Exact Mass: 242.1306728
Exact Mass Matches: 242.1306728
Found 500 metabolites which its exact mass value is equals to given mass value 242.1306728,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Thiopental
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920) D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CA - Barbiturates, plain N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AF - Barbiturates, plain D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators D002491 - Central Nervous System Agents > D000927 - Anticonvulsants C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent EAWAG_UCHEM_ID 2742; CONFIDENCE standard compound CONFIDENCE standard compound; EAWAG_UCHEM_ID 2742
1,5-Diphenylcarbazide
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents KEIO_ID D166; [MS2] KO009100 KEIO_ID D166
Selagine
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents D020011 - Protective Agents D004791 - Enzyme Inhibitors (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
4,4a,5,6,7,8-Hexahydro-6-(p-hydroxyphenyl)-2(3H)-naphthalenone
(3S,5R,6R,7E)-3,5,6-Trihydroxy-7-megastigmen-9-one
(3S,5R,6R,7E)-3,5,6-Trihydroxy-7-megastigmen-9-one is found in herbs and spices. (3S,5R,6R,7E)-3,5,6-Trihydroxy-7-megastigmen-9-one is a constituent of New Zealand thyme honey (Thymus vulgaris). Constituent of New Zealand thyme honey (Thymus vulgaris). (3S,5R,6R,7E)-3,5,6-Trihydroxy-7-megastigmen-9-one is found in herbs and spices.
2-Carboxy-4-dodecanolide
2-Carboxy-4-dodecanolide is found in milk and milk products. 2-Carboxy-4-dodecanolide is a possible latent butter aroma compoun
(-)-Huperzine A (HupA)
2-(Ethoxymethyl)-1h-Imidazo[4,5-C]quinolin-4-Amine
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(3-hydroxy-1-methylbutyl)-
Diethylene glycol dimethacrylate
Huperzine_A
LSM-1581 is a quinolone. (+/-)-Huperzine A is a natural product found in Streptomyces coelicoflavus and Huperzia with data available. D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents D020011 - Protective Agents D004791 - Enzyme Inhibitors Huperzine A is a sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimers disease. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a neuroprotective agent, a plant metabolite and a nootropic agent. It is a sesquiterpene alkaloid, a pyridone, a primary amino compound and an organic heterotricyclic compound. It is a conjugate base of a huperzine A(1+). Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer’s disease. Huperzine A is a natural product found in Phlegmariurus varius, Phlegmariurus tetrastichus, and other organisms with data available. A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimers disease. C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
(4R)-4-(Hydroxymethyl)-3-(6-methylheptanoyl)dihydro-2(3H)-furanone
Methyl 5-methyl-8-isopropyl-2-naphthalenecarboxylate
[1R-(1alpha,2beta,3beta)]-3-Hydroxy-2-(hydroxymethyl)-3-methyl-gamma-methylene-cyclopentanebutanoic acid methyl ester
