Polaprezinc (BioDeep_00000855538)

   


代谢物信息卡片


Polaprezinc

化学式: C9H13N4O3Zn- (289.0279)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(NC=N1)CC(C(=O)O)[N-]C(=O)CCN.[Zn]
InChI: /m0./s1

描述信息

D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents

同义名列表

1 个代谢物同义名

Polaprezinc



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Wenbo Xie, Lu An, Zhaoyang Liu, Xindi Wang, Xueqi Fu, Junfeng Ma. Therapeutic Effect of Polaprezinc on Reflux Esophagitis in the Rat Model. Digestive diseases and sciences. 2023 Jun; ?(?):. doi: 10.1007/s10620-023-07990-6. [PMID: 37335414]
  • Kensaku Sakae, Machi Suka, Hiroyuki Yanagisawa. Polaprezinc (Zinc-L-Carnosine Complex) as an Add-on Therapy for Binge Eating Disorder and Bulimia Nervosa, and the Possible Involvement of Zinc Deficiency in These Conditions: A Pilot Study. Journal of clinical psychopharmacology. 2020 Nov; 40(6):599-606. doi: 10.1097/jcp.0000000000001284. [PMID: 33044355]
  • Teppei Okamoto, Shingo Hatakeyama, Kyo Togashi, Tomoko Hamaya, Yoshimi Tanaka, Kengo Imanishi, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki, Chikara Ohyama. Pre-dialysis serum creatinine as an independent predictor of responsiveness to zinc supplementation among patients on hemodialysis. Clinical and experimental nephrology. 2020 Oct; 24(10):955-962. doi: 10.1007/s10157-020-01911-x. [PMID: 32557260]
  • Teppei Okamoto, Shingo Hatakeyama, Sakae Konishi, Kazutaka Okita, Yoshimi Tanaka, Kengo Imanishi, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki, Chikara Ohyama. Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single-center, open-label, prospective randomized study. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2020 Oct; 24(5):568-577. doi: 10.1111/1744-9987.13461. [PMID: 31794152]
  • Kei Furihata, Masaru Tsuchikawa, Takaki Miwa, Yuji Naito, Koji Oba, Masafumi Sakagami. Efficacy and Safety of Polaprezinc (Zinc Compound) on Zinc Deficiency: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials Using Individual Patient Data. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041128. [PMID: 32316581]
  • Fumitsugu Yoshikawa, Tetsu Nakajima, Masaharu Hanada, Kazuo Hirata, Tohru Masuyama, Ryuichi Aikawa. Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial. Medicine. 2019 Mar; 98(10):e14637. doi: 10.1097/md.0000000000014637. [PMID: 30855449]
  • Zhao Yang Liu, Wen Bo Xie, Ming Ru Li, Nan Teng, Xiao Liang, Zi Qiang Zhang. Effects of polaprezinc on gastric mucosal damage and neurotransmitters in a rat model of chemotherapy-induced vomiting. The Journal of international medical research. 2018 Jun; 46(6):2436-2444. doi: 10.1177/0300060518771492. [PMID: 29756515]
  • Yasuhiro Taki, Naohiko Imai, Yugo Shibagaki. Zinc deficiency anaemia in haemodialysis patients: Often overlooked but a treatable cause of anaemia. Nephrology (Carlton, Vic.). 2017 12; 22(12):1037-1038. doi: 10.1111/nep.12993. [PMID: 29145703]
  • Hiroki Kobayashi, Masanori Abe, Kazuyoshi Okada, Ritsukou Tei, Noriaki Maruyama, Fumito Kikuchi, Terumi Higuchi, Masayoshi Soma. Oral zinc supplementation reduces the erythropoietin responsiveness index in patients on hemodialysis. Nutrients. 2015 May; 7(5):3783-95. doi: 10.3390/nu7053783. [PMID: 25988769]
  • Masahiro Murakami-Nakayama, Maho Tsubota, Saki Hiruma, Fumiko Sekiguchi, Kenji Matsuyama, Takeshi Kimura, Masahiro Moriyama, Atsufumi Kawabata. Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice. Journal of pharmacological sciences. 2015 Feb; 127(2):223-8. doi: 10.1016/j.jphs.2015.01.004. [PMID: 25727961]
