Clebopride (BioDeep_00000600237)

   


代谢物信息卡片


Clebopride

化学式: C20H24ClN3O2 (373.1556954)
中文名称: 氯波必利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=C(C=C1C(=O)NC2CCN(CC2)CC3=CC=CC=C3)Cl)N
InChI: InChI=1S/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25)

描述信息

A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents

同义名列表

1 个代谢物同义名

Clebopride



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Zhirong Tan, Dongsheng Ouyang, Yao Chen, Gan Zhou, Shan Cao, Yicheng Wang, Xiujuan Peng, Honghao Zhou. Development and validation of a LC-MS/MS method for the determination of clebopride and its application to a pharmacokinetics study in healthy Chinese volunteers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Aug; 878(23):2072-6. doi: 10.1016/j.jchromb.2010.06.006. [PMID: 20598654]
  • Oliver Distler, Angela Del Rosso, Roberto Giacomelli, Paola Cipriani, Maria L Conforti, Serena Guiducci, Renate E Gay, Beat A Michel, Pius Brühlmann, Ulf Müller-Ladner, Steffen Gay, Marco Matucci-Cerinic. Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers. Arthritis research. 2002; 4(6):R11. doi: 10.1186/ar596. [PMID: 12453314]
  • J M Herrerías Gutiérrez, J García Montes. The effect of clebopride-simethicone combination therapy on echographic visualization of retrogastric organs. Clinical therapeutics. 1994 May; 16(3):483-9. doi: NULL. [PMID: 7923315]
  • P R Robinson, M D Jones, J Maddock, L W Rees. Simultaneous determination of clebopride and a major metabolite N-desbenzylclebopride in plasma by capillary gas chromatography-negative-ion chemical ionization mass spectrometry. Journal of chromatography. 1991 Mar; 564(1):147-61. doi: 10.1016/0378-4347(91)80077-p. [PMID: 1860909]
  • P R Robinson, M D Jones, J Maddock. Determination of clebopride in plasma by capillary gas chromatography-negative-ion chemical ionization mass spectrometry. Journal of chromatography. 1988 Nov; 432(?):153-63. doi: 10.1016/s0378-4347(00)80641-6. [PMID: 3220885]
  • M Yano, K Nakamichi, T Yamaki, T Fukami, K Ishikawa, I Matsumoto. Radioimmunoassay for clebopride, a new benzamide drug with antidopaminergic activity. Chemical & pharmaceutical bulletin. 1984 Apr; 32(4):1491-7. doi: 10.1248/cpb.32.1491. [PMID: 6467458]
  • F R Pérez-López, C M González-Moreno, M D Abós, J A Andonegui, R H Corvo. Pituitary response to a dopamine antagonist at different times of the day in normal women. Acta endocrinologica. 1982 Aug; 100(4):481-5. doi: 10.1530/acta.0.1000481. [PMID: 6812337]
  • J Segura, I García, L Borja, E Tarrús, O M Bakke. The pharmacokinetics of a new benzamide drug clebopride, in the rat and the dog. The Journal of pharmacy and pharmacology. 1981 Apr; 33(4):214-8. doi: 10.1111/j.2042-7158.1981.tb13760.x. [PMID: 6115902]
  • F R Perez-Lopez, A Legido, M Sisskin, M D Abos. Stimulatory effect of clebopride on human prolactin secretion. Fertility and sterility. 1980 Nov; 34(5):452-5. doi: . [PMID: 6777202]
  • J Segura, O M Bakke, G Huizing, A H Beckett. In vivo metabolism of clebopride in three animal species and in man. Drug metabolism and disposition: the biological fate of chemicals. 1980 Mar; 8(2):87-92. doi: NULL. [PMID: 6103794]