1-Acetoxy-7-hydroperoxy-3,7-dimethyl-2E,5E-octadien-4-one
Huperzine A
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents Origin: Plant; SubCategory_DNP: Sesquiterpenoids D020011 - Protective Agents D004791 - Enzyme Inhibitors (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
4,N2,N6-trimethyl-1H-cyclohepta[1,2-d;4,5-d]diimidazole-2,6-diamine|Parazoanthoxanthin
(-)-butane-1,3-diyl 1-((Z)-2-methyl-2-butenoate) 3-isobutyrate
5-hydroxy-hexadeca-6t,8t,14t-triene-10,12-diynal cyclohemiacetal|6-undeca-1,3t,9t-triene-5,7-diyn-t-yl-tetrahydro-pyran-2-ol
3-(4-Hydroxy-3,5-dimethoxyphenyl)-3-methoxy-1-propanol
(all-E)-form-16-Hydroxy-2,8,10-hexadecatriene-4,6-diynal|16-hydroxy-hexadeca-2E,8E,10E-trien-4,6-diyn-1-al
trans-6-hydroxymethyl-3-methyl-7-oxo-undecan-4-olide
Me ether-(2R*,5R*,1E,3E,9Z)-form-Tetrahydro-5-(1,3,9-undecatriene-5,7-diynyl)-2-furanol,
8-Hydroxy-2,7-dimethyl-2,4-decadienedioic acid|8-Hydroxy-2,7-dimethyl-decadien-(2,4)-disaeure-(1,10)
1,4,N8-trimethyl-1H-cyclohepta[1,2-d;3,4-d]diimidazole-2,8-diamine
(2R,3S,4R,4aS,7R,8aS)-hexahydro-3,4-dihydroxy-7-methyl-2-[(1E)-prop-1-enyl]pyrano[4,3-b]pyran-5(7H)-one|(?)-dinemasone B|dinemasone B
trans-8,9-dihydroxy-3-methyldodec-cis-6-en-4-olide
1-Hydroxy-6-(2-methypropyl)-3-[2-(methylthio)-ethyl]-2(1H)-pyrazinone
Ac-6-Tetrdecene-8,10,12-triyn-3-ol|artemisia acetate
(1S,2R,2S,6S)-4-(2-Hydroxy-2,6-dimethyl-5-oxocyclohexyl)-2-methylbutanoic acid
1-Acetoxy-tetradeca-4,6,12-trien-8,10-diin|1-Acetoxy-tetradeca-4t,6t,12t-trien-8,10-diin|1-Acetoxy-tetradecatrien-(4,6,12)-diin-(8,10)|14-acetoxy-tetradeca-2t,8t,10t-triene-4,6-diyne|Ac-4,6,12-Tetradecatriene-8,10-diyn-1-ol,
cordysinin E
A member of the class of beta-carbolines that is beta-carboline substituted by a (2R)-2,3-dihydroxypropyl group at position 1. It has been isolated from the mycelia of Cordyceps sinensis.
(2R)-4-(2,2-dimethyl-5-oxotetrahydrofuran-3-yl)-2-hydroxypent-3-anoic acid methyl ester|dasycarpus ester B
(3R,4R,5S,6R)-4-hydroxy-6-((R,E)-3-hydroxy-3-methylpent-1-en-1-yl)-3,5-dimethyltetrahydro-2H-pyran-2-one|3-hydroxy-8-((E)-10-hydroxy-10-methylpentenyl)-2,4-dimethyltetrahydropyranone
(all-E)-6,8,14-Hexadecatriene-10,12-diyn-1-ol|6,8,14-Hexadecatriene-10,12-diyn-1-ol
8-N-desmethylparagracine|Dimethuylpseudozoanthoxanthin A
1-Hydroxy-3-(2-methylpropul)-6-[2-(methylthio)-ethyl]-2-(1H)-pyrazinone
S-(trans-3-Oxoundec-4-enyl)thioacetat|S-Ac-1-Mercapto-4-undecen-3-one
6-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene
(4aS),( 10bS)-7-amino-3,4,4a,5,6,10b-hexahydro-2,4-dimethyl-6-oxobenzo[f]quinoline
2,5,6-Trihydroxy-7-megastigmen-9-one|trihydroxy-beta-ionone
2-methylpropane-1,3-diyl 1-((Z)-2-methyl-2-butenoate) 3-isobutyrate
(+)-isoacetylsaturejol|Acetylsaturejol|isoacetylsaturejol
1-ethyl-4-methoxy-9H-pyrido<3,4-b>indol-5-ol|5-hydroxycrenatine
(2E,4E)-8-Hydroxy-2,7-dimethyl-decadien-(2,4)-disaeure-(1,10)-dioic acid
Dihydrolapachenole
Dihydrolapachenole is a naturally occurring quinone[1].
