Exact Mass: 223.0856
Exact Mass Matches: 223.0856
Found 187 metabolites which its exact mass value is equals to given mass value 223.0856,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
bendiocarb
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor CONFIDENCE standard compound; INTERNAL_ID 8476 CONFIDENCE standard compound; INTERNAL_ID 4024 CONFIDENCE standard compound; INTERNAL_ID 2606 D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals
N-acetyltyrosine
N-Acetyl-L-tyrosine or N-Acetyltyrosine, belongs to the class of organic compounds known as N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. N-Acetyltyrosine can also be classified as an alpha amino acid or a derivatized alpha amino acid. Technically, N-Acetyltyrosine is a biologically available N-terminal capped form of the proteinogenic alpha amino acid L-tyrosine. N-acetyl amino acids can be produced either via direct synthesis of specific N-acetyltransferases or via the proteolytic degradation of N-acetylated proteins by specific hydrolases. N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins (PMID: 16465618). About 85\\\% of all human proteins and 68\\\% of all yeast proteins are acetylated at their N-terminus (PMID: 21750686). Several proteins from prokaryotes and archaea are also modified by N-terminal acetylation. The majority of eukaryotic N-terminal-acetylation reactions occur through N-acetyltransferase enzymes or NAT’s (PMID: 30054468). These enzymes consist of three main oligomeric complexes NatA, NatB, and NatC, which are composed of at least a unique catalytic subunit and one unique ribosomal anchor. The substrate specificities of different NAT enzymes are mainly determined by the identities of the first two N-terminal residues of the target protein. The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G) (PMID: 30054468). NatA also exists in a monomeric state and can post-translationally acetylate acidic N-termini residues (D-, E-). NatB and NatC acetylate N-terminal methionine with further specificity determined by the identity of the second amino acid. N-acetylated amino acids, such as N-acetyltyrosine can be released by an N-acylpeptide hydrolase from peptides generated by proteolytic degradation (PMID: 16465618). In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free tyrosine can also occur. Many N-acetylamino acids, including N-acetyltyrosine are classified as uremic toxins if present in high abundance in the serum or plasma (PMID: 26317986; PMID: 20613759). Uremic toxins are a diverse group of endogenously produced molecules that, if not properly cleared or eliminated by the kidneys, can cause kidney damage, cardiovascular disease and neurological deficits (PMID: 18287557). N-Acetyl-L-tyrosine, has also been associated with several inborn metabolic disorders including tyrosinemia I and aromatic l-amino acid decarboxylase deficiency. N-acetyltyrosine, is used in place of as a tyrosine precursor and administered as a source of nutritional support where oral nutrition is inadequate or cannot be tolerated (PMID: 14621123). N-acetyltyrosine has also been identified as an endogenous stress response factor. Under stress conditions, mitochondria release low levels of reactive oxygen species (ROS), which triggers a cytoprotective response, called "mitohormesis". N-acetyltyrosine has recently been identified as an intrinsic triggering factor of mitohormesis in stressed animals (PMID: 32118349). Interventions and small molecules, which promote formation of reactive oxygen species (ROS), have been shown to increase stress resistance and lifespan of different model organisms. These phenotypes occur only in response to low concentrations of ROS, while higher concentrations of ROS exert opposing effects. In this regard, a stress-dependent increase in N-acetyltyrosine was recently found to occur in insect larvae that had endured high temperatures (i.e. thermal stress). N-acetyltyrosine treatment has also been demonstrated to induce thermotolerance in several tested insect species. N-acetyltyrosine has been identified in the serum of humans as well as mice, and its concentration in mice was shown to be increased by heat s... Acetyltyrosine is a side chain reaction of tyrosine. It converts to tyrosine and then can be used in neurotransmitter treatment as a precursor of cathecholamine (http://www.neuroassist.com/). [HMDB] N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.
Norketamine
Norketamine is the main metabolite of Ketamine. Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative. When administered orally, it undergoes first-pass metabolism, where it is biotransformed in the liver by CYP3A4 (major), CYP2B6 (minor), and CYP2C9 (minor) isoenzymes into norketamine (through N-demethylation) and finally dehydronorketamine. (Wikipedia)
Salsolinol 1-carboxylate
Salsolinol-1-carboxylic acid is an intermediate metabolite formed during the synthesis with dopamine and pyruvate towards the endogenous neurotoxin, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol),which has been considered a potential causative factor for Parkinsons disease (PD). Salsolinol-1-carboxylic acid can be directly metabolized by an unknown enzyme to salsolinol or at first to 1,2-dehydrosalsolinol and then to salsolinol. Salsolinol-1-carboxylic acid is an intermediate metabolite formed during the synthesis with dopamine and pyruvate towards the endogenous neurotoxin, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol),which has been considered a potential causative factor for Parkinsons disease (PD)
2-hydroxyphenylpropionylglycine
2-Hydroxyphenylpropionylglycine is classified as a member of the N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. 2-Hydroxyphenylpropionylglycine is considered to be practically insoluble (in water) and acidic.
