Exact Mass: 374.109
Exact Mass Matches: 374.109
Found 310 metabolites which its exact mass value is equals to given mass value 374.109,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Chrysosplenetin
Chrysosplenetin, also known as quercetagetin 3,6,7,3-tetramethyl ether or 3,6,7,3-tetra-methylquercetagetin, is a member of the class of compounds known as 7-o-methylated flavonoids. 7-o-methylated flavonoids are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, chrysosplenetin is considered to be a flavonoid lipid molecule. Chrysosplenetin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Chrysosplenetin can be found in german camomile, which makes chrysosplenetin a potential biomarker for the consumption of this food product. Chrysosplenetin is an O-methylated flavonol. It can be found in the root of Berneuxia thibetica and in Chamomilla recutita . Chrysosplenetin is a tetramethoxyflavone that is the 3,6,7,3-tetramethyl ether derivative of quercetagetin. It has a role as an antiviral agent and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a quercetagetin. Chrysosplenetin is a natural product found in Haplophyllum myrtifolium, Cleome amblyocarpa, and other organisms with data available. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
Skullcapflavone II
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
Portulacaxanthin II
Portulacaxanthin II is involved in betaxanthin biosynthesis (via dopaxanthin) pathway. This pathway demonstrates the formation of betaxanthins such as portulacaxanthin II and dopaxanthin by means of non-enzymatic condensation from the amino acids L-tyrosine and L-DOPA, respectively. Tyrosinases have been described as capable to use those betaxanthins [ GandiaHerr05a ] as substrates for further metabolization. [HMDB]. Portulacaxanthin II is found in many foods, some of which are pineappple sage, peppermint, japanese pumpkin, and medlar. Portulacaxanthin II is involved in betaxanthin biosynthesis (via dopaxanthin) pathway. This pathway demonstrates the formation of betaxanthins such as portulacaxanthin II and dopaxanthin by means of non-enzymatic condensation from the amino acids L-tyrosine and L-DOPA, respectively. Tyrosinases have been described as capable to use those betaxanthins [ GandiaHerr05a ] as substrates for further metabolization.
Casticin
Casticin is a tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4 have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii. It has a role as an apoptosis inducer and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a quercetagetin. Casticin is a natural product found in Psiadia viscosa, Psiadia dentata, and other organisms with data available. See also: Chaste tree fruit (part of). A tetramethoxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6, 7 and 4 have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii. Casticin is found in fruits. Casticin is a constituent of Vitex agnus-castus (agnus castus) seeds Casticin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=479-91-4 (retrieved 2024-07-01) (CAS RN: 479-91-4). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0). Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3. Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
Methylrosmarinic acid
Methyl rosmarinate is a hydroxycinnamic acid. Methyl rosmarinate is a natural product found in Dimetia scandens, Bourreria pulchra, and other organisms with data available. Methylrosmarinic acid is found in herbs and spices. Methylrosmarinic acid is isolated from Salvia (sage) species. Isolated from Salvia (sage) subspecies Methyl rosmarinate is found in herbs and spices. Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1]. Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1].
Neobaicalein
Scullcapflavone II is a tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6 and hydroxy groups at positons 5 and 2 respectively. It has a role as a plant metabolite and an anti-asthmatic drug. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a flavone. Skullcapflavone II is a natural product found in Lagochilus leiacanthus, Scutellaria guatemalensis, and other organisms with data available. A tetramethoxyflavone that is flavone substituted by methoxy groups at positions 6, 7, 8 and 6 and hydroxy groups at positons 5 and 2 respectively. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
5,8-Dihydroxy-3,3',4',7-tetramethoxyflavone
5,8-Dihydroxy-3,3,4,7-tetramethoxyflavone is found in citrus. 5,8-Dihydroxy-3,3,4,7-tetramethoxyflavone is isolated from sweet orange oi
3-O-Methylrosmarinic acid
3-O-Methylrosmarinic acid is a polyphenol metabolite detected in biological fluids (PMID: 20428313). A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Comosin
Comosin is found in herbs and spices. Comosin is a constituent of Muscari comosum (tassel hyacinth). Constituent of Muscari comosum (tassel hyacinth). Comosin is found in herbs and spices.
3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxy}propanoic acid
Pebrellin
Constituent of Mentha piperita and Thymus piperella. Pebrellin is found in many foods, some of which are spearmint, peppermint, pot marjoram, and herbs and spices. Pebrellin is found in herbs and spices. Pebrellin is a constituent of Mentha piperita and Thymus piperella
Hymenoxin
Isolated from Mentha piperita (peppermint). Hymenoxin is found in sunflower, peppermint, and herbs and spices. Hymenoxin is found in herbs and spices. Hymenoxin is isolated from Mentha piperita (peppermint).
