):3200-3209. doi:
10.1039/d0tb02719g. [PMID: 33885624] - Wei Zhao, Ying Cong, Hong-Mei Li, Shengying Li, Yuemao Shen, Qingsheng Qi, Youming Zhang, Yue-Zhong Li, Ya-Jie Tang. Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy.
Natural product reports.
2021 03; 38(3):470-488. doi:
10.1039/d0np00041h. [PMID: 32895676] - Pierre Boyé, François Serres, Franck Floch, Corinne Fournel-Fleury, Dominique Tierny. Prognostic value of pretreatment plasma D-dimer level in dogs with intermediate to high-grade non-Hodgkin lymphoma.
Veterinary and comparative oncology.
2021 Mar; 19(1):44-52. doi:
10.1111/vco.12629. [PMID: 32643242] - Mohd Afsahul Kalam, Akhtar H Malik, Aijaz Hassan Ganie, Tariq Ahmad Butt. Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine.
Journal of complementary & integrative medicine.
2021 Jan; 18(3):485-490. doi:
10.1515/jcim-2020-0178. [PMID: 33544520] - Ya-Nan Li, Ni Ning, Lei Song, Yun Geng, Jun-Ting Fan, Chao-Ying Ma, He-Zhong Jiang. Derivatives of Deoxypodophyllotoxin Induce Apoptosis through Bcl-2/Bax Proteins Expression.
Anti-cancer agents in medicinal chemistry.
2021; 21(5):611-620. doi:
10.2174/1871520620999200730160952. [PMID: 32748757] - Chang Zu, Yinglan Yu, Caiwei Yu, Yi Li, Runing Sun, Birendra Chaurasiya, Baoqiang Tang, Daquan Chen, Jiasheng Tu, Yan Shen. Highly loaded deoxypodophyllotoxin nano-formulation delivered by methoxy polyethylene glycol-block-poly (D,L-lactide) micelles for efficient cancer therapy.
Drug delivery.
2020 Dec; 27(1):248-257. doi:
10.1080/10717544.2020.1716875. [PMID: 32003255] - Davide Decembrino, Esther Ricklefs, Stefan Wohlgemuth, Marco Girhard, Katrin Schullehner, Guido Jach, Vlada B Urlacher. Assembly of Plant Enzymes in E. coli for the Production of the Valuable (-)-Podophyllotoxin Precursor (-)-Pluviatolide.
ACS synthetic biology.
2020 11; 9(11):3091-3103. doi:
10.1021/acssynbio.0c00354. [PMID: 33095000] - Cheng-Ting Zi, Liu Yang, Fa-Wu Dong, Qing-Hua Kong, Zhong-Tao Ding, Jun Zhou, Zi-Hua Jiang, Jiang-Miao Hu. Synthesis and antitumor activity of camptothecin- 4β-triazolopodophyllotoxin conjugates.
Natural product research.
2020 Aug; 34(16):2301-2309. doi:
10.1080/14786419.2018.1538223. [PMID: 30636439] - Xiangxiang Zhou, Na Chen, Hongzhi Xu, Xiaoming Zhou, Jianhong Wang, Xiaosheng Fang, Ya Zhang, Ying Li, Juan Yang, Xin Wang. Regulation of Hippo-YAP signaling by insulin-like growth factor-1 receptor in the tumorigenesis of diffuse large B-cell lymphoma.
Journal of hematology & oncology.
2020 06; 13(1):77. doi:
10.1186/s13045-020-00906-1. [PMID: 32546241] - Minglan Shi, Zhijia Li, Jingying Wang, Junpeng Li, Mei Zhang, Lijuan Lang, Kang Zeng. Successful treatment of refractory genital warts using 0.5\% podophyllotoxin-loaded nanostructured lipid carriers.
Dermatologic therapy.
2020 03; 33(2):e13245. doi:
10.1111/dth.13245. [PMID: 32020754] - Mabel Fragoso-Serrano, Rogelio Pereda-Miranda. Dereplication of podophyllotoxin and related cytotoxic lignans in Hyptis verticillata by ultra-high-performance liquid chromatography tandem mass spectrometry.
Phytochemical analysis : PCA.
