Exact Mass: 373.1848912

Exact Mass Matches: 373.1848912

Found 500 metabolites which its exact mass value is equals to given mass value 373.1848912, within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error 0.01 dalton.

Hasubanonine

3,4,7,8-Tetramethoxy-17-methyl-7,8-didehydrohasubanan-6-one #

C21H27NO5 (373.18891320000006)

Dihydrolycorine acetate

1,2-O-Diacetylzephyranthine

C20H23NO6 (373.1525298)

Endoxifen

4-[(1Z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol

C25H27NO2 (373.2041682)

Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity. (PMID: 23274567) Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. (Wikipedia) The pharmacological activity of Tamoxifen is dependent on its conversion to its active metabolite, endoxifen, by CYP2D6. (PMID: 23711794) Tamoxifen is a largely inactive pro-drug, requiring metabolism into its most important metabolite endoxifen. Since the cytochrome P450 (CYP) 2D6 enzyme is primarily involved in this metabolism, genetic polymorphisms of this enzyme, but also drug-induced CYP2D6 inhibition can result in considerably reduced endoxifen formation and as a consequence may affect the efficacy of tamoxifen treatment. (PMID: 23760858)

alpha-Hydroxy-N-desmethyltamoxifen

(3E)-4-{4-[2-(methylamino)ethoxy]phenyl}-3,4-diphenylbut-3-en-2-ol

C25H27NO2 (373.2041682)

alpha-Hydroxy-N-desmethyltamoxifen is a metabolite of tamoxifen. Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. (Wikipedia)

Autumnaline

(1S)-1-[2-(3-hydroxy-4,5-dimethoxyphenyl)ethyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol

C21H27NO5 (373.1889132)

(S)-Autumnaline is an isoquinoline alkaloid. (S)-autumnaline has been reported in Colchicum autumnale, Colchicum ritchii Autumnaline is a natural organic compound classified as a protoberberine alkaloid, which is a subset of the larger category of alkaloids. It is primarily derived from plants, particularly those of the Colchicum genus, including Colchicum autumnale. This compound shares structural similarities with other alkaloids, such as colchicine, and is known for its potential biological activities. The biological functions of autumnaline are not as extensively studied as those of colchicine, but research suggests it may have several notable effects: Cytotoxic Properties: Like many alkaloids, autumnaline exhibits cytotoxicity, meaning it has the ability to damage or inhibit the growth of cells. This property could be exploited in cancer research, as cytotoxic compounds are often investigated for their potential to Inhibit tumor growth. Antioxidant Activity: Some studies have indicated that autumnaline may possess antioxidant properties. Antioxidants are important in protecting cells from damage caused by reactive oxygen species, which are implicated in various diseases and aging processes. Anti-inflammatory Effects: There is emerging evidence suggesting that certain alkaloids, including some protoberberine alkaloids, may have anti-inflammatory effects. This could be significant in the context of treating inflammatory conditions. Potential Medicinal Uses: Due to its complex structure and biological activities, autumnaline could be of interest for medicinal purposes. However, further research is needed to fully understand its potential therapeutic applications, as well as its safety and efficacy. (1S)-1,2,3,4-Tetrahydro-1-[2-(3-hydroxy-4,5-dimethoxyphenyl)ethyl]-6-methoxy-2-methyl-7-isoquinolinol. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=23068-65-7 (retrieved 2024-10-11) (CAS RN: 23068-65-7). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Pseudoargiopinin III

(2S)-N-(5-aminopentyl)-2-[[2-(1H-indol-3-yl)acetyl]amino]butanediamide

C19H27N5O3 (373.2113792)

Spirotetramat

Pesticide7_Spirotetramat_C21H27NO5_Carbonic acid, 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en-4-yl ethyl ester

C21H27NO5 (373.18891320000006)

D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals CONFIDENCE standard compound; INTERNAL_ID 686; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9268; ORIGINAL_PRECURSOR_SCAN_NO 9267 CONFIDENCE standard compound; INTERNAL_ID 686; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9334; ORIGINAL_PRECURSOR_SCAN_NO 9333 CONFIDENCE standard compound; INTERNAL_ID 686; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9232; ORIGINAL_PRECURSOR_SCAN_NO 9231 CONFIDENCE standard compound; INTERNAL_ID 686; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9326; ORIGINAL_PRECURSOR_SCAN_NO 9325 CONFIDENCE standard compound; INTERNAL_ID 686; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9276; ORIGINAL_PRECURSOR_SCAN_NO 9275 CONFIDENCE standard compound; INTERNAL_ID 686; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9319; ORIGINAL_PRECURSOR_SCAN_NO 9318

N-Jasmonoyltyrosine

C21H27NO5 (373.18891320000006)

SB 202327

C20H27N3O4 (373.20014620000006)

CHEMBL518407

C24H23NO3 (373.16778480000005)

7beta-Hydroxycatuabine D

C19H23N3O5 (373.16376280000003)

SCHEMBL8214462

C20H23NO6 (373.1525298)

Cliviasindhine

C20H23NO6 (373.1525298)

(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-yliden)-amin|(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-yliden)-amine|1,5,5-trimethyl-2,2-diphenyl-1,2,2,4-tetrahydro-4,4-azanylylidene-bis-pyrazol-3-one|Methylrubazonsaeure

(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-yliden)-amin|(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-pyrazol-4-yliden)-amine|1,5,5-trimethyl-2,2-diphenyl-1,2,2,4-tetrahydro-4,4-azanylylidene-bis-pyrazol-3-one|Methylrubazonsaeure