4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone
4,5-Dihydroxy-3,5,7,8-tetramethoxyflavone is isolated from Lepidium sativum (garden cress). Isolated from Lepidium sativum (garden cress).
Menadiol disuccinate
Prothrombogenic vitamin. Prothrombogenic vitamin
Succinylaminoimidazole carboxamide riboside
Succinylaminoimidazole carboxamide riboside, also known as SAICAr, is the riboside form of the better known compound SAICAR (the ribotide). Ribosides chemically resemble ribotides except they do not contain a phosphate group. The appearance of succinylaminoimidazolecarboxamide riboside (SAICAriboside) and succinyladenosine (S-Ado) in cerebrospinal fluid, in urine, and, to a lesser extent, in plasma is characteristic of a heritable deficiency known as adenylosuccinate lyase deficiency (ADSL). Adenylosuccinate lyase deficiency is responsible for a range of symptoms that involve psychomotor retardation, often accompanied by epileptic seizures, and autistic features. In adenylosuccinate lyase deficiency it is believed that the buildup of SAICAr causes neurotoxic effects. In the severely affected individuals, the concentration levels of SAICAr and S-Ado are comparable, whereas in people with milder forms of the disease, the concentration of S-Ado is more than double that of those more severely affected, while SAICAr concentration levels remain comparable. Therefore, when present in sufficiently high levels, SAICAr can act as a metabotoxin and an acidogen. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart, liver, and kidney abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of untreated adenylosuccinate lyase deficiency. Many affected children with organic acidemias experience intellectual disability or delayed development.
3-(6-((4-(Trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide
Harmol glucuronide
Parmelin
Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2].
(2R,3R)-5,2-Dihydroxy-7,8-dimethoxy-3-O-acetylflavanone
5,4-Dihidroxy-6,7,3,5-tetramethoxyflavone
5,3-Dihydroxy-6,7,4,5-tetramethoxyflavone
Quercetagetin 6,7,34-tetramethyl ether
Gossypetin 3,7,8,4-tetramethyl ether
Myricetin 3,3,4,5-tetramethyl ether
8-C-Methylquercetagetin 3,6,7-trimethyl ether
8-C-Methylquercetagetin 3,6,3-trimethyl ether
5,4-Dihydroxy-7,2,3,5-tetramethoxyflavone
5,7-Dihydroxy-2,3,4,5-tetramethoxyflavone
3,5-Dihydroxy-6,7,8,4-tetramethoxyflavone
3,5-Dihydroxy-7,3,4,5-tetramethoxyflavone
Arteanoflavone
Arteanoflavone is a natural product found in Artemisia lucentica with data available.
Polycladin
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
Casticin
[Raw Data] CB178_Casticin_pos_50eV_CB000067.txt [Raw Data] CB178_Casticin_pos_40eV_CB000067.txt [Raw Data] CB178_Casticin_pos_30eV_CB000067.txt [Raw Data] CB178_Casticin_pos_20eV_CB000067.txt [Raw Data] CB178_Casticin_pos_10eV_CB000067.txt Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3. Casticin is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.
Neobaicalein
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
3,5-dihydroxy-3,4,5,7-tetramethoxyflavone
A tetramethoxyflavone that is myricetin in which the hydroxy groups at positions 3, 7, 4 and 5 have been replaced by methoxy groups. It has been isolated from Combretum quadrangulare.
4-Hydroxybenzophenone glucuronide|O1-(4-benzoyl-phenyl)-beta-D-glucopyranuronic acid|O1-(4-Benzoyl-phenyl)-beta-D-glucopyranuronsaeure
5-hydroxy-2-(4-hydroxy-2,3,5-trimethoxyphenyl)-7-methoxychromen-4-one
4alpha,10alpha-dihydroxy-1alpha,2alpha-epoxy-5alpha,7alphaH-guaia-11(13)-en-12,6alpha-olide
Diplotrin A
A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 2 and 5 and methoxy groups at positions 3, 7, 8 and 4. It has been isolated from the aerial parts of Mimosa diplotricha.
5-hydroxy-2-(2-hydroxy-3,4,5-trimethoxy-phenyl)-7-methoxy-chromen-4-one
7-Hydroxy-2-(3-methoxy-4-hydroxyphenyl)-3,5,8-trimethoxy-4H-1-benzopyran-4-one
3,8-epoxy-5-hydroxyvalechlorin-1-yl isovalerate|jatamanin O|rel-(2R,4S,4aS,5S,7S,7aS)-7-(acetyloxy)-7a-(chloromethyl)hexahydro-8-methylene-2,5-methanocyclopenta-1,3-dioxin-4-yl 3-methylbutanoate
Me glycoside,4,6-O-benzylidene,2-mesyl-3-O-Methylgalactose
3,7-diacetoxy epicatechin|3,7-diacetyl (-) epicatechin|3,7-O-diacetyl-(-)-epicatechin
Atranorin
Atranorin is a carbonyl compound. Atranorin is a natural product found in Candelaria concolor, Loxospora elatina, and other organisms with data available. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2]. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity[1][2].