2020 Jan; 31(1):81-87. doi:
10.1002/pca.2868. [PMID: 31328323] - Mendi G Márquez, Rachel Dotson, Sally Pias, Liliya V Frolova, Michaelann S Tartis. Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery.
Nanotheranostics.
2020; 4(1):40-56. doi:
10.7150/ntno.37738. [PMID: 31911893] - Palaniyandi Karuppaiya, Hsin Sheng Tsay. Enhanced production of podophyllotoxin, kaempferol, and quercetin from callus culture of Dysosma pleiantha (Hance) Woodson: An endangered medicinal plant.
Biotechnology and applied biochemistry.
2020 Jan; 67(1):95-104. doi:
10.1002/bab.1810. [PMID: 31489710] - Qinghua Cui, Ruikun Du, Miaomiao Liu, Lijun Rong. Lignans and Their Derivatives from Plants as Antivirals.
Molecules (Basel, Switzerland).
2020 Jan; 25(1):. doi:
10.3390/molecules25010183. [PMID: 31906391] - Yongfei Li, Mie Chen, Bowen Yao, Xun Lu, Xiaoqing Zhang, Peng He, Shauna N Vasilatos, Xiaomei Ren, Weihe Bian, Chang Yao. Transferrin receptor-targeted redox/pH-sensitive podophyllotoxin prodrug micelles for multidrug-resistant breast cancer therapy.
Journal of materials chemistry. B.
2019 10; 7(38):5814-5824. doi:
10.1039/c9tb00651f. [PMID: 31495855] - Zhi-Ping Che, Yue-E Tian, Sheng-Ming Liu, Jia Jiang, Mei Hu, Gen-Qiang Chen. Stereoselective synthesis of 4β-acyloxypodophyllotoxin derivatives as insecticidal agents.
Journal of Asian natural products research.
2019 Oct; 21(10):1028-1041. doi:
10.1080/10286020.2018.1490275. [PMID: 29974799] - Yilin Qiao, Nathan K Sunada, Alyssa E Hatada, Ingo Lange, Manana Khutsishvili, Valida Alizade, Daniel Atha, Dana-Lynn Ko'omoa-Lange, Robert P Borris. Potential anti-neuroblastoma agents from Juniperus oblonga.
Biochemical and biophysical research communications.
2019 08; 516(3):733-738. doi:
10.1016/j.bbrc.2019.06.123. [PMID: 31255282] - Alexandra Leary, Christophe Le Tourneau, Andrea Varga, Marie-Paule Sablin, Carlos Gomez-Roca, Nicolas Guilbaud, Aurelie Petain, Mariya Pavlyuk, Jean-Pierre Delord. Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
Investigational new drugs.
2019 08; 37(4):693-701. doi:
10.1007/s10637-018-0688-4. [PMID: 30547316] - Xiao-Ming Tan, Li-Ying Yu, Hong-Zhen Tang, Li-Chun Zhao, Ya-Qin Zhou. [Effects of exogenous IBA and fungal elicitor on growth of in vitro roots culture of Dysosma versipellis and production of podophyllotoxin].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Jun; 44(11):2226-2230. doi:
10.19540/j.cnki.cjcmm.20190301.012. [PMID: 31359646] - Zeyu Wu, Tingting Wang, Yonghong Song, Yang Lu, Tianyun Chen, Pengpeng Chen, Ailing Hui, Yan Chen, Haixiang Wang, Wencheng Zhang. Optimization on conditions of podophyllotoxin-loaded liposomes using response surface methodology and its activity on PC3 cells.
Journal of liposome research.
2019 Jun; 29(2):133-141. doi:
10.1080/08982104.2018.1502303. [PMID: 30022692] - Kunyong Ou, Yang Kang, Long Chen, Xinyu Zhang, Xuewen Chen, Yinghao Zheng, Jun Wu, Shuyu Guan. H2O2-responsive nano-prodrug for podophyllotoxin delivery.
Biomaterials science.
2019 May; 7(6):2491-2498. doi:
10.1039/c9bm00344d. [PMID: 30957821] - Crescencio Bazaldúa, Alexandre Cardoso-Taketa, Gabriela Trejo-Tapia, Brenda Camacho-Diaz, Jesús Arellano, Elsa Ventura-Zapata, María Luisa Villarreal. Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets.