  • Kensaku Sakae, Hiroyuki Yanagisawa. Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial. Biological trace element research. 2014 Jun; 158(3):280-8. doi: 10.1007/s12011-014-9943-5. [PMID: 24691900]
  • Shota Nishijima, Toru Yanase, Yuki Hata, Ryo Tamura, Ikunosuke Tsuneki, Masaki Tamura, Takumi Kurabayashi. [Orally administered polaprezinc significantly improves taste disorders in ovarian cancer patient undergoing chemotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy. 2011 Apr; 38(4):689-92. doi: NULL. [PMID: 21499007]
  • Joshua K Ko, Catherine C Leung. Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats. Journal of gastroenterology and hepatology. 2010 Dec; 25(12):1861-8. doi: 10.1111/j.1440-1746.2010.06347.x. [PMID: 21091998]
  • W Opoka, D Adamek, M Plonka, W Reczynski, B Bas, D Drozdowicz, P Jagielski, Z Sliwowski, P Adamski, T Brzozowski. Importance of luminal and mucosal zinc in the mechanism of experimental gastric ulcer healing. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2010 Oct; 61(5):581-91. doi: . [PMID: 21081802]
  • Tsukasa Takaoka, Nobuko Sarukura, Chizuru Ueda, Yoshiaki Kitamura, Bukasa Kalubi, Naoki Toda, Koji Abe, Shigeru Yamamoto, Noriaki Takeda. Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment. Auris, nasus, larynx. 2010 Apr; 37(2):190-4. doi: 10.1016/j.anl.2009.07.003. [PMID: 19716667]
  • Hiroki Hamano, Koji Yoshinaga, Takao Tanaka, Runa Eta, Takayuki Horii, Yoshihiro Kawabata, Shigeru Furuta, Mineo Takei. Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats. Life sciences. 2009 Nov; 85(21-22):759-64. doi: 10.1016/j.lfs.2009.10.006. [PMID: 19846043]
  • Masafumi Sakagami, Minoru Ikeda, Hiroshi Tomita, Akihiro Ikui, Tsunemasa Aiba, Noriaki Takeda, Akira Inokuchi, Yuichi Kurono, Mitsuyoshi Nakashima, Yuji Shibasaki, Osamu Yotsuya. A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study. Acta oto-laryngologica. 2009 Oct; 129(10):1115-20. doi: 10.1080/00016480802552550. [PMID: 19037756]
  • Tatsuo Fukushima, Hideyuki Horike, Shigeatsu Fujiki, Shingo Kitada, Tamaki Sasaki, Naoki Kashihara. Zinc deficiency anemia and effects of zinc therapy in maintenance hemodialysis patients. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2009 Jun; 13(3):213-9. doi: 10.1111/j.1744-9987.2009.00656.x. [PMID: 19527468]
  • Haruko Sugino, Naoki Kumagai, Sakiko Watanabe, Kyoko Toda, Osamu Takeuchi, Satoshi Tsunematsu, Shojiroh Morinaga, Kanji Tsuchimoto. Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis. Journal of gastroenterology and hepatology. 2008 Dec; 23(12):1909-16. doi: 10.1111/j.1440-1746.2008.05393.x. [PMID: 18422963]
  • Yoko Nakata, Tomonori Hirashima, Yoko Kondou, Yoshie Tokuoka, Hitomi Imazato, Kaori Iwata, Yukari Oomori, Akihiro Yamato, Saburou Shimizu, Sadako Nagao, Kaoru Matsui, Noriko Abe. [Involvement of zinc in taste disturbance occurring during treatment for malignant tumor in the chest and the effects of polaprezinc oral disintegrating tablets (a retrospective study)]. Gan to kagaku ryoho. Cancer & chemotherapy. 2008 Jun; 35(6):955-9. doi: NULL. [PMID: 18633224]
  • Takashi Himoto, Naoki Hosomi, Seiji Nakai, Akihiro Deguchi, Fumihiko Kinekawa, Michiko Matsuki, Mikage Yachida, Tsutomu Masaki, Kazutaka Kurokochi, Seishiro Watanabe, Shoichi Senda, Shigeki Kuriyama. Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease. Scandinavian journal of gastroenterology. 2007 Sep; 42(9):1078-87. doi: 10.1080/00365520701272409. [PMID: 17710674]
