Exact Mass: 288.9843
Exact Mass Matches: 288.9843
Found 122 metabolites which its exact mass value is equals to given mass value 288.9843,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Quinethazone
Quinethazone is only found in individuals that have used or taken this drug. It is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.As a diuretic, quinethazone inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of quinethazone is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D049990 - Membrane Transport Modulators
Tillmans Reagent
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
2-[2,6-Bis(methylsulfinyl)-4-hydroxyphenyl]diazenecarboxamide
(-)-8S-3-bromo-5-hydroxy-4-methoxyphenylalanine|2-amino-3-(3-bromo-5-hydroxy-4-methoxyphenyl)propanoic acid
2-AMINO-4-[2-CHLORO-5-(TRIFLUOROMETHYL)PHENYLAMINO]-1,3,5-TRIAZINE 98
6-Bromo-2-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline
2-Nitro-4-(trifluoromethyl)benzenesulfonyl chloride
3-AMINO-3-(3-BROMO-4-HYDROXY-5-METHOXY-PHENYL)-PROPIONIC ACID
3-AMINO-3-(5-BROMO-3-METHOXY-2-HYDROXY-PHENYL)-PROPIONIC ACID
5-(4-CHLOROBENZYLSULFONYL)-1,3,4-THIADIAZOL-2-AMINE
2-(4-BROMO-3-METHYLPHENYL)ISOTHIAZOLIDINE 1,1-DIOXIDE
2-(5-CHLORO-THIOPHEN-2-YL)-QUINOLINE-4-CARBOXYLIC ACID
(5r)-3-(4-bromo-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one
2-(4-bromo-2,5-dimethoxyphenyl)-2-methoxyethanamine
3-(4-BROMO-3-FLUOROPHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE
1-[(2,2,2-TRICHLOROETHOXY)CARBONYL]-PYRROLIDINE-2-CARBOXYLIC ACID
1-(4-bromophenyl)-2,2,2-trifluoroethan-1-aminehydrochloride
PYRIDINE-4-CARBOXYLIC ACID PENTAFLUOROPHENYL ESTER
2-Ethylsulfonylimidazo[1,2-a]pyridine-3-sulfonamide
Tizanidine hydrochloride
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents D002491 - Central Nervous System Agents > D000927 - Anticonvulsants D002491 - Central Nervous System Agents > D000700 - Analgesics Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Target: α2-adrenergic receptor Tizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia. Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5\% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment.
3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE-4-CARBONYL CHLORIDE
6-(CHLOROMETHYL)-2-[5-(TRIFLUOROMETHYL)-2-PYRIDYL]PYRIMIDIN-4-OL
6-BROMO-3-(3H-IMIDAZOL-4-YLMETHYLENE)-1,3-DIHYDRO-INDOL-2-ONE
(R)-1-(4-BROMOPHENYL)-2,2,2-TRIFLUOROETHYLAMINE HCL
4-(6-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-pyrimidinamine
4-(4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-pyrimidinamine
methyl 4-chloro-2-(trifluoromethyl)quinoline-6-carboxylate
3-[(2-HYDROXYETHYL)THIO]-6-NITRO-2,3-DIHYDRO-1H-1LAMBDA6-BENZO[B]THIOPHENE-1,1-DIONE
2-(5-BROMO-FURAN-2-YL)-2,3-DIHYDRO-BENZOFURAN-5-CARBONITRILE
Carbamic acid, N-(5-bromo-2-nitro-3-pyridinyl)-, ethyl ester
5-Bromo-1,2-dicarboxylic acid-1H-Pyrrole 1-(1,1-dimethylethyl) ester
Propanedinitrile, 2-(4-oxo-3- phenyl-2-selenazolidinylidene)-
METHYL 4-CHLORO-6-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLATE
2-Bromo-N-methyl-5-(trifluoromethyl)aniline hydrochloride
4-Bromo-N-methyl-2-(trifluoromethyl)aniline hydrochloride
(3-(4-CHLOROBENZO[D]THIAZOL-2-YL)PHENYL)BORONIC ACID
dicarbonyl(pentamethylcyclopentadienyl)molybdenum dimer
Benzenesulfonylchloride, 4-nitro-3-(trifluoromethyl)-
5-Hydroxy-7-(4-nitrophenyl)-1,3-benzoxathiol-2-one
5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate(3-)
5-Chloropyridin-3-yl benzo[b]thiophene-2-carboxylate
(2Z)-2-[(4-chlorophenyl)sulfonylmethylidene]-1,3-thiazolidin-4-one
6-Chloro-3-[2-(2-furanyl)-2-oxoethyl]-1,4-benzoxazin-2-one
QUINETHAZONE
C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents D049990 - Membrane Transport Modulators