PloS one.
2019; 14(9):e0222464. doi:
10.1371/journal.pone.0222464. [PMID: 31513694] - Cheng-Ting Zi, Liu Yang, Qing-Hua Kong, Hong-Mei Li, Xing-Zhi Yang, Zhong-Tao Ding, Zi-Hua Jiang, Jiang-Miao Hu, Jun Zhou. Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity.
Drug design, development and therapy.
2019; 13(?):3683-3692. doi:
10.2147/dddt.s215895. [PMID: 31695335] - Lishi Liu, Kai Han, Qi Wang, Yan Gao, Jingying Wang, Kang Zeng. [Acute and chronic toxicity of 0.5\% podophyllotoxin-loaded nanostructured lipid carriers to vaginal mucosa in rabbits and rats].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2018 Dec; 38(12):1527-1532. doi:
10.12122/j.issn.1673-4254.2018.12.21. [PMID: 30613025] - Kwang-Youn Kim, Kwang-Il Park, Seul Gi Lee, Su Youn Baek, Eun Hye Lee, Sang Chan Kim, Sang-Hun Kim, Sul-Gi Park, Sun-Nyoung Yu, Tae Woo Oh, Joung-Hee Kim, Keuk-Jun Kim, Soon-Cheol Ahn, Young Woo Kim. Deoxypodophyllotoxin in Anthriscus sylvestris alleviates fat accumulation in the liver via AMP-activated protein kinase, impeding SREBP-1c signal.
Chemico-biological interactions.
2018 Oct; 294(?):151-157. doi:
10.1016/j.cbi.2018.08.025. [PMID: 30148990] - Liliana Lalaleo, Pilar Testillano, Maria-Carmen Risueño, Rosa M Cusidó, Javier Palazon, Ruben Alcazar, Mercedes Bonfill. Effect of in vitro morphogenesis on the production of podophyllotoxin derivatives in callus cultures of Linum album.
Journal of plant physiology.
2018 Sep; 228(?):47-58. doi:
10.1016/j.jplph.2018.05.007. [PMID: 29852334] - Yang Chen, Kaijing Zhao, Fei Liu, Ying Li, Zeyu Zhong, Shijin Hong, Xiaodong Liu, Li Liu. Predicting Antitumor Effect of Deoxypodophyllotoxin in NCI-H460 Tumor-Bearing Mice on the Basis of In Vitro Pharmacodynamics and a Physiologically Based Pharmacokinetic-Pharmacodynamic Model.
Drug metabolism and disposition: the biological fate of chemicals.
2018 06; 46(6):897-907. doi:
10.1124/dmd.117.079830. [PMID: 29618575] - Ying-Lan Yu, Ya-Nan Li, Yong Zhang, Ru-Ning Sun, Jia-Sheng Tu, Yan Shen. Optimization and characterization of deoxypodophyllotoxin loaded mPEG-PDLLA micelles by central composite design with response surface methodology.
Chinese journal of natural medicines.
2018 Jun; 16(6):471-480. doi:
10.1016/s1875-5364(18)30081-5. [PMID: 30047469] - Xiaojie Zang, Guangji Wang, Qingyun Cai, Xiao Zheng, Jingwei Zhang, Qianying Chen, Baojin Wu, Xiong Zhu, Haiping Hao, Fang Zhou. A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport.
Drug metabolism and disposition: the biological fate of chemicals.
2018 05; 46(5):542-551. doi:
10.1124/dmd.117.079442. [PMID: 29523600] - Yan Gao, Kai Han, Qi Wang, Zhili Hu, Qingxiu Liu, Lishi Liu, Kang Zeng. Development of podophyllotoxin‑loaded nanostructured lipid carriers for the treatment of condyloma acuminatum.
Molecular medicine reports.
2018 05; 17(5):6506-6514. doi:
10.3892/mmr.2018.8696. [PMID: 29512736] - Fangxue Xu, Shiyuan Wang, Yujuan Li, Mengmeng Zheng, Xiaozhi Xi, Hui Cao, Xiaowei Cui, Hong Guo, Chunchao Han. Yield enhancement strategies of rare pharmaceutical metabolites from endophytes.