  • Yasuko Murakami, Tomoko Koyabu, Aiko Kawashima, Naoko Kakibuchi, Takayo Kawakami, Kouichi Takaguchi, Keiji Kita, Misako Okita. Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon alpha-2b and ribavirin. Journal of nutritional science and vitaminology. 2007 Jun; 53(3):213-8. doi: 10.3177/jnsv.53.213. [PMID: 17874825]
  • A Mahmood, A J FitzGerald, T Marchbank, E Ntatsaki, D Murray, S Ghosh, R J Playford. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut. 2007 Feb; 56(2):168-75. doi: 10.1136/gut.2006.099929. [PMID: 16777920]
  • Tsuyoshi Takada, Naoto Suzuki, Emi Ito-Kato, Yoshihiro Noguchi, Mitsuyasu Ito, Masao Maeno, Kichibee Otsuka. Effect of beta-alanyl-L-histidinato zinc on the differentiation of C2C12 cells. Life sciences. 2004 Dec; 76(5):509-20. doi: 10.1016/j.lfs.2004.06.014. [PMID: 15556164]
  • Masao Maeno, Emi Ito-Kato, Naoto Suzuki, Tsuyoshi Takada, Tadahiro Takayama, Koichi Ito, Kichibee Otsuka. Effect of beta-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cells. Life sciences. 2004 Apr; 74(20):2493-504. doi: 10.1016/j.lfs.2003.09.069. [PMID: 15010260]
  • H Takagi, T Nagamine, T Abe, H Takayama, K Sato, T Otsuka, S Kakizaki, Y Hashimoto, T Matsumoto, A Kojima, J Takezawa, K Suzuki, S Sato, M Mori. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. Journal of viral hepatitis. 2001 Sep; 8(5):367-71. doi: 10.1046/j.1365-2893.2001.00311.x. [PMID: 11555194]
  • H Suzuki, M Mori, K Seto, M Miyazawa, A Kai, M Suematsu, T Yoneta, S Miura, H Ishii. Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils--a study using intravital videomicroscopy. Alimentary pharmacology & therapeutics. 2001 May; 15(5):715-25. doi: 10.1046/j.1365-2036.2001.00960.x. [PMID: 11328267]
  • Y Naito, T Yoshikawa, N Yagi, K Matsuyama, N Yoshida, K Seto, T Yoneta. Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury. Digestive diseases and sciences. 2001 Apr; 46(4):845-51. doi: 10.1023/a:1010716804594. [PMID: 11330422]
  • T Sugiyama, H Tanaka, S Kawai. Improvement of periarticular osteoporosis in postmenopausal women with rheumatoid arthritis by beta-alanyl-L-histidinato zinc: a pilot study. Journal of bone and mineral metabolism. 2000; 18(6):335-8. doi: 10.1007/s007740070005. [PMID: 11052466]
  • T Nagamine, H Takagi, H Takayama, A Kojima, S Kakizaki, M Mori, K Nakajima. Preliminary study of combination therapy with interferon-alpha and zinc in chronic hepatitis C patients with genotype 1b. Biological trace element research. 2000; 75(1-3):53-63. doi: 10.1385/bter:75:1-3:53. [PMID: 11051596]
  • K Seto, T Yoneta, H Suda, H Tamaki. Effect of polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc), a novel antiulcer agent containing zinc, on cellular proliferation: role of insulin-like growth factor I. Biochemical pharmacology. 1999 Jul; 58(2):245-50. doi: 10.1016/s0006-2952(99)00078-7. [PMID: 10423164]
  • S Furuta, M Suzuki, S Toyama, M Miwa, H Sano. Tissue distribution of polaprezinc in rats determined by the double tracer method. Journal of pharmaceutical and biomedical analysis. 1999 Mar; 19(3-4):453-61. doi: 10.1016/s0731-7085(98)00236-2. [PMID: 10704111]
  • N Sugawara, M Katakura, C Sugawara. Preventive effect of zinc compounds, polaprezinc and zinc acetate against the onset of hepatitis in Long-Evans Cinnamon rat. Research communications in molecular pathology and pharmacology. 1999 Feb; 103(2):167-76. doi: NULL. [PMID: 10461683]
  • S Kato, H Nishiwaki, A Konaka, K Takeuchi. Mucosal ulcerogenic action of monochloramine in rat stomachs: effects of polaprezinc and sucralfate. Digestive diseases and sciences. 1997 Oct; 42(10):2156-63. doi: 10.1023/a:1018847324172. [PMID: 9365151]