HuperzineA
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors relative retention time with respect to 9-anthracene Carboxylic Acid is 0.361 D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents D020011 - Protective Agents D004791 - Enzyme Inhibitors relative retention time with respect to 9-anthracene Carboxylic Acid is 0.348 (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
1-(2,4,5-trimethoxyphenyl)propane-1,2-diol
C13H22O4_6-Oxabicyclo[3.2.1]octane-3,8-diol, 8-[(1E)-3-hydroxy-1-buten-1-yl]-1,5-dimethyl
C13H22O4_(3E)-4-(1,2,4-Trihydroxy-2,6,6-trimethylcyclohexyl)-3-buten-2-one
thiopental
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CA - Barbiturates, plain N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AF - Barbiturates, plain D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators D002491 - Central Nervous System Agents > D000927 - Anticonvulsants C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
Huperzin A
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2242 D020011 - Protective Agents D004791 - Enzyme Inhibitors INTERNAL_ID 2242; CONFIDENCE Reference Standard (Level 1) (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5]. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
14-METHOXY-4,4-BISNOR-4,8,11,13-PODOCARPATETRAEN-3-ONE
(3S,5R,6R,7E)-3,5,6-Trihydroxy-7-megastigmen-9-one
Ieodomycin A
A natural product found in Bacillus species.
2-hydroxy-N-methyl-N-(pyridin-4-ylmethyl)benzamide
N-(TERT-BUTYL)-3-(2-HYDROXYPROPAN-2-YL)-5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOLE-1-CARBOXAMIDE
2-METHYL-3-((PYRIDIN-2-YLMETHYL)AMINO)BENZOIC ACID
3-(dimethylaminomethyl)-1,2,3,9-tetrahydro-4h-carbazole-4-one
4-AMINOMETHYL-1-N-BUTYLPIPERIDINE 2HCL
C10H24Cl2N2 (242.13164439999997)
7-ISOPROPYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5-CARBOXYLIC ACID
2-{5-[(1H-1,2,4-TR IAZOOL-1-YL)METHYL]INDOOL-3-YL}ETHAAN-1-OL
vinylmethylbis(methylethylketoximino)silane
C11H22N2O2Si (242.14504720000002)
6-(4-Tert-butylphenoxy)pyridin-3-amine
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
Benzeneacetic acid, a-hydroxy-a-phenyl-, hydrazide
1-(2-Ethoxyphenyl)piperazinium chloride
C12H19ClN2O (242.11858339999998)
isonixin
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
5-ISOPROPYL-4-METHOXY-2-METHYL-BENZENESULFONYL CHLORIDE
METHYL 5-CYCLOPROPYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE
ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclopentane-1-carboxylate
6-Benzyl-5,7-dioxo-hexahydropyrrolo[3,4-b]pyridine
[[[[3-(aminomethyl)phenyl]methyl]amino]methyl]phenol
7-(2-FURYLMETHYL)-5,6-DIMETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE
methyl 2-cyano-3-(2,3-dihydro-2-methyl-1H-indol-1-yl)acrylate
BENZO[1,3]DIOXOL-5-YLMETHYL-PYRIDIN-3-YLMETHYL-AMINE
Phenol,4-chloro-2,6-bis[(dimethylamino)methyl]-