Biotechnology letters.
2018 May; 40(5):797-807. doi:
10.1007/s10529-018-2531-6. [PMID: 29605937] - Christel L C Seegers, Pieter G Tepper, Rita Setroikromo, Wim J Quax. Cytotoxic Deoxypodophyllotoxin Can Be Extracted in High Purity from Anthriscus sylvestris Roots by Supercritical Carbon Dioxide.
Planta medica.
2018 May; 84(8):544-550. doi:
10.1055/s-0043-123938. [PMID: 29253908] - Cheng-Ting Zi, Liu Yang, Feng-Qing Xu, Fa-Wu Dong, Dan Yang, Yan Li, Zhong-Tao Ding, Jun Zhou, Zi-Hua Jiang, Jiang-Miao Hu. Synthesis and anticancer activity of dimeric podophyllotoxin derivatives.
Drug design, development and therapy.
2018; 12(?):3393-3406. doi:
10.2147/dddt.s167382. [PMID: 30349193] - Ajaswrata Dutta, Manju Lata Gupta, Savita Verma. Podophyllotoxin and rutin in combination prevents oxidative stress mediated cell death and advances revival of mice gastrointestine following lethal radiation injury.
Free radical research.
2018 Jan; 52(1):103-117. doi:
10.1080/10715762.2017.1418982. [PMID: 29251020] - Krishnadas Nandagopal, Mihir Halder, Biswabhusan Dash, Sanghamitra Nayak, Sumita Jha. Biotechnological Approaches for Production of Anti-Cancerous Compounds Resveratrol, Podophyllotoxin and Zerumbone.
Current medicinal chemistry.
2018; 25(36):4693-4717. doi:
10.2174/0929867324666170404145656. [PMID: 28393691] - Wen-Xue Sun, Ya-Jing Ji, Yun Wan, Hong-Wei Han, Hong-Yan Lin, Gui-Hua Lu, Jin-Liang Qi, Xiao-Ming Wang, Yong-Hua Yang. Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.
Bioorganic & medicinal chemistry letters.
2017 09; 27(17):4066-4074. doi:
10.1016/j.bmcl.2017.07.047. [PMID: 28757065] - Anita Kumari, Dharam Singh, Sanjay Kumar. Biotechnological interventions for harnessing podophyllotoxin from plant and fungal species: current status, challenges, and opportunities for its commercialization.
Critical reviews in biotechnology.
2017 Sep; 37(6):739-753. doi:
10.1080/07388551.2016.1228597. [PMID: 27644897] - Zi-Zhen Wang, Wen-Xue Sun, Xue Wang, Ya-Han Zhang, Han-Yue Qiu, Jin-Liang Qi, Yan-Jun Pang, Gui-Hua Lu, Xiao-Ming Wang, Fu-Gen Yu, Yong-Hua Yang. Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents.
Chemical biology & drug design.
2017 08; 90(2):236-243. doi:
10.1111/cbdd.12942. [PMID: 28079286] - Debasis Nayak, Anmol Kumar, Souneek Chakraborty, Reyaz Ur Rasool, Hina Amin, Archana Katoch, Veena Gopinath, Vidushi Mahajan, Mahesh K Zilla, Bilal Rah, Sumit G Gandhi, Asif Ali, Lekha Dinesh Kumar, Anindya Goswami. Inhibition of Twist1-mediated invasion by Chk2 promotes premature senescence in p53-defective cancer cells.
Cell death and differentiation.
2017 07; 24(7):1275-1287. doi:
10.1038/cdd.2017.70. [PMID: 28498365] - Xiaoyan Zhi, Yuanyuan Zhang, Jiulin Huang, Hui Xu. Seven-Membered Lactam Derivatives of Podophyllotoxins as New Pesticidal Agents.
Scientific reports.
2017 06; 7(1):3917. doi:
10.1038/s41598-017-04136-3. [PMID: 28634395] - Neda Javadian, Ghasem Karimzadeh, Mohsen Sharifi, Ahmad Moieni, Mehrdad Behmanesh. In vitro polyploidy induction: changes in morphology, podophyllotoxin biosynthesis, and expression of the related genes in Linum album (Linaceae).