6-(Hydroxymethyl)-1,2,3,5-tetramethoxy-8-hydroxy-9,10-anthraquinone
2,3,5,7-Tetra-Me ether-2,3,5,5,6,7-Hexahydroxyflavone|6,5-dihydroxy-3,5,7,2-tetramethoxyflavone
2-(5-Hydroxy-2,3-dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one
3,4,7-Tri-Me ether-3,3,4,5,5,7-Hexahydroxy-8-methylflavone
6-(1,2-dihydroxy-ethyl)-8-D-ribitol-1-yl-1H,8H-pteridine-2,4,7-trione|Photolumazin A
5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxychromen-4-one
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one [IIN-based: Match]
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one [IIN-based on: CCMSLIB00000848808]
5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one
2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-chromen-4-one
4',5-Dihydroxy-3',5',7,8-tetramethoxyflavone
Methyl rosmarinate
Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1]. Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase[1].
3-O-Methylrosmarinic acid
4-Methylphenyl 4,6-O-benzylidene-1-thio-b-D-glucopyranoside
4-METHYLPHENYL4,6-O-[(R)-PHENYLMETHYLENE]-1-THIO-BETA-D-GLUCOPYRANOSIDE
4-Methylphenyl 4,6-O-benzylidene-1-thio-b-D-galactopyranoside
(11ar)-(+)-10,11,12,13-tetrahydrodiindeno[7,1-de:1,7-fg][1,3,2]dioxaphosphocin-5-phenoxy
ethyl (2S)-3-(4-aminophenyl)-2-(1,3-dioxoisoindol-2-yl)propanoate,hydrochloride
3-O-(4-TOLUENESULFONYL)-2-O-ACETYL-L-METHYLFUCOSIDE
3-(4-(2-chlorophenoxy)piperidine-1-carboxamido)benzoic acid
1-(2,6-Dichlorobenzyl)-3-(1-Pyrrolidinylmethyl)-1H-Indazol-6-Amine
1-[2-[(4-CHLORO-2-NITROPHENYL)AMINO]BENZOYL]-4-METHYL-PIPERAZINE
4-Amino-5-cyano-6-ethoxy-N-[4-(methylsulfonyl)benzyl]-2-pyridinec arboxamide
((2R,3R,4R,5R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate
6-deoxy-1,2-O-isopropylidene-6-(4-methylbenzene)sulfonyloxy-D-glucofuranose
6-(difluoro(6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)Methyl)quinoline
17-Beta-Estradiol-3-O-Sulfate Sodium
17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].
Ethyl 3-(benzylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
4-(1,3-Benzodioxol-5-Yloxy)-2-[4-(1h-Imidazol-1-Yl)phenoxy]pyrimidine
NCI60_040650
Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2]. Skullcapflavone II, a flavonoid derived from Scutellaria baicalensis, has anti-inflammatory, anti-microbial activities. Skullcapflavone II regulates osteoclast differentiation, survival, and function. Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG[1][2].
603-56-5
Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
4H-1-Benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4,5-dimethoxyphenyl)-3,7-dimethoxy-
(4E)-4-[2-[1-carboxy-2-(4-hydroxyphenyl)ethyl]iminoethylidene]-2,3-dihydro-1H-pyridine-2,6-dicarboxylic acid
2-[[5-(2-Furanyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]-1-(4-morpholinyl)ethanone
N-[2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide
N-[3-chloro-2-(4-morpholinyl)phenyl]-2,3-dihydro-1,4-benzodioxin-6-carboxamide
4-[2-[(4-Fluorophenyl)methylamino]-2-oxoethyl]-2-methyl-5-thieno[3,2-b]pyrrolecarboxylic acid ethyl ester
4-[(E)-{2-[2-(2-fluorophenyl)quinazolin-4-yl]hydrazinylidene}methyl]benzene-1,3-diol
5-[(3-Formyl-2-hydroxy-4-methoxy-6-methylphenyl)-oxomethoxy]-2-hydroxy-3,6-dimethylbenzoic acid
(2R,3R,4S)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)azetidine-2-carbonitrile
(2R,3S,4S)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)-2-azetidinecarbonitrile
(2S,3R,4R)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)azetidine-2-carbonitrile
(2S,3S,4R)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)-2-azetidinecarbonitrile
Chrysosplenetin
Chrysosplenetin is a tetramethoxyflavone that is the 3,6,7,3-tetramethyl ether derivative of quercetagetin. It has a role as an antiviral agent and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It is functionally related to a quercetagetin. Chrysosplenetin is a natural product found in Haplophyllum myrtifolium, Cleome amblyocarpa, and other organisms with data available. A tetramethoxyflavone that is the 3,6,7,3-tetramethyl ether derivative of quercetagetin. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].