C12H19ClN2O (242.11858339999998)
1-(PIPERIDIN-4-YL)SPIRO[CYCLOPROPANE-1,3-INDOLIN]-2-ONE
Pyrrolidine, 1-[(4-hydroxy-3-quinolinyl)carbonyl]- (9CI)
7-Isopropoxy-6-methyl-4-oxo-1,4-dihydro-3-quinolinecarbonitrile
2-(1,3-DIOXOLAN-2-ON-4-YL)-1-ETHYLBORONIC ACID PINACOL ESTER
C11H19BO5 (242.13254740000002)
2-(4-(TERT-BUTYL)PHENOXY)ACETIMIDAMIDE HYDROCHLORIDE
C12H19ClN2O (242.11858339999998)
(2,5-DIMETHOXY-BENZYL)-(2-METHOXY-1-METHYL-ETHYL)-AMINE
Ethyl 8-formyl-1,4-dioxaspiro[4.5]decane-8-carboxylate
2,2-[5-(Hydroxymethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
3-[(2,5-DIMETHYLBENZYL)OXY]-6-METHYLPYRIDIN-2-AMINE
N,N-Diethyl-cyclohexane-1,4-diamine dihydrochloride
C10H24Cl2N2 (242.13164439999997)
tert-butyl ((3S,4S)-4-azidotetrahydro-2H-pyran-3-yl)carbamate
1-(2-BENZO[1,3]DIOXOL-5-YL-IMIDAZO[1,2-A]PYRIMIDIN-3-YLMETHYL)-PIPERIDINE-3-CARBOXYLICACID
Morpholine,4,4-(1,3-dioxo-1,3-propanediyl)bis- (9CI)
TERT-BUTYL 3-OXOTETRAHYDRO-1H-OXAZOLO[3,4-A]PYRAZINE-7(3H)-CARBOXYLATE
4-Oxo-1,1-cyclohexanedicarboxylic acid 1,1-diethyl ester
5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole
C11H19ClN4 (242.12981639999998)
(2,4-DICHLOROPHENOXY)ACETICACID-BUTOXYPOLYPROPYLENEGLYCOLESTER
4-N-(4,6-dimethylpyrimidin-2-yl)-4-N-ethylbenzene-1,4-diamine
(1-((2-(TRIMETHYLSILYL)ETHOXY)METHYL)-1H-PYRAZOL-5-YL)BORONIC ACID
C9H19BN2O3Si (242.12579340000002)
2-[(4,4-Diethoxy-2-butyn-1-yl)oxy]tetrahydro-2H-pyr
Monoethylglycinexylidide hydrochloride
C12H19ClN2O (242.11858339999998)
2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-5-[[(trimethylsilyl)oxy]methyl]-
CID 4369233
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents D020011 - Protective Agents D004791 - Enzyme Inhibitors (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease. (±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
8-[(E)-3-hydroxybut-1-enyl]-1,5-dimethyl-6-oxabicyclo[3.2.1]octane-3,8-diol
N-[(E)-Cyclohexylmethylideneamino]-1H-benzimidazol-2-amine
(5-Ethyl-8-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)hydrazine
3,4-Epoxy-4-(trimethylsilylmethyl)-1-cyclohexanecarboxylic acid methyl ester
C12H22O3Si (242.13381420000002)
(3R,4R)-4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one
A butan-4-olide that is gamma-butyrolactone with a 6-methylheptanoyl substituent at position 3 and a hydroxymethyl substituent at position 4 (the 3R,4R-stereoisomer).
Diphenylcarbazide
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(3-hydroxy-1-methylbutyl)-
4,10-dihydroxy-12-methyl-1-oxacyclododec-5-ene-2,8-dione
2-methyl-2-(4-methylpenta-1,3-dien-1-yl)chromen-6-ol
1-[5-(2-hydroxybutyl)furan-2-yl]-3-methoxybutan-2-ol
7,8-dihydroxy-10-(1-hydroxypropyl)-7,8,9,10-tetrahydrooxecin-2-one
4,5-dihydroxy-3-[3-(2-hydroxypropan-2-yl)oxiran-2-yl]-6-methylcyclohex-2-en-1-one