Planta.
2017 Jun; 245(6):1165-1178. doi:
10.1007/s00425-017-2671-2. [PMID: 28293732] - Filiberto Gutiérrez-Gutiérrez, Ana María Puebla-Pérez, Sirenia González-Pozos, José Manuel Hernández-Hernández, Armando Pérez-Rangel, Laura Patricia Alvarez, Gabriela Tapia-Pastrana, Araceli Castillo-Romero. Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides.
Molecules (Basel, Switzerland).
2017 May; 22(5):. doi:
10.3390/molecules22050799. [PMID: 28505094] - Xiang Yu, Zhiping Che, Hui Xu. Recent Advances in the Chemistry and Biology of Podophyllotoxins.
Chemistry (Weinheim an der Bergstrasse, Germany).
2017 Apr; 23(19):4467-4526. doi:
10.1002/chem.201602472. [PMID: 27726183] - Joël Doussot, Véronique Mathieu, Cyril Colas, Roland Molinié, Cyrielle Corbin, Josiane Montguillon, Laeticia Moreno Y Banuls, Sullivan Renouard, Frédéric Lamblin, Patricia Dupré, Benoit Maunit, Robert Kiss, Christophe Hano, Eric Lainé. Investigation of the Lignan Content in Extracts from Linum, Callitris and Juniperus Species in Relation to Their In Vitro Antiproliferative Activities.
Planta medica.
2017 Apr; 83(6):574-581. doi:
10.1055/s-0042-118650. [PMID: 27776375] - Wei Zhao, Chen Zhou, Ze-Yuan Guan, Ping Yin, Fusheng Chen, Ya-Jie Tang. Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin.
ACS chemical biology.
2017 03; 12(3):746-752. doi:
10.1021/acschembio.6b00842. [PMID: 28035796] - Jiulin Huang, Ming Xu, Shaochen Li, Jiani He, Hui Xu. Synthesis of some ester derivatives of 4'-demethoxyepipodophyllotoxin/2'-chloro-4'-demethoxyepipodophyllotoxin as insecticidal agents against oriental armyworm, Mythimna separata Walker.
Bioorganic & medicinal chemistry letters.
2017 02; 27(3):511-517. doi:
10.1016/j.bmcl.2016.12.026. [PMID: 28007447] - Pawan Kumar, Varun Jaiswal, Tarun Pal, Jagdish Singh, Rajinder S Chauhan. Comparative whole-transcriptome analysis in Podophyllum species identifies key transcription factors contributing to biosynthesis of podophyllotoxin in P. hexandrum.
Protoplasma.
2017 Jan; 254(1):217-228. doi:
10.1007/s00709-015-0938-7. [PMID: 26733390] - O J Nieto-Yañez, A A Resendiz-Albor, P A Ruiz-Hurtado, N Rivera-Yañez, M Rodriguez-Canales, M Rodriguez-Sosa, I Juarez-Avelar, M G Rodriguez-Lopez, M M Canales-Martinez, M A Rodriguez-Monroy. IN VIVO AND IN VITRO ANTILEISHMANIAL EFFECTS OF METHANOLIC EXTRACT FROM BARK OF BURSERA APTERA.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2017; 14(2):188-197. doi:
10.21010/ajtcam.v14i2.20. [PMID: 28573235] - Marie Kašparová, Jand Martina, Lenka Tůmová, Jiřina Spilková. Production of Podophyllotoxin by Plant Tissue Cultures of Juniperus virginiana.
Natural product communications.
2017 Jan; 12(1):101-103. doi:
". [PMID: 30549838] - Shreya Routh, Krishnadas Nandagopal. Patent Survey of Resveratrol, Taxol, Podophyllotoxin, Withanolides and Their Derivatives Used in Anticancer Therapy.
Recent patents on biotechnology.
2017; 11(2):85-100. doi:
10.2174/1872208311666170127114804. [PMID: 28137207] - Yutong Wang, Liping Huang, Yan Shen, Lidan Tang, Runing Sun, Di Shi, Thomas J Webster, Jiasheng Tu, Chunmeng Sun. Electrostatic interactions between polyglutamic acid and polylysine yields stable polyion complex micelles for deoxypodophyllotoxin delivery.