3-hydroxyphenylpropionylglycine
3-Hydroxyphenylpropionylglycine is classified as a member of the N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. 3-Hydroxyphenylpropionylglycine is considered to be practically insoluble (in water) and acidic.
4-hydroxyphenylpropionylglycine
4-Hydroxyphenylpropionylglycine is classified as a member of the N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. 4-Hydroxyphenylpropionylglycine is considered to be practically insoluble (in water) and acidic.ÂÂ
5-hydroxyphenylpropionylglycine
5-Hydroxyphenylpropionylglycine is classified as a member of the N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. 5-Hydroxyphenylpropionylglycine is considered to be practically insoluble (in water) and acidic.
6-hydroxyphenylpropionylglycine
6-Hydroxyphenylpropionylglycine is classified as a member of the N-acyl-alpha amino acids. N-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. 6-Hydroxyphenylpropionylglycine is considered to be practically insoluble (in water) and acidic.ÂÂ
Salsolinol-1-carboxylic acid
4,6-Dimethyl-1-nitro-4-(trifluoromethyl)cyclohexene
5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one
MEPHENOXALONE
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics
(4aS,7aS)-methyl 7-(hydroxymethyl)-1-oxo-2,4a,5,7a-tetrahydro-1H-cyclopenta[c]pyridine-4-carboxylate|gardenamide|gardenamide A
2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-, (E)-
5-hydroxy-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one
N,N-dihydroxytrihomomethionine
An N,N-dihydroxy-alpha-amino acid having a 6-thiaheptyl substituent at the 2-position.
N-Acetyl-L-tyrosine
An N-acetyltyrosine in which the chiral centre has L configuration. N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.
Acetyl-L-tyrosine
N-Acetyl-L-tyrosine originates from tyrosine through an AA acetylase, is associated with aromatic L-amino acid decarboxylase deficiency and tyrosinemia I.
Ethyl 7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate
N-(4-cyano-3-methyl-1,2-thiazol-5-yl)-3-methylbutanamide
(5-(Cyclopropylcarbamoyl)-2-fluorophenyl)boronic acid
5-(2-METHYL-3-FURYL)-4-PROPYL-4H-1,2,4-TRIAZOLE-3-THIOL
5-METHYL-1-PHENYL-(1H-PYRAZOL-4-YLMETHYL)AMINE HYDROCHLORIDE
3-AMINO-3-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-PROPIONIC ACID
5-(hydroxymethyl)-3-(4-methoxyphenyl)-1,3-oxazolidin-2-one
1-Propanone,3-chloro-1-(3,4-dihydro-2(1H)-isoquinolinyl)-
(4-(Cyclopropylcarbamoyl)-3-fluorophenyl)boronic acid
4,7-Methano-2H-isoindole-2-aceticacid, octahydro-1,3-dioxo-
(6-(Dimethoxymethyl)furo[3,2-b]pyridin-2-yl)methanol
(4-CYCLOPROPYL-6-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-HYDRAZINE
1,2,3,4-TETRAHYDRO-7-HYDROXY-6-METHOXY-3-ISOQUINOLINECARBOXYLIC ACID
(4-(cyclopropylcarbamoyl)-2-fluorophenyl)boronic acid
N-METHOXY-N-METHYL-2,3-DIHYDROBENZO[B][1,4]DIOXINE-2-CARBOXAMIDE
2-ACETAMIDO-2,4-DIDEOXY-4-FLUORO-ALPHA-D-GLUCOPYRANOSE
2-CHLORO-1-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-PROPAN-1-ONE
3-(2,3-dihydro-1,4-benzodioxin-6-ylamino)propanoic acid
Methyl 5-amino-4-fluoro-1-methyl-1H-benzimidazole-6-carboxylate
(S)-1-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHANAMINE HYDROCHLORIDE
ETHYL 8-AMINO-2,3-DIHYDROBENZO[1,4]DIOXINE-5-CARBOXYLATE
(4-((1H-PYRAZOL-1-YL)METHYL)PHENYL)METHANAMINE HYDROCHLORIDE
Imafen hydrochloride
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acid
(2S)-2-(dihydroxyamino)-7-(methylsulfanyl)heptanoic acid
4-N-Hydroxyiminomethyl-2,5-dimethoxy-6-methyltropone
bendiocarb
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor D010575 - Pesticides > D007306 - Insecticides D016573 - Agrochemicals
N-Acetyltyrosine
An N-acetyl-amino acid that is tyrosine with an amine hydrogen substituted by an acetyl group.