(5e,7s)-5-propylidene-3,9-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),10,12-trien-2-one
(1s,6s,7r)-6,7-dihydroxy-1-[(1r)-1-hydroxybutyl]-3,5,6,7-tetrahydro-1h-2-benzofuran-4-one
(6r,7s)-6-ethenyl-6-methyl-7-(prop-1-en-2-yl)-7,8-dihydro-5h-naphthalene-1,4-dione
3,4-dihydroxy-7-methyl-2-(prop-1-en-1-yl)-hexahydro-2h-pyrano[3,2-c]pyran-5-one
ethyl (4r,4ar,7s,7as)-7-hydroxy-7-methyl-1-oxo-hexahydrocyclopenta[c]pyran-4-carboxylate
(1r,2s,3s)-2-[(2r)-butan-2-yl]-2,3-dihydroxy-3-methyl-5-methylidene-4-oxocyclopentane-1-carboxylic acid
4-(2,5-dihydroxycyclohexyl)-2-methylbut-2-en-1-yl acetate
(5s,6s,7ar)-7a-hydroxy-3,3,6-trimethyl-6,7-dihydro-5h-1,2-benzodioxol-5-yl acetate
7-amino-2,4-dimethyl-3h,4ah,5h,10bh-benzo[f]quinolin-6-one
(3r,4r,5s,6r)-4-hydroxy-6-[(1e)-3-hydroxy-3-methylpent-1-en-1-yl]-3,5-dimethyloxan-2-one
(3s,8as)-8a-hydroperoxy-1-hydroxy-3-(2-methylpropyl)-3h,6h,7h,8h-pyrrolo[1,2-a]pyrazin-4-one
(2e,8e,10e)-16-hydroxyhexadeca-2,8,10-trien-4,6-diynal
(5s)-2-(2-ethoxy-2-methylpropylidene)-5-hydroxy-5,6-dihydropyran-4-carboxylic acid
(1s,2s)-1-(2,4,5-trimethoxyphenyl)propane-1,2-diol
6-ethenyl-6-methyl-7-(prop-1-en-2-yl)-7,8-dihydro-5h-naphthalene-1,4-dione
(1s,9r,10r)-17-hydroxy-17-azatetracyclo[7.5.3.0¹,¹⁰.0²,⁷]heptadeca-2,4,6,13-tetraen-17-ium
4-(1,3,6-trihydroxy-2,2,6-trimethylcyclohexyl)but-3-en-2-one
13-acetoxy-9-tetradecene-2,4,6-triyne
{"Ingredient_id": "HBIN001122","Ingredient_name": "13-acetoxy-9-tetradecene-2,4,6-triyne","Alias": "NA","Ingredient_formula": "C16H18O2","Ingredient_Smile": "NA","Ingredient_weight": "242.31","OB_score": "NA","CAS_id": "6581-88-0","SymMap_id": "NA","TCMID_id": "NA","TCMSP_id": "NA","TCM_ID_id": "9335","PubChem_id": "NA","DrugBank_id": "NA"}
2,5,6-trihydroxy-7-megastigmen-9-one
{"Ingredient_id": "HBIN004583","Ingredient_name": "2,5,6-trihydroxy-7-megastigmen-9-one","Alias": "NA","Ingredient_formula": "C13H22O4","Ingredient_Smile": "NA","Ingredient_weight": "242.31","OB_score": "NA","CAS_id": "135447-37-9","SymMap_id": "NA","TCMID_id": "NA","TCMSP_id": "NA","TCM_ID_id": "8872","PubChem_id": "NA","DrugBank_id": "NA"}
3-n-butyl-3-hydroxy-4,5,6,7-tetrahydro-6,7-dihydrox phthalide
{"Ingredient_id": "HBIN008976","Ingredient_name": "3-n-butyl-3-hydroxy-4,5,6,7-tetrahydro-6,7-dihydrox phthalide","Alias": "NA","Ingredient_formula": "C12H18O5","Ingredient_Smile": "Not Available","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "30693","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}
annuionone f
{"Ingredient_id": "HBIN016244","Ingredient_name": "annuionone f","Alias": "NA","Ingredient_formula": "C13H22O4","Ingredient_Smile": "CC1CC(=O)CC(C1(C=CC(C)O)O)(C)CO","Ingredient_weight": "NA","OB_score": "NA","CAS_id": "NA","SymMap_id": "NA","TCMID_id": "1337","TCMSP_id": "NA","TCM_ID_id": "NA","PubChem_id": "NA","DrugBank_id": "NA"}