International journal of nanomedicine.
2017; 12(?):7963-7977. doi:
10.2147/ijn.s140573. [PMID: 29133981] - Yun Shen, Ri-Dao Chen, Ke-Bo Xie, Jian-Hua Zou, Jun-Gui Dai. [Cloning,expression and functional identification of secoisolariciresinol dehydrogenase gene from Dysosma versipellis callus].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Dec; 41(24):4568-4571. doi:
10.4268/cjcmm20162414. [PMID: 28936839] - Jihui Zhao, Xianghua Piao, Xiaoqin Shi, Aiyong Si, Yongtai Zhang, Nianping Feng. Podophyllotoxin-Loaded Nanostructured Lipid Carriers for Skin Targeting: In Vitro and In Vivo Studies.
Molecules (Basel, Switzerland).
2016 Nov; 21(11):. doi:
10.3390/molecules21111549. [PMID: 27869698] - Xiangming Zhang, Huijuan Liu, Bo Sun, Yan Sun, Weilong Zhong, Yanrong Liu, Shuang Chen, Honglei Ling, Lei Zhou, Xiangyan Jing, Yuan Qin, Ting Xiao, Tao Sun, Honggang Zhou, Cheng Yang. Novel Podophyllotoxin Derivatives as Partial PPARγ Agonists and their Effects on Insulin Resistance and Type 2 Diabetes.
Scientific reports.
2016 11; 6(?):37323. doi:
10.1038/srep37323. [PMID: 27853282] - Tobias Cohen, Toni M Schwarz, Frederic Vigant, Thomas J Gardner, Rosmel E Hernandez, Benhur Lee, Domenico Tortorella. The Microtubule Inhibitor Podofilox Inhibits an Early Entry Step of Human Cytomegalovirus.
Viruses.
2016 10; 8(10):. doi:
10.3390/v8100295. [PMID: 27783035] - De Long Yang, Ping Sun, Meng Fei Li. Chilling temperature stimulates growth, gene over-expression and podophyllotoxin biosynthesis in Podophyllum hexandrum Royle.
Plant physiology and biochemistry : PPB.
2016 Oct; 107(?):197-203. doi:
10.1016/j.plaphy.2016.06.010. [PMID: 27314513] - Dipto Bhattacharyya, Saptarshi Hazra, Anindyajit Banerjee, Riddhi Datta, Deepak Kumar, Saikat Chakrabarti, Sharmila Chattopadhyay. Transcriptome-wide identification and characterization of CAD isoforms specific for podophyllotoxin biosynthesis from Podophyllum hexandrum.
Plant molecular biology.
2016 Sep; 92(1-2):1-23. doi:
10.1007/s11103-016-0492-5. [PMID: 27387305] - Mayra Antúnez-Mojica, Javier Rodríguez-Salarichs, Mariano Redondo-Horcajo, Alejandra León, Isabel Barasoain, Ángeles Canales, F J Cañada, Jesús Jiménez-Barbero, Laura Alvarez, J Fernando Díaz. Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin.
Journal of natural products.
2016 08; 79(8):2113-21. doi:
10.1021/acs.jnatprod.6b00428. [PMID: 27518758] - Jing Zhang, Kai Han, Chun-Hui Wang, Ping-Jiao Chen, Yan Gao, Qi Wang, Meng-Lei Wang, Shan-Shan Wei, Zheng-Hui Yang, Zhi-Li Hu, Mei Zeng, Kang Zeng. [Distribution of podophyllotoxin-loaded nanostructured lipid carriers after topical application on cervical mucosa in Tibet minipigs].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2016 08; 36(9):1237-1241. doi:
". [PMID: 27687657] - Omar Aristeo Peña-Morán, María Luisa Villarreal, Laura Álvarez-Berber, Angélica Meneses-Acosta, Verónica Rodríguez-López. Cytotoxicity, Post-Treatment Recovery, and Selectivity Analysis of Naturally Occurring Podophyllotoxins from Bursera fagaroides var. fagaroides on Breast Cancer Cell Lines.
Molecules (Basel, Switzerland).
2016 Aug; 21(8):. doi:
10.3390/molecules21081013. [PMID: 27527135]