Quinethazone (BioDeep_00000006477)

 

Secondary id: BioDeep_00001867884

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulphonamide

化学式: C10H12ClN3O3S (289.0287872)
中文名称: 喹乙宗
谱图信息: 最多检出来源 Homo sapiens(blood) 14.29%

分子结构信息

SMILES: CCC1NC(=O)C2=CC(=C(Cl)C=C2N1)S(N)(=O)=O
InChI: InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)

描述信息

Quinethazone is only found in individuals that have used or taken this drug. It is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.As a diuretic, quinethazone inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of quinethazone is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
C - Cardiovascular system > C03 - Diuretics > C03B - Low-ceiling diuretics, excl. thiazides > C03BA - Sulfonamides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators

同义名列表

12 个代谢物同义名

7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulphonamide; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide; 7-chloro-2-ethyl-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide; Quinethazone, (+-)-isomer; Quinethazone, (+)-isomer; Quinethazone, (-)-isomer; Chinethazonum; QUINETHAZONE; Chinetazone; Quinethazon; Hydromox; Quinethazone



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • J K WALES. PRELIMINARY STUDIES ON THE ACTION OF QUINETHAZONE IN NORMAL SUBJECTS AND IN HYPERTENSIVE PATIENTS. The British journal of clinical practice. 1965 Jul; 19(?):387-92. doi: NULL. [PMID: 14308190]
  • D E HUTCHEON. PROBLEMS IN THE HUMAN PHARMACOLOGY OF DIURETIC DRUGS. The Journal of new drugs. 1965 Jan; 5(1):13-20. doi: 10.1002/j.1552-4604.1965.tb00218.x. [PMID: 14283064]
  • P A SERRANO, L B CHAVEZ. CHANGES OF TISSUE CATECHOLAMINES IN THIAZIDE-FED RATS. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1964 Oct; 117(?):31-4. doi: 10.3181/00379727-117-29489. [PMID: 14219952]
  • G SANDLER. QUINETHAZONE, A NEW ORAL DIURETIC. British medical journal. 1964 Aug; 2(5404):288-92. doi: 10.1136/bmj.2.5404.288. [PMID: 14160213]
  • D E HUTCHEON, G B LEONARD, A E LONIEWSKI. BIOASSAY OF DIURETICS IN CONGESTIVE HEART FAILURE. A COMPARISON OF QUINETHAZONE WITH HYDROCHLOROTHIAZIDE. The Journal of new drugs. 1964 May; 4(3):148-53. doi: 10.1002/j.1552-4604.1964.tb00195.x. [PMID: 14185005]
  • S C FREED. MECHANISM OF ANTI-HYPERTENSIVE ACTION OF QUINETHAZONE. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1963 Nov; 114(?):421-2. doi: 10.3181/00379727-114-28694. [PMID: 14101206]
  • K K DATEY, V N PANDYA. QUINETHAZONE AS A DIURETIC AGENT. Journal of postgraduate medicine. 1963 Jul; 9(?):99-105. doi: NULL. [PMID: 14066683]