3,3,4,5-tetramethylmyricetin
A tetramethoxyflavone that is myricetin in which the hydroxy groups at positions 3, 3, 4 and 5 are replaced by methoxy groups. It is isolated from Bridelia ferruginea, a subtropical medicinal plant widely used in traditional African medicine.
6-CEPN
6-CEPN is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase)[1].
RK-9123016
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50?value of 0.18?μM but not other human sirtuin members including SIRT1 and SIRT3 at 100?μM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression[1].
3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate
(1r,2r,4s,5r,6s,9s,10s,11s,12r,13r)-12-chloro-2,11-dihydroxy-2,6,11-trimethyl-7-oxo-8,14-dioxatetracyclo[8.4.0.0¹,¹³.0⁵,⁹]tetradecan-4-yl acetate
3,5-dihydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
6-(1,2-dihydroxyethyl)-2,4-dihydroxy-8-(2,3,4,5-tetrahydroxypentyl)pteridin-7-one
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7,8-trimethoxychromen-4-one
(5r,5's,9s)-5'-(furan-3-yl)-2',3,6-trioxo-4,7,8,9-tetrahydro-1h-spiro[cycloocta[c]furan-5,3'-oxolan]-9-yl acetate
10-hydroxy-5-methoxy-2-(1,2,3-trihydroxypropan-2-yl)-1h,2h-furo[2,3-c]xanthen-6-one
[(1s,6s,7s,7as)-1-(acetyloxy)-7-(chloromethyl)-6,7-dihydroxy-1h,6h,7ah-cyclopenta[c]pyran-4-yl]methyl 3-methylbutanoate
5-hydroxy-2-(3-hydroxy-2,4,5-trimethoxyphenyl)-7-methoxychromen-4-one
(5r)-5-[(2r)-2-hydroxy-2-[(2s)-9-oxo-2h,3h-[1,4]dioxino[2,3-h]chromen-2-yl]propyl]-3-(hydroxymethyl)-5h-furan-2-one
3-(acetyloxy)-2-(3,4-dihydroxyphenyl)-5-hydroxy-3,4-dihydro-2h-1-benzopyran-7-yl acetate
2-(3,4-dimethoxyphenyl)-3,5-dihydroxy-7,8-dimethoxychromen-4-one
5-hydroxy-3-(3-hydroxy-2-methoxyphenyl)-6,7,8-trimethoxychromen-4-one
5-hydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-3,7-dimethoxychromen-4-one
(1s)-1-(3,4-dihydroxyphenyl)-3-methoxy-3-oxopropyl (2e)-3-(3,4-dihydroxyphenyl)prop-2-enoate
6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one
methyl 5-hydroxy-4-methoxy-2-[4-methoxy-2-(methoxycarbonyl)benzoyl]benzoate
2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-3,8-dimethoxychromen-4-one
(2s,4z)-4-(2-{[(1s)-1-carboxy-2-(4-hydroxyphenyl)ethyl]imino}ethylidene)-2,3-dihydro-1h-pyridine-2,6-dicarboxylic acid
5,3'-dihydroxy-3,7,4',5'-tetramethoxyflavone
{"Ingredient_id": "HBIN011018","Ingredient_name": "5,3'-dihydroxy-3,7,4',5'-tetramethoxyflavone","Alias": "NA","Ingredient_formula": "C19H18O8","Ingredient_Smile": "COC1=CC(=C2C(=C1)OC(=C(C2=O)OC)C3=CC(=C(C=C3OC)OC)O)O","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "6146","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
6-methoxyboeravinone c
{"Ingredient_id": "HBIN012518","Ingredient_name": "6-methoxyboeravinone c","Alias": "NA","Ingredient_formula": "C19H18O8","Ingredient_Smile": "CC1=C(C=C2C(=C1O)C(=O)C3(C(O2)C(OC4=C3C=CC=C4O)OC)O)OC","Ingredient_weight": "374.3 g/mol","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "13853","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "487169","DrugBank_id": "NA"}
ariseminone
{"Ingredient_id": "HBIN016751","Ingredient_name": "ariseminone","Alias": "NA","Ingredient_formula": "C19H18O8","Ingredient_Smile": "NA","Ingredient_weight": "374.34","OB_score": "NA","CAS_id": "149575-60-0","SymMap_id": "NA","TCMID_id": "NA","TCMSP_id": "NA","TCM_ID_id": "6679","PubChem_id": "NA","DrugBank_id": "NA"}