  • I Yamaguchi, K Shibata, M Takei, K Matsuda. Changes in tissue contents of zinc, copper and iron in rats and beagle dogs treated with polaprezinc. The Journal of toxicological sciences. 1996 Aug; 21(3):177-87. doi: 10.2131/jts.21.3_177. [PMID: 8887886]
  • M Yamaguchi, Y Ehara. Zinc decrease and bone metabolism in the femoral-metaphyseal tissues of rats with skeletal unloading. Calcified tissue international. 1995 Sep; 57(3):218-23. doi: 10.1007/bf00310262. [PMID: 8574940]
  • K Matsuda, I Yamaguchi, H Wada. Toxicity of the novel anti-peptic ulcer agent polaprezinc in beagle dogs. Arzneimittel-Forschung. 1995 Jan; 45(1):52-60. doi: NULL. [PMID: 7893270]
  • M Yamaguchi, M Hashizume. Effect of beta-alanyl-L-histidinato zinc on protein components in osteoblastic MC3T3-El cells: increase in osteocalcin, insulin-like growth factor-I and transforming growth factor-beta. Molecular and cellular biochemistry. 1994 Jul; 136(2):163-9. doi: 10.1007/bf00926077. [PMID: 7845370]
  • S Kishi, Y Segawa, M Yamaguchi. Histomorphological confirmation of the preventive effect of beta-alanyl-L-histidinato zinc on bone loss in ovariectomized rats. Biological & pharmaceutical bulletin. 1994 Jun; 17(6):862-5. doi: 10.1248/bpb.17.862. [PMID: 7951157]
  • M Hashizume, M Yamaguchi. Effect of beta-alanyl-L-histidinato zinc on differentiation of osteoblastic MC3T3-E1 cells: increases in alkaline phosphatase activity and protein concentration. Molecular and cellular biochemistry. 1994 Feb; 131(1):19-24. doi: 10.1007/bf01075720. [PMID: 8047061]
  • S Kisi, M Yamaguchi. Stimulatory effect of beta-alanyl-L-histidinato zinc on alkaline phosphatase activity in bone tissues from elderly rats: comparison with zinc sulfate action. Biological & pharmaceutical bulletin. 1994 Feb; 17(2):345-7. doi: 10.1248/bpb.17.345. [PMID: 8205136]
  • M Yamaguchi, S Kishi. Prolonged administration of beta-alanyl-L-histidinato zinc prevents bone loss in ovariectomized rats. Japanese journal of pharmacology. 1993 Oct; 63(2):203-7. doi: 10.1254/jjp.63.203. [PMID: 8283831]
  • Y Segawa, N Tsuzuike, Y Itokazu, E Tagashira, M Yamaguchi. Effect of beta-alanyl-L-histidinato zinc on bone metabolism in rats with adjuvant arthritis. Biological & pharmaceutical bulletin. 1993 Jul; 16(7):656-9. doi: 10.1248/bpb.16.656. [PMID: 8401397]
  • M Hashizume, M Yamaguchi. Stimulatory effect of beta-alanyl-L-histidinato zinc on cell proliferation is dependent on protein synthesis in osteoblastic MC3T3-E1 cells. Molecular and cellular biochemistry. 1993 May; 122(1):59-64. doi: 10.1007/bf00925737. [PMID: 8350864]
  • Y Segawa, N Tsuzuike, E Tagashira, M Yamaguchi. Preventive effect of beta-alanyl-L-histidinato zinc on the deterioration of bone metabolism in ovariectomized rats. Biological & pharmaceutical bulletin. 1993 May; 16(5):486-9. doi: 10.1248/bpb.16.486. [PMID: 8364496]
  • O P Green, P Deoraj, C Gopinath, D Crook, K Matsuda. Toxicity of the novel anti-peptic ulcer agent catena-(S)-[mu-[Na- (3-aminopropionyl)histidinato(2-)-N1,N2,Q:N tau]-zinc in male cynomolgus monkeys. Arzneimittel-Forschung. 1993 May; 43(5):562-9. doi: NULL. [PMID: 8329001]
  • Y Segawa, N Tsuzuike, E Tagashira, M Yamaguchi. Preventive effect of beta-alanyl-L-histidinato zinc on bone metabolism in rats fed on low-calcium and vitamin D-deficient diets. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. 1992; 192(3):213-9. doi: 10.1007/bf02576277. [PMID: 1636066]
  • M Yamaguchi, Y Segawa, N Shimokawa, N Tsuzuike, E Tagashira. Inhibitory effect of beta-alanyl-L-histidinato zinc on bone resorption in tissue culture. Pharmacology. 1992; 45(5):292-300. doi: 10.1159/000139013. [PMID: 1465476]
