Sepimostat (BioDeep_00000668725)
代谢物信息卡片
化学式: C21H19N5O2 (373.1538674)
中文名称: 司匹司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN=C(N1)NC2=CC=C(C=C2)C(=O)OC3=CC4=C(C=C3)C=C(C=C4)C(=N)N
InChI: InChI=1S/C21H19N5O2/c22-19(23)16-2-1-15-12-18(8-5-14(15)11-16)28-20(27)13-3-6-17(7-4-13)26-21-24-9-10-25-21/h1-8,11-12H,9-10H2,(H3,22,23)(H2,24,25,26)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7?μM[1].
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Tsuruda, S Kanno, H Ohtani, R Suzuki, M Nishioka, Y Koshiyama, M Kurumi. Effect of sepimostat mesilate on experimental venous thrombosis in rats.
Thrombosis research.
2001 Feb; 101(3):193-201. doi:
10.1016/s0049-3848(00)00400-x. [PMID: 11228342] - C Yuasa, K Irimura, M Oda, K Fukui, T Oka. Oral administration of sepimostat mesilate prevents acute alcohol pancreatic injury in rats.
The Journal of pharmacy and pharmacology.
1999 Jul; 51(7):867-71. doi:
10.1211/0022357991773087. [PMID: 10467964] - T Hirano. Pancreatic injuries in rats with fecal peritonitis: protective effect of a new synthetic protease inhibitor, sepinostat mesilate (FUT-187).
The Journal of surgical research.
1996 Mar; 61(2):301-6. doi:
10.1006/jsre.1996.0120. [PMID: 8656599] - Z H Wang, T Manabe, G Ohshio, T Hirano, N Okada, T Imamura, Y Kawaguchi, F Yotsumoto, K Yamaki, M Imamura. Effect of the oral administration of sepimostat mesilate on cerulein induced acute pancreatitis in rats.
Arzneimittel-Forschung.
1995 Oct; 45(10):1082-6. doi:
NULL. [PMID: 8595064] - K Nakamura, A Johmura, M Oda, Y Ino, H Uchiyama, H Ohtani, H Miyazaki, M Kurumi, Y Akizawa, T Oka. [Inhibitory effects of sepimostat mesilate (FUT-187) on the activities of trypsin-like serine proteases in vitro].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1995 Mar; 115(3):201-12. doi:
10.1248/yakushi1947.115.3_201. [PMID: 7738778] - E J Spicer, A Maruden, K Terazawa. The evaluation of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) by oral administration in cynomolgus monkeys in a 13 week subacute toxicity study.
The Journal of toxicological sciences.
1992 Dec; 17 Suppl 4(?):101-23. doi:
10.2131/jts.17.supplementiv_101. [PMID: 1296020] - S Nakano, H Yada, K Irimura, H Asanoma, T Hirota, K Terazawa. [A 52-week chronic oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) in dogs].
The Journal of toxicological sciences.
1992 Dec; 17 Suppl 4(?):163-99. doi:
10.2131/jts.17.supplementiv_163. [PMID: 1296022] - K Watanabe, K Terazawa, M Terabayashi, S Kuramoto, Y Yokomoto, K Otani, K Sato, M Kurotori, K Shimamura, K Yamashita. [A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) in dogs.
The Journal of toxicological sciences.
1992 Dec; 17 Suppl 4(?):61-99. doi:
10.2131/jts.17.supplementiv_61. [PMID: 1296028] - S Kuramoto, M Oda, K Terazawa, M Terabayashi, K Otani, K Shimamura, A Ouchida. [Antigenicity study of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) in guinea pigs and mice.
The Journal of toxicological sciences.
1992 Dec; 17 Suppl 4(?):287-301. doi:
10.2131/jts.17.supplementiv_287. [PMID: 1296027] - S Okazaki, A Todate, E Yamazaki, K Anabuki, K Tamura, T Hoshiya, A Maruden, K Terazawa. [A 13-week subacute oral toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) in rats].
The Journal of toxicological sciences.
1992 Dec; 17 Suppl 4(?):17-59. doi:
10.2131/jts.17.supplementiv_17. [PMID: 1296023] - S Okazaki, E Yamazaki, K Hatayama, K Tamura, T Aikawa, K Terazawa, A Maruden. [A 52-week oral chronic toxicity study of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) in rats with a recovery period of 5 weeks.
The Journal of toxicological sciences.
1992 Dec; 17 Suppl 4(?):125-62. doi:
10.2131/jts.17.supplementiv_125. [PMID: 1296021] - H Murakami, M Togawa, S Takahashi, N Kasahara, J Yamamoto, N Matsuura, Y Koshiyama, Y Ino, M Oda. Pharmacological studies of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate. Effects on experimental pancreatitis.
Arzneimittel-Forschung.
1990 Dec; 40(12):1352-8. doi:
. [PMID: 2095132] - T Marunaka, M Maniwa, E Matsushima, K Yoshida, R Azuma, M Kurotori, S Komatsu. High-performance liquid chromatographic determination of 6-amidino-2-naphthyl [4-(4,5-dihydro-1H-imidazol-2-yl) amino]benzoate dimethanesulphonate and its metabolites in biological fluids.
Journal of chromatography.
1988 Dec; 433(?):177-86. doi:
10.1016/s0378-4347(00)80596-4. [PMID: 3266216]