  • Y Segawa, N Tsuzuike, Y Itokazu, E Tagashira, M Yamaguchi. beta-Alanyl-L-histidinato zinc prevents hydrocortisone-induced disorder of bone metabolism in rats. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. 1992; 192(5):317-22. doi: 10.1007/bf02576288. [PMID: 1439196]
  • T Yoshikawa, Y Naito, T Tanigawa, T Yoneta, M Kondo. The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-L-histidinato zinc. Biochimica et biophysica acta. 1991 Nov; 1115(1):15-22. doi: 10.1016/0304-4165(91)90005-2. [PMID: 1659910]
  • K Shibata, K Matsuda, H Wada, F Aruga, Y Yamada. Antigenicity studies on catena-(S)-[mu-[N alpha-(3-aminopropionyl)histidinato(2-)-N1,N2,O:N tau]-zinc]. Arzneimittel-Forschung. 1991 Oct; 41(10):1048-52. doi: NULL. [PMID: 1799382]
  • K Matsuda, Y Mera, H Wada, H Aruga, Y Saik, Y Taniguchi. Repeated dose toxicity studies on catena-(S)-[mu-[N alpha-(3-aminopropionyl) histidinato(2-)-N1,N2,O:N tau]-zinc] in rats. Arzneimittel-Forschung. 1991 Oct; 41(10):1036-41. doi: NULL. [PMID: 1799380]
  • S Furuta, S Toyama, M Miwa, Y Ikeda, H Sano, K Matsuda. Study on the metabolic fate of catena-(S)-[mu-[N alpha-(3-aminopropionyl)histidinato(2-)-N1,N2,O:N tau]-zinc]. 4th communication: disposition of zinc and amino acids in rats, dogs and monkeys. Arzneimittel-Forschung. 1991 Sep; 41(9):992-5. doi: NULL. [PMID: 1796930]
  • H Sano, S Furuta, S Toyama, M Miwa, Y Ikeda, M Suzuki, H Sato, K Matsuda. Study on the metabolic fate of catena-(S)-[mu-[N alpha-(3- aminopropionyl)histidinato(2-)-N1,N2,O:N tau]-zinc]. 1st communication: absorption, distribution, metabolism and excretion after single administration to rats. Arzneimittel-Forschung. 1991 Sep; 41(9):965-75. doi: NULL. [PMID: 1796927]
  • S Toyama, S Furuta, M Miwa, M Suzuki, H Sano, K Matsuda. Study on the metabolic fate of catena-(S)-[mu-[N alpha-(3- aminopropionyl)histidinato(2-)-N1,N2,O:N tau]-zinc]. 2nd communication: absorption, distribution, metabolism and excretion after repeated administration to rats. Arzneimittel-Forschung. 1991 Sep; 41(9):976-83. doi: NULL. [PMID: 1796928]
  • T Yoshikawa, Y Naito, T Tanigawa, T Yoneta, M Yasuda, S Ueda, H Oyamada, M Kondo. Effect of zinc-carnosine chelate compound (Z-103), a novel antioxidant, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Free radical research communications. 1991; 14(4):289-96. doi: 10.3109/10715769109088958. [PMID: 1874458]
  • M Yamaguchi, H Miwa. Stimulatory effect of beta-alanyl-L-histidinato zinc on bone formation in tissue culture. Pharmacology. 1991; 42(4):230-40. doi: 10.1159/000138802. [PMID: 1852783]
  • M Yamaguchi, J Ohtaki. Effect of beta-alanyl-L-histidinato zinc on osteoblastic MC3T3-E1 cells: increases in alkaline phosphatase and proliferation. Pharmacology. 1991; 43(4):225-32. doi: 10.1159/000138849. [PMID: 1771175]
  • M Yamaguchi, K Ozaki. Beta-alanyl-L-histidinato zinc prevents the toxic effect of aluminium on bone metabolism in weanling rats. Pharmacology. 1990; 41(6):338-44. doi: 10.1159/000138751. [PMID: 2096394]
  • T Tanigawa, T Yoshikawa, Y Naito, T Yoneta, S Ueda, H Oyamada, T Takemura, Y Morita, K Tainaka, N Yoshida. Antioxidative action of zinc-carnosine compound Z-103. Advances in experimental medicine and biology. 1990; 264(?):223-8. doi: 10.1007/978-1-4684-5730-8_36. [PMID: 2173871]
  • M Yamaguchi, K Ozaki. Effect of the new zinc compound beta-alanyl-L-histidinato zinc on bone metabolism in elderly rats. Pharmacology. 1990; 41(6):345-9. doi: 10.1159/000138752. [PMID: 2096395]